Levofloxacin combined with Sodium Bicarbonate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
International Normalised Ratio Increased 6/30/2004 53 9/12/2005 Pharmacist United States
Primary
Concomitant
Liver Function Test Abnormal 11/1/2004 61 9/12/2005 Pharmacist United States
Primary
Concomitant
International Normalised Ratio Increased 4/30/2004 60 9/12/2005 Physician United States
Primary
Concomitant
International Normalised Ratio Increased 8/24/2004 65 9/12/2005 Physician United States
Primary
Concomitant
International Normalised Ratio Increased 7/22/2004 9/12/2005 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 1/15/2006 59 Male 6/7/2006 Japan
Primary
Concomitant
Vomiting Hospitalization 7/11/2005 40 Female 9/15/2006 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 1/15/2006 59 Male 9/19/2006 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/30/2006 59 Male 9/26/2006 Japan
Primary
Secondary
Concomitant
Clostridial Infection Hospitalization 10/11/2006 83 Male 158 lb 10/13/2006 Pharmacist United States
Primary
Concomitant
Blood Pressure Decreased Other Serious 11/3/2006 39 Male 11/10/2006 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/4/2006 71 Male 1/17/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/4/2006 71 Male 1/25/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/4/2006 71 Male 2/5/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/4/2006 71 Male 2/12/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/4/2006 71 Male 2/28/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/4/2006 71 Male 5/18/2007 Physician Japan
Primary
Concomitant
Pulmonary Mass Other Serious 12/4/2006 71 Male 5/24/2007 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/4/2006 71 Male 6/28/2007 Physician Japan
Primary
Concomitant
Urine Output Decreased Disability 2/14/2007 67 Female 121 lb 7/13/2007 Physician Japan
Primary
Concomitant
Urine Output Decreased Other Serious 2/14/2007 67 Female 121 lb 8/6/2007 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/4/2006 71 Male 106 lb 8/16/2007 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/4/2006 71 Male 106 lb 9/18/2007 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/4/2006 71 Male 106 lb 11/22/2007 Physician Japan
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 10/9/2007 58 Male 11/26/2007 Physician Japan
Primary
Concomitant
Unresponsive To Stimuli Life Threatening 9/28/2007 21 Female 150 lb 12/3/2007 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/8/2006 71 Male 106 lb 12/14/2007 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/4/2007 64 Male 139 lb 12/20/2007 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 8/24/2007 67 Female 1/9/2008 Other Health Professional United States
Primary
Concomitant
Pyrexia Other Serious 12/8/2006 71 Male 106 lb 1/31/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/4/2007 64 Male 139 lb 2/1/2008 Physician Japan
Primary
Secondary
Concomitant
Ventricular Fibrillation Death 1/15/2008 79 Male 212 lb 2/6/2008 Pharmacist United States
Primary
Secondary
Concomitant
Cardiac Failure Congestive Disability 4/16/2007 46 Female 108 lb 4/22/2008 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Death 9/7/2007 62 Male 123 lb 5/14/2008 Japan
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 5/21/2008 71 Male 101 lb 6/26/2008 Physician Japan
Primary
Secondary
Concomitant
Intestinal Obstruction Hospitalization 11/13/2007 75 Male 126 lb 7/29/2008 Physician Japan
Primary
Concomitant
Vulval Abscess Death 6/23/2008 60 Female 95 lb 10/2/2008 Physician Japan
Primary
Concomitant
Urinary Retention Death 6/5/2008 60 Female 95 lb 10/31/2008 Physician Japan
Primary
Concomitant
Myocardial Ischaemia Life Threatening 3/20/2008 80 Female 86 lb 12/24/2008 Physician Japan
Primary
Concomitant
Coronary Artery Stenosis Life Threatening 3/20/2008 80 Female 86 lb 2/5/2009 Physician Japan
Primary
Concomitant
