Levofloxacin combined with Voriconazole

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
International Normalised Ratio Increased 6/30/2004 53 9/12/2005 Pharmacist United States
Primary
Concomitant
International Normalised Ratio Increased 7/22/2004 9/12/2005 Physician United States
Primary
Concomitant
Sepsis Syndrome Required Intervention 11/1/2005 23 Female 139 lb 12/5/2005 United States
Primary
Concomitant
Productive Cough Disability 10/26/2005 42 Female 120 lb 1/25/2006 United States
Primary
Secondary
Concomitant
Platelet Count Decreased Hospitalization 10/30/2004 29 Female 121 lb 2/18/2006 Other Health Professional United States
Primary
Concomitant
Lymphocyte Count Decreased Hospitalization 10/30/2004 29 Female 121 lb 4/1/2006 United States
Primary
Concomitant
Vomiting Hospitalization 4/28/2005 72 Male 126 lb 6/30/2006 Physician Spain
Primary
Secondary
Concomitant
Thrombocytopenia Death 2/13/2006 69 Male 168 lb 7/6/2006 Physician Germany
Primary
Concomitant
Thrombocytopenia Other Serious 11/14/2005 63 Male 8/15/2006 Pharmacist United States
Primary
Concomitant
Retinal Haemorrhage Hospitalization 4/17/2006 58 Male 8/21/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Retinal Haemorrhage Hospitalization 4/17/2006 58 Male 8/30/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Retinal Haemorrhage Hospitalization 4/17/2006 58 Male 9/7/2006 Physician United States
Primary
Secondary
Concomitant
Vomiting 2/8/2006 36 Male Physician United States
Primary
Concomitant
Somnolence Hospitalization 12/21/2006 Male 1/15/2007 Physician Japan
Primary
Concomitant
Interacting
Respiratory Distress Life Threatening 11/27/2006 Male 137 lb 4/5/2007 Physician Italy
Primary
Concomitant
Pneumonia Life Threatening 11/27/2006 Male 137 lb 6/20/2007 Physician Italy
Primary
Concomitant
Oxygen Saturation Decreased Other Serious 10/24/2006 41 Male 151 lb 10/24/2006 United States
Primary
Secondary
Concomitant
Septic Shock Other Serious 5/23/2007 61 Male 148 lb 7/6/2007 Physician Korea, Republic Of
Primary
Concomitant
Staphylococcal Infection Other Serious 53 Male 7/26/2007 Switzerland
Primary
Concomitant
Pseudomonas Infection Other Serious 6/17/2007 65 Male 229 lb 8/3/2007 Physician United States
Primary
Secondary
Concomitant
Tongue Neoplasm Malignant Stage Unspecified Other Serious 6/17/2007 65 Male 229 lb 8/10/2007 Physician United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 5/12/2007 Male 8/17/2007 Pharmacist United States
Primary
Secondary
Concomitant
Leukoencephalopathy Hospitalization 12/5/2006 70 Female 9/6/2007 Physician Japan
Primary
Secondary
Concomitant
Urine Output Decreased Hospitalization 2/9/2007 57 Female Physician United States
Primary
Concomitant
Metabolic Acidosis Other Serious 55 Female 10/24/2007 United States
Primary
Concomitant
Respiratory Distress Life Threatening 11/27/2006 Male 137 lb 11/19/2007 Physician Italy
Primary
Concomitant
Staphylococcal Infection Other Serious 21 Male 12/3/2007 Other Health Professional Greece
Primary
Secondary
Unresponsive To Stimuli Life Threatening 9/28/2007 21 Female 150 lb 12/3/2007 Physician United States
Primary
Secondary
Concomitant
Metabolic Acidosis Hospitalization 10/28/2007 Female 143 lb 2/15/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Metabolic Acidosis Hospitalization 10/28/2007 Female 143 lb 2/23/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 21 Male 2/29/2008 Other Health Professional United States
Primary
Secondary
Vomiting 2/9/2007 57 Female 5/2/2008 Physician United States
Primary
Concomitant
Electrocardiogram Qt Prolonged Life Threatening 3/12/2008 Male 195 lb 3/13/2008 Pharmacist United States
Primary
Concomitant
Nephropathy Toxic Hospitalization 12/7/2007 58 Male 178 lb 6/22/2008 Pharmacist United States
Primary
Secondary
Concomitant
Nephropathy Toxic Hospitalization 12/4/2007 69 Male 183 lb 6/22/2008 Pharmacist United States
Primary
Secondary
Concomitant
Nephropathy Toxic Hospitalization 12/5/2007 43 Male 197 lb 6/22/2008 Pharmacist United States
Primary
Secondary
Concomitant
