Levothyroxine Sodium combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Syncope Hospitalization 2/7/2005 68 Male 170 lb 10/31/2005 Other Health Professional United States
Primary
Secondary
Concomitant
Electrocardiogram St Segment Elevation Other Serious 10/5/2005 59 Male 181 lb 1/17/2006 Consumer United Kingdom
Primary
Concomitant
Vitreous Detachment Other Serious 11/1/2005 60 Female 1/11/2006 Consumer France
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 5/11/2002 73 Male 201 lb 1/19/2006 Lawyer United States
Primary
Concomitant
Hypercalcaemia 12/19/2005 65 Male 1/16/2006 United Kingdom
Primary
Concomitant
Weight Decreased 66 Male 1/30/2006 Physician United States
Primary
Concomitant
Neutropenia Hospitalization 11/20/2005 70 Female 1/25/2006 Switzerland
Primary
Secondary
Concomitant
Arrhythmia Required Intervention 10/31/2005 58 Male 269 lb 10/31/2005 Pharmacist United States
Primary
Concomitant
Pneumonitis Death 6/1/2005 69 Male 1/30/2006 United Kingdom
Primary
Concomitant
Vomiting Death 1/1/2004 Female 2/7/2006 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 2/9/2006 United States
Primary
Concomitant
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 2/9/2006 United States
Primary
Concomitant
Pneumonitis Death 6/1/2005 69 Male 2/6/2006 United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 10/27/2005 87 Male 127 lb 12/1/2005 Pharmacist United States
Primary
Secondary
Concomitant
Epistaxis 12/12/2005 69 Male 177 lb 12/16/2005 Other Health Professional United States
Primary
Concomitant
Osteoporosis Hospitalization 1/5/2006 65 Male 217 lb 1/27/2006 Other Health Professional Denmark
Primary
Concomitant
Prostate Cancer Other Serious 3/7/2005 62 Male 214 lb 2/10/2006 Physician Netherlands
Primary
Concomitant
Lymphadenopathy Other Serious 11/1/2004 68 Female 194 lb 2/9/2006 Physician Germany
Primary
Secondary
Concomitant
Myocardial Infarction Other Serious 5/15/2003 76 Female 77 lb 2/21/2006 Lawyer United Kingdom
Primary
Concomitant
Leukopenia Hospitalization 8/21/2005 76 Male 160 lb 1/30/2006 Pharmacist United States
Primary
Concomitant
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 2/23/2006 United States
Primary
Concomitant
Vomiting Other Serious 8/1/2001 76 Female 99 lb 2/24/2006 Physician United Kingdom
Primary
Concomitant
Osteoporosis Hospitalization 1/5/2006 65 Male 217 lb 2/10/2006 Physician Denmark
Primary
Concomitant
Vomiting Other Serious 8/1/2001 76 Female 99 lb 3/2/2006 Physician United Kingdom
Primary
Concomitant
Vascular Calcification Hospitalization 4/19/2002 73 Male 201 lb 3/6/2006 Physician United States
Primary
Concomitant
Night Sweats Hospitalization 86 Female 3/4/2006 United Kingdom
Primary
Secondary
Concomitant
Tricuspid Valve Incompetence Other Serious 2/1/2006 64 Female 161 lb 3/2/2006 Physician Germany
Primary
Secondary
Concomitant
Venous Pressure Jugular Increased Hospitalization 79 Female 3/8/2006 United Kingdom
Primary
Concomitant
Pulmonary Alveolar Haemorrhage Hospitalization 8/29/2004 75 Female 170 lb 12/29/2005 Other Health Professional United States
Primary
Concomitant
Factor V Leiden Mutation Hospitalization 2/17/2006 85 Male 187 lb 3/14/2006 Pharmacist United States
Primary
Concomitant
Weight Increased Hospitalization 51 Female 3/20/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Neutropenia Other Serious 2/22/2005 38 Male 245 lb 4/1/2005 Pharmacist United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 70 Male 3/13/2006 Physician United States
Primary
Secondary
Concomitant
Vascular Calcification Hospitalization 4/19/2002 73 Male 201 lb 3/23/2006 Physician United States
Primary
Concomitant
Thrombocytopenia Death 3/15/2005 62 Male 3/27/2006 Physician Canada
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/8/2006 59 Male 224 lb 3/28/2006 United States
Primary
Secondary
Concomitant
Nervous System Disorder Hospitalization 3/14/2006 77 Female 4/14/2006 Other Health Professional United Kingdom
Primary
Concomitant
