Lorazepam combined with Methadone

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Suicide Attempt Hospitalization 12/19/2005 26 Male 1/25/2006 Physician Germany
Primary
Secondary
Upper Respiratory Tract Infection Hospitalization 1/13/2006 44 Male 249 lb 2/10/2006 Pharmacist United States
Primary
Concomitant
Somnolence Life Threatening 12/17/2005 47 Male 150 lb 4/11/2006 Other Health Professional Denmark
Primary
Secondary
Concomitant
Throat Tightness Other Serious 4/7/2006 31 Male 240 lb 4/21/2006 Consumer United States
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 2/16/2006 30 Male 5/17/2006 Pharmacist Canada
Primary
Secondary
Concomitant
Pulmonary Congestion Hospitalization 10/1/2006 54 Female 190 lb 1/2/2007 Physician United States
Primary
Concomitant
Rash 1/1/2006 Male 10/19/2006 Physician United States
Primary
Concomitant
Vomiting Hospitalization 54 Male 9/12/2007
Primary
Concomitant
Vomiting Hospitalization 45 Female 9/13/2007
Primary
Secondary
Concomitant
Small Intestinal Obstruction Hospitalization 10/30/2007 3 Female 162 lb 11/10/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Completed Suicide Death 9/13/2005 28 Male 154 lb 11/27/2007 Physician Switzerland
Primary
Concomitant
Ventricular Tachycardia Life Threatening 10/5/2007 49 Male 6/23/2008 Pharmacist United States
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Other Serious 10/10/2007 Male 190 lb 3/27/2009 Consumer
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Other Serious 10/10/2007 Male 190 lb 3/30/2009 Consumer
Primary
Secondary
Concomitant
Vomiting Other Serious 56 Male 3/31/2009
Primary
Secondary
Type 2 Diabetes Mellitus Death 1/1/1996 45 Male 4/2/2009 United States
Primary
Concomitant
Weight Increased Other Serious 8/1/2005 42 Female 257 lb 4/3/2009 United States
Primary
Concomitant
Tearfulness Other Serious 8/11/2004 60 Female 160 lb 4/3/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious Male 190 lb 4/14/2009 Consumer United States
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Other Serious Male 190 lb 4/16/2009 Consumer United States
Primary
Secondary
Concomitant
Wound Dehiscence Hospitalization 7/19/2001 45 Female 189 lb 4/29/2009 United States
Primary
Concomitant
Neuropathy Peripheral Other Serious 10/13/2008 48 Female 245 lb 5/7/2009 United States
Primary
Concomitant
Vein Disorder Other Serious 1/1/2009 Female 5/20/2009 Consumer United States
Primary
Concomitant
Rhabdomyolysis Other Serious 1/28/2009 Male 165 lb 5/28/2009 Physician United States
Primary
Concomitant
Insulin-requiring Type 2 Diabetes Mellitus Other Serious 4/29/2002 50 Female 388 lb 6/1/2009 United States
Primary
Concomitant
Hepatic Failure Other Serious 5/16/2009 Female 148 lb 6/25/2009 Physician United States
Primary
Concomitant
Electrocardiogram Qt Prolonged Required Intervention 1/29/2009 55 Female 196 lb 5/5/2009 Pharmacist United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/30/2008 Female 108 lb 7/2/2009 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2005 47 Male 208 lb 8/31/2009 United States
Primary
Concomitant
Visual Acuity Reduced Hospitalization 7/9/2005 52 Female 153 lb 9/23/2009 United States
Primary
Concomitant
Ventricular Extrasystoles Hospitalization 5/9/1996 Male 9/23/2009 Physician
Primary
Secondary
Ventricular Extrasystoles Other Serious 5/1/1996 Male 10/2/2009 Physician United States
Primary
Secondary
Neonatal Respiratory Distress Syndrome Other Serious 4/28/2009 Male 10/22/2009 Physician Denmark
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/1/2005 Female 142 lb 11/30/2009 Consumer United States
Primary
Concomitant
Vomiting Other Serious 12/4/2009 Physician United States
Primary
Secondary
Vision Blurred Other Serious 1/1/2002 Female 195 lb 12/28/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 1/1/2002 Female 195 lb 1/15/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Other Serious 12/1/2009 Female 223 lb 1/20/2010 Physician United States