Pneumonia Aspiration Hospitalization 7/3/2008 Male 7/30/2008 Physician Japan
Primary
Secondary
Concomitant
Electrocardiogram Qt Interval Abnormal Life Threatening 3/12/2008 65 Male 195 lb 8/4/2008 Pharmacist United States
Primary
Concomitant
Rash Life Threatening 3/12/2008 Male 195 lb 8/27/2008 United States
Primary
Concomitant
Metabolic Acidosis Hospitalization 10/28/2007 Female 143 lb 9/2/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Metabolic Acidosis Life Threatening 10/28/2007 Female 143 lb 9/17/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Life Threatening 6/24/2008 Female 163 lb 6/29/2008 Pharmacist United States
Primary
Concomitant
Rash Erythematous Life Threatening 3/12/2008 Male 195 lb 11/21/2008 Pharmacist United States
Primary
Concomitant
Interacting
Pulmonary Haemorrhage Other Serious 7/25/2007 69 Male 11/28/2008 China
Primary
Concomitant
Sepsis Hospitalization 8/21/2008 Male 12/24/2008 Japan
Primary
Concomitant
Oesophagitis Hospitalization 6/9/2008 60 Male 249 lb 12/22/2008 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 11/9/2007 1/16/2009 Physician Singapore
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 11/9/2007 1/26/2009 Physician Singapore
Primary
Secondary
Concomitant
Refusal Of Treatment By Relative Life Threatening 11/21/2008 24 Male 1/19/2009 Physician United States
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Other Serious 5 Female 2/27/2009 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 1/30/2008 38 Female 139 lb 3/9/2009 Physician United States
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 4/1/2008 Female 3/27/2009 Physician United States
Primary
Concomitant
Hepatic Function Abnormal Other Serious 12/9/2007 4/17/2009 Physician Egypt
Primary
Concomitant
Hepatic Function Abnormal Other Serious 12/9/2007 5/4/2009 Physician Egypt
Primary
Concomitant
Respiratory Distress Death 1/18/2009 48 5/21/2009 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 11/9/2007 57 6/5/2009 Physician Singapore
Primary
Secondary
Concomitant
Urinary Retention Other Serious 10/14/2004 Male 7/2/2009 Physician Germany
Primary
Secondary
Concomitant
Sudden Death Other Serious 7/6/2009 Other Health Professional United States
Primary
Concomitant
Thrombotic Thrombocytopenic Purpura Hospitalization 11/14/2007 54 Male 132 lb 8/31/2009 Physician Japan
Primary
Secondary
Concomitant
Disorientation Hospitalization 6/30/2008 65 Male 168 lb 9/17/2009 Physician Germany
Primary
Concomitant
Cerebral Haemorrhage Death 2/17/2009 48 10/6/2009 Physician Korea, Republic Of
Primary
Concomitant
Urinary Hesitation Hospitalization 7/28/2008 65 Male 207 lb 10/6/2009 United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 9/23/2009 Male 255 lb 10/28/2009 United States
Primary
Secondary
Concomitant
Urticaria Other Serious 1/1/2008 Male 11/2/2009 Physician United States
Primary
Concomitant
Interacting
White Blood Cell Count Decreased Other Serious 9/23/2009 Male 255 lb 12/2/2009 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 9/23/2009 Male 255 lb 12/2/2009 United States
Primary
Secondary
Concomitant
Respiratory Distress Life Threatening 11/27/2006 Male 137 lb 12/15/2009 Physician Italy
Primary
Concomitant
Renal Failure Chronic Other Serious 12/4/2009 Male 302 lb 12/22/2009 Other Health Professional United States
Primary
Concomitant
Multi-organ Failure Death 10/1/2009 52 Male 12/22/2009 Physician Japan
Primary
Concomitant
Cerebral Haemorrhage Death 2/17/2009 48 Male 121 lb 1/27/2010 Physician Korea, Republic Of
Primary
Concomitant
Renal Failure Chronic Other Serious 12/4/2009 Male 302 lb 2/3/2010 Other Health Professional United States
Primary
Concomitant
Renal Failure Chronic Other Serious 12/4/2009 Male 302 lb 2/8/2010 Other Health Professional United States
Primary
Concomitant
Hypersensitivity Hospitalization 1/24/2010 Male 200 lb 2/12/2010 Other Health Professional United States
Primary
Concomitant
Pyrexia Hospitalization 6/10/2009 Female 104 lb 3/4/2010 Physician Japan
Primary
Concomitant