Ototoxicity Other Serious 51 Female 315 lb 3/16/2009
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Other Serious 10/9/2007 58 Male 3/19/2009 Physician Japan
Primary
Concomitant
Transaminases Increased Other Serious 4/1/2008 Female 3/27/2009 Physician United States
Primary
Concomitant
Tumour Lysis Syndrome Life Threatening 10/9/2007 58 Male 4/23/2009 Physician Japan
Primary
Concomitant
Thrombocytopenia Other Serious 6/4/2007 64 Male 139 lb 10/13/2009 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 6/4/2007 64 Male 139 lb 10/24/2009 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 7/8/2008 34 Female 1/7/2010 Consumer United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 3/22/2009 15 Male 110 lb 2/26/2010 Physician Japan
Primary
Concomitant
Thrombocytopenia Other Serious 6/1/2008 34 Female 117 lb 3/31/2010 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/28/2010 33 Male 99 lb 4/1/2010 Physician Japan
Primary
Concomitant
Oedema Peripheral Other Serious 3/6/2010 49 Male 184 lb 4/8/2010 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/28/2010 33 Male 99 lb 4/9/2010 Physician Japan
Primary
Concomitant
Unresponsive To Stimuli Other Serious 1/1/2007 69 Female 4/19/2010 United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 11/1/2007 58 Female 123 lb 4/26/2010 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/28/2010 33 Male 99 lb 5/7/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 1/28/2010 33 Male 99 lb 5/25/2010 Physician Japan
Primary
Concomitant
Pneumonia Hospitalization 2/11/2010 82 Female 106 lb 6/4/2010 Other Health Professional Italy
Primary
Concomitant
Pneumonia Hospitalization 2/11/2010 82 Female 106 lb 6/22/2010 Other Health Professional Italy
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Other Serious 11/1/2008 13 Female 64 lb 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Ventricular Fibrillation Other Serious 1/1/2007 69 Female 148 lb 7/1/2010 Lawyer United States
Primary
Secondary
Concomitant
Ventricular Fibrillation Life Threatening 12/4/2007 69 Female 326 lb 7/19/2010 Lawyer United States
Primary
Secondary
Concomitant
Substance Abuse Other Serious 1/1/2008 54 Female 8/18/2010 Lawyer United States
Primary
Concomitant
Vomiting Other Serious 1/16/2008 41 Male 225 lb 8/23/2010 Lawyer United States
Primary
Concomitant
Urinary Incontinence Other Serious 1/1/2009 59 Female 132 lb 8/23/2010 Consumer United States
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 6/1/2009 59 Female 132 lb 9/1/2010 Physician Germany
Primary
Secondary
Concomitant
Leukopenia Life Threatening 8/4/2010 60 Female 97 lb 9/2/2010 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 1/16/2008 41 Male 225 lb 9/22/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Peripheral Motor Neuropathy Hospitalization 9/8/2010 58 Male 146 lb 10/7/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Substance Abuse Other Serious 1/1/2008 54 Female 10/11/2010 Lawyer United States
Primary
Concomitant
Peripheral Motor Neuropathy Hospitalization 9/8/2010 58 Male 146 lb 11/2/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 11/1/2007 58 Female 123 lb 11/22/2010 Lawyer United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 7/1/2008 34 Female 117 lb 11/29/2010 Consumer United States
Primary
Secondary
Concomitant
Peripheral Motor Neuropathy Hospitalization 9/8/2010 58 Male 146 lb 12/2/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious 11/11/2009 72 Female 126 lb 12/27/2010 Physician Japan
Primary
Concomitant
Reticulocyte Count Increased Other Serious Female 99 lb 2/28/2011 Consumer Canada
Primary
Secondary
Concomitant
Stress Hospitalization 1/1/1996 37 Female 143 lb 2/28/2011 Consumer United States
Primary
Concomitant
Pain Other Serious 1/1/1996 37 Female 143 lb 2/28/2011 Other Health Professional United States
Primary
Concomitant
