Levofloxacin combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Post Procedural Complication Death 34 Male 2/7/2006 Physician Japan
Primary
Concomitant
Hemiplegia Death 34 Male 2/16/2006 Physician Japan
Primary
Concomitant
Mammogram Abnormal Other Serious 1/1/2006 46 Female 80 lb 3/28/2006 Other Health Professional United States
Primary
Concomitant
Respiratory Failure Death 8/3/2005 43 Male 4/28/2006 Physician Japan
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 2/22/2003 61 Male 95 lb 5/16/2006 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 6/5/2002 42 Female 112 lb 5/15/2006 Physician Japan
Primary
Secondary
Concomitant
Human Herpesvirus 6 Infection Death 34 Male 5/23/2006 Physician Japan
Primary
Concomitant
Venoocclusive Liver Disease Disability 1/1/2004 61 Female 98 lb 6/7/2006 Physician Japan
Primary
Secondary
Concomitant
Toxic Induced Encephalopathy Life Threatening 8/3/2005 43 Male 6/8/2006 Physician Japan
Primary
Concomitant
Venoocclusive Liver Disease Life Threatening 6/5/2002 42 Female 112 lb 6/7/2006 Physician Japan
Primary
Secondary
Concomitant
Renal Tubular Acidosis Other Serious 5/5/2005 20 Male 8/30/2006 Consumer United States
Primary
Secondary
Concomitant
Oral Mucosal Disorder Hospitalization 2/9/2006 10 Male 8/30/2006 Consumer United States
Primary
Secondary
Concomitant
Vitreous Haemorrhage Other Serious 12/1/2003 38 Male 9/6/2006 Japan
Primary
Secondary
Concomitant
Peritoneal Tuberculosis Other Serious 12/26/2003 Female 9/14/2006 Physician Japan
Primary
Concomitant
Venoocclusive Liver Disease Required Intervention 55 Female 10/5/2006 Germany
Primary
Secondary
Concomitant
Renal Failure Life Threatening 1/28/2005 54 Female 106 lb 11/9/2006 Physician Japan
Primary
Concomitant
Retroperitoneal Neoplasm Life Threatening 1/28/2005 54 Female 106 lb 11/20/2006 Physician Japan
Primary
Concomitant
Toxic Epidermal Necrolysis Other Serious Female 1/23/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Other Serious Unknown 4/16/2007 Germany
Primary
Secondary
International Normalised Ratio Increased Hospitalization 10/28/2006 42 Male 1/14/2007 Pharmacist United States
Primary
Secondary
Concomitant
Vomiting Other Serious 12/25/2004 Female 110 lb 6/25/2007 Consumer United States
Primary
Concomitant
Bursitis Hospitalization 5/14/2007 Female 121 lb 6/27/2007 Italy
Primary
Concomitant
Bursitis Hospitalization 5/14/2007 Female 121 lb 7/12/2007 Italy
Primary
Concomitant
Bursitis Infective Hospitalization 5/14/2007 Female 121 lb 8/10/2007 Italy
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/27/2007 8 Male 44 lb 8/27/2007 Physician Japan
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious 12/5/2006 70 Female 9/3/2007 Pharmacist Japan
Primary
Secondary
Leukoencephalopathy Hospitalization 12/5/2006 70 Female 9/6/2007 Physician Japan
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Death 54 9/27/2007 Physician United States
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Death 61 9/27/2007 Physician United States
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Death 79 9/27/2007 Physician United States
Primary
Secondary
Concomitant
Nodal Marginal Zone B-cell Lymphoma Other Serious 10/15/2007 Female 152 lb 11/7/2007 United States
Primary
Concomitant
Skin Ulcer Hospitalization 76 Female 11/19/2007
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection 1/1/2005 Female 140 lb 12/14/2007 Consumer United States
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 10/1/2007 Female 196 lb 1/3/2008 Consumer United States
Primary
Concomitant
Stomatitis Other Serious 36 Female 265 lb 1/8/2008
Primary
Secondary
Concomitant
Vomiting Other Serious 12/25/2004 Female 110 lb 1/15/2008 Consumer United States
Primary
Concomitant
