Leucovorin combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Tongue Disorder Other Serious 12/5/2005 Male 216 lb 12/27/2005 United States
Primary
Secondary
Breast Cancer Life Threatening Female 122 lb 1/17/2006 Pharmacist United States
Primary
Concomitant
Multiple Fractures Hospitalization 2/2/2004 64 Female 2/1/2006 Physician United States
Primary
Secondary
Concomitant
Coronary Artery Stenosis Hospitalization 1/31/2006 Male 194 lb 2/8/2006 Other Health Professional United States
Primary
Concomitant
Acute Myocardial Infarction Life Threatening 1/31/2006 Male 194 lb 2/17/2006 Physician United States
Primary
Secondary
Concomitant
Carcinoid Syndrome Hospitalization 1/1/2005 Female 190 lb 2/17/2006 Consumer United States
Primary
Concomitant
Acute Myocardial Infarction Life Threatening 1/31/2006 Male 194 lb 2/23/2006 Physician United States
Primary
Secondary
Concomitant
Sepsis Other Serious 9/1/2001 Female 159 lb 3/27/2006 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Ventricular Fibrillation Hospitalization 11/20/2003 71 Female 3/27/2006 Physician United States
Primary
Secondary
Concomitant
Bone Neoplasm Malignant Other Serious 12/1/2004 Male 3/28/2006 Physician United States
Primary
Concomitant
Paraesthesia Required Intervention 3/18/2006 Female 90 lb 3/27/2006 Other Health Professional United States
Primary
Concomitant
Ventricular Fibrillation Hospitalization 1/1/2003 71 Female 185 lb 4/11/2006 Physician United States
Primary
Secondary
Concomitant
Urticaria Other Serious 11/27/2003 Female 95 lb 4/20/2006 Physician Japan
Primary
Concomitant
Urinary Tract Infection Other Serious 2/21/2006 Female 139 lb 4/24/2006 Physician Canada
Primary
Concomitant
Squamous Cell Carcinoma Other Serious 12/1/2005 Female 180 lb 4/24/2006 Physician United States
Primary
Concomitant
Upper Respiratory Tract Infection Life Threatening 9/1/2001 30 Male 187 lb 4/24/2006 Physician United States
Primary
Concomitant
Vomiting Hospitalization 9/14/2001 Female 253 lb 4/26/2006 Physician United States
Primary
Secondary
Concomitant
Vith Nerve Paralysis Hospitalization 69 Female 5/5/2006 Physician United States
Primary
Concomitant
Squamous Cell Carcinoma Other Serious 9/1/2005 Female 125 lb 5/11/2006 Physician United States
Primary
Concomitant
Pulmonary Congestion Other Serious 3/10/2003 44 Male 238 lb 5/12/2006 Physician United States
Primary
Concomitant
Vith Nerve Paralysis Hospitalization 69 Female 5/19/2006 Physician United States
Primary
Concomitant
Thrombocytopenia Other Serious 16 Male 6/6/2006 Physician United States
Primary
Concomitant
Urinary Tract Infection Other Serious 2/21/2006 Female 139 lb 11/30/2006 Physician Canada
Primary
Concomitant
Squamous Cell Carcinoma Other Serious 7/24/2007 79 Male 10/1/2007 Other Health Professional United States
Primary
Concomitant
Atrioventricular Block Second Degree Hospitalization 7/5/2007 Female 176 lb 10/5/2007 Other Health Professional United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 8/30/2007 43 Male 233 lb 10/4/2007 Pharmacist United States
Primary
Concomitant
Rash Pruritic Other Serious 74 Male 10/11/2007 United States
Primary
Secondary
Concomitant
Rash Pruritic Other Serious 74 Male 10/19/2007 Other Health Professional United States
Primary
Secondary
Squamous Cell Carcinoma Other Serious 7/24/2007 79 Male 10/22/2007 Other Health Professional United States
Primary
Concomitant
Sepsis Death 10/24/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Atrioventricular Block Second Degree Hospitalization 7/2/2007 Female 176 lb 10/26/2007 Other Health Professional United States
Primary
Concomitant
Sepsis Death 10/30/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 7/24/2007 79 Male 10/31/2007 Other Health Professional United States