Primary
Concomitant
Neuropathy Peripheral Other Serious 1/1/2007 47 Female 254 lb 1/29/2010 United States
Primary
Concomitant
Skin Fissures 11/1/2009 Female 175 lb 1/30/2010 United States
Primary
Concomitant
Neuropathy Peripheral Other Serious 1/1/2007 47 Female 254 lb 2/2/2010 United States
Primary
Concomitant
Poisoning Death 1/1/2008 46 Female 1/28/2010 Physician United States
Primary
Secondary
Completed Suicide Death 12/1/2009 46 Female 2/1/2010 Physician United States
Primary
Secondary
Drug Withdrawal Syndrome Hospitalization 1/19/2010 Male 2/18/2010 Physician
Primary
Secondary
Concomitant
Pulmonary Oedema Death 25 Male 2/19/2010 Other Health Professional United States
Primary
Secondary
Pulmonary Oedema Death 25 Male 2/22/2010 Physician United States
Primary
Concomitant
Interacting
Pulmonary Oedema Death 25 Male 2/22/2010 Physician United States
Primary
Concomitant
Interacting
Electrocardiogram Qt Prolonged Other Serious 1/19/2010 Male 2/22/2010 Physician
Primary
Secondary
Concomitant
Paranoid Personality Disorder Other Serious 1/1/2007 47 Female 254 lb 2/23/2010 United States
Primary
Concomitant
Wound Other Serious 2/23/2005 Male 190 lb 2/26/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Platelet Count Decreased 9/18/2009 61 Female 1/28/2010 Other Health Professional United States
Primary
Concomitant
Wound Drainage Other Serious 10/29/2001 Female 144 lb 3/2/2010 Physician United States
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 6/1/2009 Female 3/2/2010 Physician United Kingdom
Primary
Concomitant
Tooth Extraction Other Serious 1/1/2002 Female 3/3/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 1/1/2002 Female 195 lb 3/8/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Wound Drainage Other Serious 10/29/2001 Female 144 lb 3/19/2010 Physician United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2002 Female 195 lb 3/25/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Death Death 1/1/2008 46 Female 3/24/2010 Other Health Professional United States
Primary
Secondary
Tooth Extraction Other Serious 1/1/2002 Female 3/26/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Tricuspid Valve Incompetence Other Serious 1/1/2004 3/29/2010 Physician United States
Primary
Concomitant
Unevaluable Event Other Serious 1/1/2003 Male 3/29/2010 Physician United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2002 Female 195 lb 3/30/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Rash Other Serious 3/19/2010 54 Male 121 lb 4/23/2010 Physician United States
Primary
Concomitant
Suicide Attempt Other Serious Male 4/28/2010 Physician United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2002 56 Female 195 lb 5/12/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Rash Other Serious 3/19/2010 54 Male 121 lb 5/18/2010 Physician United States
Primary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 1/19/2010 65 Male 5/24/2010 Physician
Primary
Secondary
Concomitant
Tooth Infection Other Serious 3/4/1996 25 Female 5/27/2010 Pharmacist United States
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Other Serious 8/25/2002 43 Male 257 lb 6/1/2010 United States
Primary
Concomitant
Haemolysis Other Serious 3/19/2010 13 Female 126 lb 5/7/2010 United States
Primary
Concomitant
Withdrawal Syndrome Hospitalization 2/24/2010 49 Female 6/11/2010 Other Health Professional Italy
Primary
Concomitant
Weight Decreased Other Serious 1/1/2004 6/15/2010 United States
Primary
Concomitant
Vomiting Other Serious 1/1/2005 47 Male 208 lb 6/16/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2004 6/17/2010 United States
Primary
Concomitant
Venous Occlusion Other Serious 1/1/2003 59 Male 6/21/2010 United States
Primary
Concomitant