Oxygen Saturation Decreased Hospitalization 9/20/2007 Female 132 lb 1/17/2008 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 10/1/2007 Female 196 lb 2/6/2008 Physician United States
Primary
Concomitant
Thrombocytopenia Other Serious 1/1/2004 Female 137 lb 3/6/2008 Physician France
Primary
Secondary
Concomitant
Cardiac Failure Congestive Disability 4/16/2007 46 Female 108 lb 4/22/2008 Physician Japan
Primary
Concomitant
Nodal Marginal Zone B-cell Lymphoma Other Serious 10/15/2007 Female 152 lb 5/2/2008 United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 9/21/2007 25 Male 112 lb 6/4/2008 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 9/21/2007 25 Male 112 lb 6/19/2008 Physician Japan
Primary
Secondary
Concomitant
Shoulder Operation Other Serious 6/19/2008 Female 138 lb 6/27/2008 Consumer United States
Primary
Concomitant
Thrombocytopenia Other Serious 9/21/2007 25 Male 7/3/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Venous Occlusion Other Serious 1/1/2007 Female 7/3/2008 Consumer United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 9/21/2007 25 Male 112 lb 6/27/2008 Physician Japan
Primary
Secondary
Concomitant
Rotator Cuff Syndrome Hospitalization 6/19/2008 Female 138 lb 7/11/2008 Consumer United States
Primary
Concomitant
Thrombocytopenia Other Serious 9/21/2007 25 Male 112 lb 7/28/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Pancytopenia Life Threatening 1/31/2008 Male 8/6/2008 Physician Japan
Primary
Concomitant
Respiratory Failure Hospitalization 5/26/2008 Female 8/6/2008 Physician United States
Primary
Secondary
Concomitant
Psoriasis 12/1/2006 Female 190 lb 9/12/2008 Consumer United States
Primary
Concomitant
Skin Ulcer Other Serious 1/1/2007 Female 177 lb 9/15/2008 Physician United States
Primary
Secondary
Concomitant
Fungal Rhinitis Other Serious 41 Male 7/8/2008 Other Health Professional Italy
Primary
Secondary
Concomitant
Tendon Rupture Other Serious 1/1/2008 Female 138 lb 10/13/2008 United States
Primary
Secondary
Concomitant
Neuropathy Peripheral Other Serious 8/1/2008 42 Female 11/20/2008 Consumer United States
Primary
Concomitant
Serotonin Syndrome Other Serious 73 Female 12/4/2008
Primary
Secondary
Pneumonitis Other Serious 42 Female 12/11/2008
Primary
Concomitant
Pneumonitis Other Serious 47 Female 12/11/2008
Primary
Secondary
Concomitant
Asthenia 11/24/2008 Female 139 lb 12/10/2008 Physician United States
Primary
Concomitant
Urinary Tract Infection Life Threatening 10/29/2002 Female 3/9/2009 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/1/2004 70 Male 4/14/2009 Physician France
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/1/2004 70 Male 4/22/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 57 Female 110 lb 4/17/2009 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 5/28/2008 Female 5/22/2009 Physician United States
Primary
Secondary
Concomitant
Osteonecrosis Hospitalization 63 Male 5/22/2009 Consumer Japan
Primary
Concomitant
Osteonecrosis Other Serious 8/1/2006 63 Male 5/28/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Urine Output Decreased Death 1/25/2009 40 Female 6/2/2009 Japan
Primary
Secondary
Concomitant
Osteonecrosis Hospitalization 63 Male 6/8/2009 Consumer Japan
Primary
Concomitant
Osteonecrosis Hospitalization 63 Male 6/18/2009 Consumer Japan
Primary
Concomitant
Herpes Zoster Hospitalization 6/18/2009 Female 112 lb 7/20/2009 Other Health Professional Argentina
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 9/1/2007 63 Male 8/24/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 75 8/28/2009 Japan
Primary
Concomitant
Febrile Bone Marrow Aplasia Life Threatening 7/28/2009 Male 8/28/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Staphylococcal Sepsis Life Threatening 6/9/2008 62 Male 154 lb 9/1/2009 Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 8/8/2008 51 Male 97 lb 9/3/2009 Physician Japan
