Levothyroxine Sodium combined with Valproate Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Salivary Hypersecretion Life Threatening 10/23/2005 72 Female 176 lb 1/4/2006 Physician France
Primary
Concomitant
Syncope Hospitalization 2/18/2002 Male 1/4/2006 France
Primary
Concomitant
Aneurysm Death 43 Male 1/11/2006 United States
Primary
Concomitant
Hallucination, Auditory Hospitalization 12/21/2005 41 Male 262 lb 1/12/2006 Physician Japan
Primary
Concomitant
Therapy Non-responder Hospitalization 12/21/2005 41 Male 262 lb 1/24/2006 Physician Japan
Primary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 2/10/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Wrong Technique In Drug Usage Process Life Threatening 10/23/2005 72 Female 176 lb 2/13/2006 Physician France
Primary
Concomitant
Leukopenia Required Intervention 42 Male 2/8/2006 United States
Primary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 2/14/2006 United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 2/15/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rash Erythematous 2/3/2005 58 Female 2/17/2006 Canada
Primary
Concomitant
Pharmaceutical Product Complaint Hospitalization 51 Female 3/7/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/7/2006 United Kingdom
Primary
Secondary
Concomitant
Therapy Non-responder Hospitalization 12/21/2005 41 Male 262 lb 3/21/2006 Physician Japan
Primary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 3/22/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 4/6/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Swelling Hospitalization 3/8/2006 50 Female 4/14/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 3/8/2006 50 Female 5/23/2006 Physician United States
Primary
Secondary
Concomitant
Cardiac Disorder Death 1/1/2006 90 Female 5/22/2006 United States
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Hospitalization 63 Female 6/22/2006 United Kingdom
Primary
Secondary
Concomitant
Cardiac Death Death 5/27/2006 62 Male 6/21/2006 United States
Primary
Concomitant
Aortic Dissection Death 1/1/2006 90 Female 6/21/2006 United States
Primary
Concomitant
Suicidal Ideation Hospitalization 4/26/2006 Female 7/7/2006 Other Health Professional France
Primary
Secondary
Concomitant
Hypothyroidism Hospitalization 12/21/2005 41 Male 262 lb 7/17/2006 Physician Japan
Primary
Concomitant
Cardiac Disorder Death 5/27/2006 62 Male 7/19/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/7/2005 55 Female 5/16/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/1/2005 61 Male 173 lb 5/12/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/4/2005 17 Male 6/20/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 9/6/2005 46 Male 5/24/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/3/2005 42 Male 1/25/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/11/2005 46 Female 2/7/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 10/31/2005 48 Female 3/7/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/8/2005 59 Female 3/22/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 4/11/2006 56 Female 5/23/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/9/2005 46 Male 1/13/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/13/2005 46 Male 5/31/2006 United States
Primary
Concomitant
Hyperthyroidism Hospitalization 7/9/2005 61 Female 10/6/2005 France
Primary
Secondary
Concomitant
Malnutrition Other Serious 9/22/2004 47 Male 99 lb 7/25/2006 Physician Japan
Primary
Concomitant
Suicidal Ideation Hospitalization 4/26/2006 Female 8/3/2006 Other Health Professional France
Primary
Secondary
Concomitant
Renal Failure Other Serious 9/22/2004 47 Male 99 lb 7/31/2006 Physician Japan
Primary
Concomitant
Granulocytopenia Required Intervention 2/22/2006 46 Female 5/8/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/31/2005 28 Female 2/15/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 3/21/2006 50 Male 5/17/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/6/2005 43 Male 1/6/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/6/2005 19 Female 6/16/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/6/2005 57 Female 1/9/2006 Consumer United States
Primary
Concomitant
Shock Hospitalization 6/1/2006 80 Female 9/8/2006 France
Primary
Secondary
Concomitant
Peritoneal Fluid Analysis Other Serious 63 Female 9/26/2006 United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Required Intervention 2/27/2006 15 Female 9/28/2006 Physician Japan
Primary
Concomitant
Tumour Haemorrhage Hospitalization Female 10/30/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Psychotic Disorder Required Intervention 35 Male 11/7/2006 United States
Primary
Concomitant
Hallucination, Auditory Hospitalization 12/21/2005 41 Male 262 lb 11/8/2006 Physician Japan
Primary
Concomitant
Petit Mal Epilepsy Other Serious 10/1/2006 36 Female 168 lb 11/22/2006 Physician Greece
