Levoleucovorin Calcium combined with Oxaliplatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Blood Creatinine Increased Hospitalization 5/22/2007 Male 6/6/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 5/22/2007 Male 6/11/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Death 7/6/2007 55 Male 7/23/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Anaphylactoid Reaction Other Serious 8/19/2008 Male 123 lb 9/26/2008 Physician Japan
Primary
Concomitant
Duodenal Stenosis Hospitalization 12/21/2007 Male 176 lb 10/30/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 10/9/2008 35 Male 10/30/2008 Other Health Professional France
Primary
Secondary
Plantar Erythema Other Serious 4/23/2008 Female 11/7/2008 Consumer Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 4/2/2008 Male 115 lb 11/11/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Intestinal Obstruction Other Serious 62 Female 12/3/2009 Consumer United Kingdom
Primary
Concomitant
Osteonecrosis Of Jaw Other Serious 8/1/2009 64 Female 3/3/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Malaise Hospitalization 12/1/2010 63 Male 3/11/2011 Physician Japan
Primary
Concomitant
Stomatitis Other Serious 8/1/2009 64 Female 3/15/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Stomatitis Other Serious 8/1/2009 64 Female 3/29/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/3/2010 63 Male 3/31/2011 Physician Japan
Primary
Concomitant
Nausea Hospitalization 12/3/2010 63 Male 5/13/2011 Physician Japan
Primary
Concomitant
Stomatitis Other Serious 8/1/2009 64 Female 7/5/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Hepatic Failure Other Serious 63 Male 10/3/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Back Pain Death 10/1/2007 65 Male 10/3/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Ileus Other Serious 7/10/2010 56 Male 146 lb 10/4/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Epistaxis Hospitalization 8/1/2009 66 Female 84 lb 10/4/2011 Physician Japan
Primary
Concomitant
Leukoencephalopathy Hospitalization 9/15/2011 72 Male 10/5/2011 Consumer Japan
Primary
Secondary
Concomitant
Septic Shock Death 8/1/2009 66 Female 83 lb 10/5/2011 Consumer Japan
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 8/26/2011 77 Male 121 lb 10/7/2011 Consumer Japan
Primary
Secondary
Concomitant
Skin Fissures Life Threatening 5/7/2011 83 Male 99 lb 10/7/2011 Other Health Professional Japan
Primary
Concomitant
Decreased Appetite Death 9/22/2010 77 Male 121 lb 10/7/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Hepatic Encephalopathy Other Serious 10/2/2010 66 Male 154 lb 10/7/2011 Other Health Professional Japan
Primary
Concomitant
Dry Skin Hospitalization 10/19/2010 55 Male 108 lb 10/11/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 10/29/2010 73 Male 119 lb 10/11/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Stomatitis Disability 1/20/2011 72 Male 152 lb 10/12/2011 Consumer Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Death 71 Male 10/12/2011 Consumer Japan
Primary
Secondary
Concomitant
Decreased Appetite Death 10/24/2010 75 Female 121 lb 10/12/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Cholinergic Syndrome Hospitalization 9/22/2011 62 Male 157 lb 10/14/2011 Physician Japan
Primary
Secondary
Concomitant
Drug Hypersensitivity Other Serious 12/3/2010 66 Male 165 lb 10/14/2011 Physician Japan
Primary
Secondary
Concomitant
Skin Disorder Death 10/14/2010 52 Male 123 lb 10/14/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Drug Hypersensitivity Other Serious 1/1/2009 79 Male 10/18/2011 Other Health Professional Japan
Primary
Concomitant
Leukoencephalopathy Other Serious 9/14/2011 Male 117 lb 10/18/2011 Consumer Japan
Primary
Secondary
Concomitant
Neutropenia Death 10/19/2011 Physician France
Primary
Secondary