Empyema Hospitalization 1/8/2011 41 Female 99 lb 3/4/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Peripheral Motor Neuropathy Hospitalization 9/8/2010 58 Male 146 lb 3/18/2011 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Death 6/4/2007 64 Male 139 lb 3/30/2011 Physician Japan
Primary
Secondary
Concomitant
Renal Disorder Death 5/9/2011 44 Male 5/13/2011 Other Health Professional United States
Primary
Concomitant
C-reactive Protein Increased Hospitalization 12/20/2010 60 Female 6/10/2011 Physician Japan
Primary
Concomitant
Hypertension Life Threatening 4/22/2010 13 Male 90 lb 7/5/2011 Physician Japan
Primary
Concomitant
Anaemia Hospitalization 1/1/1996 48 Female 143 lb 7/13/2011 Other Health Professional United States
Primary
Concomitant
Platelet Count Decreased Life Threatening 1/24/2011 67 Male 7/19/2011 Physician Japan
Primary
Secondary
Concomitant
Encephalitis Fungal Death Male 139 lb 8/1/2011 Physician Japan
Primary
Secondary
Concomitant
Dysstasia Death 10/1/2002 76 Female 188 lb 8/1/2011 Consumer United States
Primary
Concomitant
Fungaemia Death 6/22/2005 46 Male 126 lb 8/2/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 2/11/2010 82 Female 106 lb 8/2/2011 Italy
Primary
Concomitant
Pneumonia Other Serious 5/6/2011 76 Female 8/4/2011 Other Health Professional Japan
Primary
Concomitant
Bronchitis Other Serious 6/22/2010 56 Female 8/29/2011 Other Health Professional Japan
Primary
Secondary
Infection Death 8/21/2010 48 Female 95 lb 9/1/2011 Physician Japan
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 56 Female 9/2/2011 Other Health Professional Japan
Primary
Concomitant
Pulmonary Embolism Hospitalization 9/8/2011 69 Male 144 lb 9/15/2011 Physician Japan
Primary
Secondary
Concomitant
Neutropenia Other Serious 11/24/2010 63 Male 9/15/2011 Physician Japan
Primary
Secondary
Concomitant
Bronchopulmonary Aspergillosis Death 5/15/2011 66 Female 9/21/2011 Physician United States
Primary
Concomitant
Depressed Level Of Consciousness Death 1/1/2011 74 Female 9/26/2011 Other Health Professional Japan
Primary
Concomitant
Deep Vein Thrombosis Hospitalization 9/8/2011 69 Male 144 lb 10/3/2011 Physician Japan
Primary
Secondary
Concomitant
Nikolsky's Sign Other Serious 8/15/2009 45 Male 176 lb 10/5/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Neutropenia Death 10/7/2009 44 Female 104 lb 10/17/2011 Pharmacist Japan
Primary
Concomitant
Bronchopulmonary Aspergillosis Death 5/1/2011 66 Female 10/28/2011 Physician Japan
Primary
Concomitant
Scab Death 8/15/2009 45 Male 176 lb 11/1/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Blood Glucose Increased Other Serious 2/11/2011 55 Female 123 lb 11/11/2011 Physician Japan
Primary
Concomitant
Renal Impairment Life Threatening Female 12/12/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Febrile Neutropenia Other Serious 1/24/2011 67 Male 12/12/2011 Physician Japan
Primary
Secondary
Concomitant
Graft Versus Host Disease In Skin Other Serious 4/22/2010 13 Male 90 lb 1/9/2012 Physician Japan
Primary
Concomitant
Shock Haemorrhagic Life Threatening 1/24/2011 67 Male 1/13/2012 Physician Japan
Primary
Secondary
Concomitant
Infection Death 4/7/2011 75 Female 1/19/2012 Other Health Professional Japan
Primary
Concomitant
Oedema Peripheral Hospitalization 1/8/2012 76 Female 1/20/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Decreased Appetite Death 11/2/2011 76 Male 106 lb 1/30/2012 Physician Japan
Primary
Concomitant
Peripheral Arterial Occlusive Disease Hospitalization 1/14/2012 66 Female 146 lb 2/6/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Infection Hospitalization 1/29/2009 3 Female 35 lb 2/10/2012 Physician Japan
Primary
Concomitant
Pancytopenia Hospitalization 1/14/2012 66 Female 146 lb 2/14/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Pneumonia Life Threatening 1/14/2012 66 Female 146 lb 3/7/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Graft Versus Host Disease In Skin Death 4/20/2010 13 Male 90 lb 3/26/2012 Physician Japan
