Levothyroxine combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Musculoskeletal Stiffness 4/7/2008 83 Female 7/23/2008 United States
Primary
Concomitant
Rash Generalised Life Threatening 4/1/2008 8/25/2008 Other Health Professional United Kingdom
Primary
Concomitant
Erectile Dysfunction 7/25/2008 Male 8/28/2008 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis Death 1/9/2008 Male 223 lb 8/28/2008 United Kingdom
Primary
Concomitant
Angioedema Hospitalization 12/10/2008 73 Female 170 lb 12/11/2008 Pharmacist United States
Primary
Concomitant
Renal Mass Hospitalization 7/1/2008 77 Female 100 lb 8/22/2008 Consumer United States
Primary
Concomitant
Weight Decreased Death 1/1/2008 74 Male 12/16/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Dyspnoea Other Serious 10/25/2008 75 Female 118 lb 12/29/2008 Physician United Kingdom
Primary
Concomitant
Therapy Cessation Death 10/31/2008 Female 128 lb 12/31/2008 Physician United Kingdom
Primary
Concomitant
Pelvic Mass Hospitalization 1/1/2007 Female 1/5/2009 Other Health Professional United Kingdom
Primary
Concomitant
Memory Impairment Other Serious 9/1/2007 Female 146 lb 1/6/2009 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Life Threatening 11/23/2008 88 Male 176 lb 1/7/2009 Other Health Professional United Kingdom
Primary
Concomitant
Angina Unstable Other Serious 7/9/2001 Male 194 lb 1/8/2009 Physician United States
Primary
Concomitant
Angina Unstable Hospitalization 7/5/2001 Male 194 lb 1/9/2009 Physician United States
Primary
Concomitant
Angina Unstable Hospitalization 7/5/2001 Male 194 lb 1/21/2009 Physician United States
Primary
Concomitant
Ulcer Haemorrhage Hospitalization 1/7/2009 82 Female 157 lb 1/23/2009 Consumer United States
Primary
Concomitant
Pneumonia Hospitalization Male 198 lb 1/23/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Angina Unstable Other Serious 7/9/2001 Male 194 lb 1/24/2009 Physician United States
Primary
Concomitant
Liver Function Test Abnormal Hospitalization 1/1/2008 88 Male 176 lb 1/26/2009
Primary
Concomitant
Staphylococcal Sepsis Other Serious 7/14/2008 Female 205 lb 2/2/2009 United States
Primary
Concomitant
Retching Other Serious 11/20/2008 2/4/2009 Other Health Professional United Kingdom
Primary
Concomitant
Idiopathic Pulmonary Fibrosis Hospitalization 12/29/2008 Male 198 lb 2/9/2009 Physician United States
Primary
Secondary
Concomitant
Skin Burning Sensation Other Serious 66 Male 2/17/2009 Pharmacist United States
Primary
Concomitant
Skin Necrosis Other Serious 66 Male 2/18/2009 Pharmacist United States
Primary
Concomitant
Psychotic Disorder Hospitalization 85 Female 3/3/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Urinary Tract Infection Life Threatening 77 Female 3/2/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Life Threatening 77 Female 3/2/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Hospitalization 67 Male 3/5/2009 United Kingdom
Primary
Concomitant
Bipolar I Disorder Other Serious 2/1/2009 Female 3/10/2009 Consumer United States
Primary
Concomitant
Rhabdomyolysis Other Serious 77 Female 3/18/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Life Threatening 77 Female 3/11/2009
Primary
Secondary
Concomitant
Wheezing 83 Male 165 lb 3/18/2009 Consumer United States
Primary
Concomitant
Lower Respiratory Tract Infection Other Serious 2/6/2009 Male 132 lb 3/19/2009 Physician United Kingdom
Primary
Concomitant
Rhabdomyolysis Other Serious 77 Female 3/20/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Troponin Increased Hospitalization 1/29/2009 74 Male 3/17/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 1/1/2009 77 Female 3/20/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Somnolence Other Serious 2/1/2009 Female 529 lb 3/23/2009 Consumer United States
Primary
Concomitant