Haemoptysis Hospitalization 12/1/2010 69 Male 10/19/2011 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 9/1/2011 71 Male 10/19/2011 Physician Japan
Primary
Concomitant
Hypersensitivity Other Serious 65 Male 10/20/2011 Other Health Professional Japan
Primary
Secondary
Hyperammonaemia Other Serious 8/26/2011 72 Female 10/21/2011 Physician Japan
Primary
Secondary
Concomitant
Thrombosis Hospitalization 9/1/2011 76 Female 10/24/2011 Physician Japan
Primary
Concomitant
Dermatitis Acneiform Death 8/11/2010 60 Male 150 lb 10/24/2011 Other Health Professional Japan
Primary
Concomitant
Febrile Neutropenia Other Serious 8/18/2010 71 Male 10/25/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Neutrophil Count Decreased Other Serious 76 Male 10/25/2011 Japan
Primary
Concomitant
Device Occlusion Other Serious 12/8/2010 56 Male 128 lb 10/25/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Neutrophil Count Decreased Hospitalization 7/21/2010 71 Female 79 lb 10/26/2011 Physician Japan
Primary
Secondary
Concomitant
Fall Other Serious 8/19/2011 58 Female 10/21/2011 Other Health Professional Italy
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 8/16/2011 65 Male 134 lb 10/27/2011 Physician Japan
Primary
Secondary
Concomitant
Dyschezia Other Serious 11/1/2010 71 Female 10/27/2011 Japan
Primary
Concomitant
Stomatitis Hospitalization 8/31/2010 72 Male 176 lb 10/27/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 6/29/2011 75 Male 112 lb 10/27/2011 Other Health Professional Japan
Primary
Concomitant
Interstitial Lung Disease Hospitalization 7/29/2010 65 Male 104 lb 10/27/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Lower Gastrointestinal Haemorrhage Death 59 Male 101 lb 10/27/2011 Japan
Primary
Concomitant
Disease Progression Death 10/25/2009 61 Female 10/27/2011 Physician Japan
Primary
Concomitant
Chromaturia Hospitalization 9/1/2011 76 Female 10/27/2011 Physician Japan
Primary
Secondary
Drug Hypersensitivity Other Serious 12/3/2010 66 Male 165 lb 10/28/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Ileus Hospitalization 7/6/2011 74 Male 10/28/2011 Physician Japan
Primary
Concomitant
Hyperammonaemia Other Serious 78 Male 10/31/2011 Pharmacist Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 9/25/2011 72 Male 152 lb 11/2/2011 Physician Japan
Primary
Secondary
Concomitant
Congestive Cardiomyopathy Hospitalization 5/24/2010 68 Male 11/2/2011 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Anastomotic Leak Hospitalization 1/1/2009 64 Male 84 lb 11/3/2011 Physician Japan
Primary
Secondary
Concomitant
Aortic Dissection Rupture Other Serious 1/1/2011 63 Male 119 lb 11/3/2011 Physician Japan
Primary
Concomitant
Gastric Ulcer Hospitalization 9/22/2011 62 Male 157 lb 11/3/2011 Physician Japan
Primary
Secondary
Concomitant
Dry Skin Death 9/24/2010 64 Male 154 lb 11/4/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Rash Hospitalization 12/20/2010 80 Male 119 lb 11/4/2011 Physician Japan
Primary
Concomitant
Neutrophil Count Decreased Hospitalization 4/30/2009 83 Female 134 lb 11/8/2011 Other Health Professional Japan
Primary
Concomitant
Dermatitis Acneiform Death 10/5/2010 69 Male 141 lb 11/9/2011 Other Health Professional Japan
Primary
Concomitant
Colorectal Cancer Hospitalization 9/6/2010 55 Male 137 lb 11/9/2011 Physician Japan
Primary
Secondary
Concomitant
Hypomagnesaemia Hospitalization 7/26/2010 68 Male 141 lb 11/11/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Intestinal Fistula Death 77 Female 11/14/2011 Physician Japan
Primary
Secondary
Angina Pectoris Life Threatening 7/22/2011 Male 139 lb 11/14/2011 Consumer Japan
Primary
Concomitant
Gastrointestinal Perforation Death 10/7/2011 80 Male 99 lb 11/15/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Leukoencephalopathy Hospitalization 55 Male 11/16/2011 Japan
Primary
Secondary
Concomitant
Hyperammonaemia Other Serious 60 Male 11/16/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Haemolytic Uraemic Syndrome Hospitalization 11/1/2011 60 Male 11/16/2011 Physician Japan