Thrombosis In Device Other Serious 1 Female 5/27/2010
Primary
Secondary
Upper Gastrointestinal Haemorrhage Other Serious 11/1/2008 13 Female 64 lb 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pathogen Resistance Death 11 Female 7/22/2010 Physician Italy
Primary
Secondary
Concomitant
Respiratory Failure Life Threatening 8/4/2010 68 Male 8/13/2010 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 6/10/2009 74 Female 104 lb 9/24/2010 Physician Japan
Primary
Concomitant
Dermatitis Exfoliative Other Serious 5/21/2010 59 Male 163 lb 9/28/2010 Physician Netherlands
Primary
Secondary
Concomitant
Dermatitis Exfoliative Other Serious 5/21/2010 59 Male 163 lb 10/20/2010 Physician Netherlands
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 1/1/2000 60 Male 141 lb 11/9/2010 Physician Japan
Primary
Concomitant
Hypotension Life Threatening 8/5/2010 1 Female 27 lb 11/12/2010 Pharmacist United States
Primary
Concomitant
Zygomycosis Death 75 Male 112 lb 12/10/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/29/2010 49 Male 110 lb 12/13/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/29/2010 49 Male 110 lb 12/13/2010 Physician Japan
Primary
Concomitant
Enterococcal Sepsis Death 11 Female 12/17/2010 Physician Italy
Primary
Secondary
Concomitant
Pancytopenia Death 11 Female 12/21/2010 United States
Primary
Secondary
Concomitant
Cardiac Failure Hospitalization 5/17/2010 2/18/2011 Physician Japan
Primary
Concomitant
Chills Death 1/21/2011 62 Female 110 lb 3/4/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 58 Male 209 lb 3/22/2011 Physician United States
Primary
Concomitant
Circulatory Collapse Hospitalization 1/21/2011 62 Female 110 lb 3/27/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 2/8/2009 46 Female 220 lb 4/8/2011 Physician United States
Primary
Concomitant
Fungal Infection Other Serious 10/13/2009 36 Male 143 lb 4/27/2011 Physician Japan
Primary
Concomitant
Petechiae Other Serious 1/29/2010 49 Male 110 lb 5/20/2011 Physician Japan
Primary
Concomitant
Clostridium Difficile Colitis Death 4/29/2011 75 Male 157 lb 6/3/2011 Other Health Professional Canada
Primary
Concomitant
Off Label Use Other Serious 67 Male 6/6/2011 Physician Greece
Primary
Secondary
Bronchopulmonary Aspergillosis Other Serious 67 Male 6/30/2011 Physician Greece
Primary
Secondary
Acute Graft Versus Host Disease In Skin Other Serious 7/21/2010 7/5/2011 Physician Japan
Primary
Secondary
Concomitant
Hypertension Life Threatening 4/22/2010 13 Male 90 lb 7/5/2011 Physician Japan
Primary
Concomitant
Alanine Aminotransferase Increased Other Serious 6/17/2011 67 Male 7/6/2011 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Death 4/29/2011 75 Male 157 lb 7/8/2011 Other Health Professional Canada
Primary
Concomitant
Device Related Infection Other Serious 8/26/2009 66 Female 115 lb 7/20/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Pseudomonal Sepsis Other Serious 8/25/2009 66 Male 110 lb 7/29/2011 Physician Japan
Primary
Concomitant
Respiratory Failure Hospitalization 11/17/2010 57 Female 7/21/2011 Other Health Professional United States
Primary
Concomitant
Drug Ineffective Other Serious 65 Male 8/8/2011 Italy
Primary
Secondary
Renal Tubular Necrosis Hospitalization 4/29/2011 75 Male 157 lb 8/15/2011 Other Health Professional Canada
Primary
Concomitant
Hepatic Failure Hospitalization 8/26/2009 66 Female 115 lb 8/22/2011 Physician Germany
Primary
Secondary
Concomitant
Drug Interaction Other Serious 26 Female 8/25/2011 Other Health Professional France
Primary
Concomitant
Interacting
Pulmonary Cavitation Other Serious 61 Male 93 lb 9/13/2011 Other Health Professional Japan
Primary
Concomitant
Interacting
Arrhythmia Supraventricular Other Serious 26 Female 9/19/2011 Other Health Professional France
Primary
Concomitant
Interacting
Arrhythmia Supraventricular Other Serious 26 Female 9/19/2011 Other Health Professional France
Primary
Concomitant
Interacting
Multi-organ Failure Life Threatening 5/7/2009 50 Female 90 lb 10/6/2011 Physician Japan
Primary
Concomitant
