Levothyroxine Sodium combined with Topiramate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Cardiomegaly Death Female 1/16/2006 United States
Primary
Concomitant
Cardiomegaly Death 12/1/2005 49 Female 3/7/2006 United States
Primary
Concomitant
Transient Ischaemic Attack Other Serious 9/1/2001 70 Female 126 lb 4/14/2006 Physician Canada
Primary
Concomitant
Somnolence Life Threatening 6/5/2006 Female 7/27/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/6/2005 17 Male 2/6/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/2/2005 24 Female 1/24/2006 Consumer United States
Primary
Concomitant
Somnolence Life Threatening 6/5/2006 Female 336 lb 8/18/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/6/2005 19 Female 6/16/2006 United States
Primary
Concomitant
Somnolence Life Threatening 6/5/2006 Female 336 lb 9/6/2006 Consumer United States
Primary
Concomitant
Deep Vein Thrombosis Other Serious 67 Male 10/6/2006 Other Health Professional United States
Primary
Concomitant
Treatment Noncompliance Other Serious 3/31/2004 56 Female 225 lb 10/12/2006 Physician United States
Primary
Concomitant
Swelling Face Other Serious Female 188 lb 10/17/2006 Pharmacist United States
Primary
Concomitant
Synovial Cyst Other Serious 1/1/2006 Female 111 lb 1/19/2007 Physician United States
Primary
Concomitant
Prescribed Overdose Death 9/2/2003 20 Female 2/27/2007 Physician United States
Primary
Concomitant
Suicidal Ideation Hospitalization 35 Female 5/8/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Hyperhidrosis Hospitalization 7/1/2005 61 Female 129 lb 12/13/2006 Consumer United States
Primary
Concomitant
Tongue Ulceration Other Serious 35 Female 6/1/2007 United States
Primary
Secondary
Concomitant
Road Traffic Accident Other Serious 6/25/2007 Female 140 lb 9/28/2007 United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 11/5/2007 Male 231 lb 11/19/2007 Other Health Professional United States
Primary
Concomitant
Bone Marrow Failure Death 9/22/2007 80 Female 11/16/2007 Pharmacist Denmark
Primary
Secondary
Concomitant
Treatment Failure 7/1/2007 45 Female 12/14/2007 Physician United States
Primary
Concomitant
Muscle Strain Hospitalization 10/24/2007 53 Female 12/11/2007 Canada
Primary
Concomitant
Muscle Strain Other Serious 11/1/2007 53 Female 12/19/2007 Canada
Primary
Concomitant
Lethargy 7/4/2007 Male 43 lb 1/16/2008 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Life Threatening 6/1/2002 49 Female 127 lb 1/14/2008 Consumer United Kingdom
Primary
Concomitant
Blindness Other Serious 34 Female 2/11/2008 Physician United States
Primary
Concomitant
Flat Anterior Chamber Of Eye Other Serious 2/28/2008 Other Health Professional United States
Primary
Concomitant
Weight Decreased Life Threatening 6/1/2002 49 Female 127 lb 2/25/2008 Consumer United Kingdom
Primary
Concomitant
Vision Blurred 2/1/2007 Female 153 lb 3/14/2008 United States
Primary
Concomitant
Tremor Other Serious 1/1/2000 Female 165 lb 4/24/2008 United States
Primary
Concomitant
Interacting
Systemic Lupus Erythematosus Other Serious 1/1/2008 38 Female 5/6/2008 Other Health Professional United States
Primary
Concomitant
Tremor Other Serious 1/1/2000 Female 165 lb 5/14/2008 United States
Primary
Concomitant
Interacting
Sciatica Female 157 lb 6/12/2008 United States
Primary
Concomitant
Precancerous Skin Lesion 1/1/2008 Female 168 lb 6/12/2008 United States
Primary
Concomitant
Malaise 5/3/2008 Female 96 lb 6/13/2008 Consumer United States
Primary
Concomitant
Rash Generalised Life Threatening 4/1/2008 66 Female 8/8/2008 Other Health Professional United Kingdom
Primary
Concomitant
Rash Generalised Life Threatening 4/1/2008 8/8/2008 Other Health Professional United Kingdom
Primary
Concomitant
Rash Generalised Life Threatening 4/1/2008 66 Female 8/18/2008 Other Health Professional United Kingdom
Primary
Concomitant
