Levofloxacin combined with Warfarin Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Liver Function Test Abnormal 11/1/2004 61 9/12/2005 Pharmacist United States
Primary
Concomitant
International Normalised Ratio Increased 4/30/2004 60 9/12/2005 Physician United States
Primary
Concomitant
International Normalised Ratio Increased 10/18/2004 54 9/16/2005 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 1/25/2006 65 Female 190 lb 2/10/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 5/20/2002 56 Female 2/23/2006 Physician Japan
Primary
Concomitant
Somnolence Hospitalization 1/5/2006 84 Male 2/26/2006 Other Health Professional France
Primary
Secondary
Concomitant
Hypophosphataemia Life Threatening 8/31/2005 61 Female 5/1/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Ulcerative Keratitis Hospitalization 2/22/2006 77 Male 4/21/2006 Physician Japan
Primary
Secondary
Concomitant
International Normalised Ratio Decreased Life Threatening 1/31/2006 29 Female 2/14/2006 United States
Primary
Concomitant
Pain In Extremity 12/1/2005 70 Male 225 lb 4/6/2006 Consumer United States
Primary
Secondary
Concomitant
Liver Disorder Other Serious 3/30/2006 39 Female 115 lb 7/5/2006 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/29/2006 75 Male 184 lb 7/17/2006 Pharmacist United States
Primary
Secondary
Prothrombin Level Decreased Other Serious 6/26/2006 Male 7/27/2006 Physician Japan
Primary
Concomitant
Rash Erythematous 81 Male 8/8/2006 Consumer United States
Primary
Concomitant
Prothrombin Level Decreased Other Serious 6/26/2006 71 Male 170 lb 8/3/2006 Physician Japan
Primary
Secondary
Concomitant
Liver Disorder Other Serious 3/1/2006 39 Female 115 lb 8/7/2006 Japan
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 6/20/2005 62 Male 8/11/2006 Pharmacist United States
Primary
Secondary
Respiratory Depression Other Serious 7/12/2006 Female 120 lb 8/14/2006 Pharmacist United States
Primary
Secondary
Concomitant
International Normalised Ratio Increased Hospitalization 5/30/2006 74 Female 132 lb 7/25/2006 Pharmacist United States
Primary
Secondary
Concomitant
International Normalised Ratio Increased Other Serious 74 Male 7/11/2006 United States
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 5/30/2006 74 Female 132 lb 7/25/2006 Pharmacist United States
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 9/8/2006 78 Male 9/19/2006 Pharmacist Japan
Primary
Secondary
Concomitant
Hypoalbuminaemia Required Intervention 1/17/2006 40 Female 106 lb 9/20/2006 Physician Japan
Primary
Concomitant
Injection Site Pain Hospitalization 9/13/2006 68 Male 157 lb 10/5/2006 Physician Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 10/13/2006 75 Male 115 lb 10/16/2006 Pharmacist United States
Primary
Secondary
Injection Site Pain Hospitalization 9/13/2006 68 Male 157 lb 11/9/2006 Physician Japan
Primary
Secondary
Concomitant
Tachycardia Hospitalization 5/2/2003 55 Male 238 lb 11/6/2006 Physician United States
Primary
Secondary
Concomitant
Urine Leukocyte Esterase Positive Hospitalization 10/31/2006 75 Male 110 lb 11/9/2006 Pharmacist United States
Primary
Secondary
Melaena Hospitalization 11/6/2006 83 Male 196 lb 12/7/2006 Pharmacist United States
Primary
Concomitant
Sedation Life Threatening 5/29/2006 82 Male 12/15/2006 Pharmacist United States
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 76 Male 12/20/2006 Physician France
Primary
Secondary
Renal Failure Required Intervention 5/16/2006 76 Female 12/13/2006 Pharmacist United States
Primary
Secondary
Concomitant
Oxygen Saturation Decreased Life Threatening 10/10/2006 79 Female 141 lb 12/21/2006 United States
Primary
Secondary
Concomitant
Pneumonia Required Intervention 7/23/2006 68 Female 148 lb 7/28/2006 Pharmacist United States
Primary
Secondary
Concomitant
Venous Thrombosis Hospitalization 1/1/2007 49 Female 192 lb 1/31/2007 Other Health Professional United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 8/15/2006 78 Female 3/5/2007 Pharmacist Japan
Primary
Secondary
Concomitant
