Loperamide combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Fluid Overload Other Serious 9/9/2005 71 Female 179 lb 1/4/2006 Other Health Professional United States
Primary
Concomitant
Pneumonia Aspiration Hospitalization 4/22/2006 70 Male 178 lb 4/24/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Haemorrhage Hospitalization 1/5/2006 67 Male 191 lb 5/8/2006 Other Health Professional United States
Primary
Concomitant
Thrombotic Thrombocytopenic Purpura Other Serious 2/26/2006 35 Female 220 lb 5/18/2006 Physician Canada
Primary
Secondary
Concomitant
Rectal Haemorrhage Hospitalization 1/20/2006 Male 5/16/2006 Pharmacist United States
Primary
Concomitant
Urethral Haemorrhage 4/18/2006 76 Male 5/16/2006 Other Health Professional United Kingdom
Primary
Concomitant
Staphylococcal Infection Other Serious 1/1/2006 63 Male 121 lb 5/18/2006 Physician United States
Primary
Secondary
Concomitant
Gynaecomastia Other Serious 4/1/2005 38 Male 139 lb 5/5/2006 United States
Primary
Concomitant
Vomiting Hospitalization 7/25/2006 67 Male 8/7/2006 Physician United Kingdom
Primary
Concomitant
Vomiting Hospitalization 7/25/2006 67 Male 8/18/2006 Physician United Kingdom
Primary
Concomitant
International Normalised Ratio Increased Other Serious 2/15/2006 69 Male 130 lb 9/11/2006 United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 9/5/2006 56 Male 142 lb 9/13/2006 Pharmacist United States
Primary
Secondary
Concomitant
Fluid Overload Other Serious 9/9/2005 71 Female 179 lb 10/6/2006 Other Health Professional United States
Primary
Concomitant
Vomiting Required Intervention 8/7/2006 88 Male 169 lb 9/20/2006 Pharmacist United States
Primary
Concomitant
International Normalised Ratio Increased Other Serious 2/15/2006 69 Male 130 lb 10/16/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 11/7/2006 57 Male 158 lb 11/17/2006 Pharmacist United States
Primary
Concomitant
Weight Decreased Other Serious 54 Female 12/1/2006 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Syncope Death 2/4/2008 63 Male 165 lb 2/25/2008 United Kingdom
Primary
Secondary
Concomitant
Syncope Life Threatening 2/4/2008 63 Male 2/29/2008 United Kingdom
Primary
Secondary
Concomitant
Tongue Ulceration Hospitalization 1/10/2008 67 Female 2/29/2008 United Kingdom
Primary
Secondary
Concomitant
Tongue Ulceration Hospitalization 1/10/2008 67 Female 3/5/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hypotension Hospitalization 4/1/2008 57 Female 4/18/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Hypotension Hospitalization 4/1/2008 57 Female 4/30/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 5/3/2008 75 Male 6/9/2008 Physician Australia
Primary
Concomitant
Hypotension Hospitalization 4/1/2008 57 Female 7/14/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 2/6/2006 Male 183 lb 11/5/2008 Germany
Primary
Concomitant
Pleural Effusion Hospitalization 2/6/2006 Male 183 lb 11/11/2008 Germany
Primary
Concomitant
Ulcerative Keratitis Hospitalization 11/6/2008 Male 138 lb 11/20/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Ulcerative Keratitis Hospitalization 11/6/2008 Male 138 lb 11/25/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Nausea Hospitalization 2/25/2009 3/10/2009 Physician Sweden
Primary
Secondary
Concomitant
Nausea Hospitalization 2/25/2009 3/18/2009 Physician Sweden
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 2/6/2006 4/3/2009 Germany
Primary
Concomitant
Renal Failure Acute Other Serious 2/11/2009 4/6/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/18/2009 4/6/2009 Physician Sweden
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/18/2009 4/10/2009 Physician Sweden
Primary
Secondary
Concomitant
