Leucovorin Calcium combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pancytopenia Hospitalization 69 Male 1/3/2006
Primary
Concomitant
Myocardial Infarction Hospitalization 4/29/2001 55 Female 148 lb 1/20/2006 Lawyer United States
Primary
Concomitant
Stomatitis Other Serious 11/21/2005 Female 138 lb 1/17/2006 United States
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 1/11/2006 Male 141 lb 1/30/2006 United States
Primary
Secondary
Aspartate Aminotransferase Increased Other Serious 1/18/2006 Female 130 lb 1/31/2006 United States
Primary
Secondary
Renal Impairment Hospitalization 10/2/2005 Female 131 lb 2/24/2006 Physician Japan
Primary
Secondary
Concomitant
Visual Disturbance Hospitalization 1/1/1999 37 Female 148 lb 2/28/2006 Physician United States
Primary
Concomitant
Acute Myocardial Infarction Life Threatening 1/31/2006 Male 194 lb 2/28/2006 Physician United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 1/1/2005 Female 155 lb 3/1/2006 Consumer United States
Primary
Concomitant
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 4/18/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/7/2006 70 Female 5/12/2006 United States
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 69 Male 5/19/2006 Physician United Kingdom
Primary
Concomitant
Weight Increased Other Serious 35 Male 4/18/2006 Physician United States
Primary
Concomitant
Pyrexia Other Serious 5/8/2006 Female 122 lb 6/7/2006 United States
Primary
Secondary
Myalgia Other Serious 51 Female 4/20/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Drug Clearance Decreased Required Intervention 2/24/2004 17 Male 152 lb 7/12/2006 Pharmacist United States
Primary
Concomitant
Transaminases Increased Hospitalization 3/8/2006 Male 141 lb 7/26/2006 United States
Primary
Secondary
Lung Adenocarcinoma Hospitalization 12/12/2005 Male 8/1/2006 Physician United States
Primary
Concomitant
Mucosal Inflammation Hospitalization 7/31/2006 Male 168 lb 8/1/2006 United States
Primary
Secondary
Pulmonary Oedema Life Threatening 4/7/2006 Female 116 lb 8/10/2006 Physician United States
Primary
Secondary
Concomitant
Breast Cancer Other Serious 4/20/2006 Female 148 lb 8/10/2006 Physician United States
Primary
Concomitant
Syncope Other Serious 7/18/2006 49 Female 165 lb 8/11/2006 Physician United States
Primary
Concomitant
Tachycardia Hospitalization 3/4/2006 Male 311 lb 8/11/2006 United States
Primary
Secondary
Vith Nerve Paralysis Hospitalization 69 Female 8/23/2006 Physician United States
Primary
Concomitant
Respiratory Failure Life Threatening 8/19/2005 74 Male 126 lb 9/13/2006 Physician Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 2/21/2006 Female 139 lb 9/22/2006 Physician Canada
Primary
Concomitant
Ovarian Cancer Other Serious 9/9/2004 Female 9/26/2006 Physician United States
Primary
Concomitant
Septic Shock Death 10/2/2006 Consumer France
Primary
Secondary
Concomitant
Neurotoxicity Other Serious 10/2/2006 Consumer France
Primary
Secondary
Concomitant
Nodule On Extremity Hospitalization 8/1/2005 Female 157 lb 10/6/2006 Physician United States
Primary
Concomitant
Skin Infection Hospitalization 5/1/2005 Female 305 lb 10/19/2006 Physician United States
Primary
Concomitant
Pain Hospitalization 9/21/2006 Male 168 lb 10/11/2006 United States
Primary
Secondary
Staphylococcal Infection Hospitalization 10/9/2006 Male 52 lb 10/20/2006 United States
Primary
Secondary
Vomiting Hospitalization 8/4/2005 Female 170 lb 10/24/2006 United States
Primary
Secondary
Concomitant
Respiratory Failure Required Intervention 31 Female 10/23/2006 Japan
Primary
Secondary
Concomitant
Neutropenic Sepsis Death Female 10/23/2006 Physician Egypt
Primary
Secondary
Neutropenic Sepsis Death Female 10/23/2006 Physician Egypt
Primary
Secondary
Hip Fracture Other Serious 83 Female 11/1/2006 Other Health Professional Canada