Hypophosphataemia Life Threatening 8/31/2005 61 Female 3/16/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Shock Hospitalization 8/15/2006 Female 3/21/2007 Pharmacist Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Life Threatening 4/12/2007 87 Male 137 lb 4/20/2007 Pharmacist United States
Primary
Secondary
Nausea Death 4/3/2007 41 Male 152 lb 5/2/2007 Other Health Professional United States
Primary
Concomitant
Cardiac Arrest Life Threatening 1/27/2007 51 Female 463 lb 5/10/2007 Consumer United States
Primary
Concomitant
Pneumonia Hospitalization 1/25/2006 65 Female 190 lb 5/2/2007 Physician United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 5/7/2007 79 Male 5/24/2007 Other Health Professional Italy
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 10/28/2006 42 Male 1/14/2007 Pharmacist United States
Primary
Secondary
Concomitant
Staphylococcal Bacteraemia Hospitalization 10/10/2006 81 Male 117 lb 1/14/2007 Pharmacist United States
Primary
Secondary
Concomitant
Injection Site Pain Hospitalization 9/13/2006 68 Male 157 lb 6/5/2007 Physician Japan
Primary
Secondary
Concomitant
Injection Site Pain Hospitalization 9/13/2006 68 Male 157 lb 6/18/2007 Physician Japan
Primary
Secondary
Concomitant
Nausea Hospitalization 11/8/2006 85 Female 6/19/2007 Pharmacist United States
Primary
Secondary
Pneumonia Life Threatening 9/21/2006 Male 146 lb 5/17/2007 Pharmacist United States
Primary
Secondary
Concomitant
Hypophosphataemia Life Threatening 8/31/2005 61 Female 6/27/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 6/4/2007 76 Male 6/28/2007 Consumer United States
Primary
Secondary
Multi-organ Failure Hospitalization 70 Female 8/1/2007 Physician United States
Primary
Interacting
Pericardial Haemorrhage Hospitalization 80 Female 8/1/2007 Physician United States
Primary
Interacting
Retroperitoneal Haematoma Other Serious 34 Female 8/1/2007 Physician United States
Primary
Secondary
Concomitant
Interacting
Sepsis Other Serious 70 Female 8/2/2007 Other Health Professional United States
Primary
Interacting
Sepsis Death 5/15/2007 Male 8/2/2007 Physician Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 34 Female 8/3/2007 Other Health Professional United States
Primary
Interacting
Prothrombin Time Prolonged Hospitalization 80 Female 8/3/2007 Other Health Professional United States
Primary
Interacting
Sepsis Hospitalization 70 Female 8/2/2007 United States
Primary
Secondary
International Normalised Ratio Abnormal Hospitalization 8/6/2007 54 Male 8/10/2007 Pharmacist United States
Primary
Secondary
Vomiting Required Intervention 80 Female 8/10/2007 United States
Primary
Secondary
Urinary Tract Infection Required Intervention 34 Female 8/10/2007 United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Required Intervention 70 Male 8/10/2007 United States
Primary
Secondary
White Blood Cell Count Increased Hospitalization 80 Female 8/9/2007 United States
Primary
Secondary
Sepsis Hospitalization 70 Female 8/9/2007 United States
Primary
Secondary
Sepsis Death 5/15/2007 Male 9/13/2007 Physician Japan
Primary
Secondary
Concomitant
Pneumonitis Life Threatening 7/6/2007 61 Female 165 lb 9/13/2007 United States
Primary
Secondary
Concomitant
Orthostatic Hypotension Hospitalization 11/20/2007 68 Male 11/29/2007 Physician United States
Primary
Secondary
Concomitant
Orthostatic Hypotension Hospitalization 11/20/2007 68 Male 12/10/2007 Physician United States
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 8/24/2007 67 Female 1/9/2008 Other Health Professional United States
Primary
Concomitant
Oesophagitis Life Threatening 1/4/2008 Male 161 lb 1/24/2008 Physician United States
Primary
Secondary
Concomitant
Oesophagitis Life Threatening 1/4/2008 Male 161 lb 2/8/2008 Physician United States
Primary
Secondary
Concomitant
Oesophagitis Life Threatening 1/4/2008 Male 161 lb 2/13/2008 Physician United States
Primary
Secondary
Concomitant
Ventricular Fibrillation Death 1/15/2008 79 Male 212 lb 2/6/2008 Pharmacist United States
Primary
Secondary
Concomitant
Respiratory Rate Increased Hospitalization 10/15/2007 86 Male 3/3/2008 Pharmacist United States
Primary
Secondary
Concomitant
Oesophageal Cancer Metastatic Hospitalization 3/5/2008 69 Male 174 lb 3/11/2008 United States
