Levothyroxine Sodium combined with Valproic Acid

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Loss Of Consciousness Hospitalization 51 Female 2/13/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 2/28/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Male 3/1/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/7/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/7/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/3/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Unknown 3/3/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 51 Male 3/2/2006 United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/16/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/2/2006 United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/10/2006 United Kingdom
Primary
Secondary
Concomitant
Neutropenia Other Serious 2/22/2005 38 Male 245 lb 4/1/2005 Pharmacist United States
Primary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/16/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 51 Female 3/27/2006 United Kingdom
Primary
Secondary
Concomitant
Pharmaceutical Product Complaint Hospitalization 51 Female 3/29/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 4/6/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Disorder Other Serious 1/1/2006 52 Male 5/14/2006 Consumer Canada
Primary
Concomitant
Renal Disorder Other Serious 1/1/2006 52 Male 5/24/2006 Consumer Canada
Primary
Concomitant
Rash Macular Other Serious 2/2/2006 7/6/2006 Physician Colombia
Primary
Secondary
Concomitant
Leukopenia Required Intervention 4/10/2006 64 Female 5/22/2006 Consumer United States
Primary
Concomitant
Renal Disorder Other Serious 1/1/2006 52 Male 7/10/2006 Consumer Canada
Primary
Concomitant
Urinary Tract Infection Other Serious 6/19/2006 60 Female 8/10/2006 Other Health Professional United States
Primary
Concomitant
Granulocytopenia Required Intervention 2/13/2006 48 Female 203 lb 5/18/2006 Consumer United States
Primary
Concomitant
Loss Of Consciousness Other Serious 8/9/2006 54 Female 170 lb 9/7/2006 Pharmacist United States
Primary
Concomitant
Syncope Other Serious 6/2/2006 48 Male 9/19/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Fall Hospitalization 9/14/2006 36 Male 10/4/2006 Consumer United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 6/19/2006 60 Female 10/4/2006 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Life Threatening 6/18/2006 60 Female 10/5/2006 Other Health Professional United States
Primary
Concomitant
Pulmonary Oedema Other Serious 10/4/2006 65 Male 180 lb 10/24/2006 Pharmacist United States
Primary
Concomitant
Tremor Other Serious 2/6/2005 80 Female 11/2/2006 Other Health Professional Canada
Primary
Concomitant
Blood Sodium Decreased Other Serious 68 Female 11/13/2006 Other Health Professional United Kingdom
Primary
Concomitant
Cardiac Arrest Life Threatening 1/23/2007 57 Female 2/2/2007 Physician Canada
Primary
Concomitant
Unevaluable Event Other Serious 11/5/2006 Male 156 lb 2/12/2007 Physician France
Primary
Concomitant
Pancreatitis Acute Hospitalization 58 Female 8/21/2004 Pharmacist United States
Primary
Secondary
Concomitant
Faecaloma Hospitalization 10/2/2006 Male 115 lb 3/11/2007 Pharmacist United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 2/16/2002 40 Female 5/26/2007 Physician Canada
Primary
Secondary
Concomitant
Mental Status Changes Hospitalization 1/24/2007 Female 263 lb 6/19/2007 Other Health Professional United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 191 lb Physician United States
Primary
Secondary
Concomitant
Oxygen Saturation Decreased Hospitalization 8/6/2007 Male 112 lb 8/20/2007 Pharmacist United States
Primary
Concomitant
Encephalopathy Hospitalization 8/20/2007 76 Female 137 lb 9/12/2007 Physician France
