Lorazepam combined with Phenytoin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Tachycardia Other Serious 53 Male 1/5/2006 Pharmacist United States
Primary
Secondary
International Normalised Ratio Increased 7/22/2004 9/12/2005 Physician United States
Primary
Concomitant
Hemiparesis Hospitalization 3/13/2004 61 Female 128 lb 1/18/2006 Physician United States
Primary
Concomitant
Neuroleptic Malignant Syndrome Other Serious 12/14/2005 Male 2/22/2006 Pharmacist United States
Primary
Concomitant
Anticonvulsant Drug Level Below Therapeutic 9/1/2005 55 Male 2/28/2006 Consumer United States
Primary
Concomitant
Psychotic Disorder Required Intervention 3/31/2006 42 Male 216 lb 6/21/2006 Physician Germany
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 81 Female 7/7/2006 Canada
Primary
Secondary
Concomitant
Grand Mal Convulsion Other Serious 5/10/2006 52 Female 155 lb 8/18/2006 Physician United States
Primary
Concomitant
Rash Other Serious 8/1/2006 47 Male 166 lb 8/14/2006 United States
Primary
Secondary
Concomitant
Purple Glove Syndrome Other Serious 8/1/2006 47 Male 166 lb 8/17/2006 Pharmacist United States
Primary
Secondary
Concomitant
Convulsion Hospitalization 6/22/2006 Male 9/11/2006 Pharmacist United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 9/9/2004 55 Female 10/20/2006 United States
Primary
Concomitant
Intra-uterine Death Death 11/30/2006 Physician Canada
Primary
Secondary
Concomitant
Renal Impairment Required Intervention 31 Female 11/30/2006 Physician Canada
Primary
Secondary
Concomitant
Rash Erythematous Required Intervention 2/15/2007 45 Male 185 lb 2/16/2007 Pharmacist United States
Primary
Concomitant
Legal Problem Hospitalization 12 Male 3/8/2007 New Zealand
Primary
Concomitant
Urinary Tract Infection Hospitalization 2/17/2007 60 Female 150 lb 4/11/2007 Pharmacist United States
Primary
Concomitant
Psychotic Disorder Hospitalization 4/24/1998 16 Male 1/9/2007 Consumer United States
Primary
Concomitant
Phaeochromocytoma Other Serious 34 Female 5/3/2007 Physician United States
Primary
Concomitant
Confusional State Hospitalization 9/29/2006 51 Female 3/14/2007 Consumer United States
Primary
Concomitant
Splenomegaly Death 3/12/2007 32 Male 165 lb 8/31/2007 United States
Primary
Secondary
Concomitant
Respiratory Failure Life Threatening 5/19/2007 76 Female 132 lb 10/15/2007 Pharmacist United States
Primary
Concomitant
Skin Laceration Hospitalization 8/1/2007 72 Female 132 lb 10/22/2007 Physician United States
Primary
Concomitant
Pulmonary Oedema Death 3/12/2007 32 Male 165 lb 10/11/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Skin Laceration Hospitalization 8/8/2007 72 Female 132 lb 1/15/2008 Physician United States
Primary
Concomitant
Fall Hospitalization 10/26/2007 69 Male 146 lb 1/11/2008 Physician United States
Primary
Concomitant
Intra-uterine Death Other Serious 31 Female 1/18/2008 Physician Canada
Primary
Secondary
Concomitant
Renal Impairment Other Serious 31 Female 1/18/2008 Physician Canada
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 7/13/2007 71 Female 1/14/2008 Physician United States
Primary
Concomitant
Intra-uterine Death Other Serious 31 Female 1/21/2008 Physician Canada
Primary
Secondary
Concomitant
Tachycardia Other Serious 1/1/2002 52 Female 150 lb 1/25/2008 Other Health Professional United States
Primary
Concomitant
Supraventricular Extrasystoles Required Intervention 3/13/2007 70 Female 1/24/2008 Other Health Professional United States
Primary
Concomitant
Rhabdomyolysis Life Threatening 1/1/2008 37 Female 231 lb 2/8/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Life Threatening 1/1/2008 37 Female 231 lb 2/20/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Status Epilepticus Life Threatening 1/1/2008 37 Female 231 lb 2/19/2008 United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 12/18/2002 76 Male 2/26/2008 Physician Germany