Primary
Secondary
Concomitant
Weight Decreased Other Serious 54 Female 12/1/2006 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Parkinsonism Hospitalization 54 Female 150 lb 2/9/2007 Physician Turkey
Primary
Concomitant
Neutropenia Other Serious 12/14/2006 60 Female 128 lb 2/15/2007 Other Health Professional United Kingdom
Primary
Concomitant
Loss Of Consciousness Hospitalization 51 Female 2/15/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 10 Male 3/7/2007 Other Health Professional United States
Primary
Concomitant
Interacting
White Blood Cell Count Decreased Hospitalization 60 Female 3/14/2007 Other Health Professional New Zealand
Primary
Concomitant
Polyserositis Other Serious 11/1/2005 60 Female 3/19/2007 Physician New Zealand
Primary
Concomitant
Sedation Hospitalization 60 Female 3/28/2007 Physician New Zealand
Primary
Concomitant
Parkinsonism Hospitalization 8/1/2006 54 Female 150 lb 4/4/2007 Physician Turkey
Primary
Concomitant
Oedema Peripheral Other Serious 3/22/2007 Female 169 lb 4/23/2007 Physician Australia
Primary
Concomitant
Tonsillitis Other Serious 63 Female 5/12/2007 United Kingdom
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Hospitalization 1/1/2007 36 Female 5/16/2007 Consumer Australia
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 1/1/2007 36 Female 5/17/2007 Consumer Australia
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/4/2007 55 Male 189 lb 5/29/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Tachycardia Life Threatening 24 Female 6/4/2007 Other Health Professional United Kingdom
Primary
Concomitant
Neutropenia Hospitalization 2/26/2007 57 Female 6/29/2007 Other Health Professional Germany
Primary
Concomitant
Tachycardia Life Threatening 8/1/2006 24 Female 7/27/2007 Other Health Professional United Kingdom
Primary
Concomitant
Loss Of Consciousness Other Serious 1/14/2005 Male 8/8/2007 Physician United Kingdom
Primary
Concomitant
Heart Rate Increased Other Serious 6/2/2007 Female 154 lb 9/25/2007 Other Health Professional United Kingdom
Primary
Concomitant
Loss Of Consciousness Other Serious 1/14/2005 Male 9/27/2007 Physician United Kingdom
Primary
Concomitant
Tremor Other Serious 10/9/2007 Female 11/16/2007 Pharmacist United Kingdom
Primary
Concomitant
Tremor Hospitalization 10/9/2007 Female 11/15/2007 United Kingdom
Primary
Secondary
Concomitant
Tremor Other Serious 10/9/2007 Female 11/28/2007 Pharmacist United Kingdom
Primary
Concomitant
Interacting
Tremor Other Serious 10/9/2007 Female 12/7/2007 Pharmacist United Kingdom
Primary
Concomitant
Interacting
White Blood Cell Count Increased Hospitalization 5/14/2007 56 Female 154 lb 1/28/2008 Physician Austria
Primary
Concomitant
Urinary Incontinence Other Serious 39 Male 2/15/2008 Consumer United Kingdom
Primary
Concomitant
Granulocytopenia Other Serious 2/6/2008 Male 2/19/2008 Physician United States
Primary
Secondary
Concomitant
Hyponatraemia Other Serious 8/1/2005 69 Male 3/4/2008 Other Health Professional India
Primary
Concomitant
Muscle Spasms 12/6/2007 Female 150 lb 3/14/2008 United States
Primary
Concomitant
Injection Site Irritation 2/11/2008 Female 185 lb 3/15/2008 United States
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 10/14/2004 Female 3/25/2008 France
Primary
Secondary
Concomitant
Urinary Incontinence Disability 1/1/2008 49 Male 4/11/2008 Physician United Kingdom
Primary
Concomitant
Myxoedema Coma Hospitalization 27 Female 5/23/2008 France
Primary
Secondary
Concomitant
Teratoma Other Serious 3/1/1993 Female 5/27/2008 United Kingdom
Primary
Concomitant
Antipsychotic Drug Level Increased Hospitalization 36 Female 5/28/2008 Consumer Australia
Primary
Concomitant
Interacting
Neoplasm Recurrence Other Serious 5/8/2008 46 6/12/2008 United Kingdom
Primary
Concomitant
Metabolic Encephalopathy Hospitalization 76 Male 6/13/2008 France
Primary
Secondary
Concomitant
Metabolic Encephalopathy Hospitalization 76 Male 7/2/2008 France
Primary
Concomitant
Posture Abnormal Other Serious 2/22/2008 48 Female 7/8/2008 United Kingdom
Primary
Concomitant
White Blood Cell Disorder Other Serious Male 8/4/2008 Other Health Professional United Kingdom
Primary
Concomitant
Rash Pruritic Other Serious 7/27/2008 Female 8/26/2008 Physician France
Primary
Concomitant
Drug Interaction Other Serious 8/5/2008 91 Female 132 lb 9/2/2008 Other Health Professional Portugal
Primary
Concomitant
Interacting
Staring Other Serious 1/1/2008 Male 209 lb 9/11/2008 Physician Germany
Primary
Secondary
Concomitant
Convulsion Hospitalization 9/13/2007 Female 161 lb 9/16/2008 Physician Germany
Primary
Concomitant
Renal Failure Other Serious 3/20/2008 Male 183 lb 9/16/2008 Physician Germany
Primary
Concomitant
Rash Pruritic Other Serious 7/27/2008 Female 9/23/2008 Physician France
Primary
Concomitant
Drug Interaction Other Serious 8/5/2008 91 Female 132 lb 9/23/2008 Other Health Professional Portugal