Respiratory Failure Life Threatening 11/17/2010 57 Female 10/10/2011 Physician United States
Primary
Concomitant
Cough Other Serious 61 Male 93 lb 10/19/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Interacting
Liver Disorder Hospitalization 3/30/2011 24 Female 101 lb 10/21/2011 Physician Japan
Primary
Concomitant
Bronchopulmonary Aspergillosis Hospitalization 2/26/2010 56 Male 134 lb 10/25/2011 Physician Japan
Primary
Concomitant
Drug Interaction Other Serious 73 Male 110 lb 10/25/2011 Other Health Professional Japan
Primary
Concomitant
Interacting
Syncope Hospitalization 7/8/2011 49 Female 11/4/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Neutropenia Other Serious 1/1/2009 51 Male 11/10/2011 Other Health Professional Italy
Primary
Secondary
Concomitant
Liver Disorder Other Serious 12/7/2009 21 Male 132 lb 12/1/2011 Physician Japan
Primary
Concomitant
Cardiac Arrest Life Threatening 5 Female 12/9/2011 Physician Greece
Primary
Secondary
Extrasystoles Other Serious 4/24/2009 26 Female 165 lb 12/14/2011 Other Health Professional France
Primary
Concomitant
Interacting
Acute Myeloid Leukaemia Recurrent Death 8/5/2011 68 Female 88 lb 12/23/2011 Physician Japan
Primary
Concomitant
Graft Versus Host Disease In Skin Other Serious 4/22/2010 13 Male 90 lb 1/9/2012 Physician Japan
Primary
Concomitant
Pancreatitis Death 6/5/2009 1/23/2012 Physician Japan
Primary
Concomitant
Peripheral Arterial Occlusive Disease Hospitalization 1/14/2012 66 Female 146 lb 2/6/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Infection Hospitalization 1/29/2009 3 Female 35 lb 2/10/2012 Physician Japan
Primary
Concomitant
Pancytopenia Hospitalization 1/14/2012 66 Female 146 lb 2/14/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 7/8/2011 49 Female 172 lb 2/21/2012 Physician United States
Primary
Secondary
Concomitant
Blood Bilirubin Increased Hospitalization 2/5/2012 59 Male 2/28/2012 Physician Italy
Primary
Secondary
Concomitant
Pneumonia Fungal Hospitalization 7/8/2011 49 Female 172 lb 2/29/2012 Physician United States
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Skin Hospitalization 8/25/2009 66 Male 110 lb 3/5/2012 Physician Japan
Primary
Concomitant
Blood Bilirubin Increased Hospitalization 2/5/2012 59 Male 3/6/2012 Physician Italy
Primary
Secondary
Concomitant
Pneumonia Life Threatening 1/14/2012 66 Female 146 lb 3/7/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Hospitalization 51 Male 3/19/2012 Physician Japan
Primary
Secondary
Concomitant
Arrhythmia Supraventricular Other Serious 4/24/2009 26 Female 165 lb 3/21/2012 Other Health Professional France
Primary
Concomitant
Interacting
Arrhythmia Supraventricular Other Serious 4/24/2009 26 Female 165 lb 3/21/2012 Other Health Professional France
Primary
Concomitant
Interacting
Pulmonary Mycosis Death 75 Male 3/23/2012 Physician United States
Primary
Concomitant
Graft Versus Host Disease In Skin Death 4/20/2010 13 Male 90 lb 3/26/2012 Physician Japan
Primary
Concomitant
Acute Myeloid Leukaemia Recurrent Death 8/5/2011 68 Female 88 lb 3/30/2012 Physician Japan
Primary
Concomitant
Dyspnoea Hospitalization 3/26/2012 59 Male 205 lb 4/26/2012 Consumer United States
Primary
Concomitant
Pancytopenia Life Threatening 1/14/2012 66 Female 146 lb 5/18/2012 Physician United States
Primary
Secondary
Concomitant
Graft Versus Host Disease In Skin Death 4/20/2010 13 Male 90 lb 6/1/2012 Physician Japan
Primary
Secondary
Concomitant
Drug Intolerance Hospitalization 1/1/2012 37 Female 6/13/2012 Physician United States
Primary
Concomitant
Granuloma Other Serious 6/5/2009 6/13/2012 Physician Japan
Primary
Concomitant
Pneumothorax Death 55 Female 6/13/2012 Other Health Professional Italy
Primary
Secondary
Pyrexia Life Threatening 10/28/2007 64 Female 143 lb 6/19/2012 Physician Spain
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 3/26/2012 46 Male 170 lb 6/29/2012 Spain
Primary
Secondary
Concomitant
Rash Erythematous Hospitalization 3/12/2008 65 Male 195 lb 2/9/2009 Pharmacist United States
Primary
Secondary
Concomitant

Drug Data