Primary
Secondary
Toxic Epidermal Necrolysis Life Threatening 10/27/2004 76 Female 2/29/2008 Physician Germany
Primary
Secondary
Concomitant
Vomiting Death 2/24/2008 Male 99 lb 2/25/2008 Physician United States
Primary
Concomitant
Vomiting Hospitalization 2/18/2008 Male 99 lb 2/19/2008 Physician United States
Primary
Concomitant
Rhabdomyolysis Life Threatening 1/1/2008 37 Female 231 lb 3/7/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 11/1/2002 Male 3/3/2008 Physician Germany
Primary
Secondary
Toxic Epidermal Necrolysis Life Threatening 10/24/2004 Female 3/6/2008 Physician Germany
Primary
Secondary
Concomitant
Pallor Hospitalization 1/4/2008 Female 189 lb 3/14/2008 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 7/13/2007 71 Female 3/14/2008 Physician United States
Primary
Concomitant
Anticonvulsant Drug Level Increased Other Serious 58 Male 3/20/2008 Belgium
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 41 Female 4/9/2008 Physician Canada
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 12/18/2002 76 Male 4/10/2008 Physician Germany
Primary
Secondary
Weight Decreased Hospitalization 1/1/2007 49 Male 5/5/2008 Consumer Canada
Primary
Concomitant
Sedation Hospitalization 42 Male 5/8/2008
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Other Serious 61 Female 6/18/2008 Other Health Professional United Kingdom
Primary
Concomitant
Drug Exposure During Pregnancy Other Serious 34 Female 6/20/2008
Primary
Concomitant
Shock Death 64 Male 6/19/2008 Other Health Professional United States
Primary
Concomitant
Spinal Osteoarthritis Hospitalization 5/12/2008 60 Female 200 lb 6/18/2008 Physician United States
Primary
Secondary
Concomitant
Swollen Tongue Life Threatening 6/8/2008 81 Male 222 lb 6/26/2008 Pharmacist United States
Primary
Concomitant
Shock Required Intervention 64 Male 6/30/2008 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Other Serious 41 Female 7/7/2008 Canada
Primary
Concomitant
Stem Cell Transplant Hospitalization 5/12/2008 60 Female 200 lb 7/14/2008 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 41 Female 7/17/2008 Canada
Primary
Concomitant
Somnolence 6/30/2008 80 Male 152 lb 9/3/2008 Pharmacist United States
Primary
Secondary
Hepatotoxicity Other Serious 4 9/23/2008 Consumer United States
Primary
Secondary
Concomitant
Mental Disorder Hospitalization 1/1/2007 Female 202 lb 9/26/2008 United States
Primary
Secondary
Concomitant
Metabolic Acidosis Other Serious 59 Female 10/7/2008 United States
Primary
Concomitant
Status Epilepticus Required Intervention 3/13/2007 70 Female 11/7/2008 Other Health Professional United States
Primary
Concomitant
Serotonin Syndrome Other Serious 46 Female 12/4/2008
Primary
Secondary
Concomitant
Seasonal Allergy 7/1/2008 Female 12/12/2008 Consumer United States
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 12/1/2005 48 Female 12/17/2008 Physician Germany
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 12/15/2008 50 Male 12/16/2008 Pharmacist United States
Primary
Concomitant
Urinary Tract Infection Life Threatening 2/6/2008 14 Female 97 lb 12/19/2008 Physician United States
Primary
Secondary
Concomitant
Completed Suicide Death 69 Male 12/29/2008 Pharmacist United States
Primary
Secondary
Completed Suicide Death 69 Male 12/31/2008 Physician United States
Primary
Secondary
Concomitant
Oesophagitis Hospitalization 6/9/2008 60 Male 249 lb 12/22/2008 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 11/23/2008 1/5/2009 Physician Chile
Primary
Secondary
Concomitant
Status Epilepticus Hospitalization 9/1/2004 59 Female 1/13/2009
Primary
Secondary
Concomitant