Primary
Concomitant
Haemopneumothorax Hospitalization 10/12/2006 Male 269 lb 10/30/2006 United States
Primary
Secondary
Concomitant
Renal Tubular Necrosis Other Serious 58 Male 11/1/2006 United States
Primary
Concomitant
Respiratory Failure Required Intervention 6/25/2004 31 Female 11/3/2006 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 6/25/2004 31 Female 11/3/2006 Japan
Primary
Secondary
Concomitant
Pleural Effusion Life Threatening 6/13/2006 61 Male 134 lb 11/23/2006 Physician Germany
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 10/9/2006 Male 52 lb 11/22/2006 United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 11/16/2006 Male 136 lb 11/17/2006 United States
Primary
Secondary
Weight Decreased Hospitalization 8/14/2006 Male 160 lb 12/4/2006 Physician United States
Primary
Concomitant
Stomatitis Hospitalization 7/2/2006 Female 51 lb 11/30/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Skin Cancer Other Serious 4/1/2006 Female 123 lb 12/7/2006 Physician United States
Primary
Concomitant
Mucosal Inflammation Other Serious 5/1/1999 55 Female 12/12/2006
Primary
Secondary
Neutropenia 10/25/2005 Female 155 lb 11/30/2006 United States
Primary
Secondary
Concomitant
Hodgkin's Disease Other Serious 9/4/2006 Female 126 lb 12/13/2006 Physician Japan
Primary
Secondary
Concomitant
Lymphadenitis Other Serious 4/14/2000 Female 12/13/2006 Physician United States
Primary
Secondary
Concomitant
Lip And/or Oral Cavity Cancer Other Serious 5/1/1999 54 Female 12/15/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Nerve Injury 7/15/2006 Female 180 lb 12/18/2006 Physician United States
Primary
Concomitant
Panic Attack 7/26/2006 Female 12/18/2006 Consumer United States
Primary
Concomitant
Stress 11/9/2004 Female 158 lb 12/18/2006 Physician United States
Primary
Concomitant
Vomiting Hospitalization 12/10/2006 Female 100 lb 12/13/2006 United States
Primary
Secondary
Lip And/or Oral Cavity Cancer Other Serious 5/1/1999 54 Female 12/20/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Diabetes Mellitus Non-insulin-dependent 12/23/2005 Female 12/20/2006 Other Health Professional United States
Primary
Concomitant
Cardiac Failure Congestive Death Female 116 lb 12/22/2006 Physician United States
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 12/3/2006 Female 147 lb 12/15/2006 United States
Primary
Secondary
Transient Ischaemic Attack Other Serious 1/1/2006 50 Female 1/4/2007 Pharmacist Canada
Primary
Concomitant
Lip And/or Oral Cavity Cancer Other Serious 5/1/1999 55 Female 1/9/2007 United States
Primary
Secondary
Concomitant
Lip And/or Oral Cavity Cancer Other Serious 5/1/1999 Female 1/10/2007 United States
Primary
Secondary
Nervous System Disorder Required Intervention 12/31/2005 14 Female 3/14/2006 Other Health Professional United States
Primary
Concomitant
Vomiting Hospitalization 12/10/2006 Female 100 lb 1/12/2007 United States
Primary
Secondary
Sepsis Death 1/14/2007 Female 14 lb 1/17/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2006 Male 153 lb 1/19/2007 Physician United States
Primary
Concomitant
Vith Nerve Paralysis Other Serious 10/22/2006 23 Male 172 lb 1/10/2007 Physician Finland
Primary
Secondary
Concomitant
Malignant Melanoma Other Serious Female 2/1/2007 Other Health Professional Canada
Primary
Concomitant
Infusion Related Reaction Other Serious 1/24/2007 Male 2/9/2007 Other Health Professional Canada
Primary
Concomitant
Weight Decreased Other Serious 1/1/2006 Male 153 lb 2/20/2007 Physician United States
Primary
Concomitant
Aspartate Aminotransferase Increased Hospitalization 8/31/2006 Female 105 lb 2/16/2007 United States
Primary
Secondary
Concomitant
Hepatic Neoplasm Malignant Other Serious 4/26/2006 Female 2/28/2007 Other Health Professional Canada