Agitation Hospitalization 4/1/2006 Male 280 lb 4/14/2006 Physician United States
Primary
Concomitant
Transient Ischaemic Attack Other Serious 9/1/2001 70 Female 126 lb 4/14/2006 Physician Canada
Primary
Concomitant
Myalgia Other Serious 7/22/2005 51 Male 227 lb 4/13/2006 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/8/2006 59 Male 224 lb 4/7/2006 United States
Primary
Secondary
Concomitant
Pulmonary Toxicity Required Intervention 4/26/2005 72 Male 175 lb 4/20/2006 Pharmacist United States
Primary
Concomitant
Rhabdomyolysis Required Intervention 4/13/2006 76 Male 160 lb 4/18/2006 Pharmacist United States
Primary
Concomitant
Refusal Of Treatment By Patient Hospitalization 4/1/2006 Male 280 lb 4/26/2006 Physician United States
Primary
Concomitant
Pneumonia Aspiration Hospitalization 4/22/2006 70 Male 178 lb 4/24/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Hallucination, Visual Hospitalization 10/28/2005 79 Male 148 lb 4/18/2006 Physician Canada
Primary
Concomitant
Vertigo Hospitalization 7/1/2003 55 Female 4/28/2006 Physician Norway
Primary
Concomitant
Tachycardia Hospitalization 12/1/2001 63 Male 4/28/2006 Norway
Primary
Concomitant
Blood Glucose Decreased Hospitalization 4/14/2006 85 Male 194 lb 4/27/2006 Pharmacist United States
Primary
Concomitant
Supraventricular Tachycardia Hospitalization 2/14/2006 69 Female 4/12/2006 Physician United Kingdom
Primary
Concomitant
Supraventricular Tachycardia Hospitalization 2/14/2006 69 Female 4/27/2006 Physician United Kingdom
Primary
Concomitant
Syncope Life Threatening 4/2/2006 Female 331 lb 5/11/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Therapeutic Response Decreased Other Serious 1/1/2005 Male 5/15/2006 Physician Canada
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/8/2006 59 Male 224 lb 5/11/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Toxic Skin Eruption Hospitalization 3/30/2006 64 Male 5/3/2006 Switzerland
Primary
Secondary
Concomitant
Prothrombin Time Prolonged Hospitalization 1/16/2006 Male 5/16/2006 Pharmacist United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 12/6/2005 Male 5/16/2006 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/8/2006 59 Male 224 lb 5/18/2006 Physician United States
Primary
Secondary
Concomitant
Heart Rate Decreased Required Intervention 3/19/2006 78 Male 185 lb 4/16/2006 Pharmacist United States
Primary
Concomitant
Hypertensive Crisis Hospitalization 5/1/2006 59 Male 231 lb 5/26/2006 Physician Germany
Primary
Concomitant
Cystitis Hospitalization 11/3/2005 78 Female 6/9/2006 Other Health Professional Germany
Primary
Concomitant
Toxic Skin Eruption Other Serious 4/26/2006 70 Female 6/1/2006 Physician France
Primary
Concomitant
Cystitis Hospitalization 6/17/2005 77 Female 150 lb 6/13/2006 Other Health Professional Germany
Primary
Concomitant
Tachycardia Hospitalization 67 Female 6/2/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Peptic Ulcer Hospitalization 4/1/2006 74 Female 6/14/2006 Physician
Primary
Secondary
Concomitant
Agitation Hospitalization 4/1/2006 Male 280 lb 6/15/2006 Physician United States
Primary
Concomitant
Vomiting Other Serious 5/1/2006 65 Female 6/16/2006 United Kingdom
Primary
Secondary
Concomitant
Weight Decreased 8/1/2005 68 Male 204 lb 3/17/2006 Consumer United States
Primary
Concomitant
Vomiting Other Serious 5/17/2006 65 Female 6/22/2006 United Kingdom
Primary
Secondary
Concomitant
Vomiting Life Threatening 5/17/2006 65 Male 6/22/2006 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Heart Rate Increased Other Serious Female 132 lb 6/22/2006 Physician Germany
Primary
Concomitant
Thrombocytopenia Life Threatening 5/15/2006 69 Female 6/22/2006 Physician Hong Kong
Primary
Concomitant
Personality Change Hospitalization 6/3/2006 59 Male 217 lb 6/14/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/21/2006 82 Male 174 lb 7/6/2006 Physician United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 4/24/2006 67 Male 7/5/2006 Pharmacist United States
