Levetiracetam combined with Valproic Acid

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Rash Other Serious 1/1/2005 53 Female 2/6/2006 Physician Denmark
Primary
Secondary
Concomitant
Subacute Sclerosing Panencephalitis Hospitalization 10 Male 5/26/2006 France
Primary
Secondary
Subacute Sclerosing Panencephalitis Hospitalization Female 10/12/2006 United States
Primary
Secondary
Concomitant
Vomiting Death 7/13/2006 Male 88 lb 12/22/2006 Pharmacist United States
Primary
Concomitant
Spina Bifida Congenital Anomaly Female 3/9/2007 United Kingdom
Primary
Secondary
Neutropenia Hospitalization 11/23/2006 72 Female 4/25/2007 Other Health Professional France
Primary
Secondary
Concomitant
Blood Creatine Phosphokinase Increased Other Serious 7 Female 35 lb 5/11/2007 Israel
Primary
Concomitant
Confusional State Hospitalization 9/29/2006 51 Female 3/14/2007 Consumer United States
Primary
Concomitant
Visual Acuity Reduced Disability 3/7/2007 50 Female 7/2/2007 Other Health Professional France
Primary
Concomitant
Visual Acuity Reduced Other Serious 50 Female 8/17/2007 Physician France
Primary
Concomitant
Vitamin B12 Increased Death 1/1/2007 36 Female 135 lb 8/30/2007 Physician United States
Primary
Secondary
Psychotic Disorder Hospitalization 52 Female 8/31/2007 Germany
Primary
Secondary
Concomitant
Urine Ketone Body Present Death 36 Female 8/23/2007 United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Hospitalization 36 Female 135 lb 9/13/2007 Physician United States
Primary
Secondary
Concomitant
Traumatic Brain Injury Other Serious 7/1/2004 24 Male 10/19/2007 Canada
Primary
Concomitant
Neuroleptic Malignant Syndrome Hospitalization 1/1/2007 36 Female 10/17/2007 Physician United States
Primary
Secondary
Erythema Multiforme Disability 6/27/2007 78 Female 104 lb 11/23/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 8/30/2006 Female 11/29/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Thrombocytopenic Purpura Other Serious 7/1/2006 19 Male 3/4/2008 Other Health Professional United Kingdom
Primary
Secondary
Convulsion Other Serious 12 Female 3/6/2008 Consumer Germany
Primary
Concomitant
Hepatitis Cholestatic Hospitalization 11/15/2007 Female 3/7/2008 Other Health Professional France
Primary
Secondary
Epilepsy Other Serious 51 Male 4/4/2008 Pharmacist France
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 5/9/2007 Male 105 lb 4/11/2008 Consumer United States
Primary
Secondary
Interacting
Cardiac Arrest Death 5/22/2008 19 Male 93 lb 6/3/2008 Physician Greece
Primary
Concomitant
Cardiac Arrest Death 5/22/2008 19 Male 93 lb 6/23/2008 Physician Greece
Primary
Concomitant
Thrombocytopenia Other Serious 64 Female 6/25/2008 Germany
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 7/3/2008 0 Male 15 lb 7/18/2008 Other Health Professional China
Primary
Secondary
Vesicoureteric Reflux Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Vesicoureteric Reflux Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Vesicoureteric Reflux Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Vesicoureteric Reflux Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Vesicoureteric Reflux Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Vesicoureteric Reflux Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Vesicoureteric Reflux Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Vesicoureteric Reflux Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Vesicoureteric Reflux Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Vesicoureteric Reflux Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Hyperglycaemia Death 51 Male 9/30/2008 Netherlands
Primary
Secondary
Concomitant
Pancreatitis Necrotising Death 9/29/2008 Female 44 lb 10/8/2008 Pharmacist United States
Primary
Concomitant
Hyperglycaemia Death 51 Male 10/21/2008 Netherlands
Primary
Secondary
Concomitant
Hyperhidrosis Other Serious 9/21/2008 20 Female 10/10/2008 Pharmacist United States
Primary
Concomitant
Visual Field Defect Other Serious 1/23/2009 Other Health Professional France
Primary
Concomitant
Therapeutic Agent Toxicity Required Intervention 19 Male 1/19/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 3/1/2007 23 Female 2/11/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Disorder Other Serious 7/1/2008 2/23/2009 Other Health Professional France
Primary
Secondary
Vomiting Hospitalization 11/13/2008 37 Male 2/11/2009 United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/9/2007 13 Male 105 lb 2/27/2009 Consumer United States
Primary
