Levothyroxine Sodium combined with Phenytoin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
International Normalised Ratio Increased 7/22/2004 9/12/2005 Physician United States
Primary
Concomitant
Vomiting Other Serious 11/30/2005 85 Female 143 lb 12/9/2005 Pharmacist United States
Primary
Concomitant
West Nile Viral Infection Other Serious 64 Male 211 lb 2/16/2006 Consumer United States
Primary
Concomitant
Psychomotor Retardation Hospitalization 4/9/2002 72 Female 3/3/2006 Other Health Professional France
Primary
Secondary
Concomitant
Vomiting Other Serious 2/22/2006 85 Female 153 lb 2/22/2006 Pharmacist United States
Primary
Concomitant
Therapy Non-responder Required Intervention 3/24/2006 63 Male 114 lb 4/3/2006 Pharmacist United States
Primary
Concomitant
Therapeutic Response Decreased Other Serious 1/1/2005 Male 5/15/2006 Physician Canada
Primary
Secondary
Concomitant
Insomnia 1/1/2005 59 Female 130 lb 4/3/2006 Consumer United States
Primary
Concomitant
Hypotension Other Serious 5/8/2006 80 Male 166 lb 5/8/2006 Pharmacist United States
Primary
Concomitant
Loss Of Consciousness Other Serious 8/9/2006 54 Female 170 lb 9/7/2006 Pharmacist United States
Primary
Concomitant
Wound Secretion Other Serious 9/8/2006 80 Male 152 lb 9/22/2006 Other Health Professional United States
Primary
Concomitant
Wound Infection Staphylococcal Other Serious 9/8/2006 80 Male 335 lb 10/6/2006 Other Health Professional United States
Primary
Concomitant
Urine Ketone Body Present Other Serious 12/1/2005 Female 12/26/2006 Other Health Professional United Kingdom
Primary
Concomitant
Drug Ineffective Hospitalization 1/3/2007 Female 148 lb 2/6/2007 Consumer United States
Primary
Secondary
Concomitant
Sudden Death Hospitalization 12/31/2006 74 Female 2/12/2007 Physician United States
Primary
Concomitant
Wound Drainage Other Serious 9/8/2006 80 Male 152 lb 3/9/2007 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/15/2007 77 Female 190 lb 3/26/2007 Pharmacist United States
Primary
Concomitant
Post Procedural Haematoma Required Intervention 2/5/2007 71 Female 166 lb 2/13/2007 Pharmacist United States
Primary
Concomitant
Thrombocytopenia Hospitalization 10/2/2006 82 Female 4/4/2007 Pharmacist United States
Primary
Concomitant
Sudden Death Hospitalization 12/31/2006 74 Female 4/2/2007 Physician United States
Primary
Concomitant
Urinary Tract Infection Life Threatening 72 Female 5/2/2007 Czech Republic
Primary
Secondary
Leiomyosarcoma Other Serious 12/1/2006 14 Male 5/9/2007 Physician Canada
Primary
Concomitant
Asthenia Hospitalization 3/22/2007 Male 153 lb 5/10/2007 Pharmacist United States
Primary
Concomitant
Constipation Hospitalization 63 Female 138 lb 7/27/2007 Canada
Primary
Concomitant
Constipation Hospitalization 63 Female 138 lb 8/10/2007 Canada
Primary
Concomitant
Gastrointestinal Disorder Hospitalization 59 Male 197 lb 9/25/2007 Physician United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 10/2/2007 68 Male 10/11/2007
Primary
Concomitant
Pituitary Tumour Benign Hospitalization 6/8/2007 Male 221 lb 10/4/2007 Physician Belgium
Primary
Concomitant
Ileus Death 12/2/2006 77 Female 143 lb 10/12/2007 Physician Germany
Primary
Concomitant
Enteritis Infectious Hospitalization 8/31/2007 59 Male 197 lb 10/17/2007 Physician United Kingdom
Primary
Concomitant
Cerebrovascular Accident Hospitalization 10/2/2007 68 Male 10/31/2007
Primary
Secondary
Concomitant
Urticaria 1/1/1999 Female 175 lb 11/8/2007 Consumer United States
Primary
Concomitant
Drug Interaction Hospitalization 6/5/2006 70 Female 12/10/2007 Physician Canada
Primary
Secondary
Concomitant
Rash Generalised Other Serious 10/23/2007 67 Female 12/14/2007 Other Health Professional United Kingdom
Primary
Concomitant
Emotional Distress Other Serious 1/1/2007 Male 12/14/2007 Consumer United States
Primary
Secondary
Concomitant
Loss Of Consciousness Required Intervention 70 Female 1/7/2008 Physician Canada
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 5/29/2006 70 Female 1/17/2008