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 7/19/2007 53 Female 9/14/2007 Other Health Professional United States
Primary
Concomitant
Vessel Puncture Site Haematoma Hospitalization 8/16/2007 76 Female 137 lb 10/4/2007 Physician France
Primary
Secondary
Concomitant
Vessel Puncture Site Haematoma Hospitalization 8/16/2007 76 Female 137 lb 10/11/2007 Physician France
Primary
Secondary
Concomitant
Oxygen Saturation Decreased Hospitalization 8/6/2007 42 Male 112 lb 10/24/2007 Pharmacist United States
Primary
Concomitant
Urethral Cancer Metastatic Other Serious 66 Male 12/14/2007 Physician Canada
Primary
Concomitant
Urethral Cancer Metastatic Death 5/7/2007 65 Male 12/18/2007 Physician Canada
Primary
Concomitant
Cerebral Haemorrhage Life Threatening 1/21/2008 52 Female 143 lb 2/18/2008 Physician Israel
Primary
Concomitant
Cerebral Haemorrhage Life Threatening 1/21/2008 52 Female 143 lb 2/29/2008 Physician Israel
Primary
Concomitant
Drug Toxicity Death 9/11/2004 Female 125 lb 4/10/2008 Lawyer United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 8/1/2004 27 Female 4/4/2008 Italy
Primary
Secondary
Concomitant
Maternal Drugs Affecting Foetus Other Serious Male 5/29/2008 France
Primary
Secondary
Thyroid Disorder Hospitalization 40 Female 7/8/2008
Primary
Concomitant
Unresponsive To Stimuli Other Serious 1/1/2005 53 Female 7/2/2008 United States
Primary
Concomitant
Drug Toxicity Death 9/11/2004 Female 125 lb 7/22/2008 Other Health Professional United States
Primary
Concomitant
Sedation Death 10/29/2007 58 Female 154 lb 8/26/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Other Serious 8/5/2008 91 Female 132 lb 9/2/2008 Other Health Professional Portugal
Primary
Concomitant
Interacting
Drug Interaction Other Serious 8/5/2008 91 Female 132 lb 9/23/2008 Other Health Professional Portugal
Primary
Concomitant
Interacting
Peripheral Coldness Hospitalization 8/1/2004 27 Female 9/24/2008 Other Health Professional Italy
Primary
Concomitant
Somnolence Death 10/29/2007 58 Female 181 lb 10/17/2008 Physician United Kingdom
Primary
Concomitant
Interacting
Sedation Other Serious 10/29/2007 58 Female 181 lb 10/22/2008 Other Health Professional United Kingdom
Primary
Concomitant
Sedation Death 10/29/2007 58 Female 181 lb 10/23/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Speech Disorder Other Serious 7/7/2008 Female 10/31/2008 Physician France
Primary
Concomitant
Vision Blurred Other Serious 1/1/2008 Female 10/31/2008 Consumer France
Primary
Concomitant
Trigger Finger Other Serious 6/1/2008 Female 11/3/2008 Consumer United States
Primary
Concomitant
Somnolence Other Serious 10/29/2007 58 Female 181 lb 11/6/2008 Other Health Professional United Kingdom
Primary
Concomitant
Neutropenia Other Serious 9/4/2008 Female 11/12/2008 Physician Germany
Primary
Secondary
Concomitant
Death Death 8/16/2008 Female 287 lb 11/14/2008 Physician United States
Primary
Concomitant
Pulmonary Embolism Death 3/4/2008 70 Female 11/19/2008 Physician Germany
Primary
Secondary
Concomitant
Chronic Obstructive Pulmonary Disease Death 8/15/2008 Female 287 lb 11/24/2008 Physician United States
Primary
Concomitant
Sepsis Hospitalization 9/25/2008 69 Female 130 lb 11/21/2008 Portugal
Primary
Secondary
Concomitant
Vision Blurred Other Serious 1/1/2008 Female 12/5/2008 Consumer France
Primary
Concomitant
Vision Blurred Other Serious 1/1/2008 Female 12/8/2008 Consumer France
Primary
Concomitant
Tic 7/28/2008 64 157 lb 12/9/2008 Consumer United States
Primary
Secondary
Concomitant
Chronic Obstructive Pulmonary Disease Death 8/15/2008 Female 287 lb 12/22/2008 Physician United States
Primary
Concomitant
Trigger Finger Other Serious 6/1/2008 Female 211 lb 12/24/2008 Physician United States