Primary
Concomitant
Liver Disorder Hospitalization 10/17/2007 Female 187 lb 11/6/2007 Consumer United States
Primary
Concomitant
Injection Site Reaction Other Serious 50 Female 10/3/2007 Other Health Professional United States
Primary
Concomitant
Electrocardiogram Abnormal Other Serious Female 12/27/2007 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious Male 12/31/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 1/19/2007 Female 1/7/2008 United States
Primary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 1/19/2007 Female 1/8/2008 Physician United States
Primary
Concomitant
Metastases To Skin Life Threatening 12/18/2006 20 Male 115 lb 1/4/2008 Physician Japan
Primary
Concomitant
Stomatitis Other Serious 3/3/2008 Female 223 lb 4/17/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2009 Female 10/30/2009 Consumer United States
Primary
Concomitant
Pneumonia Hospitalization 10/12/2009 Female 183 lb 11/5/2009 Physician United States
Primary
Concomitant
Pain Other Serious 8/1/2009 Female 11/9/2009 Other Health Professional United States
Primary
Concomitant
Vomiting Other Serious 1/1/2009 Female 11/16/2009 Physician United States
Primary
Concomitant
Respiratory Syncytial Virus Infection Life Threatening 11/16/2010 14 Female 130 lb 12/3/2010 Physician United States
Primary
Secondary
Concomitant
Pneumonitis Life Threatening 11/16/2010 14 Female 130 lb 12/17/2010 Physician United States
Primary
Secondary
Concomitant
Pneumonitis Life Threatening 11/16/2010 14 Female 130 lb 12/27/2010 Physician United States
Primary
Secondary
Concomitant
Blood Bilirubin Increased Life Threatening 11/16/2010 14 Female 130 lb 1/5/2011 Physician United States
Primary
Secondary
Concomitant
Nerve Injury Hospitalization 50 Male 243 lb 12/23/2010 Pharmacist United States
Primary
Concomitant
Muscular Weakness Other Serious 1/1/2008 58 Female 200 lb 1/25/2011 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis 1/1/2010 70 Female 195 lb 1/28/2011 Consumer United States
Primary
Concomitant
Injection Site Pain 1/29/2011 Consumer United States
Primary
Concomitant
Swelling Face 6/11/2010 48 Female 1/29/2011 Consumer United States
Primary
Concomitant
Fatigue 7/15/2010 48 Female 1/29/2011 Consumer United States
Primary
Concomitant
Influenza Like Illness 8/15/2010 67 Female 1/29/2011 Consumer United States
Primary
Concomitant
Injection Site Erythema 58 Female 1/30/2011 Consumer United States
Primary
Concomitant
Incorrect Dose Administered By Device 9/16/2010 56 Female 1/30/2011 Consumer United States
Primary
Concomitant
Death Death 3/3/2011 65 Female 3/24/2011 Other Health Professional Canada
Primary
Concomitant
Deep Vein Thrombosis Hospitalization 9/17/2007 57 Female 168 lb 3/25/2011 Physician United States
Primary
Concomitant
Herpes Zoster Hospitalization 11/1/2010 66 Female 101 lb 3/29/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Respiratory Distress Syndrome Life Threatening 11/16/2010 14 Female 130 lb 3/29/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Death 4/4/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Metastasis Death 4/4/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Medication Error Other Serious 3/22/2011 16 Female 140 lb 3/28/2011 Consumer United States
Primary
Concomitant
Diffuse Large B-cell Lymphoma Life Threatening 8/22/2010 79 Female 155 lb 4/11/2011 Physician Canada
Primary
Concomitant
Febrile Neutropenia Death 4/11/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Dyspnoea Other Serious 4/14/2011 Physician United Kingdom
Primary
Secondary
Osteoporotic Fracture Other Serious Female 166 lb 4/15/2011 Consumer United States
Primary
Concomitant
Osteoporotic Fracture Other Serious 2/1/2011 76 Female 166 lb 4/18/2011 Consumer United States