Primary
Secondary
Concomitant
Supraventricular Extrasystoles Required Intervention 3/13/2007 70 Female 1/24/2008 Other Health Professional United States
Primary
Concomitant
Pancytopenia Hospitalization 56 Male 176 lb 3/5/2008 United Kingdom
Primary
Concomitant
Vision Blurred Other Serious 1/1/2008 Female 3/31/2008 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 2/13/2008 Female 140 lb 4/25/2008 Consumer United States
Primary
Secondary
Concomitant
Interacting
Skin Papilloma Other Serious 1/26/2007 30 Female 4/28/2008 Physician France
Primary
Concomitant
Drug Level Below Therapeutic Other Serious 2/6/2008 9 Female 82 lb 5/20/2008 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Injection Site Pain 12/1/2007 Female 240 lb 6/12/2008 United States
Primary
Concomitant
Cerebrovascular Accident Hospitalization 10/2/2007 68 Male 6/23/2008 Physician Germany
Primary
Secondary
Concomitant
Hypotension Hospitalization 5/16/2008 78 Female 7/9/2008 Other Health Professional France
Primary
Concomitant
Vision Blurred Other Serious 1/1/2008 Female 8/20/2008 Physician United States
Primary
Concomitant
Splenic Infarction Hospitalization 52 Male 9/17/2008 United States
Primary
Secondary
Vena Cava Thrombosis Hospitalization 12/1/2004 5 Female 10/23/2008 India
Primary
Concomitant
Vena Cava Thrombosis Hospitalization 12/1/2005 4 Male 10/23/2008 India
Primary
Concomitant
Status Epilepticus Required Intervention 3/13/2007 70 Female 11/7/2008 Other Health Professional United States
Primary
Concomitant
Treatment Noncompliance Life Threatening 10/14/2008 43 Female 12/3/2008 Other Health Professional United States
Primary
Concomitant
Nasopharyngitis 10/21/2008 Female 182 lb 12/12/2008 United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/15/2008 61 Female 1/9/2009 Physician United Kingdom
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 47 Female 1/14/2009
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 11/23/2008 1/20/2009 Physician Chile
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 11/23/2008 1/22/2009 Physician Chile
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/15/2008 61 Female 1/19/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/15/2008 61 Female 1/19/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Deep Vein Thrombosis Other Serious 9/1/2008 Female 1/27/2009 Physician Japan
Primary
Concomitant
No Therapeutic Response Hospitalization 38 Female 1/20/2009 Physician United States
Primary
Secondary
Concomitant
Urosepsis Hospitalization 10/14/2008 75 Female 135 lb 2/18/2009 Pharmacist United States
Primary
Concomitant
Flushing 2/1/2009 Female 2/24/2009 United States
Primary
Concomitant
White Blood Cell Count Decreased 12/15/2008 61 Female 2/19/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Deep Vein Thrombosis Other Serious 9/1/2008 Female 3/2/2009 Physician Japan
Primary
Concomitant
Pituitary Tumour Benign Hospitalization 4/9/2007 Male 185 lb 3/17/2009 Physician Belgium
Primary
Concomitant
Respiratory Failure Other Serious 11/23/2008 3/24/2009 Physician Chile
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 11/23/2008 4/7/2009 Physician Chile
Primary
Secondary
Concomitant
Pituitary Tumour Benign Hospitalization 4/9/2007 Male 185 lb 4/23/2009 Physician Belgium
Primary
Concomitant
Rectal Haemorrhage Required Intervention 11/24/2008 83 Female 212 lb 12/23/2008 United States
Primary
Concomitant
Laceration Hospitalization 3/17/2009 72 Male 194 lb 4/27/2009 Pharmacist United States
Primary
Concomitant
Serotonin Syndrome 3/1/2009 55 Female 156 lb 3/30/2009 Pharmacist United States
Primary
Concomitant
Product Substitution Issue Other Serious 55 Female 4/29/2009 Australia
Primary
Concomitant
Drug Ineffective 4/30/2009 80 Male 5/22/2009 Consumer
Primary
Concomitant
Rash Maculo-papular Other Serious 12 Male 88 lb 7/1/2009 Consumer Canada
Primary
Secondary
Concomitant
Atrial Fibrillation Other Serious 6/18/2009 Female 8/3/2009 Physician United Kingdom
Primary
Concomitant