Secondary
Suicide Attempt Other Serious Male 3/11/2009
Primary
Secondary
Concomitant
Unresponsive To Stimuli Hospitalization 6 Male 5/7/2009 United States
Primary
Concomitant
Maculopathy Other Serious 41 Female 5/21/2009 Other Health Professional Luxembourg
Primary
Concomitant
Maculopathy Other Serious 41 Female 5/22/2009 Other Health Professional Luxembourg
Primary
Concomitant
Convulsion Other Serious 5/27/2009 Male 182 lb 6/17/2009 United States
Primary
Secondary
Drug Ineffective Other Serious 85 Female 7/2/2009
Primary
Concomitant
Status Epilepticus Hospitalization Male 165 lb 8/10/2009 Physician Netherlands
Primary
Concomitant
Spina Bifida Other Serious 8/21/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Maternal Drugs Affecting Foetus Congenital Anomaly 6/23/2009 9/29/2009 Physician Italy
Primary
Concomitant
Suicide Attempt Other Serious Male 10/26/2009 Other Health Professional Netherlands
Primary
Concomitant
Product Substitution Issue Male 286 lb 10/23/2009 Physician United States
Primary
Concomitant
Drug Ineffective Other Serious 32 Male 11/5/2009 Physician Spain
Primary
Concomitant
Drug Ineffective Other Serious 11 Female 11/5/2009 Physician Spain
Primary
Concomitant
Drug Ineffective Other Serious 50 Male 11/5/2009 Spain
Primary
Concomitant
Hyperammonaemic Encephalopathy Other Serious 53 Female 1/1/2010 Other Health Professional United States
Primary
Secondary
Sweat Gland Disorder Hospitalization 9 Male 1/4/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hyperammonaemic Encephalopathy Other Serious 53 Female 1/6/2010 Other Health Professional United States
Primary
Secondary
Stevens-johnson Syndrome Hospitalization 12/10/2009 Female 95 lb 1/19/2010 Other Health Professional Portugal
Primary
Concomitant
Convulsion Other Serious 12 Female 1/22/2010
Primary
Secondary
No Therapeutic Response Hospitalization 9 Male 1/21/2010 Physician United States
Primary
Concomitant
Tremor Other Serious 10/1/2002 48 Male 1/29/2010
Primary
Secondary
Iron Overload Other Serious 18 1/23/2010 Other Health Professional United States
Primary
Secondary
Suicidal Ideation Other Serious 30 Male 1/26/2010 United States
Primary
Concomitant
Thrombocytopenia Other Serious 9/30/2009 43 Male 2/18/2010 Pharmacist United States
Primary
Concomitant
Metabolic Acidosis Other Serious 9 Female 4/7/2010 Physician United States
Primary
Concomitant
Metabolic Acidosis Hospitalization 9 Female 4/26/2010
Primary
Secondary
Concomitant
Pseudomonas Infection Hospitalization 37 Male 5/12/2010 Netherlands
Primary
Secondary
Concomitant
Metabolic Acidosis Hospitalization 9 Female 5/8/2010 Physician United States
Primary
Concomitant
Hypocalcaemia Hospitalization 57 Male 5/17/2010 Physician United States
Primary
Concomitant
Leukocytosis Required Intervention 57 Male 5/17/2010 Physician United States
Primary
Concomitant
Pseudomonas Infection Hospitalization 37 Male 5/20/2010 Physician Netherlands
Primary
Secondary
Concomitant
Convulsion Death Female 101 lb 5/28/2010 Other Health Professional Singapore
Primary
Concomitant
Hypersomnia-bulimia Syndrome Other Serious 18 Male 6/9/2010 United States
Primary
Concomitant
Encephalitis Other Serious 70 Female 6/18/2010 Other Health Professional United Kingdom
Primary
Secondary
Psychotic Disorder Other Serious 3/1/2009 24 Female 126 lb 6/18/2010 Physician Germany
Primary
Concomitant
Drug Effect Decreased Hospitalization Female 22 lb 6/22/2010 United States
Primary
Concomitant
Roseolovirus Test Positive Other Serious 18 Female 110 lb 6/24/2010 Spain
Primary
Concomitant
Tonic Convulsion Other Serious 20 Female 6/23/2010 Germany
Primary
Concomitant
Convulsion Death Female 101 lb 7/6/2010 Other Health Professional Singapore
Primary
Concomitant
Incoherent Other Serious 19 Female 7/9/2010 Physician United States
Primary
Secondary
Weight Decreased Death Female 93 lb 7/23/2010 Other Health Professional Singapore
Primary
Concomitant
Partial Seizures Other Serious 18 Female 7/30/2010
Primary
Secondary
Therapeutic Agent Toxicity Other Serious 7/7/2010 26 Female 176 lb 8/2/2010 Physician Portugal
Primary
Secondary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 4/8/2010 59 Male 8/19/2010 Other Health Professional Spain
Primary
Concomitant
Drug Resistance Other Serious 3 Female 8/19/2010 Other Health Professional Germany
Primary
Secondary
Inappropriate Antidiuretic Hormone Secretion Other Serious 4/8/2010 59 Male 8/21/2010 Other Health Professional Spain
Primary
Concomitant
Somnolence Female 8/20/2010 Consumer United States