Primary
Secondary
Concomitant
Febrile Bone Marrow Aplasia Life Threatening 7/28/2009 Male 9/3/2009 Physician France
Primary
Secondary
Concomitant
Pancytopenia Life Threatening 1/31/2008 Male 9/10/2009 Japan
Primary
Concomitant
Renal Impairment Life Threatening 7/2/2008 49 Male 141 lb 9/11/2009 Physician Japan
Primary
Secondary
Concomitant
Vomiting Death 3/2/2008 69 Female 9/8/2009 United States
Primary
Concomitant
Renal Impairment Life Threatening 7/2/2008 49 Male 141 lb 9/25/2009 Physician Japan
Primary
Secondary
Concomitant
Visual Impairment Life Threatening 7/28/2009 Male 10/14/2009 Physician France
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 5/7/2009 43 Female 201 lb 8/31/2009 Pharmacist United States
Primary
Secondary
Concomitant
Agranulocytosis Hospitalization 7/7/2009 Male 10/14/2009 Physician United Kingdom
Primary
Concomitant
Vomiting Death 3/2/2008 78 Female 10/17/2009 United States
Primary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 7/28/2009 Male 10/29/2009 Physician France
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 49 Female 11/23/2009 Spain
Primary
Concomitant
Pancreatic Necrosis Hospitalization 12/1/2008 63 Female 11/18/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 7/28/2009 Male 12/1/2009 Physician France
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 49 Female 12/8/2009 Spain
Primary
Concomitant
Staphylococcal Infection Other Serious 11/17/2009 Female 162 lb 12/11/2009 Physician Argentina
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 50 Female 12/7/2009 Japan
Primary
Secondary
Concomitant
Graft Versus Host Disease Other Serious 56 Male 12/7/2009 Japan
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 11/17/2009 Female 162 lb 12/15/2009 Argentina
Primary
Concomitant
Staphylococcal Infection Other Serious 11/17/2009 Female 162 lb 12/28/2009 Physician Argentina
Primary
Concomitant
Multi-organ Failure Death 10/1/2009 52 Male 12/22/2009 Physician Japan
Primary
Concomitant
Agranulocytosis Hospitalization 7/7/2009 Male 1/26/2010 Physician United Kingdom
Primary
Concomitant
Bone Marrow Failure Other Serious 42 Female 1/27/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 3/12/2008 Female 194 lb 2/3/2010 Physician United States
Primary
Secondary
Concomitant
Hypersensitivity Hospitalization 1/24/2010 Male 200 lb 2/12/2010 Other Health Professional United States
Primary
Concomitant
Pneumonia Hospitalization 3/12/2008 Female 194 lb 2/12/2010 Physician United States
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 11/17/2009 Female 162 lb 2/1/2010 Argentina
Primary
Concomitant
Pyrexia Other Serious 3/22/2009 15 Male 110 lb 2/26/2010 Physician Japan
Primary
Concomitant
Wheezing Hospitalization 2/16/2010 Female 105 lb 3/3/2010 United States
Primary
Concomitant
Renal Impairment Life Threatening 1/31/2008 Male 3/19/2010 Japan
Primary
Concomitant
Interacting
Overdose Other Serious 52 Female 3/19/2010 Other Health Professional United States
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2004 70 Male 3/29/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 5/28/2008 Female 142 lb 3/30/2010 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 2/16/2010 Female 105 lb 3/30/2010 Other Health Professional United States
Primary
Concomitant
Weight Decreased Hospitalization 2/16/2010 50 Female 105 lb 3/30/2010 United States
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 9/25/2007 48 Female 115 lb 4/5/2010 Physician Japan
Primary
Secondary
Concomitant
Arthritis Bacterial Hospitalization 3/23/2010 33 Male 366 lb 4/16/2010 Physician Argentina
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 3/23/2010 33 Male 366 lb 4/26/2010 Physician Argentina
Primary
Secondary
Concomitant
Skin Toxicity Other Serious 4/29/2010 United States