Primary
Concomitant
Hypophosphataemia Life Threatening 8/31/2005 61 Female 3/18/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
International Normalised Ratio Increased Hospitalization 11/25/2007 46 Female 11/28/2007 Pharmacist United States
Primary
Secondary
Concomitant
Muscle Injury Other Serious 3/20/2008 74 Female 4/2/2008 Consumer United States
Primary
Concomitant
Vomiting Life Threatening 3/19/2008 77 Female 155 lb 4/1/2008 Pharmacist United States
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 78 Female 4/17/2008 Other Health Professional United States
Primary
Interacting
Upper Respiratory Tract Infection Hospitalization 78 Female 187 lb 4/16/2008 Pharmacist United States
Primary
Secondary
Concomitant
Urticaria Required Intervention 10/12/2007 73 Female 4/15/2008 Pharmacist United States
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 78 Female 187 lb 4/24/2008 Other Health Professional United States
Primary
Concomitant
Interacting
Drug Interaction Life Threatening 78 Female 187 lb 5/1/2008 United States
Primary
Concomitant
Interacting
Sepsis Death 70 Female 4/28/2008 Physician United States
Primary
Secondary
Muscle Injury Other Serious 3/20/2008 74 Female 152 lb 5/2/2008 Consumer United States
Primary
Concomitant
Retroperitoneal Haematoma Hospitalization 34 Female 4/29/2008 Physician United States
Primary
Secondary
Drug Interaction Other Serious 78 Female 187 lb 5/9/2008 United States
Primary
Concomitant
Interacting
Urinary Tract Infection Hospitalization 10/1/2007 86 Female 5/10/2008 Pharmacist United States
Primary
Secondary
International Normalised Ratio Increased Hospitalization 9/1/2007 89 Male 5/10/2008 Pharmacist United States
Primary
Secondary
Tremor Hospitalization 4/23/2008 62 Male 190 lb 6/17/2008 Pharmacist United States
Primary
Concomitant
Idiopathic Thrombocytopenic Purpura Hospitalization 6/18/2008 77 Female 7/2/2008 Japan
Primary
Secondary
Concomitant
Therapeutic Response Decreased Other Serious 12/7/2006 42 Female 7/3/2008 Physician Japan
Primary
Concomitant
International Normalised Ratio Increased 5/6/2008 74 Male 6/23/2008 Pharmacist United States
Primary
Secondary
Treatment Noncompliance 5/31/2008 56 Male 6/18/2008 Pharmacist United States
Primary
Secondary
International Normalised Ratio Increased Hospitalization 78 Female 187 lb 8/15/2008 United States
Primary
Secondary
Concomitant
Ventricular Septal Defect Other Serious Female 8/12/2008 United Kingdom
Primary
Concomitant
International Normalised Ratio Hospitalization 78 Female 187 lb 8/28/2008 Other Health Professional Japan
Primary
Concomitant
Interacting
Lobar Pneumonia Required Intervention 12/5/2007 68 Male 190 lb 10/21/2008 Pharmacist United States
Primary
Concomitant
Multi-organ Failure Death 11/7/2008 Other Health Professional United States
Primary
Interacting
Pericardial Effusion Other Serious 80 Female 11/11/2008 Other Health Professional United States
Primary
Interacting
Retroperitoneal Haematoma Other Serious 34 Female 11/14/2008 Other Health Professional United States
Primary
Secondary
Interacting
Pleural Effusion Death 70 Female 11/14/2008 Other Health Professional United States
Primary
Interacting
Retroperitoneal Haematoma Other Serious 34 Female 11/17/2008 Other Health Professional United States
Primary
Secondary
Interacting
Pericardial Effusion Other Serious 80 Female 11/20/2008 Other Health Professional United States
Primary
Interacting
Upper Gastrointestinal Haemorrhage Life Threatening 10/27/2008 Female 10/28/2008 Pharmacist United States
Primary
Concomitant
International Normalised Ratio Increased Required Intervention 8/18/2008 54 Male 8/25/2008 Pharmacist United States
Primary
Concomitant
Retroperitoneal Haematoma Other Serious 34 Female 11/26/2008 Other Health Professional Japan
Primary
Interacting
Pleural Effusion Death 70 Female 11/26/2008 Other Health Professional Japan
Primary
Interacting
Retroperitoneal Haematoma Other Serious 34 Female 11/27/2008 Other Health Professional United States
Primary
Secondary
Interacting
Pericardial Effusion Other Serious 80 Female 12/1/2008 Other Health Professional Japan
