Leucovorin Calcium combined with Mesna

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 4/18/2006 Physician United States
Primary
Secondary
Concomitant
Vomiting Required Intervention 4/11/2006 Female 4/13/2006 United States
Primary
Secondary
Vomiting Hospitalization 4/11/2006 Female 214 lb 4/28/2006 United States
Primary
Secondary
White Blood Cell Count Decreased Life Threatening 4/7/2006 70 Female 5/12/2006 United States
Primary
Secondary
Concomitant
Pulmonary Oedema Life Threatening 4/7/2006 Female 116 lb 8/10/2006 Physician United States
Primary
Secondary
Concomitant
Tachycardia Hospitalization 3/4/2006 Male 311 lb 8/11/2006 United States
Primary
Secondary
Stomatitis Hospitalization 7/2/2006 Female 51 lb 11/30/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Death 1/14/2007 Female 14 lb 1/17/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Vith Nerve Paralysis Other Serious 10/22/2006 23 Male 172 lb 1/10/2007 Physician Finland
Primary
Secondary
Concomitant
Thrombocytopenia 1/1/2006 31 Male 3/28/2007 Physician United States
Primary
Concomitant
Staphylococcal Infection Hospitalization 4/19/2007 Male 198 lb 5/8/2007 United States
Primary
Secondary
Tachycardia Hospitalization 6/3/2007 Male 188 lb 6/8/2007 United States
Primary
Secondary
Wound Abscess Hospitalization 6/6/2007 Male 45 lb 6/21/2007 United States
Primary
Secondary
Vith Nerve Paralysis Other Serious 10/22/2006 23 Male 172 lb 7/9/2007 United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 7/18/2007 Female 141 lb 7/20/2007 United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/25/2007 Male 187 lb 7/30/2007 United States
Primary
Secondary
White Blood Cell Count Increased Hospitalization 3 Male 35 lb 8/28/2007
Primary
Secondary
Urinary Tract Infection Other Serious 21 Female 9/5/2007 Other Health Professional United States
Primary
Secondary
White Blood Cell Count Increased Other Serious 21 Female 8/16/2007 Physician United States
Primary
Secondary
Sepsis Neonatal Hospitalization Male 8/16/2007 Physician United States
Primary
Secondary
Tumour Lysis Syndrome Hospitalization 9/18/2007 Male 492 lb 10/2/2007 United States
Primary
Secondary
Wound Secretion Hospitalization 9/27/2007 Male 467 lb 10/8/2007 United States
Primary
Secondary
Vomiting Other Serious 11/11/2007 Male 289 lb 12/4/2007 United States
Primary
Secondary
Pseudomonas Infection Hospitalization 12/12/2007 Female 166 lb 1/2/2008 United States
Primary
Secondary
Tachycardia Hospitalization 12/21/2007 Male 289 lb 1/7/2008 United States
Primary
Secondary
Condition Aggravated Hospitalization 2/7/2008 Male 190 lb 2/12/2008 United States
Primary
Secondary
Treatment Noncompliance Hospitalization 2/19/2008 Male 187 lb 2/28/2008 United States
Primary
Secondary
Petechiae Other Serious 7/23/2007 Female 179 lb 3/10/2008 Physician Germany
Primary
Concomitant
Generalised Erythema Other Serious 11/14/2007 Female 132 lb 3/10/2008 Physician Germany
Primary
Concomitant
Thrombocytopenia 1/1/2006 31 Male 3/28/2008 Physician United States
Primary
Concomitant
Hypocalcaemia Hospitalization 3/4/2008 Male 183 lb 5/8/2008 United States
Primary
Secondary
Neutropenic Sepsis Other Serious 4/16/2008 52 Male 157 lb 5/21/2008 Physician Malaysia
Primary
Concomitant
Muscle Disorder Disability 5/13/2006 Male 6/23/2008 Consumer Germany
Primary
Secondary
Concomitant
Sepsis Other Serious 63 Male 7/3/2008 Consumer Japan
Primary
Secondary
Concomitant
Neutropenia Other Serious 39 Male 7/3/2008 Consumer Japan
Primary
Secondary
Concomitant
Pancytopenia Other Serious 28 Male 7/3/2008 Consumer Japan
Primary
Secondary
Concomitant
Neutropenia Other Serious 57 Male 7/3/2008 Consumer Japan
Primary
Secondary
Concomitant
Neutropenia Other Serious 33 Male 7/3/2008 Consumer Japan
Primary
Secondary
Concomitant
Malabsorption 7/28/2008 Male 125 lb 7/28/2008 United States
Primary
Secondary
Transient Ischaemic Attack Hospitalization 7/22/2008 9 Male 76 lb 8/8/2008 Physician United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 5/29/2008 Female 114 lb 8/13/2008 Other Health Professional Brazil
Primary
Concomitant
Weight Increased Other Serious 5/16/2008 Female 8/15/2008 Other Health Professional Brazil
Primary
Concomitant
Wound Infection Bacterial Hospitalization 5/27/2007 Female 141 lb 6/20/2007 United States
Primary
Secondary
Weight Increased Other Serious 5/29/2008 Female 114 lb 10/10/2008 Other Health Professional Brazil
Primary
Concomitant
Urine Leukocyte Esterase Positive Hospitalization 10/5/2008 Male 209 lb 10/9/2008 United States
Primary
Secondary
Weight Increased Other Serious 5/16/2008 Female 10/16/2008 Other Health Professional Brazil
Primary
Concomitant