Primary
Secondary
Skin Toxicity Death 4/30/2010 Physician United Kingdom
Primary
Secondary
Septic Arthritis Staphylococcal Hospitalization 3/23/2010 33 Male 366 lb 4/30/2010 Physician Argentina
Primary
Secondary
Concomitant
Septic Arthritis Staphylococcal Hospitalization 3/23/2010 33 Male 366 lb 5/10/2010 Physician Argentina
Primary
Secondary
Concomitant
Pneumonia Hospitalization 3/12/2008 67 Female 194 lb 5/12/2010 Physician United States
Primary
Secondary
Concomitant
Respiratory Disorder Other Serious 1/20/2008 8 Female 50 lb 5/26/2010 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 5/28/2008 68 Female 142 lb 6/18/2010 Physician United States
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 1/1/2009 61 Female 6/15/2010 Physician Germany
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 4/14/2010 60 Male 110 lb 6/25/2010 Physician Japan
Primary
Concomitant
Sepsis Hospitalization 1/1/2008 56 Female 101 lb 8/5/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Lipase Increased Other Serious 6/24/2010 20 Female 159 lb 8/9/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 1/9/2009 58 Female 97 lb 7/28/2010 Physician Japan
Primary
Concomitant
Retrograde Amnesia Disability 7/15/2010 59 Male 8/12/2010 Other Health Professional Japan
Primary
Concomitant
Urinary Incontinence Other Serious 1/1/2009 59 Female 132 lb 8/23/2010 Consumer United States
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 6/1/2009 59 Female 132 lb 9/1/2010 Physician Germany
Primary
Secondary
Concomitant
Lipase Increased Other Serious 6/24/2010 20 Female 159 lb 9/8/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Cellulitis Hospitalization 2/22/2010 48 Female 161 lb 10/27/2010 Other Health Professional United States
Primary
Concomitant
Encephalitis Fungal Death Male 139 lb 11/15/2010 Physician Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/17/2010 Male 168 lb 11/22/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/29/2010 49 Male 110 lb 12/13/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/29/2010 49 Male 110 lb 12/13/2010 Physician Japan
Primary
Concomitant
Renal Hypertrophy Hospitalization 6/17/2010 40 Female 11/30/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Enterococcal Sepsis Death 11 Female 12/17/2010 Physician Italy
Primary
Secondary
Concomitant
Renal Hypertrophy Hospitalization 6/17/2010 40 Female 12/6/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Pancytopenia Death 11 Female 12/21/2010 United States
Primary
Secondary
Concomitant
Overdose Other Serious 52 Female 12/21/2010 Other Health Professional United States
Primary
Concomitant
Vomiting Other Serious 3/15/2010 54 Female 95 lb 12/22/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 12/12/2009 76 Male 119 lb 12/23/2010 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious 3/19/2010 31 Male 139 lb 12/27/2010 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 3/12/2010 54 Female 95 lb 12/27/2010 Physician Japan
Primary
Concomitant
Liver Disorder Hospitalization 3/26/2010 54 Female 95 lb 12/28/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Life Threatening 12/12/2009 76 Male 119 lb 12/29/2010 Physician Japan
Primary
Concomitant
Multiple Allergies Other Serious 2/22/2010 48 Female 161 lb 12/15/2010 Other Health Professional United States
Primary
Concomitant
Renal Hypertrophy Hospitalization 6/17/2010 40 Female 12/16/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Pseudomonal Sepsis Life Threatening 11/7/2010 49 Female 97 lb 12/30/2010 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Bacteraemia Hospitalization 9/8/2010 49 Female 161 lb 12/20/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Staphylococcal Infection Death 4/14/2010 60 Male 110 lb 1/20/2011 Physician Japan
Primary
Concomitant

Drug Data