Diabetic Retinopathy Other Serious 6/1/2005 41 Female 3/23/2009 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Acute Hospitalization 2/11/2009 Female 173 lb 3/23/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Nocturia 1/1/2008 82 Male 3/30/2009 Consumer
Primary
Concomitant
Atrial Fibrillation Hospitalization 1/1/2009 Female 3/31/2009 Physician United States
Primary
Concomitant
Psychotic Disorder Hospitalization 85 Female 3/31/2009 Physician United States
Primary
Secondary
Concomitant
Anal Abscess Hospitalization 3/30/2009 4/7/2009 Pharmacist Brazil
Primary
Concomitant
Visual Impairment Other Serious Female 107 lb 4/13/2009 Consumer United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 2/1/2009 Female 529 lb 4/14/2009 Consumer United States
Primary
Concomitant
Pain Hospitalization 3/27/2009 Female 164 lb 4/17/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Anal Abscess Other Serious 3/30/2009 4/20/2009 Brazil
Primary
Concomitant
Diabetic Retinopathy Other Serious 4/17/2009 Other Health Professional United Kingdom
Primary
Concomitant
Atrial Fibrillation Hospitalization 1/1/2009 Female 4/24/2009 Physician United States
Primary
Concomitant
Urinary Tract Infection Other Serious 2/1/2009 Female 205 lb 4/24/2009 Consumer United States
Primary
Concomitant
Pain Hospitalization 3/27/2009 Female 164 lb 5/4/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 3/1/2009 Female 199 lb 5/8/2009 Consumer United States
Primary
Concomitant
Anal Abscess Hospitalization 3/30/2009 51 5/15/2009 Pharmacist Brazil
Primary
Concomitant
Pancytopenia Hospitalization 5/14/2009 54 Female 264 lb 5/26/2009 Pharmacist United States
Primary
Concomitant
Percutaneous Coronary Intervention Hospitalization 3/23/2009 Male 6/2/2009 Consumer United States
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 77 Female 5/27/2009 Physician United Kingdom
Primary
Concomitant
Visual Acuity Reduced Other Serious 1/1/2008 Male 148 lb 6/2/2009 Consumer United States
Primary
Secondary
Concomitant
Soft Tissue Necrosis Hospitalization 1/14/2009 Female 134 lb 6/2/2009 United States
Primary
Concomitant
Palpitations Hospitalization 73 Female 5/28/2009 United States
Primary
Concomitant
Tongue Neoplasm Malignant Stage Unspecified Hospitalization 65 Female 192 lb 5/22/2009 Other Health Professional United States
Primary
Concomitant
Skin Plaque Other Serious 2/1/2007 85 Female 150 lb 6/4/2009 Lawyer United States
Primary
Secondary
Concomitant
Skin Plaque Other Serious 2/1/2007 85 Female 150 lb 6/5/2009 Lawyer United States
Primary
Secondary
Concomitant
Hepatic Neoplasm Malignant Other Serious 3/10/2009 Female 177 lb 6/5/2009 United States
Primary
Concomitant
Hypergammaglobulinaemia Benign Monoclonal Other Serious 7/21/2008 Female 188 lb 6/3/2009 Physician United States
Primary
Concomitant
Vomiting Hospitalization 4/15/2009 Female 6/8/2009 Physician United States
Primary
Concomitant
Rhabdomyolysis Other Serious 77 Female 6/9/2009 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Percutaneous Coronary Intervention Hospitalization 3/23/2009 Male 6/9/2009 Consumer United States
Primary
Secondary
Concomitant
Psoriasis 2/16/2009 Male 235 lb 6/11/2009 United States
Primary
Concomitant
Trismus 1/1/2009 Female 215 lb 6/12/2009 United States
Primary
Concomitant
Injection Site Pain 5/1/2009 Female 152 lb 6/12/2009 Consumer United States
Primary
Concomitant
Weight Decreased 5/1/2008 Female 6/15/2009 Consumer
Primary
Concomitant
Knee Arthroplasty Hospitalization 4/22/2009 Female 187 lb 6/15/2009 Czech Republic
Primary
Concomitant
Loss Of Consciousness Other Serious 3/1/2009 Female 199 lb 6/23/2009 Consumer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2000 52 Female 298 lb 6/24/2009 United States
Primary
Concomitant
Recurrent Cancer Hospitalization 2/1/2009 Male 200 lb 6/24/2009 Consumer United States