Renal Failure Acute Hospitalization 10/2/2008 64 Female 10/18/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 11/1/2007 43 Male 10/7/2008 Physician United States
Primary
Concomitant
Renal Failure Acute Other Serious 11/1/2007 56 Male 10/7/2008 Physician United States
Primary
Concomitant
Renal Failure Acute Other Serious 12/1/2007 53 Male 10/7/2008 Physician United States
Primary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Weight Increased Other Serious 5/16/2008 Female 166 lb 11/5/2008 Other Health Professional Brazil
Primary
Concomitant
Death Death 67 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 66 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Urine Leukocyte Esterase Positive Hospitalization 11/23/2008 Male 209 lb 1/8/2009 United States
Primary
Secondary
Pharyngeal Oedema Hospitalization 12/27/2008 Male 183 lb 12/30/2008 United States
Primary
Secondary
Sepsis Hospitalization 11/15/2008 Male 192 lb 2/9/2009 United States
Primary
Secondary
Weight Decreased Hospitalization 10/6/2008 Male 192 lb 2/11/2009 United States
Primary
Secondary
Neutropenic Sepsis Death 83 5/13/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Neutropenic Sepsis Death 73 5/13/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Pyrexia Hospitalization 5/2/2009 Male 157 lb 5/19/2009 United States
Primary
Secondary
Thrombocytopenia Other Serious 6/16/2009 Other Health Professional United Kingdom
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 6/12/2009 Male 163 lb 6/23/2009 United States
Primary
Secondary
Somnolence Other Serious 1/11/2010 United States
Primary
Secondary
Concomitant
Tachypnoea Hospitalization 11/12/2009 Female 15 lb 1/12/2010 United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 4/15/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Syncope Other Serious 10/6/2007 50 Male 194 lb 6/30/2010 Lawyer United States
Primary
Concomitant
Urinary Incontinence Other Serious 1/1/2009 59 Female 132 lb 8/23/2010 Consumer United States
Primary
Secondary
Concomitant
Tachycardia Other Serious 9/20/2007 50 Male 194 lb 8/27/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Headache Other Serious 9/1/2007 50 Male 194 lb 1/12/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Blood Calcium Decreased Hospitalization 1/26/2011 15 Female 118 lb 1/28/2011 Physician United States
Primary
Secondary
Toothache Other Serious 54 Male 2/10/2011 Other Health Professional Israel
Primary
Concomitant
Blood Potassium Decreased Death 1/26/2011 15 Female 118 lb 2/9/2011 Physician United States
Primary
Secondary
Haemorrhage Other Serious 3/1/2011 Physician United States
Primary
Secondary
Concomitant
Liver Function Test Abnormal Other Serious 3/1/2011 Physician United States
Primary
Secondary
Concomitant
Burning Sensation Hospitalization Male 101 lb 3/3/2011 Other Health Professional Canada
Primary
Concomitant
Bone Marrow Failure Death 5/5/2011 Physician United States
Primary
Secondary
Concomitant
Infection In An Immunocompromised Host Other Serious 5/5/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Septic Shock Death 5/5/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Bone Marrow Failure Death 5/5/2011 Physician United States
Primary
Secondary
Concomitant
Septic Shock Other Serious 5/5/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Bone Marrow Failure Other Serious 5/5/2011 Physician United States
Primary
Secondary
Concomitant
Bone Marrow Failure Other Serious 5/5/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Septic Shock Other Serious 5/5/2011 Physician United States
Primary
Secondary
Concomitant
Bone Marrow Failure Death 5/5/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Infection In An Immunocompromised Host Death 5/5/2011 Physician United States
Primary
Secondary
Concomitant
Petechiae Other Serious 1/29/2010 49 Male 110 lb 5/20/2011 Physician Japan
Primary
Concomitant
Dyspnoea Other Serious 12 Male 132 lb 5/26/2011 Pharmacist Brazil
Primary
Concomitant
Cardiotoxicity Other Serious 15 Female 5/27/2011 Other Health Professional Norway
Primary
Secondary
Concomitant
Cardiotoxicity Other Serious 15 Female 5/27/2011 Other Health Professional Norway
Primary
Secondary
Concomitant
Neuralgia Other Serious 54 Male 6/24/2011 Other Health Professional Israel
Primary
Secondary
Concomitant
Sepsis Death 8/1/2008 54 Male 6/29/2011 Other Health Professional Israel
Primary
Secondary
Concomitant
Dyspnoea Other Serious 3/23/2011 22 Male 132 lb 7/7/2011 Pharmacist Brazil
Primary
Concomitant
Dyspnoea Other Serious 3/23/2011 22 Male 132 lb 9/23/2011 Pharmacist Brazil
Primary
Concomitant
Myelodysplastic Syndrome Hospitalization 3/9/2011 43 Male 202 lb 9/29/2011 United States