Thirst Hospitalization 2/11/2009 74 Male 146 lb 4/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 2/11/2009 5/4/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 2/11/2009 74 6/11/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hypovolaemia Life Threatening 5/1/2009 Female 8/10/2009 Physician Norway
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 7/20/2009 55 Male 8/18/2009 Other Health Professional United Kingdom
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 65 Female 155 lb 8/24/2009 United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 8/1/2007 76 Male 198 lb 9/3/2009 Lawyer United States
Primary
Concomitant
Renal Failure Acute Hospitalization 7/20/2009 55 Male 9/9/2009 Other Health Professional Denmark
Primary
Concomitant
Vomiting Hospitalization 2/18/2009 71 9/17/2009 Physician Sweden
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Hospitalization 64 Female 155 lb 9/17/2009 United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 Female 10/1/2009 Physician United States
Primary
Concomitant
Therapeutic Agent Toxicity Required Intervention 64 Female 155 lb 9/24/2009 United States
Primary
Concomitant
Renal Failure Acute Other Serious 2/11/2009 74 10/14/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 9/11/2009 77 Female 10/16/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Required Intervention 64 Female 10/12/2009 United States
Primary
Concomitant
Vertigo Hospitalization 8/31/2009 Female 151 lb 10/27/2009 Physician Germany
Primary
Concomitant
White Blood Cell Count Increased Other Serious 8/1/2007 76 Male 198 lb 11/17/2009 Other Health Professional United States
Primary
Concomitant
Vertigo Hospitalization 8/31/2009 Female 151 lb 11/18/2009 Physician Germany
Primary
Concomitant
Pyrexia Hospitalization 10/28/2009 58 Male 11/18/2009 Physician United States
Primary
Secondary
Concomitant
Neutropenic Sepsis Hospitalization 7/15/2008 84 Male 165 lb 11/19/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 2/6/2006 50 Male 184 lb 11/20/2009 Germany
Primary
Concomitant
Therapeutic Agent Toxicity Required Intervention 64 Female 155 lb 11/20/2009 United States
Primary
Concomitant
Hospitalisation Hospitalization 3/23/2009 Male 12/1/2009 Physician United Kingdom
Primary
Concomitant
Hypoglycaemia Life Threatening 11/19/2009 71 Male 12/7/2009 Netherlands
Primary
Concomitant
Melaena Other Serious 11/19/2009 71 Male 12/8/2009 Netherlands
Primary
Concomitant
Melaena Other Serious 11/19/2009 71 Male 12/10/2009 Netherlands
Primary
Concomitant
Peritonitis Bacterial Other Serious 1/1/2009 62 Male 11/3/2009 Other Health Professional United States
Primary
Concomitant
Vertigo Hospitalization 8/31/2009 Female 151 lb 12/22/2009 Physician Germany
Primary
Concomitant
Melaena Other Serious 11/19/2009 71 Male 1/8/2010 Netherlands
Primary
Concomitant
Melaena Other Serious 11/19/2009 71 Male 1/14/2010 Netherlands
Primary
Concomitant
Chest Pain Hospitalization 1/2/2010 52 Male 1/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/1999 Female 1/20/2010 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/1999 Female 1/29/2010 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/1999 Female 2/13/2010 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 12/1/2007 53 Male 161 lb 2/17/2010 Other Health Professional United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 Female 3/2/2010 Physician United States
Primary
Concomitant
Troponin I Increased Other Serious 7/1/2009 65 Female 3/2/2010 United States
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 2/11/2009 74 Male 146 lb 3/5/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/1999 Female 3/12/2010 Physician United States
Primary
Concomitant
Pleural Effusion Hospitalization 10/23/2007 76 Male 154 lb 3/18/2010 Other Health Professional Germany
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 Female 3/26/2010 Physician United States