Primary
Concomitant
Arrhythmia Other Serious 11/24/2010 63 Male 3/27/2012 Physician Japan
Primary
Secondary
Concomitant
Liver Disorder Hospitalization 8/21/2010 48 Female 95 lb 4/6/2012 Physician Japan
Primary
Secondary
Concomitant
Neutropenia Other Serious 11/24/2010 63 Male 4/9/2012 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Other Serious 4/1/2010 47 Female 130 lb 4/13/2012 Lawyer United States
Primary
Concomitant
Intestinal Obstruction Hospitalization 11/13/2007 75 Male 126 lb 4/20/2012 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 6/13/2011 69 Male 136 lb 4/27/2012 Physician Japan
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 8/1/2006 28 Male 117 lb 5/10/2012 Physician Japan
Primary
Concomitant
Histiocytosis Haematophagic Hospitalization 8/21/2010 48 Female 95 lb 5/18/2012 Physician Japan
Primary
Secondary
Concomitant
Pancytopenia Life Threatening 1/14/2012 66 Female 146 lb 5/18/2012 Physician United States
Primary
Secondary
Concomitant
Blood Lactate Dehydrogenase Increased Disability 3/14/2012 37 Female 119 lb 5/25/2012 Physician Japan
Primary
Concomitant
Lymphocyte Count Decreased Death 1/13/2012 74 Female 150 lb 5/31/2012 Physician Japan
Primary
Concomitant
Graft Versus Host Disease In Skin Death 4/20/2010 13 Male 90 lb 6/1/2012 Physician Japan
Primary
Secondary
Concomitant
Bradycardia Life Threatening 5/10/2012 73 Female 79 lb 6/1/2012 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Sepsis Death 2/11/2011 55 Female 123 lb 6/8/2012 Physician Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 3/14/2012 37 Female 119 lb 6/8/2012 Physician Japan
Primary
Concomitant
Electrocardiogram Qt Prolonged Life Threatening 5/10/2012 73 Female 79 lb 6/8/2012 Physician Japan
Primary
Secondary
Concomitant
Bone Marrow Failure Hospitalization 1/19/2011 67 Male 207 lb 6/1/2012 Physician United States
Primary
Concomitant
Nephrolithiasis Hospitalization 5/11/2012 65 Female 189 lb 6/21/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 5/11/2012 65 Female 189 lb 6/27/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Haemolytic Uraemic Syndrome Death 1/29/2009 3 Female 35 lb 7/5/2012 Physician Japan
Primary
Concomitant
Neutropenia Other Serious 12/2/2010 63 Male 7/5/2012 Physician Japan
Primary
Secondary
Concomitant
Graft Versus Host Disease In Skin Death 2/11/2011 55 Female 123 lb 7/31/2012 Physician Japan
Primary
Secondary
Concomitant
Bronchopulmonary Aspergillosis Other Serious 5/1/2011 66 Female 108 lb 8/14/2012 Physician Japan
Primary
Concomitant
Febrile Neutropenia Hospitalization 6/29/2012 69 Female 106 lb 8/15/2012 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Oxygen Saturation Decreased Other Serious 3/14/2012 37 Female 119 lb 8/17/2012 Physician Japan
Primary
Concomitant
Pancreatitis Hospitalization 8/6/2011 78 Male 110 lb 8/21/2012 Physician Japan
Primary
Concomitant
Urinary Tract Infection Staphylococcal Hospitalization 1/19/2011 67 Male 207 lb 10/25/2012 Physician Us
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 2/11/2011 55 Female 123 lb 9/6/2012 Physician Jp
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 6/29/2012 69 Female 106 lb 2/27/2013 Physician Kr
Primary
Secondary
Concomitant
Pneumonia Hospitalization 3/4/2012 69 Male 137 lb 3/9/2013 Physician Kr
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 7/5/2011 42 Male 154 lb 1/24/2013 Consumer Us
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Death 11/18/2012 16 Female 101 lb 8/14/2013 Physician Jp
Primary
Secondary
Concomitant
Ulcer Death 12/2/2009 12 Male 77 lb 4/8/2013 Physician Jp
Primary
Concomitant
Urticaria Hospitalization 4/6/2013 74 Male 4/24/2013 Other Health Professional Country Not Specified
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 3/29/2013 60 Female 199 lb 7/30/2013 Physician Us
Primary
Secondary
Concomitant

Drug Data