Primary
Concomitant
Pre-existing Condition Improved 1/1/2007 50 Female 201 lb 3/27/2007 Consumer United States
Primary
Concomitant
Thrombocytopenia 1/1/2006 31 Male 3/28/2007 Physician United States
Primary
Concomitant
Weight Increased Other Serious 67 Male 3/23/2007 United States
Primary
Secondary
Concomitant
Myalgia Hospitalization 10/1/2005 52 Male 182 lb 4/2/2007 Consumer United States
Primary
Concomitant
Pyrexia Other Serious 12/23/2006 Female 163 lb 4/4/2007 Physician Bahrain
Primary
Concomitant
Meningitis Aseptic Other Serious 3/10/2007 59 Female 4/9/2007 Physician Switzerland
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 5/30/2005 48 Male 4/2/2007 Pharmacist Japan
Primary
Secondary
Concomitant
Ventricular Dysfunction Other Serious 2/26/2007 Male 173 lb 4/11/2007 Physician United States
Primary
Concomitant
Drug Interaction Other Serious 2/22/2007 14 Male 62 lb 4/12/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Renal Failure Other Serious Male 4/13/2007 Other Health Professional France
Primary
Secondary
Concomitant
Skin Toxicity Other Serious 12 Female 4/13/2007 Other Health Professional France
Primary
Secondary
Concomitant
Vomiting Other Serious 4/20/2007 Female 4/30/2007 Other Health Professional United States
Primary
Concomitant
Subcutaneous Nodule Other Serious 2/1/2007 Female 5/7/2007 Consumer United States
Primary
Secondary
Concomitant
Drug Interaction Other Serious 2/22/2007 14 Male 62 lb 5/2/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 4/19/2007 Male 198 lb 5/8/2007 United States
Primary
Secondary
Treatment Noncompliance Hospitalization 4/27/2007 Male 194 lb 5/8/2007 United States
Primary
Secondary
Hiccups 4/25/2007 Male 147 lb 6/4/2007 Pharmacist United States
Primary
Concomitant
Vomiting Other Serious 3/1/2007 Female 140 lb 6/11/2007 Other Health Professional United States
Primary
Concomitant
Tremor Other Serious 58 Male 6/11/2007 Physician Japan
Primary
Concomitant
Weight Increased Other Serious 67 Male 6/11/2007 Consumer United States
Primary
Secondary
Concomitant
Toothache Hospitalization 1/25/2005 41 Female 244 lb 6/12/2007 United States
Primary
Concomitant
Tachycardia Hospitalization 6/3/2007 Male 188 lb 6/8/2007 United States
Primary
Secondary
Hyperglycaemia 3/30/2007 50 Female 205 lb 6/25/2007 Other Health Professional United States
Primary
Concomitant
Wound Abscess Hospitalization 6/6/2007 Male 45 lb 6/21/2007 United States
Primary
Secondary
Nephropathy Toxic Hospitalization 13 Male 7/3/2007
Primary
Secondary
Nephropathy Toxic Other Serious 4/1/2005 13 Male 7/2/2007 Other Health Professional United States
Primary
Secondary
Pyrexia Hospitalization 6/10/2007 Male 240 lb 6/26/2007 United States
Primary
Secondary
Transient Ischaemic Attack Other Serious 7/6/2007 Physician United States
Primary
Concomitant
Neutrophil Count Decreased 6/18/2007 Male 198 lb 7/3/2007 United States
Primary
Secondary
Concomitant
Osteoarthritis Hospitalization 6/22/2007 Female 229 lb 7/5/2007 United States
Primary
Secondary
Squamous Cell Carcinoma Other Serious 5/1/1999 56 Female 7/9/2007 Physician United States
Primary
Secondary
Concomitant
Vith Nerve Paralysis Other Serious 10/22/2006 23 Male 172 lb 7/9/2007 United Kingdom
Primary
Concomitant
Vomiting Other Serious 3/31/2007 Female 7/13/2007 Other Health Professional Canada
Primary
Concomitant
Ureteric Obstruction Other Serious 10/1/2004 Female 7/13/2007 Physician United States
Primary
Concomitant
Toothache Other Serious 1/25/2005 41 Female 244 lb 7/16/2007 United States
Primary
Secondary
Concomitant
Bradycardia Hospitalization 7/5/2007 Female 176 lb 7/18/2007 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 7/18/2007 Female 141 lb 7/20/2007 United States
Primary
Secondary
Concomitant
Atrioventricular Block Second Degree Hospitalization 7/5/2007 Female 176 lb 8/3/2007 Other Health Professional United States