Primary
Concomitant
Vertigo Hospitalization 8/31/2009 Female 146 lb 3/31/2010 Physician Germany
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 58 Female 4/8/2010 Physician United States
Primary
Concomitant
Enterocutaneous Fistula Hospitalization 4/12/2010 60 4/19/2010 Physician Netherlands
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 12/1/2007 53 Male 161 lb 4/20/2010 Other Health Professional United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 58 Female 4/27/2010 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 58 Female 5/3/2010 Physician United States
Primary
Concomitant
Impaired Healing Hospitalization 4/12/2010 60 203 lb 6/2/2010 Physician Netherlands
Primary
Secondary
Concomitant
Middle Insomnia Hospitalization 4/8/2010 75 Male 4/19/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 58 Female 6/24/2010 Physician United States
Primary
Concomitant
Urinary Tract Infection Other Serious 10/3/2006 52 Male 161 lb 7/12/2010 Other Health Professional United States
Primary
Concomitant
Pneumonia Hospitalization 7/8/2010 74 Female 152 lb 7/14/2010 Physician Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/1995 57 Male 7/19/2010 United States
Primary
Secondary
Concomitant
Sicca Syndrome Other Serious 3/3/2009 75 Female 141 lb 7/23/2010 Physician United Kingdom
Primary
Concomitant
Hyperkeratosis Other Serious Male 182 lb 7/29/2010 Consumer United Kingdom
Primary
Concomitant
Weight Increased Other Serious 1/1/1995 57 Male 8/6/2010 United States
Primary
Secondary
Concomitant
Pneumonia Aspiration Hospitalization 7/8/2010 74 Female 152 lb 8/9/2010 Physician Japan
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 6/18/2010 69 Male 8/9/2010 Other Health Professional Sweden
Primary
Secondary
Concomitant
Actinic Keratosis Other Serious Male 190 lb 8/23/2010 Other Health Professional United Kingdom
Primary
Concomitant
Sepsis Other Serious 1/1/2010 67 Male 8/24/2010 Consumer United States
Primary
Concomitant
Vomiting Other Serious 1/1/2000 51 Male 237 lb 8/27/2010 United States
Primary
Secondary
Concomitant
Sepsis Other Serious 1/1/2010 67 Male 8/30/2010 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 58 Female 8/30/2010 Physician United States
Primary
Concomitant
White Blood Cells Urine Positive Other Serious 7/26/2010 65 Male 8/27/2010 Australia
Primary
Secondary
Concomitant
Sepsis Other Serious 7/26/2010 65 Male 9/3/2010 Australia
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/1999 58 Female 9/9/2010 Physician United States
Primary
Concomitant
Weight Increased Other Serious 1/1/1995 57 Male 9/17/2010 United States
Primary
Secondary
Concomitant
Sepsis Other Serious 7/26/2010 65 Male 9/10/2010 Australia
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/1999 58 Female 9/24/2010 Physician United States
Primary
Concomitant
Vision Blurred Other Serious 4/1/2008 46 Female 159 lb 10/4/2010 Lawyer United States
Primary
Concomitant
Sepsis Other Serious 7/26/2010 65 Male 10/1/2010 Australia
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2000 51 Male 237 lb 10/12/2010 United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/1999 58 Female 10/15/2010 Physician United States
Primary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 5/15/2010 44 Female 10/11/2010 Other Health Professional France
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/1999 58 Female 10/20/2010 Physician United States
Primary
Concomitant
Sepsis Other Serious 7/26/2010 65 Male 10/15/2010 Australia
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2000 51 Male 237 lb 10/22/2010 United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 9/1/2010 75 Female 11/14/2010 Consumer United States
Primary
Concomitant