Primary
Interacting
Hyperammonaemic Encephalopathy Hospitalization 5 Male 9/3/2010 Other Health Professional India
Primary
Secondary
Concomitant
Patent Ductus Arteriosus Congenital Anomaly 9/10/2010 Physician Sweden
Primary
Secondary
Convulsion Hospitalization 9/6/2010 42 Female 165 lb 9/17/2010 Physician Netherlands
Primary
Secondary
Concomitant
Vomiting Other Serious 28 Male 9/17/2010 Other Health Professional Saudi Arabia
Primary
Concomitant
Patent Ductus Arteriosus Congenital Anomaly 9/23/2010 Physician United Kingdom
Primary
Secondary
Grand Mal Convulsion Hospitalization 9/21/2010 Belgium
Primary
Secondary
Partial Seizures Other Serious 39 Female 10/8/2010
Primary
Secondary
Convulsion Hospitalization 9/6/2010 42 Female 165 lb 10/11/2010 Physician Netherlands
Primary
Secondary
Concomitant
Sweat Gland Disorder Hospitalization 9 Male 10/11/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Drug Rash With Eosinophilia And Systemic Symptoms Hospitalization 18 Female 110 lb 10/14/2010 Other Health Professional Spain
Primary
Concomitant
Pneumonia Hospitalization Female 10/14/2010 Consumer United States
Primary
Concomitant
Hepatitis Hospitalization 18 Female 110 lb 10/27/2010
Primary
Secondary
Hyperammonaemic Encephalopathy Hospitalization 5 Male 11/4/2010 Other Health Professional India
Primary
Secondary
Concomitant
Somnolence Hospitalization 10/8/2010 38 Male 141 lb 11/3/2010 Pharmacist United States
Primary
Concomitant
Status Epilepticus Hospitalization 12/22/2009 28 Male 11/1/2010 United States
Primary
Concomitant
Status Epilepticus Other Serious 53 Female 11/19/2010 Other Health Professional Australia
Primary
Concomitant
Psychotic Disorder Other Serious Female 126 lb 12/3/2010 Physician Germany
Primary
Concomitant
Psychomotor Retardation Other Serious 28 Male 12/20/2010 Consumer United Kingdom
Primary
Secondary
Tremor Other Serious 23 Female 132 lb 12/28/2010 Other Health Professional United States
Primary
Concomitant
Pneumonia Other Serious 23 Female 132 lb 12/30/2010 Other Health Professional Israel
Primary
Concomitant
Neutropenia Hospitalization 7/27/2010 30 Male 1/11/2011 Physician France
Primary
Concomitant
Hand Deformity Hospitalization 6/16/2008 Male 6 lb 1/31/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Agitation Neonatal Hospitalization 6/16/2008 Male 6 lb 2/2/2011 Physician Germany
Primary
Secondary
Concomitant
Feeding Disorder Neonatal Hospitalization 6/16/2008 Male 6 lb 2/7/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Agitation Neonatal Congenital Anomaly 1/1/2007 Male 6 lb 2/8/2011 Physician Germany
Primary
Secondary
Concomitant
Dysmorphism Congenital Anomaly 6/16/2008 Male 6 lb 2/10/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Neonatal Respiratory Distress Syndrome Congenital Anomaly 6/16/2008 Male 6 lb 2/10/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Hypotonia Neonatal Hospitalization 6/16/2008 Male 6 lb 2/10/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Anomaly Of External Ear Congenital Congenital Anomaly 6/16/2008 Male 2/15/2011 Other Health Professional Germany
Primary
Secondary
Drug Exposure During Pregnancy Hospitalization 1/1/2007 Male 6 lb 2/16/2011 Physician Germany
Primary
Secondary
Concomitant
Speech Disorder Other Serious 21 Female 2/2/2011 Other Health Professional Denmark
Primary
Secondary
Concomitant
Somnolence Other Serious 1/26/2011 Other Health Professional China
Primary
Concomitant
Grand Mal Convulsion Other Serious 21 Female 2/4/2011 United Kingdom
Primary
Secondary
Concomitant
Low Set Ears Congenital Anomaly 6/16/2008 Male 6 lb 2/4/2011 Germany
Primary
Secondary
Concomitant
Off Label Use Other Serious 49 Female 2/10/2011 United States
Primary
Secondary
Concomitant
Hand Deformity Congenital Anomaly 6/16/2008 Male 6 lb 2/14/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious 74 Female 3/8/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Patent Ductus Arteriosus Congenital Anomaly 2/22/2011 Norway
Primary
Secondary
Psychomotor Hyperactivity Hospitalization 12/3/2007 6 Male 45 lb 2/25/2011 Other Health Professional Germany
Primary
Concomitant
Fatigue Hospitalization 7/8/2007 13 Male 46 lb 2/25/2011 Other Health Professional Germany
Primary
Concomitant
Myoclonus Hospitalization Female 3/9/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Coma Hospitalization Female 3/9/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Coma Hospitalization Female 3/9/2011 Other Health Professional Germany
Primary
Secondary
Concomitant

Drug Data