Primary
Concomitant
Squamous Cell Carcinoma Other Serious 7/24/2007 79 Male 8/6/2007 Other Health Professional United States
Primary
Concomitant
Vomiting Hospitalization 7/25/2007 Male 187 lb 7/30/2007 United States
Primary
Secondary
Platelet Count Decreased Life Threatening 12/18/2006 20 Male 115 lb 8/2/2007 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 74 Male 8/4/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Mucoepidermoid Carcinoma Other Serious 17 Male 8/9/2007 Other Health Professional United States
Primary
Secondary
Thrombocythaemia Other Serious 9/1/2006 Female 184 lb 8/16/2007 Physician United States
Primary
Concomitant
Myocardial Infarction Death 3/20/2007 Female 165 lb 8/16/2007 Physician Canada
Primary
Concomitant
Temporomandibular Joint Syndrome Other Serious 17 Male 8/16/2007 Physician United States
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious 16 Male 8/16/2007 Physician United States
Primary
Secondary
Concomitant
Trismus Other Serious 14 Female 8/16/2007 Physician United States
Primary
Secondary
Concomitant
Tooth Disorder Other Serious 10 Female 8/16/2007 Physician United States
Primary
Secondary
Vocal Cord Disorder Other Serious 14 Male 8/16/2007 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 5 Female 8/18/2007 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 3 Male 35 lb 8/28/2007
Primary
Secondary
Urinary Incontinence Hospitalization 7/13/2007 Male 185 lb 8/15/2007 United States
Primary
Secondary
Pneumonia Other Serious 9/27/2005 Female 97 lb 8/30/2007 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 7/17/2007 Male 234 lb 8/23/2007 United States
Primary
Secondary
Concomitant
Muscular Weakness Other Serious 47 Female 9/10/2007 Other Health Professional Canada
Primary
Concomitant
Renal Failure Acute Hospitalization 6/6/2007 Male 200 lb 9/14/2007 United States
Primary
Secondary
Atrioventricular Block Second Degree Hospitalization 7/5/2007 Female 176 lb 9/21/2007 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 21 Female 8/16/2007 Physician United States
Primary
Secondary
Sepsis Neonatal Hospitalization Male 8/16/2007 Physician United States
Primary
Secondary
Vomiting Other Serious 14 Female 10/2/2007 Other Health Professional United States
Primary
Secondary
Interacting
Vomiting Other Serious 8 Male 10/2/2007
Primary
Secondary
Concomitant
Vomiting Other Serious 14 Female 10/2/2007
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 17 Female 10/2/2007
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Hospitalization 9/18/2007 Male 492 lb 10/2/2007 United States
Primary
Secondary
Mucosal Inflammation Hospitalization 10/5/2007 Female 64 lb 10/9/2007 United States
Primary
Secondary
Myelodysplastic Syndrome Other Serious 3/1/2003 Male 10/17/2007
Primary
Secondary
Wound Secretion Hospitalization 9/27/2007 Male 467 lb 10/8/2007 United States
Primary
Secondary
Depressed Level Of Consciousness 10/16/2007 Female 114 lb 10/22/2007 United States
Primary
Secondary
Concomitant
Pericardial Effusion Hospitalization 10/15/2007 Female 229 lb 10/26/2007 United States
Primary
Secondary
Liver Disorder Hospitalization 10/17/2007 Female 187 lb 11/2/2007 Consumer United States
Primary
Concomitant
Pharyngolaryngeal Pain Hospitalization 10/5/2007 Female 64 lb 10/30/2007 United States
Primary
Secondary
Pharyngolaryngeal Pain Hospitalization 10/5/2007 Female 64 lb 11/4/2007 United States
Primary
Secondary
Wound Treatment Hospitalization 1/25/2005 41 Female 220 lb 11/14/2007 United States
Primary
Secondary
Concomitant
Spinal Laminectomy Other Serious 1/1/1999 Male 180 lb 11/14/2007 Consumer United States
Primary
Concomitant
Pulmonary Embolism Other Serious 150 lb 11/15/2007 Physician United States
Primary
Concomitant

Drug Data