Subcutaneous Nodule Other Serious 8/4/2006 23 Female 154 lb 8/4/2009 Physician United States
Primary
Secondary
Concomitant
Nausea Hospitalization 64 Female 8/11/2009 United States
Primary
Concomitant
Incorrect Dose Administered 8/3/2007 Female 195 lb 9/11/2009 Consumer United States
Primary
Concomitant
Shock Hypoglycaemic Other Serious Male 9/25/2009 United States
Primary
Concomitant
Musculoskeletal Pain Hospitalization 8/4/2009 74 Female 150 lb 8/5/2009 United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Death 1/1/2007 58 Female 9/29/2009 Other Health Professional United States
Primary
Concomitant
Ventricular Fibrillation Life Threatening 4/28/2009 61 Female 236 lb 10/2/2009 Physician United States
Primary
Concomitant
Vomiting Other Serious 4/1/2008 33 Female 121 lb 10/6/2009 Other Health Professional United States
Primary
Concomitant
Rash Pruritic Hospitalization 52 Male 9/18/2009 Other Health Professional United States
Primary
Secondary
Rash Pruritic Hospitalization 52 Male 9/18/2009 United States
Primary
Secondary
Septic Shock Other Serious 11/23/2008 68 Female 165 lb 11/26/2009 Physician Chile
Primary
Secondary
Concomitant
Pituitary Tumour Benign Hospitalization 4/9/2007 Male 185 lb 12/1/2009 Physician Belgium
Primary
Concomitant
Pollakiuria 81 Male 12/9/2009 Consumer United States
Primary
Concomitant
Subcutaneous Nodule Other Serious 8/4/2006 23 Female 154 lb 12/18/2009 Physician United States
Primary
Secondary
Concomitant
Subcutaneous Nodule Other Serious 8/4/2006 23 Female 154 lb 12/28/2009 Physician United States
Primary
Secondary
Concomitant
Subcutaneous Nodule Other Serious 8/4/2006 23 Female 154 lb 12/31/2009 Physician United States
Primary
Secondary
Concomitant
Hypothyroidism Hospitalization 48 Female 1/5/2010 Physician New Zealand
Primary
Concomitant
Interacting
Injection Site Pain 1/1/2008 Male 330 lb 1/30/2010 Consumer United States
Primary
Concomitant
Visual Impairment Other Serious 48 Female 2/2/2010 Other Health Professional New Zealand
Primary
Secondary
Concomitant
Hypothyroidism Other Serious 48 Female 2/11/2010 Physician New Zealand
Primary
Concomitant
Hypotension Hospitalization 2/19/2010 28 Female 119 lb 4/15/2010 Consumer United States
Primary
Concomitant
Vomiting Other Serious 8/1/2009 72 Female 4/15/2010 Netherlands
Primary
Secondary
Concomitant
Vomiting Other Serious 8/1/2009 72 Female 4/27/2010 Netherlands
Primary
Secondary
Concomitant
Stomatitis Life Threatening 3/20/2010 58 Male 4/27/2010 Physician India
Primary
Concomitant
Hyponatraemia Hospitalization 3/20/2010 85 Female 139 lb 5/20/2010 Pharmacist United States
Primary
Concomitant
Vomiting Other Serious 4/1/2008 33 Female 121 lb 5/24/2010 Other Health Professional United States
Primary
Concomitant
Death Death 1/1/2002 9 Male 6/1/2010 Physician United Kingdom
Primary
Concomitant
Hypotension Hospitalization 2/19/2010 28 Female 119 lb 6/14/2010 Consumer United States
Primary
Concomitant
Stomatitis Life Threatening 3/20/2010 58 Male 6/15/2010 Physician India
Primary
Concomitant
Convulsion Life Threatening 5/13/2010 72 Female 155 lb 6/22/2010 Physician United Kingdom
Primary
Concomitant
Thrombosis Other Serious 2/19/2010 27 Female 112 lb 7/1/2010 Consumer United States
Primary
Secondary
Concomitant
Thoracic Vertebral Fracture Hospitalization 7/1/2010 74 Female 132 lb 7/13/2010 Pharmacist United States
Primary
Concomitant
Dyspnoea Other Serious 5/1/2010 64 Male 7/12/2010 Other Health Professional United Kingdom
Primary
Concomitant
Tinea Versicolour Hospitalization 3/28/2010 82 Male 7/23/2010 Physician United States
Primary
Secondary
Concomitant
Palpitations 56 Female 7/30/2010 Consumer United States
Primary
Concomitant
Dyspnoea Other Serious 5/1/2010 64 Female 8/4/2010 Other Health Professional United Kingdom
Primary
Concomitant
Tinea Versicolour Hospitalization 3/28/2010 82 Male 8/13/2010 Physician United States
Primary
Secondary
Concomitant
Dyspnoea Other Serious 5/1/2010 64 Male 9/1/2010 Other Health Professional United Kingdom
Primary
Concomitant