Primary
Interacting
Pyrexia Death 83 Female 1/20/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Death 83 Female 1/22/2009 Other Health Professional United States
Primary
Secondary
Concomitant
International Normalised Ratio Abnormal Hospitalization 2/24/2009 75 Male 2/27/2009 Other Health Professional United States
Primary
Secondary
Ototoxicity Other Serious 51 Female 315 lb 3/16/2009
Primary
Secondary
Concomitant
Deafness Neurosensory Hospitalization 51 Female 3/26/2009 Other Health Professional United States
Primary
Concomitant
Refusal Of Treatment By Relative Hospitalization 1/3/2009 81 Female 119 lb 3/31/2009 Pharmacist United States
Primary
Secondary
Concomitant
Catatonia Other Serious 47 Female 5/15/2009 Other Health Professional United States
Primary
Concomitant
International Normalised Ratio Increased Other Serious 91 Male 7/30/2009 Other Health Professional Spain
Primary
Secondary
Concomitant
Interacting
Pneumonia Staphylococcal Other Serious 79 Male 8/24/2009 Physician United States
Primary
Secondary
Concomitant
Catatonia Hospitalization 47 Female 9/3/2009 Other Health Professional United States
Primary
Concomitant
Pulmonary Embolism Death 4/17/2009 Female 185 lb 9/4/2009 United Kingdom
Primary
Concomitant
Platelet Count Decreased Hospitalization 6/12/2009 76 Male 148 lb 7/10/2009 Pharmacist United States
Primary
Secondary
Concomitant
Catatonia Other Serious 47 Female 10/16/2009 Other Health Professional United States
Primary
Concomitant
Thrombosis Life Threatening 6/23/2008 82 Male 238 lb 10/16/2009 Physician United States
Primary
Secondary
Concomitant
Catatonia Other Serious 47 Female 10/23/2009 Other Health Professional United States
Primary
Concomitant
Catatonia Other Serious 47 Female 10/26/2009 Other Health Professional Japan
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 6/23/2008 82 Male 238 lb 11/6/2009 Physician United States
Primary
Concomitant
Catatonia Hospitalization 47 Female 12/10/2009 Other Health Professional United States
Primary
Concomitant
Catatonia Other Serious 47 Female 12/14/2009 Other Health Professional Japan
Primary
Concomitant
Large Intestinal Ulcer Hospitalization 11/18/2009 65 Female 1/15/2010 Consumer United States
Primary
Secondary
Concomitant
Visual Impairment Other Serious 82 Female 1/21/2010 United States
Primary
Concomitant
Viral Infection Other Serious 1/9/2010 70 Female 2/19/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Viral Infection Other Serious 1/9/2010 70 Female 3/3/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 2/1/2008 75 Female 198 lb 3/3/2010 Lawyer United States
Primary
Secondary
Concomitant
Gastroenteritis Staphylococcal Death 12/20/2009 Male 165 lb 3/8/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Viral Infection Other Serious 1/9/2010 70 Female 3/18/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Visual Impairment Other Serious 7/12/1999 Female 3/22/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Visual Impairment Other Serious 7/12/1999 Female 3/26/2010 Other Health Professional United States
Primary
Secondary
Concomitant
International Normalised Ratio Increased Other Serious 91 Male 3/30/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Interacting
Thrombocytopenia Other Serious 6/1/2008 34 Female 117 lb 3/31/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Tooth Disorder Other Serious 1/1/2002 Male 4/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 58 Male 4/6/2010 Lawyer United States
Primary
Concomitant
Visual Impairment Other Serious 7/12/1999 63 Female 4/15/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 1/1/2007 69 Female 4/19/2010 United States
Primary
Secondary
Concomitant
Visual Impairment Other Serious 7/12/1999 63 Female 4/23/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Tooth Disorder Other Serious 1/1/2002 Male 5/4/2010 United States
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 3/23/2010 67 Female 118 lb 5/18/2010 Physician United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 3/14/2010 60 Female 143 lb 5/25/2010 Physician Brazil
Primary
Concomitant

Drug Data