Primary
Concomitant
Dyspnoea Other Serious 5/31/2010 70 Male 140 lb 4/22/2011 Physician Canada
Primary
Concomitant
Spinal Fracture Hospitalization 2/1/2011 76 Female 166 lb 12/10/2012 Physician Us
Primary
Concomitant
Oesophagitis Other Serious Female 192 lb 10/31/2012 Lawyer Us
Primary
Concomitant
Sepsis Death Male 170 lb 9/17/2012 Physician Country Not Specified
Primary
Concomitant
Sinusitis 7/2011 Female 227 lb 1/29/2013 Physician Country Not Specified
Primary
Concomitant
Injection Site Pain 2010 Female 1/31/2013 Consumer Us
Primary
Concomitant
Wrong Technique In Drug Usage Process 9/26/2011 69 Male 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Warmth 6/2011 Male 215 lb 1/31/2013 Consumer Country Not Specified
Primary
Secondary
Concomitant
Neutropenia Hospitalization 4/23/2012 4 Female 11/12/2012 Physician Us
Primary
Secondary
Concomitant
Underdose Hospitalization 2009 Female 168 lb 8/30/2012 Consumer Us
Primary
Concomitant
Staphylococcal Infection Hospitalization 4/23/2012 4 Female 11/19/2012 Physician Us
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 12/21/2011 70 Female 198 lb 10/11/2012 Physician Us
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious Male 200 lb 10/30/2012 Other Health Professional Ca
Primary
Concomitant
Vomiting Other Serious 7/2011 Female 188 lb 12/27/2012 Physician Ca
Primary
Concomitant
Hepatic Enzyme Abnormal Hospitalization 6/11/2012 68 Male 143 lb 10/19/2012 Physician Nl
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/8/2007 8/31/2012 Consumer Jp
Primary
Secondary
Concomitant
Off Label Use Death 9/12/2012 Other Health Professional Ca
Primary
Secondary
Concomitant
Subdural Haematoma Death 9/12/2012 Other Health Professional Ca
Primary
Secondary
Concomitant
Off Label Use Death 11/6/2012 Other Health Professional Ca
Primary
Secondary
Concomitant
Off Label Use Death 9/12/2012 Other Health Professional Ca
Primary
Secondary
Concomitant
Venoocclusive Disease Death 9/13/2012 Other Health Professional Ca
Primary
Secondary
Concomitant
Stem Cell Transplant Death 9/14/2012 Other Health Professional Ca
Primary
Secondary
Concomitant
Off Label Use Death 9/13/2012 Other Health Professional Ca
Primary
Secondary
Concomitant
Off Label Use Other Serious 9/12/2012 Other Health Professional Ca
Primary
Secondary
Concomitant
Pancreatitis Other Serious 9/12/2012 Other Health Professional Ca
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious Female 9/4/2012 Us
Primary
Concomitant
Yersinia Infection Hospitalization 70 Female 9/10/2012 Other Health Professional Us
Primary
Concomitant
Rosacea 7/26/2012 53 Female 9/26/2012 Other Health Professional Us
Primary
Concomitant
Vision Blurred Hospitalization 7/17/2012 53 Female 9/28/2012 Other Health Professional Ch
Primary
Secondary
Concomitant
Papilloedema Hospitalization 6/7/2012 54 Female 10/2/2012 Consumer Ch
Primary
Secondary
Concomitant
Central Nervous System Lymphoma Hospitalization 12/6/2011 64 Male 10/2/2012 Consumer Us
Primary
Concomitant
Weight Decreased Other Serious Male 2/14/2013 Physician Us
Primary
Secondary
Concomitant
Urinary Tract Infection Enterococcal Life Threatening 7/27/2012 13 Female 271 lb 11/9/2012 Other Health Professional Us
Primary
Secondary
Concomitant
Embolic Stroke Hospitalization 12/14/2011 69 Male 10/12/2012 Consumer Us
Primary
Concomitant
Asthenia Other Serious 30 Female 10/16/2012 Consumer Us
Primary
Concomitant
Toxicity To Various Agents Other Serious 25 Male 10/17/2012 Other Health Professional Us
Primary
Concomitant
Interacting
Sepsis Death 10/25/2012 Physician Us
Primary
Secondary
Concomitant
Renal Failure Other Serious 11/2/2012 Physician Us
Primary
Secondary
Death Death 10/24/2012 Other Health Professional Country Not Specified
Primary
Secondary