Primary
Concomitant
Endocarditis Bacterial Life Threatening 3/15/2009 58 Female 108 lb 6/24/2009 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Other Serious 2/1/2009 Female 212 lb 7/10/2009 Consumer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2003 39 Female 182 lb 7/13/2009 United States
Primary
Concomitant
Lacrimation Increased Hospitalization 11/1/2008 73 Female 233 lb 7/13/2009 United States
Primary
Concomitant
Urinary Tract Infection Other Serious 2/1/2009 Female 212 lb 7/15/2009 Consumer United States
Primary
Concomitant
Urinary Tract Infection Other Serious 2/1/2009 Female 214 lb 7/29/2009 Consumer United States
Primary
Concomitant
Pseudomembranous Colitis Hospitalization 11/7/2008 Male 129 lb 8/6/2009 Physician Belgium
Primary
Concomitant
Tubulointerstitial Nephritis Life Threatening 77 Male 7/29/2009 Other Health Professional United Kingdom
Primary
Concomitant
Toxic Encephalopathy Hospitalization 5/20/2009 50 Female 8/7/2009 Other Health Professional United States
Primary
Concomitant
Skin Burning Sensation Other Serious 66 Male 8/7/2009 Pharmacist United States
Primary
Concomitant
Renal Failure Hospitalization 1/2/2007 64 Male 272 lb 8/7/2009 Other Health Professional United States
Primary
Concomitant
Lacunar Infarction Other Serious 4/1/2009 46 Male 8/7/2009 Other Health Professional United Kingdom
Primary
Concomitant
Tricuspid Valve Incompetence Hospitalization 1/2/2007 64 Male 272 lb 8/12/2009 Pharmacist United States
Primary
Concomitant
Dyspnoea 3/9/2009 77 Male 8/13/2009 Consumer United States
Primary
Concomitant
Palpitations 7/5/2009 51 Female 7/22/2009 Consumer United States
Primary
Concomitant
Thrombocytopenia Other Serious 5/26/2009 79 Female 148 lb 8/18/2009 Physician United States
Primary
Secondary
Concomitant
Sepsis Syndrome Hospitalization Female 8/18/2009 Physician United States
Primary
Concomitant
Pancreatitis Other Serious 7/29/2009 79 Male 8/18/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 2/9/2008 Female 209 lb 8/19/2009 United Kingdom
Primary
Concomitant
Medication Error Other Serious Male 8/20/2009 United States
Primary
Concomitant
Pruritus Male 8/21/2009 United States
Primary
Concomitant
Headache Male 8/21/2009 United States
Primary
Concomitant
Pruritus 10/2/2008 Female 165 lb 8/22/2009 Other Health Professional
Primary
Concomitant
Hyperhidrosis 11/25/2008 Male 8/22/2009 United States
Primary
Concomitant
Medication Residue 12/1/2008 Male 8/22/2009 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 3/5/2003 71 Female 8/18/2009 United States
Primary
Concomitant
Off Label Use Other Serious 1/1/2009 Female 175 lb 8/26/2009 Physician United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2001 Female 8/25/2009 Consumer United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 7/30/2009 Female 8/27/2009 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Urinary Tract Infection Life Threatening 3/15/2009 58 Female 108 lb 8/28/2009 Other Health Professional United Kingdom
Primary
Concomitant
Weight Increased Other Serious Female 8/28/2009 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 8/21/2009 Male 174 lb 8/28/2009 Consumer United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 2/1/2009 Female 214 lb 9/3/2009 Consumer United States
Primary
Concomitant
Visual Acuity Reduced Other Serious Female 190 lb 9/4/2009 Consumer United States
Primary
Secondary
Concomitant
Ocular Hyperaemia Other Serious 84 Female 140 lb 9/8/2009 Consumer United States
Primary
Concomitant
Sepsis Syndrome Hospitalization Female 9/8/2009 Physician United States
Primary
Concomitant
Loss Of Consciousness Other Serious 3/1/2009 Female 199 lb 9/8/2009 Consumer United States
Primary
Concomitant
Pulmonary Oedema Hospitalization 9/10/2009 Female 150 lb 9/28/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Pathological Fracture Hospitalization 72 Male 9/23/2009 United States