Primary
Secondary
Gastrointestinal Perforation Life Threatening 1/2/2011 76 Female 77 lb 11/16/2011 Physician Japan
Primary
Concomitant
Hyponatraemia Other Serious 10/31/2011 89 Female 108 lb 11/16/2011 Physician Japan
Primary
Secondary
Concomitant
Altered State Of Consciousness Hospitalization 5/1/2010 70 Male 11/17/2011 Japan
Primary
Concomitant
Dermatitis Acneiform Hospitalization 10/2/2010 66 Male 154 lb 11/17/2011 Physician Japan
Primary
Secondary
Concomitant
Colorectal Cancer Death 9/22/2010 77 Male 121 lb 11/17/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Large Intestine Perforation Death 4/2/2010 77 Female 128 lb 11/17/2011 Physician Japan
Primary
Secondary
Concomitant
Presyncope Other Serious 8/19/2011 58 Female 11/16/2011 Other Health Professional Italy
Primary
Secondary
Concomitant
Oral Mucosa Erosion Hospitalization 10/24/2011 71 Male 11/21/2011 Physician Japan
Primary
Secondary
Hyperthermia Other Serious 60 Female 11/21/2011 Pharmacist Japan
Primary
Concomitant
Neutrophil Count Decreased Hospitalization 8/18/2011 36 Female 11/22/2011 Other Health Professional Japan
Primary
Concomitant
Decreased Appetite Death 11/24/2010 61 Male 108 lb 11/22/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Neutrophil Count Decreased Other Serious 76 Male 11/24/2011 Physician Japan
Primary
Concomitant
Retroperitoneal Fibrosis Other Serious 59 Female 11/24/2011 Pharmacist Japan
Primary
Secondary
Concomitant
Haemolytic Uraemic Syndrome Hospitalization 10/13/2011 66 Male 11/25/2011 Consumer Japan
Primary
Secondary
Concomitant
Venous Thrombosis Hospitalization 3/24/2009 34 Female 123 lb 11/25/2011 Consumer Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 9/1/2011 78 Male 11/28/2011 Physician Japan
Primary
Secondary
Tumour Lysis Syndrome Other Serious 6/28/2010 67 Female 108 lb 11/29/2011 Consumer Japan
Primary
Secondary
Concomitant
Stomatitis Hospitalization 10/5/2010 64 Male 119 lb 11/29/2011 Other Health Professional Japan
Primary
Concomitant
Mechanical Ileus Death 1/1/2008 59 Male 11/29/2011 Other Health Professional Japan
Primary
Concomitant
Palpitations Death 12/1/2010 69 Male 11/30/2011 Physician Japan
Primary
Secondary
Concomitant
Chromaturia Hospitalization 9/1/2011 76 Female 11/30/2011 Physician Japan
Primary
Secondary
Enterocolitis Death 7/9/2011 74 Male 11/30/2011 Physician Japan
Primary
Concomitant
Pneumonia Aspiration Other Serious 10/1/2011 82 Male 115 lb 11/30/2011 Physician Japan
Primary
Secondary
Concomitant
Hyponatraemia Life Threatening 6/14/2011 77 Female 146 lb 12/1/2011 Physician Japan
Primary
Concomitant
Dermatitis Acneiform Death 10/14/2010 52 Male 123 lb 12/4/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Drug Eruption Hospitalization 2/28/2011 56 Male 12/5/2011 Consumer Japan
Primary
Secondary
Hypersensitivity Death 52 Male 12/5/2011 Physician Japan
Primary
Secondary
Concomitant
Death Death 67 Female 12/6/2011 Physician Japan
Primary
Concomitant
Pharyngeal Erythema Hospitalization 10/24/2011 71 Male 132 lb 12/8/2011 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 10/12/2011 73 Male 132 lb 12/9/2011 Other Health Professional Japan
Primary
Concomitant
Stomatitis Death 12/9/2010 65 Female 117 lb 12/9/2011 Physician Japan
Primary
Concomitant
Stomatitis Hospitalization 5/27/2011 75 Male 119 lb 12/12/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Rash Other Serious 11/18/2010 75 Male 93 lb 12/12/2011 Other Health Professional Japan
Primary
Concomitant
Shock Haemorrhagic Death Male 106 lb 12/12/2011 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 11/18/2011 76 Female 12/12/2011 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 11/18/2011 76 Female 12/12/2011 Physician Japan
Primary
Secondary
Concomitant
Disease Progression Life Threatening 10/25/2009 61 Female 12/13/2011 Physician Japan