Primary
Secondary
Concomitant
International Normalised Ratio Increased Hospitalization 4/26/2006 61 Male 7/6/2006 Pharmacist United States
Primary
Concomitant
Thrombocytopenia Hospitalization 6/16/2006 75 Female 134 lb 7/5/2006 Other Health Professional Germany
Primary
Concomitant
Angioneurotic Oedema Life Threatening 6/9/2006 72 Female 144 lb 6/14/2006 Other Health Professional United States
Primary
Concomitant
Hypotension Other Serious 5/8/2006 80 Male 166 lb 5/8/2006 Pharmacist United States
Primary
Concomitant
Intracranial Pressure Increased Life Threatening 10/1/2005 64 Male 7/10/2006 Norway
Primary
Secondary
Concomitant
Post Procedural Complication Hospitalization 9/1/2005 39 Male 7/10/2006 Norway
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Other Serious 7/6/2006 63 Female 7/19/2006 Consumer Spain
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Life Threatening 5/19/2006 81 Male 110 lb 7/14/2006 Pharmacist United States
Primary
Concomitant
Wheezing Hospitalization 6/21/2006 82 Male 174 lb 7/20/2006 Physician United States
Primary
Concomitant
Thrombocytopenia Life Threatening 5/15/2006 69 Female 7/14/2006 Physician Hong Kong
Primary
Concomitant
Clostridium Difficile Colitis Hospitalization 7/15/2006 57 Female 212 lb 7/19/2006 Pharmacist United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 7/15/2006 57 Female 212 lb 7/19/2006 Pharmacist United States
Primary
Concomitant
Muscular Weakness Other Serious 10/28/2005 75 Male 268 lb 6/26/2006 Pharmacist United States
Primary
Concomitant
Thrombocytopenia Life Threatening 6/16/2006 75 Female 134 lb 7/19/2006 Other Health Professional Germany
Primary
Concomitant
Granulocytopenia Required Intervention 10/3/2005 42 Male 1/25/2006 United States
Primary
Concomitant
Therapy Non-responder Other Serious 4/1/2004 75 Female 7/20/2006 Israel
Primary
Secondary
Concomitant
Thyroxine Free Decreased Other Serious 6/1/2004 81 Male 7/20/2006 Israel
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 10/11/2005 46 Female 2/7/2006 United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 5/5/2001 77 Male 7/21/2006 United States
Primary
Concomitant
Wheezing Hospitalization 6/21/2006 82 Male 174 lb 7/28/2006 Physician United States
Primary
Concomitant
Renal Function Test Abnormal Other Serious 79 Female 7/28/2006 Physician New Zealand
Primary
Concomitant
Myalgia Other Serious 5/15/2006 88 Female 7/28/2006 United Kingdom
Primary
Concomitant
Vomiting Life Threatening 2/1/2006 75 Male 150 lb 8/4/2006 Physician Germany
Primary
Concomitant
Muscle Spasms 4/12/2006 75 Female 7/12/2006 Consumer United States
Primary
Concomitant
Intracranial Pressure Increased Life Threatening 10/1/2005 64 Male 7/27/2006 Norway
Primary
Secondary
Concomitant
Sinus Operation Hospitalization 9/1/2005 39 Male 7/28/2006 Norway
Primary
Secondary
Concomitant
Vomiting Other Serious 5/17/2006 65 Female 8/4/2006 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Therapy Cessation Other Serious 5/20/2006 67 Female 163 lb 8/7/2006 Physician Austria
Primary
Concomitant
Poor Quality Drug Administered Other Serious 7/9/2006 77 Female 8/2/2006 United States
Primary
Concomitant
Agitation Hospitalization 4/1/2006 Male 280 lb 8/16/2006 Physician United States
Primary
Concomitant
Pruritus Life Threatening 6/4/2006 55 Male 8/9/2006 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Other Serious 6/19/2006 60 Female 8/10/2006 Other Health Professional United States
Primary
Concomitant
Pulmonary Oedema Other Serious 9/4/2003 57 Female 8/21/2006 United States
Primary
Concomitant
Tremor Other Serious 6/10/2006 58 Female 198 lb 8/16/2006 Physician Belgium
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 3/8/2006 61 Female 4/10/2006 United States
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 71 Female 8/18/2006 Denmark
Primary
Concomitant
Therapy Non-responder Hospitalization 6/3/2006 Male 197 lb 6/27/2006 United States
Primary
Concomitant