Primary
Concomitant
Trigger Finger Other Serious 6/1/2008 Female 211 lb 1/9/2009 Physician United States
Primary
Concomitant
Sepsis Hospitalization 9/25/2008 69 Female 130 lb 1/13/2009 Portugal
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 12/15/2008 Female 3/6/2009 Canada
Primary
Concomitant
Suicidal Ideation Hospitalization 1/23/2009 Female 216 lb 4/8/2009 Physician Austria
Primary
Concomitant
Urinary Incontinence Other Serious 12/15/2008 Female 4/13/2009 Physician Canada
Primary
Concomitant
Dyskinesia Other Serious 1/26/2009 14 Male 4/4/2009 Canada
Primary
Concomitant
Aggression 48 Male 179 lb 4/1/2009 Physician United States
Primary
Concomitant
Urinary Incontinence Other Serious 7/11/2001 63 Male 220 lb 4/20/2009 United States
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Death 8/15/2008 Female 287 lb 7/13/2009 Physician United States
Primary
Concomitant
Apnoea Other Serious Male 7/15/2009 Other Health Professional Mexico
Primary
Concomitant
Aggression 48 Male 179 lb 7/9/2009 Physician United States
Primary
Concomitant
Vomiting Other Serious 2/16/2009 Male 7/30/2009 Physician United States
Primary
Secondary
Concomitant
Myopathy Hospitalization 85 Female 7/31/2009 Germany
Primary
Concomitant
Interacting
Subcutaneous Nodule Other Serious 8/4/2006 23 Female 154 lb 8/4/2009 Physician United States
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Hospitalization 58 Male 8/5/2009
Primary
Secondary
Concomitant
Renal Tubular Necrosis Hospitalization 4/14/2009 72 Male 7/31/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Other Serious 2/16/2009 Male 8/10/2009 Physician United States
Primary
Secondary
Concomitant
Insomnia 10/16/2008 Female 8/22/2009 Consumer United States
Primary
Concomitant
Myopathy Hospitalization 85 Female 8/18/2009 Other Health Professional Germany
Primary
Concomitant
Dyskinesia Other Serious 1/26/2009 14 Male 8/18/2009 Canada
Primary
Concomitant
Weight Decreased Other Serious 1/1/2008 Female 202 lb 9/15/2009 Consumer United States
Primary
Concomitant
Pancreatitis Other Serious 3/30/2001 48 Male 265 lb 9/23/2009 United States
Primary
Concomitant
Suicidal Ideation Other Serious Female 9/15/2009 Physician Germany
Primary
Secondary
Concomitant
Vascular Dementia Other Serious 8/21/2004 66 Male 264 lb 10/15/2009 United States
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 6/1/2006 34 Female 213 lb 11/2/2009 United States
Primary
Concomitant
Off Label Use Hospitalization 10/21/2009 52 Female 11/9/2009 Consumer Colombia
Primary
Concomitant
Pruritus 10/7/2009 Male 11/11/2009 Consumer
Primary
Concomitant
Weight Increased Other Serious 20 Female 11/5/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Polyuria Hospitalization 10/20/2009 52 Female 104 lb 11/26/2009 Consumer Colombia
Primary
Concomitant
Medication Residue Other Serious 61 Female 11/26/2009 Canada
Primary
Concomitant
Pain In Extremity Female 12/7/2009 Other Health Professional United States
Primary
Concomitant
Subcutaneous Nodule Other Serious 8/4/2006 23 Female 154 lb 12/18/2009 Physician United States
Primary
Secondary
Concomitant
Neoplasm Progression Hospitalization 4/8/2009 6 Male 55 lb 12/9/2009 Other Health Professional Germany
Primary
Concomitant
Mental Status Changes Hospitalization 1/24/2007 49 Female 263 lb 12/8/2009 Other Health Professional United States
Primary
Concomitant
Subcutaneous Nodule Other Serious 8/4/2006 23 Female 154 lb 12/28/2009 Physician United States
Primary
Secondary
Concomitant
Subcutaneous Nodule Other Serious 8/4/2006 23 Female 154 lb 12/31/2009 Physician United States
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 59 Female 157 lb 12/23/2009 Pharmacist United States
Primary
Secondary
Concomitant