Tachycardia Other Serious 9/1/2008 47 Female 595 lb 11/18/2010 Physician United States
Primary
Secondary
Concomitant
Lethargy Hospitalization 11/17/2010 79 Male 216 lb 11/23/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/1999 58 Female 12/1/2010 Physician United States
Primary
Concomitant
Vomiting Hospitalization 49 Female 12/1/2010 Consumer United States
Primary
Concomitant
Vomiting Other Serious 10/3/2006 52 Male 161 lb 12/2/2010 Other Health Professional United States
Primary
Concomitant
Lower Respiratory Tract Infection Hospitalization 11/11/2010 63 Male 12/2/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Sepsis Other Serious 6/18/2010 65 Male 11/24/2010 Australia
Primary
Secondary
Concomitant
Weight Decreased Other Serious 10/12/2010 12/21/2010 Physician United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 58 Female 12/23/2010 Physician United States
Primary
Concomitant
Infection Hospitalization 11/11/2010 12/28/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Infection Hospitalization 11/11/2010 63 Male 12/28/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Other Serious 10/12/2010 12/29/2010 Physician United Kingdom
Primary
Concomitant
Pneumonia Hospitalization 11/30/2010 79 Male 123 lb 1/3/2011 Physician Spain
Primary
Concomitant
Blood Magnesium Decreased Hospitalization 11/11/2010 63 Male 1/7/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Chronic Hepatitis Other Serious 8/6/2010 67 Male 1/12/2011 Physician France
Primary
Secondary
Concomitant
Tooth Loss Other Serious 1/18/2005 51 Female 220 lb 1/12/2011 Lawyer United States
Primary
Secondary
Concomitant
Hypertension Hospitalization 1/1/2000 51 Male 237 lb 1/12/2011 Lawyer United States
Primary
Secondary
Concomitant
Vomiting Other Serious 10/12/2010 1/17/2011 Physician United Kingdom
Primary
Concomitant
Pancreatitis Chronic Hospitalization 8/6/2010 67 Male 1/18/2011 Physician France
Primary
Secondary
Concomitant
Supraventricular Tachycardia Other Serious 12/23/2010 71 Female 1/20/2011 Physician New Zealand
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 1/1/2000 51 Male 237 lb 1/21/2011 United States
Primary
Secondary
Concomitant
Lymphocyte Count Increased Hospitalization 11/30/2010 79 Male 1/7/2011 Spain
Primary
Concomitant
Diarrhoea Hospitalization 12/10/2010 75 Male 187 lb 2/1/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 12/10/2010 Male 170 lb 2/16/2011 Physician United States
Primary
Secondary
Concomitant
Hepatosplenomegaly Death 1/27/2011 68 Male 2/15/2011 Other Health Professional United States
Primary
Concomitant
Gastrointestinal Disorder Hospitalization 1/1/1985 31 Female 220 lb 3/3/2011 Lawyer United States
Primary
Secondary
Concomitant
Sudden Death Death Male 130 lb 3/11/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Sudden Death Death 3/10/2010 77 Male 131 lb 3/15/2011 Physician France
Primary
Secondary
Concomitant
Laceration Other Serious 1/1/1999 58 Female 3/18/2011 United States
Primary
Concomitant
Hypomagnesaemia Other Serious 1/1/1995 57 Male 3/28/2011 Lawyer United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 12/10/2010 Male 170 lb 3/31/2011 Physician United States
Primary
Secondary
Concomitant
Malaise Hospitalization 12/10/2010 Male 170 lb 4/4/2011 Physician United States
Primary
Secondary
Concomitant
Atrial Fibrillation Hospitalization 12/20/2010 77 Male 4/11/2011 Physician United States
Primary
Concomitant
Incontinence Hospitalization 8/1/2009 63 Female 4/25/2011 Physician United States
Primary
Concomitant
Atrial Fibrillation Hospitalization 12/20/2010 77 Male 5/6/2011 Physician United States
Primary
Concomitant
Dehydration Hospitalization 4/8/2011 69 Male 5/16/2011 Netherlands
Primary
Concomitant
Chest Discomfort Hospitalization 4/8/2011 69 Male 5/12/2011 Netherlands
Primary
Concomitant

Drug Data