Wound Hospitalization 7/14/2006 Male 242 lb 8/25/2006 Pharmacist United States
Primary
Concomitant
Poor Quality Drug Administered Other Serious 7/9/2006 77 Female 8/28/2006 United States
Primary
Concomitant
Pain In Extremity Other Serious 6/6/2006 65 Female 8/21/2006 Pharmacist United Kingdom
Primary
Concomitant
Syncope Life Threatening 4/2/2006 Female 331 lb 9/1/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 42 Female 99 lb 8/24/2006 United States
Primary
Concomitant
Oesophageal Ulcer Other Serious 3/2/2006 77 Female 9/5/2006 United Kingdom
Primary
Concomitant
Sedation 2/1/2006 83 Male 9/6/2006 Consumer United States
Primary
Concomitant
Nausea Other Serious 4/3/2006 Female 9/6/2006 United Kingdom
Primary
Concomitant
Pulmonary Embolism Hospitalization 6/6/2006 Female 163 lb 9/13/2006 Physician United States
Primary
Concomitant
Pain In Extremity Disability 9/1/2006 64 Female 207 lb 9/25/2006 Other Health Professional United Kingdom
Primary
Concomitant
Neutropenia Hospitalization 2/8/2006 59 Male 225 lb 9/26/2006 Physician United States
Primary
Secondary
Concomitant
Type Iv Hypersensitivity Reaction Life Threatening 9/7/2006 Female 260 lb 9/26/2006 Pharmacist United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 1/1/2006 88 Male 9/30/2006 United States
Primary
Concomitant
Pallor Death 67 Female 9/25/2006 Physician Saudi Arabia
Primary
Concomitant
Serotonin Syndrome Other Serious 9/23/2006 38 Female 225 lb 9/28/2006 Pharmacist United States
Primary
Concomitant
Migraine Disability 9/2/2006 75 Female 10/5/2006
Primary
Concomitant
Sinus Disorder Hospitalization 9/1/2005 39 Male 9/28/2006 Norway
Primary
Secondary
Concomitant
Hypotension Hospitalization 7/6/2006 85 Male 172 lb 10/4/2006 Pharmacist United States
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 6/13/2006 77 Male 311 lb 10/4/2006 Pharmacist United States
Primary
Concomitant
Respiratory Tract Infection Other Serious 5/30/2006 74 Female 10/3/2006 Other Health Professional Sweden
Primary
Concomitant
Vomiting Life Threatening 2/1/2006 75 Male 148 lb 10/10/2006 Physician Germany
Primary
Concomitant
Urinary Tract Infection Other Serious 6/19/2006 60 Female 10/4/2006 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Life Threatening 6/18/2006 60 Female 10/5/2006 Other Health Professional United States
Primary
Concomitant
Haemorrhagic Stroke Hospitalization 7/4/2006 80 Female 10/11/2006 United Kingdom
Primary
Secondary
Concomitant
Hepatocellular Damage Other Serious 9/8/2005 57 Female 198 lb 9/28/2006 Physician France
Primary
Concomitant
Neutropenic Sepsis Life Threatening 9/1/2006 78 Female 10/13/2006 United Kingdom
Primary
Concomitant
Vaginal Haemorrhage Hospitalization 8/14/2006 77 Female 207 lb 10/16/2006 Other Health Professional United Kingdom
Primary
Concomitant
Vaginal Haemorrhage Hospitalization 8/14/2006 77 Female 10/19/2006 Other Health Professional United Kingdom
Primary
Concomitant
Myositis Life Threatening 7/30/2006 79 Female 110 lb 10/25/2006 United Kingdom
Primary
Concomitant
Serotonin Syndrome Other Serious 9/23/2006 38 Female 11/3/2006 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/8/2006 59 Male 225 lb 11/6/2006 Physician United States
Primary
Secondary
Concomitant
Pain In Extremity Disability 9/1/2006 64 Female 207 lb 11/9/2006 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Ischaemia Death Female 126 lb 11/9/2006 Other Health Professional United Kingdom
Primary
Concomitant
Therapy Cessation Hospitalization 10/19/2006 67 Male 122 lb 11/3/2006 Physician United Kingdom
Primary
Concomitant
Hypoaesthesia Oral Hospitalization Female 98 lb 11/13/2006 Physician Germany
Primary
Concomitant
Hypoaesthesia Oral Hospitalization Female 98 lb 11/13/2006 Physician Germany
Primary
Concomitant
Psychotic Disorder Required Intervention 35 Male 11/7/2006 United States
Primary
Concomitant
Vomiting Required Intervention 9/13/2006 62 Female 214 lb 10/31/2006 Physician Germany
Primary
Concomitant

Drug Data