Primary
Concomitant
Nasopharyngeal Cancer Other Serious 1/1/2009 Female 163 lb 10/8/2009 Physician United States
Primary
Concomitant
Renal Failure Other Serious 9/19/2009 Female 10/9/2009 Pharmacist United States
Primary
Concomitant
Cholangitis Hospitalization 8/20/2009 Female 126 lb 10/12/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Adenocarcinoma Other Serious 7/1/2008 56 10/19/2009 Other Health Professional Sweden
Primary
Concomitant
Weight Increased Other Serious 6/1/2008 20 10/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Overdose Hospitalization 10/1/2009 Female 11/11/2009 Consumer United States
Primary
Concomitant
Pseudomembranous Colitis Other Serious 11/7/2008 Male 129 lb 11/12/2009 Physician Belgium
Primary
Concomitant
Weight Decreased Hospitalization 3/5/2003 71 Female 11/9/2009 Lawyer United States
Primary
Concomitant
Paraesthesia Other Serious 68 Female 11/10/2009 United Kingdom
Primary
Concomitant
Blood Bilirubin Increased Death 3/5/2007 79 Male 11/10/2009 Other Health Professional United Kingdom
Primary
Concomitant
Rhinorrhoea Other Serious 1/1/2009 82 Female 11/25/2009 Consumer United States
Primary
Concomitant
Anal Abscess Life Threatening 10/29/2009 79 Male 173 lb 1/18/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Anal Abscess Life Threatening 10/29/2009 79 Male 173 lb 1/29/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Dermatitis Bullous 3/1/2008 Male 175 lb 2/1/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2008 74 Male 2/4/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Post Procedural Myocardial Infarction Hospitalization 6/18/2009 65 Female 2/4/2010 Physician United States
Primary
Concomitant
Urinary Retention Hospitalization 74 Male 176 lb 2/25/2010
Primary
Secondary
Concomitant
Overdose 1/1/2005 68 Female 150 lb 2/26/2010 Consumer United States
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 6/18/2009 65 Female 2/12/2010 Physician United States
Primary
Concomitant
Dizziness Hospitalization 10/29/2009 68 Female 11/12/2009 United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 2/7/2009 Female 121 lb 3/4/2010 United States
Primary
Secondary
Concomitant
Colon Cancer Other Serious 7/1/2008 56 Male 3/5/2010 Other Health Professional Sweden
Primary
Concomitant
Vomiting Hospitalization 3/8/2008 56 Female 159 lb 3/8/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 1/1/2010 Male 196 lb 3/9/2010 Physician Germany
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 1/1/2010 Male 260 lb 3/8/2010 Physician United Kingdom
Primary
Concomitant
Osteoporosis Hospitalization 3/1/2009 Female 170 lb 3/12/2010 Physician United States
Primary
Concomitant
Urosepsis Other Serious 11/1/2009 Female 99 lb 3/15/2010 Physician Germany
Primary
Secondary
Concomitant
Retching Other Serious 11/20/2008 63 Female 141 lb 3/15/2010 Other Health Professional United Kingdom
Primary
Concomitant
Hypertension Other Serious Female 3/15/2010 Consumer United States
Primary
Secondary
Concomitant
Protein Total Decreased Life Threatening 1/26/2010 65 Female 99 lb 3/16/2010 Physician Germany
Primary
Concomitant
Colon Cancer Other Serious 7/1/2008 56 Male 3/19/2010 Other Health Professional Sweden
Primary
Concomitant
Retching Other Serious 11/20/2008 63 Female 141 lb 3/25/2010 Other Health Professional United Kingdom
Primary
Concomitant
Memory Impairment Disability 1/1/2006 54 Female 3/31/2010 United Kingdom
Primary
Concomitant
Weight Increased Death 66 Male 4/6/2010 United States
Primary
Concomitant
Hypokalaemia Other Serious 6/15/2009 56 Female 4/16/2010 United Kingdom
Primary
Concomitant
Coordination Abnormal Hospitalization 4/8/2010 66 Female 4/16/2010 Pharmacist United States
Primary
Secondary
Concomitant

Drug Data