Hypoglycaemia Neonatal Hospitalization 8/11/2009 6/18/2010 Physician Switzerland
Primary
Concomitant
Failed Trial Of Labour Other Serious 11/1/2008 40 Female 6/18/2010 Physician Switzerland
Primary
Concomitant
Venous Occlusion Other Serious 1/1/2003 59 Male 6/25/2010 United States
Primary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 1/19/2010 65 Male 6/30/2010 Physician
Primary
Secondary
Concomitant
Cardiac Failure Death 5/27/2010 Male 6/30/2010 Physician United States
Primary
Concomitant
Spinal Deformity Other Serious 5/1/2005 34 Male 143 lb 7/2/2010 United States
Primary
Concomitant
Venous Occlusion Other Serious 1/1/2003 59 Male 7/2/2010 United States
Primary
Concomitant
Vision Blurred Other Serious 11/1/2006 69 Male 194 lb 7/8/2010 Other Health Professional United States
Primary
Concomitant
Venous Occlusion Other Serious 1/1/2003 59 Male 7/9/2010 United States
Primary
Concomitant
Somnolence Female 234 lb 8/3/2010 Consumer United States
Primary
Secondary
Concomitant
Interacting
Suicide Attempt Other Serious 8/11/2007 30 Female 8/24/2010 Lawyer United States
Primary
Concomitant
Wrong Technique In Drug Usage Process Hospitalization 6/1/2010 50 Female 215 lb 9/1/2010 Consumer United States
Primary
Secondary
Concomitant
Venous Occlusion Other Serious 1/1/2003 59 Male 9/1/2010 Other Health Professional United States
Primary
Concomitant
Weight Decreased Other Serious 9/26/2002 28 Female 9/1/2010 Physician United States
Primary
Secondary
Concomitant
Therapy Cessation Death 1/12/2010 68 Male 9/1/2010 Pharmacist United States
Primary
Concomitant
Toothache Other Serious 10/4/2004 57 Male 212 lb 9/8/2010 United States
Primary
Concomitant
Death Death 8/18/2010 90 Female 140 lb 9/13/2010 Consumer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 6/1/2004 51 Female 158 lb 9/17/2010 United States
Primary
Concomitant
Pancreatitis Acute Hospitalization 8/26/2004 54 Female 100 lb 9/20/2010 United States
Primary
Concomitant
Hyperphosphataemia Other Serious 8/19/2010 Male 93 lb 9/21/2010 Pharmacist United States
Primary
Concomitant
Vaginitis Bacterial Other Serious 3/4/1996 25 Female 9/28/2010 Pharmacist United States
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 1/1/2002 41 Female 9/30/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Enterobacter Sepsis Hospitalization 8/28/2007 57 Male 136 lb 10/4/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 8/8/2000 25 Female 10/4/2010 Physician United States
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 12/1/2006 43 Female 10/4/2010 United States
Primary
Secondary
Concomitant
Wound Drainage Other Serious 1/1/2002 73 Female 144 lb 10/7/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pharyngeal Oedema Other Serious 3/1/2008 28 Female 168 lb 10/7/2010 Other Health Professional United States
Primary
Concomitant
Wound Drainage Other Serious 1/1/2002 73 Female 144 lb 10/7/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2003 59 Male 10/8/2010 Other Health Professional United States
Primary
Concomitant
Weight Decreased Other Serious 8/8/2000 25 Female 10/12/2010 Physician United States
Primary
Secondary
Concomitant
Wound Drainage Other Serious 1/1/2002 73 Female 144 lb 10/12/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 6/1/2010 51 Female 10/13/2010 Physician Switzerland
Primary
Concomitant
Hyperphosphataemia Other Serious 8/19/2010 Male 93 lb 10/13/2010 Pharmacist United States
Primary
Concomitant
Lung Neoplasm Malignant Death 55 Male 10/20/2010 Consumer United States
Primary
Concomitant
Thrombocytopenia Other Serious 6/1/2010 51 Female 10/25/2010 Physician Switzerland
Primary
Concomitant
Ventricular Tachycardia Other Serious 2/1/2008 12 Female 66 lb 10/28/2010 Lawyer United States
Primary
Secondary
Concomitant
Toothache Other Serious 10/4/2004 57 Male 212 lb 11/5/2010 United States
