Leucovorin Calcium combined with Vincristine

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 4/18/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/7/2006 70 Female 5/12/2006 United States
Primary
Secondary
Concomitant
Pulmonary Oedema Life Threatening 4/7/2006 Female 116 lb 8/10/2006 Physician United States
Primary
Secondary
Concomitant
Vith Nerve Paralysis Hospitalization 69 Female 8/23/2006 Physician United States
Primary
Concomitant
Respiratory Failure Required Intervention 31 Female 10/23/2006 Japan
Primary
Secondary
Concomitant
Respiratory Failure Required Intervention 6/25/2004 31 Female 11/3/2006 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 6/25/2004 31 Female 11/3/2006 Japan
Primary
Secondary
Concomitant
Mucosal Inflammation Other Serious 5/1/1999 55 Female 12/12/2006
Primary
Secondary
Lip And/or Oral Cavity Cancer Other Serious 5/1/1999 54 Female 12/15/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Lip And/or Oral Cavity Cancer Other Serious 5/1/1999 54 Female 12/20/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Lip And/or Oral Cavity Cancer Other Serious 5/1/1999 55 Female 1/9/2007 United States
Primary
Secondary
Concomitant
Lip And/or Oral Cavity Cancer Other Serious 5/1/1999 Female 1/10/2007 United States
Primary
Secondary
Sepsis Death 1/14/2007 Female 14 lb 1/17/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Thrombocytopenia 1/1/2006 31 Male 3/28/2007 Physician United States
Primary
Concomitant
Weight Increased Other Serious 67 Male 3/23/2007 United States
Primary
Secondary
Concomitant
Meningitis Aseptic Other Serious 3/10/2007 59 Female 4/9/2007 Physician Switzerland
Primary
Secondary
Concomitant
Drug Interaction Other Serious 2/22/2007 14 Male 62 lb 4/12/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Drug Interaction Other Serious 2/22/2007 14 Male 62 lb 5/2/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Weight Increased Other Serious 67 Male 6/11/2007 Consumer United States
Primary
Secondary
Concomitant
Nephropathy Toxic Hospitalization 13 Male 7/3/2007
Primary
Secondary
Transient Ischaemic Attack Other Serious 7/6/2007 Physician United States
Primary
Concomitant
Squamous Cell Carcinoma Other Serious 5/1/1999 56 Female 7/9/2007 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 5 Female 8/18/2007 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 3 Male 35 lb 8/28/2007
Primary
Secondary
Urinary Tract Infection Other Serious 21 Female 9/5/2007 Other Health Professional United States
Primary
Secondary
White Blood Cell Count Increased Other Serious 21 Female 8/16/2007 Physician United States
Primary
Secondary
Sepsis Neonatal Hospitalization Male 8/16/2007 Physician United States
Primary
Secondary
Vomiting Other Serious 8 Male 10/2/2007
Primary
Secondary
Concomitant
Grand Mal Convulsion Death 32 Female 12/3/2007
Primary
Secondary
Concomitant
Drug Toxicity Other Serious 2/22/2007 14 Male 62 lb 11/29/2007 Physician Germany
Primary
Secondary
Concomitant
Refusal Of Treatment By Relative Other Serious 6 Male 1/22/2008 Physician Turkey
Primary
Concomitant
Petechiae Other Serious 7/23/2007 Female 179 lb 3/10/2008 Physician Germany
Primary
Concomitant
Generalised Erythema Other Serious 11/14/2007 Female 132 lb 3/10/2008 Physician Germany
Primary
Concomitant
Haemoglobin Decreased Death 6 Male 3/10/2008
Primary
Secondary
Concomitant
Nephropathy Toxic Other Serious 13 Male 3/21/2008 Pharmacist United States
Primary
Concomitant
Thrombocytopenia 1/1/2006 31 Male 3/28/2008 Physician United States
Primary
Concomitant
Rectal Haemorrhage Hospitalization 2/3/2008 Female 176 lb 4/4/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Neutropenic Sepsis Other Serious 4/16/2008 52 Male 157 lb 5/21/2008 Physician Malaysia