Dyspnoea Other Serious 5/1/2010 64 Female 9/2/2010 Other Health Professional United Kingdom
Primary
Concomitant
Subarachnoid Haemorrhage Death 8/31/2010 45 Male 9/10/2010 Physician Puerto Rico
Primary
Secondary
Concomitant
Death Death Male 179 lb 9/14/2010 Other Health Professional United States
Primary
Concomitant
Subarachnoid Haemorrhage Death 8/31/2010 45 Male 10/8/2010 Physician Puerto Rico
Primary
Secondary
Concomitant
Mental Status Changes Hospitalization 80 Male 10/12/2010 Other Health Professional United States
Primary
Concomitant
Subarachnoid Haemorrhage Death 8/31/2010 45 Male 10/29/2010 Physician Puerto Rico
Primary
Secondary
Concomitant
Hodgkin's Disease Life Threatening 12/24/2007 28 Male 227 lb 11/9/2010 Physician United Kingdom
Primary
Concomitant
Renal Failure Life Threatening 6/1/2010 41 Male 147 lb 11/16/2010 Physician United Kingdom
Primary
Concomitant
Tachycardia Hospitalization 10/26/2010 40 Female 83 lb 11/9/2010 Pharmacist United States
Primary
Concomitant
Skin Papilloma Other Serious 2/19/2008 30 Female 3/17/2011 Physician France
Primary
Concomitant
Anticonvulsant Drug Level Increased Hospitalization 48 Female 4/18/2011 Other Health Professional New Zealand
Primary
Concomitant
Anticonvulsant Drug Level Above Therapeutic Hospitalization 64 Female 4/25/2011 United States
Primary
Concomitant
Haemolytic Anaemia Disability 12/1/2010 68 Female 110 lb 7/11/2011 Pharmacist United States
Primary
Interacting
Urinary Tract Infection Other Serious 6/1/2011 47 Female 8/4/2011 Consumer Brazil
Primary
Concomitant
Hyperammonaemia 3/24/2011 27 Male 8/5/2011 Pharmacist United States
Primary
Concomitant
Blood Count Abnormal Hospitalization 1/1/2008 73 Female 8/9/2011 Consumer United States
Primary
Secondary
Concomitant
Extremity Contracture Other Serious 8/4/2006 23 Female 155 lb 8/10/2011 Consumer United States
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 1/17/2009 62 Male 8/16/2011 Physician United Kingdom
Primary
Concomitant
Headache Hospitalization 1/1/1995 59 Female 140 lb 8/19/2011 Consumer United States
Primary
Secondary
Concomitant
Brain Neoplasm Other Serious 9/1/2010 32 Female 139 lb 8/16/2011 Consumer Brazil
Primary
Concomitant
Cardiac Murmur Hospitalization 65 Male 8/16/2011 United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/1995 59 Female 140 lb 9/2/2011 Consumer United States
Primary
Secondary
Concomitant
Mental Status Changes Hospitalization 65 Male 9/8/2011 Other Health Professional United States
Primary
Concomitant
Toxicity To Various Agents Hospitalization 65 Male 9/9/2011 Other Health Professional United States
Primary
Concomitant
Dysphagia Other Serious 9/1/2010 32 Female 139 lb 9/6/2011 Consumer Brazil
Primary
Concomitant
Electrocardiogram St-t Change Hospitalization 6/29/2011 84 Female 130 lb 9/14/2011 Pharmacist United States
Primary
Concomitant
Prothrombin Time Prolonged Other Serious 4/23/2008 48 Male 138 lb 9/12/2011 Physician Japan
Primary
Secondary
Concomitant
Blood Pressure Increased Hospitalization 65 Male 9/21/2011 Other Health Professional United States
Primary
Concomitant
Osteonecrosis Of Jaw Other Serious 1/1/2009 81 Female 9/27/2011 Other Health Professional United States
Primary
Concomitant
Speech Disorder Hospitalization 65 Male 9/23/2011 Other Health Professional United States
Primary
Concomitant
Haemoglobin Decreased Other Serious 12/22/2010 68 Female 117 lb 8/18/2011 Physician United States
Primary
Concomitant
Haemorrhage Female 11/3/2011 Other Health Professional United States
Primary
Concomitant
Osteonecrosis Of Jaw Other Serious 1/1/2009 81 Female 11/9/2011 Other Health Professional United States
Primary
Concomitant
Ataxia Other Serious 8/19/2008 76 Female 11/7/2011 Other Health Professional United States
Primary
Concomitant
Injection Site Warmth 1/17/2011 75 Female 130 lb 11/17/2011 Consumer United States
Primary
Concomitant
Nervousness Other Serious 1/1/1995 59 Female 140 lb 11/23/2011 Consumer United States
Primary
Secondary
Concomitant

Drug Data