Pancytopenia Life Threatening 3/1/2008 53 Male 12/29/2009 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 88 Female 1/12/2010 Netherlands
Primary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 6/1/2006 34 Female 213 lb 1/25/2010 United States
Primary
Concomitant
Weight Increased Other Serious 55 Female 2/17/2010 Physician Switzerland
Primary
Secondary
Concomitant
Vomiting Other Serious 8/1/2009 72 Female 4/15/2010 Netherlands
Primary
Secondary
Concomitant
Vomiting Other Serious 8/1/2009 72 Female 4/27/2010 Netherlands
Primary
Secondary
Concomitant
Hyperammonaemic Encephalopathy Other Serious 51 Female 5/27/2010 Physician United States
Primary
Secondary
Concomitant
Vitamin B12 Deficiency Other Serious 1/16/2004 59 Male 6/11/2010 United States
Primary
Concomitant
Vitamin B12 Deficiency Other Serious 1/16/2004 59 Male 7/14/2010 United States
Primary
Concomitant
Somnolence Other Serious 1/1/2009 49 Male 235 lb 5/18/2010 United States
Primary
Concomitant
Paradoxical Drug Reaction Other Serious 17 Male 8/13/2010 Physician Germany
Primary
Concomitant
Myalgia Male 288 lb 8/28/2010 United States
Primary
Concomitant
Medication Residue Other Serious 61 Female 9/6/2010 Canada
Primary
Concomitant
Thyroid Disorder Other Serious 1/1/2005 31 Female 234 lb 9/20/2010 United States
Primary
Concomitant
Neuroleptic Malignant Syndrome Life Threatening 39 Female 10/12/2010
Primary
Secondary
Somnolence Hospitalization 10/8/2010 38 Male 141 lb 11/3/2010 Pharmacist United States
Primary
Concomitant
Syncope Hospitalization 6/1/2010 39 Female 150 lb 12/30/2010 Physician Germany
Primary
Secondary
Concomitant
Fatigue 2/10/2010 45 Female 150 lb 1/28/2011 United States
Primary
Concomitant
Drug Ineffective 61 Female 1/12/2011 Canada
Primary
Concomitant
Mania Hospitalization 1/31/2011 72 Female 4/27/2011 Consumer Austria
Primary
Concomitant
Rash Hospitalization 7/1/2010 83 Male 10/26/2010 Physician United States
Primary
Secondary
Concomitant
Stomatitis 11/24/2010 54 Male 2/24/2011 Consumer United States
Primary
Concomitant
Serum Ferritin Increased Hospitalization 2/16/2009 72 Male 5/26/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Nephrogenic Anaemia Hospitalization 4/14/2009 72 Male 5/25/2011 Physician United States
Primary
Secondary
Concomitant
Red Blood Cell Count Decreased Other Serious 1/1/2009 62 Female 5/31/2011 Pharmacist Canada
Primary
Concomitant
Balance Disorder Death Female 6/5/2011 Ireland
Primary
Concomitant
Central Nervous System Lesion Other Serious 11/1/2008 66 Female 6/6/2011 Consumer Ireland
Primary
Concomitant
Sepsis Hospitalization 2/14/2007 30 Female 5/30/2011 Physician United Kingdom
Primary
Concomitant
Blood Creatine Increased Other Serious Female 6/10/2011 Physician Canada
Primary
Concomitant
Choreoathetosis Hospitalization 11/1/2010 18 Male 6/14/2011 Physician Japan
Primary
Secondary
Concomitant
Choreoathetosis Hospitalization 11/1/2010 18 Male 6/16/2011 Physician Japan
Primary
Secondary
Concomitant
Mental Retardation Disability 73 Female 6/22/2011 Other Health Professional United States
Primary
Secondary
Interacting
Gastrointestinal Hypomotility Hospitalization 39 Female 6/21/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 8/7/2004 60 Male 7/5/2011 Consumer United States
Primary
Concomitant
Glomerular Filtration Rate Decreased Disability 5/28/2011 56 Female 7/8/2011 Other Health Professional Denmark
Primary
Concomitant
Rhabdomyolysis Death 5/17/2011 25 Female 7/25/2011 Physician Germany
Primary
Concomitant
Extremity Contracture Other Serious 8/4/2006 23 Female 155 lb 8/10/2011 Consumer United States
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 4/29/2011 63 Female 9/12/2011 Other Health Professional France
Primary
Secondary
Concomitant

Drug Data