Primary
Concomitant
Toothache Other Serious 10/4/2004 57 Male 212 lb 11/8/2010 United States
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 1/30/2009 28 Male 103 lb 11/2/2010 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/2010 67 Male 270 lb 11/12/2010 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 8/8/2000 25 Female 11/24/2010 Physician United States
Primary
Secondary
Concomitant
Unevaluable Event 11/1/2010 55 Male 200 lb 11/23/2010 Consumer United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization Male 103 lb 11/18/2010 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/2002 50 Female 188 lb 12/6/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 8/8/2000 25 Female 12/14/2010 Physician United States
Primary
Secondary
Concomitant
Psoriasis 2/1/2009 12/20/2010 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/2002 50 Female 188 lb 12/22/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Thrombocytosis Other Serious 41 Male 12/28/2010 Other Health Professional Netherlands
Primary
Concomitant
Bone Lesion Hospitalization 8/8/2000 25 Female 1/11/2011 United States
Primary
Secondary
Concomitant
Completed Suicide Death 20 Male 1/13/2011 Physician United States
Primary
Secondary
Hyperaesthesia Other Serious 14 Male 1/13/2011 Physician United States
Primary
Secondary
Concomitant
Convulsion Other Serious 12/1/2006 43 Female 1/18/2011 Physician United States
Primary
Secondary
Concomitant
Radiculitis Lumbosacral Hospitalization 3/4/1996 25 Female 1/18/2011 Lawyer United States
Primary
Secondary
Concomitant
Vaginal Haemorrhage Other Serious 8/8/2000 25 Female 1/19/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 1/7/2008 64 Male 1/31/2011 Lawyer United States
Primary
Concomitant
Helicobacter Gastritis Other Serious 41 Male 1/20/2011
Primary
Secondary
Completed Suicide Death 1/1/2009 39 Male 1/26/2011 Physician United States
Primary
Secondary
Poisoning Death 1/1/2009 20 Male 1/26/2011 Physician United States
Primary
Secondary
Intraocular Pressure Test Abnormal Other Serious 1/7/2008 64 Male 2/10/2011 Other Health Professional United States
Primary
Concomitant
Decreased Interest Death 10/4/2004 57 Male 212 lb 2/10/2011 Lawyer United States
Primary
Concomitant
Platelet Count Increased Hospitalization Male 103 lb 2/1/2011 Other Health Professional United States
Primary
Concomitant
Neoplasm Malignant Other Serious 10/4/2004 57 Male 212 lb 2/24/2011 Lawyer United States
Primary
Concomitant
Headache Hospitalization 1/7/2008 64 Male 2/28/2011 Other Health Professional United States
Primary
Concomitant
Purpura Hospitalization Male 103 lb 2/16/2011 Other Health Professional United States
Primary
Concomitant
Completed Suicide Death 39 Male 3/4/2011 Physician United States
Primary
Secondary
Death Death Male 3/4/2011 Pharmacist United Kingdom
Primary
Concomitant
Cardio-respiratory Arrest Death 20 Male 3/7/2011 Physician United States
Primary
Secondary
Cystitis Other Serious 6/9/2010 69 Female 139 lb 3/9/2011 Consumer United States
Primary
Secondary
Concomitant
Cardiomegaly Death 25 Male 3/7/2011 Other Health Professional United States
Primary
Concomitant
Fall Hospitalization 2/23/2005 47 Male 190 lb 3/23/2011 Lawyer United States
Primary
Secondary
Concomitant
Metastases To Meninges Other Serious 1/1/2004 3/25/2011 Physician United States
Primary
Concomitant
Acute Respiratory Distress Syndrome Life Threatening 11/16/2010 14 Female 130 lb 3/29/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gait Disturbance Hospitalization 2/23/2005 47 Male 190 lb 3/29/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Toxicity To Various Agents Hospitalization 11/28/2010 39 Female 364 lb 2/6/2011 Pharmacist United States
Primary
Concomitant
Headache Other Serious 1/1/2002 41 Female 3/30/2011 Lawyer United States
Primary
Secondary
Concomitant

Drug Data