Oesophagitis Hospitalization 6/9/2008 60 Male 249 lb 1/13/2009 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 11/23/2008 1/20/2009 Physician Chile
Primary
Secondary
Concomitant
Status Epilepticus Hospitalization 9/1/2004 59 Female 1/21/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Completed Suicide Death 69 Male 1/15/2009 Physician United States
Primary
Secondary
Respiratory Failure Other Serious 11/23/2008 1/22/2009 Physician Chile
Primary
Secondary
Concomitant
Grand Mal Convulsion Other Serious 37 Male 176 lb 1/23/2009 Pharmacist Canada
Primary
Secondary
Concomitant
Poisoning Death 69 Male 1/19/2009 Physician United States
Primary
Secondary
Drug Abuse Death 69 Male 1/26/2009
Primary
Secondary
Therapeutic Agent Toxicity Required Intervention 19 Male 1/19/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Intentional Overdose Death 69 Male 1/27/2009 Physician United States
Primary
Secondary
Poisoning Deliberate Death 69 Male 1/16/2009 Physician United States
Primary
Secondary
Completed Suicide Death 69 Male 1/21/2009 Physician United States
Primary
Secondary
Completed Suicide Death 69 Male 1/30/2009 Other Health Professional United States
Primary
Secondary
Completed Suicide Death 1/1/2007 69 Male 1/20/2009 Physician United States
Primary
Secondary
Death Death 1/1/2007 69 Male 2/3/2009 Pharmacist United States
Primary
Secondary
Intentional Overdose Death 78 Female 2/6/2009 Physician United States
Primary
Concomitant
Seasonal Allergy 7/1/2008 Female 3/14/2009 United States
Primary
Concomitant
Muscle Rigidity Other Serious 58 Male 3/16/2009 Pharmacist Belgium
Primary
Concomitant
Completed Suicide Death 69 Male 3/24/2009 Other Health Professional United States
Primary
Secondary
Intentional Overdose Death 69 Male 3/25/2009 Consumer United States
Primary
Secondary
Drug Abuse Death 69 Male 3/25/2009 Consumer United States
Primary
Secondary
Pneumonia Death 78 Female 3/23/2009 United States
Primary
Secondary
Concomitant
Drug Toxicity Death 68 Female 3/23/2009 United States
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 11/23/2008 3/24/2009 Physician Chile
Primary
Secondary
Concomitant
Intentional Overdose Death 69 Male 3/26/2009 Consumer United States
Primary
Secondary
Drug Abuse Death 69 Male 3/26/2009 Consumer United States
Primary
Secondary
Drug Abuse Death 69 Male 3/30/2009 Consumer United States
Primary
Secondary
Intentional Overdose Death 69 Male 3/30/2009 Consumer United States
Primary
Secondary
Ventricular Tachycardia Other Serious 73 Female 3/23/2009 Physician Germany
Primary
Concomitant
Respiratory Failure Other Serious 11/23/2008 4/7/2009 Physician Chile
Primary
Secondary
Concomitant
Pneumonia Death 78 Female 4/2/2009 United States
Primary
Secondary
Renal Failure Acute Hospitalization 1 Female 5/1/2009 Physician Turkey
Primary
Secondary
Concomitant
Serotonin Syndrome 3/1/2009 55 Female 156 lb 3/30/2009 Pharmacist United States
Primary
Concomitant
Hepatomegaly Other Serious 13 Female 110 lb 5/11/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 1 Female 5/15/2009 Physician Turkey
Primary
Secondary
Concomitant
Embolic Cerebral Infarction Other Serious 6 Male 6/12/2009
Primary
Secondary
Concomitant
Sepsis Death 72 Male 6/12/2009 Germany
Primary
Secondary
Concomitant
Hepatomegaly Other Serious 13 Female 6/18/2009 Physician United States
Primary
Secondary
Concomitant
Mental Disorder Hospitalization 1/1/2007 Female 202 lb 6/23/2009 Physician United States
Primary
Secondary
Concomitant
Muscle Rigidity Other Serious 58 Male 6/24/2009 Belgium
Primary
Secondary
Concomitant
Wound Infection Hospitalization 1/5/2005 60 Male 132 lb 6/23/2009 Lawyer United States
Primary
Concomitant
Leukopenia Other Serious 4/1/2009 38 Male 190 lb 6/23/2009 Physician Germany
Primary
Concomitant
Tachycardia Other Serious 1/1/2002 52 Female 140 lb 7/16/2009 United States