Nasopharyngitis Hospitalization 1/1/2004 Male 190 lb 8/22/2008 Physician United States
Primary
Secondary
Concomitant
Rash 4/15/2008 Female 143 lb 8/27/2008 Consumer United States
Primary
Concomitant
Rash Generalised Other Serious 4/1/2008 66 Female 9/15/2008 Other Health Professional United Kingdom
Primary
Concomitant
Rash Generalised Other Serious 4/1/2008 9/16/2008 Other Health Professional United Kingdom
Primary
Concomitant
Rash Generalised Other Serious 4/1/2008 66 Female 10/1/2008 Other Health Professional United Kingdom
Primary
Concomitant
Rash Generalised Other Serious 4/1/2008 66 Female 10/6/2008 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 4/1/2008 66 Female 9/30/2008
Primary
Concomitant
Rash Generalised Other Serious 5/1/2008 66 Female 11/11/2008 Other Health Professional United Kingdom
Primary
Concomitant
Rash Generalised Other Serious 5/1/2008 66 Female 11/14/2008 Other Health Professional United Kingdom
Primary
Concomitant
Rash Generalised Other Serious 5/1/2008 66 Female 11/26/2008 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 8/1/2008 51 Female 12/8/2008 Consumer United States
Primary
Concomitant
Cytolytic Hepatitis Hospitalization 9/10/2008 Female 12/8/2008 Consumer Germany
Primary
Secondary
Concomitant
Completed Suicide Death 1/1/2007 47 Female 12/29/2008 Physician United States
Primary
Secondary
Completed Suicide Death 47 Female 1/16/2009 United States
Primary
Secondary
Rash Disability 6/1/2008 73 Female 1/13/2009 Physician United States
Primary
Concomitant
Overdose Death 47 Female 1/16/2009 Physician United States
Primary
Secondary
Completed Suicide Death 47 Female 1/20/2009 Other Health Professional United States
Primary
Secondary
Intentional Drug Misuse Death 47 Female 1/15/2009 Physician United States
Primary
Secondary
Completed Suicide Death 47 Female 2/2/2009 Physician United States
Primary
Secondary
Weight Decreased Other Serious 8/1/2008 51 Female 169 lb 2/17/2009 Consumer United States
Primary
Concomitant
Fall Other Serious 1/29/2009 62 Male 1/30/2009 Physician Germany
Primary
Concomitant
Mental Status Changes Hospitalization 1/17/2009 54 Female 159 lb 4/23/2009 Pharmacist United States
Primary
Concomitant
Rectal Haemorrhage Required Intervention 11/24/2008 83 Female 212 lb 12/23/2008 United States
Primary
Concomitant
Cytolytic Hepatitis Hospitalization 9/10/2008 74 Female 203 lb 5/15/2009 Other Health Professional France
Primary
Secondary
Concomitant
Overdose Death 47 Female 6/23/2009 Physician United States
Primary
Secondary
Overdose Death 47 Female 7/13/2009 Physician United States
Primary
Secondary
Speech Disorder Other Serious 6/20/2009 53 Female 120 lb 6/22/2009 Pharmacist United States
Primary
Concomitant
Violence-related Symptom Hospitalization 5/29/2009 52 Female 550 lb 7/13/2009 United States
Primary
Concomitant
Rash Generalised Other Serious 5/1/2008 66 Female 8/19/2009 Other Health Professional United Kingdom
Primary
Concomitant
Overdose Death 1/1/2007 47 Female 8/24/2009 Physician United States
Primary
Secondary
Rash Generalised Other Serious 4/1/2008 66 Female 8/27/2009 Other Health Professional United Kingdom
Primary
Concomitant
Lupus-like Syndrome Other Serious 1/1/2009 Female 290 lb 9/21/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Pancreatitis Other Serious 3/30/2001 48 Male 265 lb 9/23/2009 United States
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 6/22/2009 Male 150 lb 10/2/2009 Physician United States
Primary
Concomitant
Weight Decreased Life Threatening 6/1/2002 49 Female 127 lb 10/19/2009 United Kingdom
Primary
Concomitant
Systemic Lupus Erythematosus Other Serious 4/1/2008 66 Female 10/23/2009 United Kingdom
Primary
Concomitant
Weight Decreased Life Threatening 6/1/2002 49 Female 127 lb 10/27/2009 Consumer United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 9/1/2009 29 Male 307 lb 10/20/2009 Physician United States
Primary
Concomitant