Primary
Concomitant
Interacting
Renal Failure Other Serious 3/20/2008 Male 183 lb 9/24/2008 Physician Germany
Primary
Concomitant
Staring Other Serious 1/1/2008 Male 209 lb 10/2/2008 Physician Germany
Primary
Secondary
Concomitant
Tremor Hospitalization 7/1/2008 Female 130 lb 10/3/2008 United States
Primary
Concomitant
Tremor Hospitalization 7/1/2008 Female 130 lb 10/6/2008 United States
Primary
Concomitant
Rash Pruritic Other Serious 7/27/2008 Female 10/9/2008 Physician France
Primary
Concomitant
Convulsion Hospitalization 9/13/2007 Female 161 lb 10/28/2008 Physician Germany
Primary
Concomitant
Encephalopathy Other Serious 61 Female 10/28/2008 Japan
Primary
Concomitant
Left Ventricular Hypertrophy Other Serious Male 10/28/2008 Other Health Professional Australia
Primary
Concomitant
Head Titubation Other Serious 5/30/2008 61 Female 11/5/2008 Other Health Professional France
Primary
Secondary
Concomitant
Convulsion Hospitalization 9/13/2007 Female 161 lb 11/26/2008 Physician Germany
Primary
Concomitant
Sepsis Hospitalization 9/25/2008 69 Female 130 lb 11/21/2008 Portugal
Primary
Secondary
Concomitant
Tremor Other Serious 61 Female 12/16/2008 Physician Japan
Primary
Concomitant
Meningioma Other Serious 5/1/2008 49 Female 1/15/2009 Other Health Professional Netherlands
Primary
Concomitant
Sepsis Hospitalization 9/25/2008 69 Female 130 lb 1/13/2009 Portugal
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Other Serious 48 Male 2/24/2009
Primary
Secondary
Periorbital Oedema Other Serious 43 Female 2/20/2009 Canada
Primary
Secondary
Concomitant
Thyroiditis Other Serious 61 Female 3/10/2009
Primary
Secondary
Concomitant
Tremor 1/1/1998 Female 130 lb 3/12/2009 Consumer United States
Primary
Concomitant
Pain Other Serious 1/1/2006 Female 240 lb 3/14/2009 Consumer United States
Primary
Concomitant
Sudden Unexplained Death In Epilepsy Death 3/9/2009 Female 3/23/2009 Germany
Primary
Concomitant
Renal Cancer Hospitalization 9/12/2008 4/3/2009 Other Health Professional France
Primary
Concomitant
Weight Increased Other Serious 3/17/2009 Male 4/8/2009 Physician United Kingdom
Primary
Concomitant
Rectal Fissure Hospitalization 3/19/2009 Female 6/16/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Granulocytopenia Other Serious 10/14/2008 53 Male 7/27/2009 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 3/17/2009 Female 8/6/2009 Other Health Professional New Zealand
Primary
Concomitant
Weight Increased Female 8/20/2009 Consumer United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 9/4/2009 Male 10/22/2009 Other Health Professional United Kingdom
Primary
Concomitant
Weight Increased Other Serious 6/1/2008 20 Female 10/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 10/13/2009 47 Female 10/23/2009 Physician Norway
Primary
Concomitant
Treatment Noncompliance Other Serious 6/1/2008 20 Female 10/27/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 6/1/2008 20 Female 10/22/2009 United States
Primary
Concomitant
Tremor Other Serious 59 Female 157 lb 10/29/2009 Physician United States
Primary
Secondary
Concomitant
Self Injurious Behaviour Other Serious 6/1/2008 20 Female 10/27/2009
Primary
Secondary
Concomitant
Transplant Failure Required Intervention 39 Female 10/27/2009 Physician United States
Primary
Secondary
Concomitant
Tremor Other Serious 59 Female 157 lb 11/4/2009 Physician United States
Primary
Secondary
Concomitant
Transplant Failure Required Intervention 39 Female 11/6/2009 Physician United States
Primary
Secondary
Concomitant
Therapy Cessation Other Serious Female 11/19/2009 Pharmacist Ireland
Primary
Concomitant
Thyroid Disorder 59 Female 11/30/2009 Physician United Kingdom
Primary
Concomitant
Therapy Cessation Other Serious Female 11/30/2009 Pharmacist Ireland
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 9/4/2009 Male 12/11/2009 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 9/4/2009 Male 12/30/2009 Other Health Professional United Kingdom
Primary
Concomitant
Leukopenia Other Serious 8/1/2005 59 Female 2/1/2010 Physician United Kingdom
Primary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 4/21/2009 65 Female 2/22/2010 Physician Germany
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 3/25/2010 61 Male 198 lb 4/5/2010
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 3/2/2010 29 Female 3/31/2010 Physician United Kingdom
Primary
Concomitant
Mental Impairment Hospitalization Male 4/15/2010 Other Health Professional United Kingdom
Primary
Concomitant
Visual Acuity Reduced Other Serious Female 4/19/2010 Consumer United Kingdom
Primary
Secondary
Cerebrovascular Accident Hospitalization 3/23/2010 61 Male 198 lb 5/3/2010
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/2007 41 Male 5/19/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Death Death 1/1/2002 9 Male 6/1/2010 Physician United Kingdom
Primary
Concomitant

Drug Data