Primary
Secondary
Acute Myeloid Leukaemia Hospitalization 3/9/2011 43 Male 202 lb 9/29/2011 United States
Primary
Secondary
Pulmonary Hypertension Other Serious 1/1/2011 8 Female 49 lb 10/6/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Methylobacterium Infection Other Serious 8 Female 49 lb 10/6/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pulmonary Hypertension Other Serious 1/1/2011 8 Female 49 lb 10/21/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cardiac Failure Other Serious 10/31/2011 Other Health Professional France
Primary
Secondary
Concomitant
Death Death 10/31/2011 Other Health Professional France
Primary
Secondary
Concomitant
Neutropenia Other Serious 41 Female 11/3/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Other Serious 26 Male 11/3/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Other Serious 54 Female 11/3/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Other Serious 51 Male 11/3/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Cytomegalovirus Infection Other Serious 22 Female 11/3/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Other Serious 49 Female 11/3/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Thrombosis Hospitalization 2/27/2011 39 Male 137 lb 11/17/2011 Physician Japan
Primary
Concomitant
Neutropenia Other Serious 53 Male 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Other Serious 69 Male 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Other Serious 36 Male 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Other Serious 18 Female 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Infection Hospitalization 2/15/2005 17 11/21/2011 United States
Primary
Secondary
Neutropenia Other Serious 22 Female 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Convulsion Life Threatening 6/14/2005 20 11/21/2011 United States
Primary
Secondary
Neutropenia Other Serious 49 Female 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Refusal Of Treatment By Patient Other Serious 36 Male 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Death 51 Male 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Other Serious 33 Female 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Other Serious 52 Female 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Pyrexia Hospitalization 10/10/2001 11 Male 11/29/2011 Physician United States
Primary
Secondary
Off Label Use Hospitalization 44 Male 11/30/2011 Other Health Professional
Primary
Secondary
Concomitant
Staphylococcal Bacteraemia Death 11/22/2010 15 Female 95 lb 12/12/2011 Physician Japan
Primary
Concomitant
Fatigue Hospitalization 9/19/2011 31 Male 12/19/2011 United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 10/1/2001 11 Male 12/22/2011 Consumer United States
Primary
Secondary
Infection Life Threatening 12/8/2001 12 Male 12/23/2011 Physician United States
Primary
Secondary
Liver Disorder Other Serious 1/1/2011 8 Female 49 lb 12/29/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pneumonia Hospitalization 9/19/2011 31 Male 1/24/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Hypotension Hospitalization 9/19/2011 31 Male 1/30/2012 Physician United States
Primary
Secondary
Concomitant
Pericardial Effusion Hospitalization 11/21/2004 16 2/16/2012 United States
Primary
Secondary
Infection Hospitalization 10/10/2001 11 Male 2/17/2012 Physician United States
Primary
Secondary
Alanine Aminotransferase Increased Other Serious 12/9/2011 48 Female 121 lb 2/18/2012 Consumer United States
Primary
Secondary
Hyponatraemia Other Serious 1/4/2004 21 Female 2/28/2012 Physician United States
Primary
Secondary
Toxicity To Various Agents Hospitalization 1/20/2012 12 Female 89 lb 3/9/2012 France
Primary
Secondary
Concomitant
Fungal Sepsis Other Serious 3/26/2012 Other Health Professional China
Primary
Secondary
Concomitant
Skin Infection Other Serious 4/2/2011 27 Female 112 lb 4/9/2012 Physician Japan
Primary
Concomitant
Soft Tissue Infection Other Serious 12/9/2011 48 Female 121 lb 5/8/2012 Consumer United States
Primary
Secondary
Anaemia Other Serious 5/10/2012 Other Health Professional China
Primary
Secondary
Concomitant
Off Label Use Other Serious 5/10/2012 Other Health Professional China
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 5/10/2012 Other Health Professional China
Primary
Secondary
Concomitant
Sepsis Other Serious 5/11/2012 Other Health Professional China
Primary
Secondary
Concomitant
Pulmonary Toxicity Other Serious 5/11/2012 Other Health Professional China
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 5/11/2012 Other Health Professional China
Primary
Secondary
Concomitant

Drug Data