Renal Failure Acute Other Serious 4/25/2009 Male 150 lb 11/26/2009 United States
Primary
Concomitant
Upper Respiratory Tract Infection Hospitalization 6/22/2009 Male 150 lb 11/23/2009 Physician United States
Primary
Concomitant
Arthralgia 1/1/2008 61 Female 185 lb 12/2/2009 Consumer United States
Primary
Concomitant
Dyspnoea 1/1/2009 Female 290 lb 12/10/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Inappropriate Schedule Of Drug Administration 10/1/2009 Female 12/14/2009 Pharmacist United States
Primary
Concomitant
Drug Administered At Inappropriate Site 1/7/2010 Female 1/18/2010 Consumer United States
Primary
Concomitant
Weight Decreased Other Serious 6/1/2002 Female 127 lb 1/18/2010 Consumer United Kingdom
Primary
Concomitant
Injection Site Swelling 10/1/2008 Female 1/30/2009 Other Health Professional United States
Primary
Concomitant
Gastric Polyps Other Serious 1/1/2010 Female 156 lb 2/11/2010 United States
Primary
Concomitant
White Blood Cell Count Increased Life Threatening 1/16/2006 Female 172 lb 3/11/2010 Germany
Primary
Secondary
Concomitant
Gastric Polyps Other Serious 1/1/2010 Female 156 lb 3/26/2010 United States
Primary
Secondary
Concomitant
Gastric Polyps Other Serious 1/1/2010 52 Female 157 lb 4/8/2010 Physician United States
Primary
Secondary
Concomitant
Treatment Failure Disability 2/24/2010 38 Female 213 lb 5/5/2010 Pharmacist United States
Primary
Secondary
Concomitant
Wheezing Hospitalization 11/1/2009 39 Female 6/2/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/1/2010 84 Female 6/9/2010 Other Health Professional France
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 8/7/2009 59 Female 176 lb 6/16/2010 Pharmacist France
Primary
Secondary
Concomitant
Drug Ineffective Other Serious Male 6/30/2010 Physician United States
Primary
Concomitant
Psychiatric Symptom Hospitalization 4/1/2010 60 Female 8/2/2010 Other Health Professional France
Primary
Concomitant
Death Life Threatening 5/15/2008 36 Male 243 lb 10/6/2010 Physician United Kingdom
Primary
Concomitant
Blepharospasm Other Serious 5/15/2010 33 Female 10/6/2010 Other Health Professional France
Primary
Concomitant
Renal Failure Other Serious 6/1/2010 49 Female 10/25/2010 United States
Primary
Concomitant
Anosmia Disability 1/1/2002 77 Female 11/17/2010 Consumer United States
Primary
Secondary
Concomitant
Death Life Threatening 5/15/2008 36 Male 243 lb 12/6/2010 Physician United Kingdom
Primary
Concomitant
Pain Hospitalization 11/15/2010 73 Female 11/22/2010 Consumer United States
Primary
Concomitant
Urinary Tract Infection 12/14/2010 Consumer United States
Primary
Concomitant
Bronchitis 12/26/2009 12/16/2010 Consumer United States
Primary
Concomitant
Anosmia Disability 1/1/2002 77 Female 12/17/2010 Consumer United States
Primary
Secondary
Concomitant
Diarrhoea 4/7/2010 12/21/2010 Consumer United States
Primary
Concomitant
Diarrhoea 4/7/2010 12/21/2010 Physician United States
Primary
Secondary
Concomitant
Nerve Compression Other Serious 39 Female 220 lb 12/3/2010 Consumer United States
Primary
Concomitant
Overdose Death 37 Female 1/13/2011 Physician United States
Primary
Secondary
Completed Suicide Death 37 Female 1/21/2011 Physician United States
Primary
Secondary
Respiratory Arrest Death 1/1/2009 37 Female 1/25/2011 Physician United States
Primary
Secondary
Stress Hospitalization 4/1/2009 37 Female 180 lb 3/24/2011 Lawyer United States
Primary
Secondary
Concomitant
Cardiac Arrest Death 37 Female 3/24/2011 Physician United States
Primary
Secondary
Convulsion Death Male 3/24/2011 Physician United States
Primary
Concomitant
Angioedema Hospitalization 1/1/2011 48 Female 309 lb 4/12/2011 Consumer United States
Primary
Concomitant
Rash Maculo-papular Other Serious 8/1/2007 64 Female 160 lb 4/7/2011 Consumer United States
Primary
Secondary
Concomitant
Wound Haemorrhage Other Serious 8/1/2007 64 Female 160 lb 4/7/2011 Consumer United States