Primary
Concomitant
Dermatitis Acneiform Hospitalization 12/15/2010 67 Male 190 lb 12/13/2011 Physician Japan
Primary
Concomitant
Myelodysplastic Syndrome Other Serious 11/24/2011 50 Male 12/14/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Aspiration Life Threatening 6/14/2011 82 Male 115 lb 12/14/2011 Physician Japan
Primary
Secondary
Concomitant
Microangiopathy Other Serious 65 Female 12/15/2011 Physician Japan
Primary
Concomitant
Colorectal Cancer Life Threatening 7/9/2011 74 Male 12/15/2011 Physician Japan
Primary
Concomitant
Hypocalcaemia Hospitalization 7/26/2010 68 Male 141 lb 12/15/2011 Physician Japan
Primary
Secondary
Concomitant
Microangiopathy Other Serious 65 Female 12/16/2011 Physician Japan
Primary
Concomitant
Pulmonary Oedema Other Serious 68 Female 12/19/2011 Physician Japan
Primary
Concomitant
Diarrhoea Death 11/16/2011 68 Female 128 lb 12/19/2011 Physician Japan
Primary
Secondary
Concomitant
Implant Site Erythema Other Serious 12/3/2010 66 Male 165 lb 12/19/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Neutrophil Count Decreased Other Serious 7/1/2011 55 Male 172 lb 12/20/2011 Consumer Japan
Primary
Secondary
Concomitant
Neutrophil Count Decreased Death 3/7/2011 62 Male 12/20/2011 Physician Japan
Primary
Concomitant
Contusion Death 5/31/2011 71 Male 123 lb 12/27/2011 Physician Japan
Primary
Concomitant
Dyschezia Other Serious 11/14/2011 52 Male 132 lb 12/27/2011 Physician Japan
Primary
Secondary
Concomitant
Abscess Other Serious 1/2/2011 76 Female 77 lb 12/27/2011 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Death 3/7/2011 62 Male 112 lb 12/27/2011 Physician Japan
Primary
Secondary
Concomitant
Necrotising Fasciitis Hospitalization 8/18/2010 71 Male 88 lb 12/27/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Hypoalbuminaemia Hospitalization 12/2/2011 78 Male 104 lb 12/28/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 12/16/2011 73 Male 12/28/2011 Other Health Professional Japan
Primary
Concomitant
Colorectal Cancer Death 8/11/2010 60 Male 150 lb 12/29/2011 Other Health Professional Japan
Primary
Concomitant
Myelodysplastic Syndrome 11/24/2011 50 Male 12/29/2011 Consumer Japan
Primary
Secondary
Concomitant
Colorectal Cancer Death 10/14/2010 52 Male 123 lb 12/30/2011 Physician Japan
Primary
Secondary
Concomitant
Infectious Peritonitis Death 4/1/2009 73 Male 1/2/2012 Physician Japan
Primary
Concomitant
Hydronephrosis Other Serious 9/29/2011 59 Female 161 lb 1/2/2012 Pharmacist Japan
Primary
Secondary
Concomitant
Compression Fracture Other Serious 67 Female 68 lb 1/3/2012 Pharmacist Japan
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious 72 Male 1/3/2012 Japan
Primary
Concomitant
Hyperammonaemia Other Serious 12/15/2011 60 Male 1/4/2012 Consumer Japan
Primary
Secondary
Concomitant
Pulmonary Oedema Hospitalization 12/10/2011 68 Female 1/4/2012 Physician Japan
Primary
Concomitant
Platelet Count Decreased Death 11/1/2011 70 Female 112 lb 1/4/2012 Physician Japan
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious 72 Male 1/5/2012 Japan
Primary
Secondary
Concomitant
Tetany Hospitalization 12/2/2011 78 Male 104 lb 1/6/2012 Physician Japan
Primary
Secondary
Concomitant
Stomatitis Hospitalization 10/5/2010 64 Male 119 lb 1/6/2012 Other Health Professional Japan
Primary
Concomitant
Asthenia Death 11/16/2011 68 Female 128 lb 1/6/2012 Physician Japan
Primary
Secondary
Concomitant
Erythema Hospitalization 8/25/2011 71 Male 1/6/2012 Other Health Professional France
Primary
Secondary
Condition Aggravated Death 8/7/2010 56 Male 123 lb 1/12/2012 Physician Japan
Primary
Secondary
Concomitant
Neutrophil Count Decreased Death 4/2/2010 77 Male 128 lb 1/13/2012 Consumer Japan
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Other Serious 11/1/2011 70 Female 112 lb 1/17/2012 Physician Japan
Primary
Secondary
Concomitant

Drug Data