Primary
Concomitant
Refusal Of Treatment By Relative Disability 6 Male 5/19/2008 Physician Turkey
Primary
Concomitant
Muscle Disorder Disability 5/13/2006 Male 6/23/2008 Consumer Germany
Primary
Secondary
Concomitant
Ileus Paralytic Other Serious 5/21/2008 3 Female 26 lb 6/18/2008 Physician Israel
Primary
Concomitant
Renal Failure Acute Hospitalization 10/2/2008 64 Female 10/18/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Chemotherapeutic Drug Level Increased Other Serious 3/11/2008 4 Male 47 lb 10/7/2008 Pharmacist United States
Primary
Concomitant
Renal Failure Acute Other Serious 11/1/2007 43 Male 10/7/2008 Physician United States
Primary
Concomitant
Renal Failure Acute Other Serious 11/1/2007 56 Male 10/7/2008 Physician United States
Primary
Concomitant
Renal Failure Acute Other Serious 12/1/2007 53 Male 10/7/2008 Physician United States
Primary
Concomitant
Vomiting Life Threatening 11/24/2008 55 Male 123 lb 12/30/2008 Physician Ecuador
Primary
Concomitant
Renal Failure Other Serious Male 1/21/2009 Consumer United Kingdom
Primary
Secondary
Neurotoxicity Other Serious 16 Male 2/25/2009
Primary
Secondary
Urine Output Decreased Hospitalization 3/29/2009 Female 15 lb 4/2/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Febrile Neutropenia Other Serious 4/14/2009 Consumer United Kingdom
Primary
Secondary
Febrile Neutropenia Other Serious 4/27/2009 Consumer United Kingdom
Primary
Secondary
Neurotoxicity Hospitalization 16 Male 4/28/2009 Physician United States
Primary
Concomitant
Thrombocytopenia Other Serious 6/16/2009 Other Health Professional United Kingdom
Primary
Secondary
Neutropenia Other Serious 57 Male 8/6/2009
Primary
Secondary
Concomitant
Pancreatitis Other Serious 17 Male 12/9/2009
Primary
Secondary
Concomitant
Somnolence Other Serious 1/11/2010 United States
Primary
Secondary
Concomitant
Tachypnoea Hospitalization 11/12/2009 Female 15 lb 1/12/2010 United States
Primary
Secondary
Concomitant
Rash Other Serious 9/1/2009 Female 116 lb 2/9/2010 Physician United States
Primary
Secondary
Concomitant
Fat Embolism Other Serious 22 Male 4/2/2010 Other Health Professional Greece
Primary
Secondary
Thrombocytopenia Other Serious 4/15/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Skin Toxicity Other Serious 4/29/2010 United States
Primary
Secondary
Skin Toxicity Death 4/30/2010 Physician United Kingdom
Primary
Secondary
Stomatitis Other Serious 16 Female 5/21/2010
Primary
Secondary
Vomiting Other Serious 36 Male 5/27/2010
Primary
Secondary
Sepsis Death 5/24/2010 Netherlands
Primary
Secondary
Therapeutic Agent Toxicity Death 5/24/2010 Netherlands
Primary
Secondary
Syncope Other Serious 10/6/2007 50 Male 194 lb 6/30/2010 Lawyer United States
Primary
Concomitant
Neutrophil Count Increased Other Serious 5/23/2010 55 Female 108 lb 7/27/2010 Physician United Kingdom
Primary
Concomitant
Tachycardia Other Serious 9/20/2007 50 Male 194 lb 8/27/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Headache Other Serious 9/1/2007 50 Male 194 lb 1/12/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Haemorrhage Other Serious 3/1/2011 Physician United States
Primary
Secondary
Concomitant
Liver Function Test Abnormal Other Serious 3/1/2011 Physician United States
Primary
Secondary
Concomitant
Anxiety Death 3/8/2011 15 Female 144 lb 3/23/2011 Physician United States
Primary
Secondary
Peripheral Nerve Palsy Other Serious 3/28/2011 Physician Italy
Primary
Secondary
Concomitant
Renal Failure Death 3/29/2011 Physician Italy
Primary
Secondary
Concomitant
Pneumonia Cytomegaloviral Death 3/29/2011 Physician Italy
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Other Serious 3/31/2011 Physician Italy
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 2/21/2011 16 Female 4/11/2011 Physician Spain