Primary
Secondary
Concomitant
Glioblastoma Death Male 187 lb 4/21/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Diabetes Mellitus Other Serious Female 5/20/2011 Consumer United States
Primary
Concomitant
Pulmonary Embolism Other Serious 11/1/2007 37 Female 181 lb 5/24/2011 Lawyer United States
Primary
Secondary
Concomitant
Hyperprolactinaemia Other Serious 3/25/2011 27 Female 5/23/2011 Pharmacist United States
Primary
Secondary
Concomitant
Deep Vein Thrombosis Hospitalization 9/9/2009 33 Female 280 lb 6/10/2011 Other Health Professional United States
Primary
Concomitant
Death Death 11/11/2010 31 Female 6/22/2011 Other Health Professional United States
Primary
Concomitant
Death Other Serious 57 Female 176 lb 6/22/2011 Pharmacist United States
Primary
Concomitant
Alanine Aminotransferase Increased Other Serious 5/25/2010 63 Female 6/24/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Device Malfunction Other Serious 11/1/2009 15 Female 6/27/2011 Physician United Kingdom
Primary
Concomitant
Depression Hospitalization 4/1/2009 37 Female 181 lb 6/30/2011 Consumer United States
Primary
Secondary
Concomitant
Completed Suicide Death 1/1/2007 47 Female 7/11/2011 Other Health Professional United States
Primary
Secondary
Device Malfunction Other Serious 11/1/2009 15 Female 7/12/2011 Physician United Kingdom
Primary
Concomitant
Completed Suicide Death 1/1/2007 47 Female 7/14/2011 Other Health Professional United States
Primary
Secondary
Completed Suicide Death 1/1/2007 47 Female 7/14/2011 Physician United States
Primary
Secondary
Sexual Relationship Change Other Serious 5/1/2011 47 Female 232 lb 7/18/2011 Physician United States
Primary
Concomitant
Myocardial Infarction Other Serious 12/9/2010 42 Female 171 lb 7/20/2011 Consumer United States
Primary
Secondary
Concomitant
Low Density Lipoprotein Increased Hospitalization 10/27/2000 50 Male 8/3/2011 Physician Canada
Primary
Concomitant
Amenorrhoea Other Serious 37 Female 8/16/2011 Physician United States
Primary
Concomitant
Interacting
Intervertebral Disc Displacement Hospitalization 1/1/2010 56 Female 8/18/2011 Physician United States
Primary
Concomitant
Antidepressant Drug Level Increased Hospitalization 37 Female 8/31/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/26/2010 57 Female 9/7/2011 Consumer United States
Primary
Concomitant
Completed Suicide Death 1/1/2007 47 Female 8/4/2011 Other Health Professional United States
Primary
Secondary
White Blood Cell Count Increased Hospitalization 6/1/2011 34 Female 9/20/2011 Consumer United States
Primary
Concomitant
Blood Glucose Increased Hospitalization 6/1/2011 34 Female 9/23/2011 Consumer United States
Primary
Concomitant
Infusion Related Reaction Other Serious 9/14/2011 72 Male 215 lb 9/28/2011 Other Health Professional United States
Primary
Concomitant
Confusional State 6/29/2011 56 Female 9/28/2011 Consumer United States
Primary
Concomitant
Agitation Hospitalization 51 Female 10/12/2011 Other Health Professional United States
Primary
Concomitant
Constipation 10/1/2010 46 Female 10/22/2011 Consumer United States
Primary
Concomitant
Lethargy Hospitalization 10/10/2011 49 Male 101 lb 10/31/2011 Pharmacist United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 4/1/2009 37 Female 181 lb 11/7/2011 Consumer United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious Female 11/10/2011 Consumer United States
Primary
Concomitant
Injury Disability 8/1/2007 24 Female 204 lb 11/28/2011 Other Health Professional United States
Primary
Concomitant
Anxiety Hospitalization 8/1/2007 24 Female 204 lb 11/28/2011 Other Health Professional United States
Primary
Concomitant
Completed Suicide Death 37 Female 12/19/2011 Other Health Professional United States
Primary
Secondary
Completed Suicide Death 37 Female 12/19/2011 Other Health Professional United States
Primary
Secondary

Drug Data