Primary
Concomitant
Ventricular Extrasystoles Hospitalization 5/9/1996 Male 9/23/2009 Physician
Primary
Secondary
Ventricular Fibrillation Life Threatening 4/28/2009 61 Female 236 lb 10/2/2009 Physician United States
Primary
Concomitant
Ventricular Extrasystoles Hospitalization 5/9/1996 Male 10/7/2009 Physician
Primary
Secondary
Toxic Epidermal Necrolysis Other Serious 6/24/2007 Male 209 lb 10/6/2009 Consumer United States
Primary
Concomitant
Status Asthmaticus Hospitalization 7/13/2009 Male 10/2/2009 Physician United States
Primary
Concomitant
Vasoconstriction Death 73 Male 143 lb 10/6/2009 Other Health Professional Switzerland
Primary
Concomitant
Muscle Rigidity Hospitalization 58 Male 10/21/2009 Other Health Professional Belgium
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Other Serious 6/24/2007 Male 209 lb 10/27/2009 Consumer United States
Primary
Concomitant
Anticonvulsant Drug Level Above Therapeutic Life Threatening 9/13/2009 66 Female 139 lb 9/14/2009 Pharmacist United States
Primary
Concomitant
X-ray Abnormal Hospitalization 0 Female 10/26/2009 Other Health Professional United States
Primary
Secondary
Weight Decreased Hospitalization 1/5/2005 60 Male 132 lb 11/2/2009 Lawyer United States
Primary
Concomitant
Tachycardia Death 10/30/2009 29 Male 247 lb 11/4/2009 Pharmacist United States
Primary
Concomitant
Status Asthmaticus Hospitalization 7/13/2009 Male 10/30/2009 Physician United States
Primary
Concomitant
Pneumonia Death 78 Female 11/4/2009 Physician United States
Primary
Secondary
Concomitant
Septic Shock Other Serious 11/23/2008 68 Female 165 lb 11/26/2009 Physician Chile
Primary
Secondary
Concomitant
Blood Glucose Increased Required Intervention 10/6/2009 40 Female 126 lb 10/7/2009 Pharmacist United States
Primary
Concomitant
Toxic Encephalopathy Other Serious 9/24/2008 50 Male 149 lb 2/10/2010 Pharmacist United States
Primary
Concomitant
Toxic Epidermal Necrolysis Other Serious 6/24/2007 Male 209 lb 3/1/2010 Consumer United States
Primary
Concomitant
Troponin Increased 4/13/2009 72 Male 160 lb 4/21/2009 Pharmacist United States
Primary
Concomitant
Urinary Tract Infection Other Serious 2/1/2008 75 Female 198 lb 3/3/2010 Lawyer United States
Primary
Secondary
Concomitant
Laboratory Test Interference Death 1/13/2010 21 Female 170 lb 1/14/2010 Pharmacist United States
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 2/18/2010 74 Male 3/29/2010 Pharmacist Japan
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 2/25/2010 74 Male 3/30/2010 Pharmacist Japan
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 2/1/2010 74 Male 4/9/2010 Pharmacist Japan
Primary
Concomitant
Thrombocytopenia Other Serious 55 Male 5/20/2010 Pharmacist United States
Primary
Concomitant
Interacting
Hypocalcaemia Hospitalization 57 Male 5/17/2010 Physician United States
Primary
Concomitant
Nervous System Disorder Other Serious 11 Female 6/1/2010 Other Health Professional United States
Primary
Concomitant
Lung Neoplasm Malignant Other Serious 1/1/2008 73 Male 6/10/2010 Lawyer United States
Primary
Concomitant
Acute Generalised Exanthematous Pustulosis Hospitalization 57 Male 6/18/2010 Physician United States
Primary
Concomitant
Dementia Death 4/20/2010 84 Male 6/24/2010 Other Health Professional United States
Primary
Concomitant
Respiratory Tract Inflammation Other Serious 4/1/2010 64 Male 6/28/2010 Physician United States
Primary
Concomitant
Anaphylactic Reaction Life Threatening 6/12/2010 3 Male 33 lb 7/1/2010 Other Health Professional United Kingdom
Primary
Concomitant
Respiratory Tract Inflammation Other Serious 4/1/2010 64 Male 7/7/2010 Physician United States
Primary
Concomitant
Hypotension Other Serious 1/3/2008 76 Male 7/7/2010 Other Health Professional United States
Primary
Concomitant

Drug Data