Primary
Secondary
Concomitant
Pleural Effusion Death 3/8/2011 15 Female 144 lb 5/24/2011 Physician United States
Primary
Secondary
Dyspnoea Other Serious 12 Male 132 lb 5/26/2011 Pharmacist Brazil
Primary
Concomitant
Dyspnoea Other Serious 3/23/2011 22 Male 132 lb 7/7/2011 Pharmacist Brazil
Primary
Concomitant
Hypotension Other Serious 3/8/2011 15 Female 144 lb 7/21/2011 Physician United States
Primary
Secondary
Colitis Other Serious 7/25/2011 67 Male 182 lb 8/5/2011 Physician United States
Primary
Concomitant
Failure To Thrive Other Serious 7/25/2011 67 Male 182 lb 8/8/2011 Physician United States
Primary
Concomitant
Anxiety Other Serious 3/8/2011 15 Female 144 lb 8/11/2011 Consumer United States
Primary
Secondary
Dyspnoea Other Serious 7/25/2011 67 Male 182 lb 8/28/2011 Physician United States
Primary
Concomitant
Colitis Other Serious 7/25/2011 67 Male 182 lb 8/30/2011 Physician United States
Primary
Concomitant
Failure To Thrive Other Serious 7/25/2011 67 Male 182 lb 9/2/2011 Physician United States
Primary
Concomitant
Dyspnoea Other Serious 3/23/2011 22 Male 132 lb 9/23/2011 Pharmacist Brazil
Primary
Concomitant
Off Label Use Hospitalization 44 Male 11/30/2011 Other Health Professional
Primary
Secondary
Concomitant
Fatigue Hospitalization 9/19/2011 31 Male 12/19/2011 United States
Primary
Secondary
Concomitant
Leukopenia Other Serious 2/26/2007 68 Male 173 lb 12/20/2011 Consumer United States
Primary
Secondary
Concomitant
Stomatitis Other Serious 8/13/2009 48 Female 133 lb 12/20/2011 Physician United States
Primary
Secondary
Concomitant
Neutropenic Infection Other Serious 8/22/2010 25 Male 238 lb 12/20/2011 Physician United States
Primary
Secondary
Blood Magnesium Abnormal Hospitalization 8/18/2010 65 Male 238 lb 12/20/2011 Physician United States
Primary
Secondary
Leukopenia Hospitalization 2/7/2009 69 Male 223 lb 12/21/2011 Other Health Professional United States
Primary
Secondary
Pyrexia Other Serious 32 Male 12/21/2011 Physician United States
Primary
Secondary
Lymphopenia Hospitalization 8/18/2010 65 Male 238 lb 12/27/2011 Physician United States
Primary
Secondary
Left Ventricular Dysfunction Other Serious 2/26/2007 68 Male 173 lb 12/27/2011 Consumer United States
Primary
Secondary
Concomitant
Left Ventricular Dysfunction Other Serious 2/26/2007 68 Male 173 lb 12/29/2011 Physician United States
Primary
Secondary
Concomitant
Hypotension Hospitalization 9/19/2011 31 Male 1/30/2012 Physician United States
Primary
Secondary
Concomitant
Leukoencephalopathy Death 51 Female 2/10/2012 Other Health Professional Korea, Democratic People's Republic Of
Primary
Secondary
Thrombocytopenia Other Serious 6/1/2009 60 Male 3/7/2012 Other Health Professional Italy
Primary
Secondary
Myelodysplastic Syndrome Other Serious 6/1/2009 60 Male 3/7/2012 Other Health Professional Italy
Primary
Secondary
Thrombocytopenia Other Serious 6/1/2009 42 Male 3/7/2012 Other Health Professional Italy
Primary
Secondary
Transaminases Increased Other Serious 3/13/2012 Physician United States
Primary
Secondary
Transaminases Increased Other Serious 3/14/2012 United States
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Other Serious 42 Male 3/19/2012 Other Health Professional Italy
Primary
Secondary
Myelodysplastic Syndrome Hospitalization 6/1/2009 42 Male 3/20/2012 Other Health Professional Italy
Primary
Secondary
Fungal Sepsis Other Serious 3/26/2012 Other Health Professional China
Primary
Secondary
Concomitant
Anaemia Other Serious Male 3/19/2012 Italy
Primary
Secondary
Toxic Epidermal Necrolysis Death 2/12/2012 16 Male 4/2/2012 Physician France