Toxicity To Various Agents Hospitalization 25 Male 10/22/2012 Us
Primary
Secondary
Concomitant
Vertigo Other Serious 9/2012 Female 10/31/2012 Consumer Country Not Specified
Primary
Secondary
Concomitant
Rash Other Serious 2012 Female 135 lb 11/5/2012 Consumer Us
Primary
Concomitant
Rheumatoid Arthritis Other Serious 2010 62 Female 128 lb 11/7/2012 Consumer Us
Primary
Secondary
Concomitant
Vomiting Other Serious 25 Female 77 lb 11/9/2012 Other Health Professional In
Primary
Concomitant
Neutropenia Hospitalization 4/23/2012 4 Female 11/20/2012 Consumer Us
Primary
Secondary
Concomitant
Liver Injury Other Serious 11/20/2012 Physician Country Not Specified
Primary
Secondary
Osteonecrosis Other Serious 7 Female 11/29/2012 Physician Us
Primary
Secondary
Vomiting Life Threatening 4/28/2012 71 Female 11/28/2012 Consumer Us
Primary
Secondary
Concomitant
Sepsis Hospitalization 11/22/2012 0 Male 16 lb 12/3/2012 Physician Us
Primary
Secondary
Ventricular Tachycardia Hospitalization 4/22/2012 10 Male 77 lb 1/28/2013 Consumer Us
Primary
Secondary
Concomitant
Macular Degeneration Other Serious 1996 Female 2/1/2013 Physician Us
Primary
Concomitant
Rheumatoid Arthritis Other Serious 2012 71 Female 2/1/2013 Physician Ca
Primary
Concomitant
Vomiting Other Serious 12/19/2012 Physician De
Primary
Secondary
Urinary Tract Infection Hospitalization Female 12/19/2012 Consumer Us
Primary
Concomitant
Toxicity To Various Agents Other Serious 25 Male 12/20/2012 Other Health Professional Country Not Specified
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 10/22/2012 13 Male 12/21/2012 Physician Us
Primary
Secondary
Concomitant
Restlessness Hospitalization 11/10/2012 48 Female 120 lb 3/8/2013 Physician Country Not Specified
Primary
Concomitant
Lung Disorder Other Serious 11/2012 Male 227 lb 2/14/2013 Consumer Us
Primary
Concomitant
Drug Level Increased Other Serious Male 12/9/2012 Us
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 12/8/2012 Female 2/22/2013 Physician Us
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 12/8/2012 9 Female 2/24/2013 Physician Us
Primary
Secondary
Concomitant
Wound 1/22/2012 49 Female 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Wheezing 61 Male 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Nephrolithiasis 2012 65 Male 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Pain 12/16/2011 55 Female 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Bruising 1/2012 NotSpecified 170 lb 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Bruising 1/2012 Female 230 lb 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Joint Swelling 12/16/2011 55 Female 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Upper Respiratory Tract Infection 9/2012 Female 200 lb 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Pruritus 7/2012 40 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Death Death NotSpecified 1/30/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Pyrexia 12/2/2012 62 Female 2/1/2013 Consumer Country Not Specified
Primary
Concomitant
Off Label Use Other Serious Male 2/12/2013 Physician Us
Primary
Secondary
Venoocclusive Disease Death NotSpecified 2/12/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Influenza Death NotSpecified 2/12/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Injection Site Swelling 11/2/2012 68 Female 140 lb 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Pain In Extremity 3/11/2012 66 Female 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Asthenia Other Serious NotSpecified 2/15/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Vomiting Other Serious 10/29/2012 Physician Us
Primary
Secondary
Concomitant
Off Label Use Other Serious 10/29/2012 Physician Us
Primary
Secondary

Drug Data