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious 17 Female 4/2/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Subileus Other Serious 17 Female 4/3/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 17 Female 4/3/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Subileus Other Serious 17 Female 4/3/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Subileus Other Serious 17 Female 4/3/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Subileus Other Serious 17 Female 4/8/2012 Other Health Professional Japan
Primary
Secondary
Hyperglycaemia Other Serious 17 Female 4/9/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Interacting
Leukoencephalopathy Other Serious 17 Female 4/24/2012 Consumer Japan
Primary
Secondary
Toxic Epidermal Necrolysis Death 2/12/2012 16 Male 4/24/2012 Physician France
Primary
Secondary
Concomitant
Rectal Haemorrhage Death 1/23/2008 38 Female 177 lb 4/26/2012 France
Primary
Secondary
Concomitant
Anaemia Other Serious 5/10/2012 Other Health Professional China
Primary
Secondary
Concomitant
Off Label Use Other Serious 5/10/2012 Other Health Professional China
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 5/10/2012 Other Health Professional China
Primary
Secondary
Concomitant
Sepsis Other Serious 5/11/2012 Other Health Professional China
Primary
Secondary
Concomitant
Pulmonary Toxicity Other Serious 5/11/2012 Other Health Professional China
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 5/11/2012 Other Health Professional China
Primary
Secondary
Concomitant
Off Label Use Other Serious 5/11/2012 Other Health Professional China
Primary
Secondary
Concomitant
Off Label Use Other Serious 5/11/2012 Other Health Professional China
Primary
Secondary
Concomitant
Hyperglycaemia Other Serious 5/16/2012 Other Health Professional Thailand
Primary
Secondary
Concomitant
Bacterial Infection Death 5/18/2012 Other Health Professional Thailand
Primary
Secondary
Concomitant
Off Label Use Other Serious 5/24/2012 Other Health Professional Thailand
Primary
Secondary
Concomitant
Treatment Failure Other Serious 5/24/2012 Other Health Professional Thailand
Primary
Secondary
Concomitant
Treatment Related Secondary Malignancy Other Serious 5/24/2012 Other Health Professional Thailand
Primary
Secondary
Concomitant
Off Label Use Other Serious 5/24/2012 Other Health Professional Thailand
Primary
Secondary
Concomitant
Off Label Use Other Serious 5/24/2012 Other Health Professional Thailand
Primary
Secondary
Concomitant
Neuropathy Peripheral Other Serious 5/24/2012 Other Health Professional Thailand
Primary
Secondary
Concomitant
Pyrexia Hospitalization 5/20/2012 10 Male 49 lb 5/24/2012 Physician United States
Primary
Secondary
Concomitant
Oligohydramnios Other Serious 31 Female 5/28/2012 Other Health Professional United States
Primary
Secondary
Foetal Growth Restriction Other Serious 0 5/28/2012 Other Health Professional United States
Primary
Secondary
Premature Baby Other Serious 0 Male 4 lb 5/28/2012 Other Health Professional United States
Primary
Secondary
Myocardial Infarction Hospitalization 10/23/2011 80 Male 130 lb 5/22/2012 Other Health Professional United Kingdom
Primary
Concomitant
Infection Death 6/8/2012 Other Health Professional Croatia (Local Name: Hrvatska)
Primary
Secondary
Concomitant
Multi-organ Failure Death 6/8/2012 Other Health Professional Croatia (Local Name: Hrvatska)
Primary
Secondary
Concomitant
Infection Death 6/8/2012 Other Health Professional Croatia (Local Name: Hrvatska)
Primary
Secondary
Concomitant
Mucosal Inflammation Death 6/12/2012 Other Health Professional Croatia (Local Name: Hrvatska)
Primary
Secondary
Concomitant
Mobility Decreased Other Serious 21 Female 6/14/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Nausea Other Serious 6/25/2012 Other Health Professional United States
Primary
Secondary
Concomitant

Drug Data