Letrozole combined with Tamoxifen Citrate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Uterine Disorder Other Serious 2/1/2004 40 Female 4/10/2006 Physician United States
Primary
Interacting
Tooth Extraction Other Serious 64 Female 9/19/2006 Other Health Professional Italy
Primary
Concomitant
Surgery Other Serious 78 Female 9/19/2006 Italy
Primary
Concomitant
Osteonecrosis Other Serious 63 Female 9/19/2006 Other Health Professional Italy
Primary
Concomitant
Sequestrectomy Other Serious 78 Female 9/19/2006 Other Health Professional Italy
Primary
Concomitant
Surgery Other Serious 58 Female 9/19/2006 Other Health Professional Italy
Primary
Concomitant
Osteonecrosis Other Serious 69 Female 9/19/2006 Other Health Professional Italy
Primary
Concomitant
Surgery Other Serious 68 Female 9/19/2006 Other Health Professional Italy
Primary
Concomitant
Vomiting Other Serious 10/1/2004 79 Female 152 lb 2/16/2007 Physician Germany
Primary
Concomitant
Wound Treatment Other Serious 1/1/1998 57 Female 150 lb 3/17/2007 Lawyer United States
Primary
Secondary
Concomitant
Vomiting Other Serious 10/1/2004 79 Female 152 lb 3/28/2007 Physician Germany
Primary
Concomitant
Syncope Other Serious 6/1/2007 56 Female 168 lb 8/1/2007 United Kingdom
Primary
Concomitant
Vaginal Haemorrhage Hospitalization 4/7/2002 75 Female 209 lb 8/16/2007 Physician Italy
Primary
Secondary
Tenosynovitis Hospitalization 6/1/2007 63 Female 141 lb 8/20/2007 Physician France
Primary
Secondary
Concomitant
Vaginal Haemorrhage Hospitalization 4/7/2002 75 Female 209 lb 9/28/2007 Physician Italy
Primary
Secondary
Tenosynovitis Hospitalization 6/1/2007 63 Female 141 lb 4/8/2008 Physician France
Primary
Secondary
Concomitant
Tenosynovitis Hospitalization 6/1/2007 63 Female 141 lb 4/8/2008 Physician France
Primary
Secondary
Concomitant
Restless Legs Syndrome Other Serious 9/1/2005 61 Female 4/10/2008 Canada
Primary
Concomitant
Uterine Haemorrhage Hospitalization 8/1/2007 70 Female 165 lb 5/1/2008 Physician Russian Federation
Primary
Secondary
Concomitant
Hepatic Cirrhosis Other Serious Female 7/2/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Hepatic Cirrhosis Other Serious 2/1/2008 45 Female 139 lb 7/10/2008 Physician Germany
Primary
Secondary
Concomitant
Cutaneous Vasculitis Other Serious 1/1/2004 63 Female 10/29/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Osteoarthritis Other Serious 1/17/2008 69 Female 80 lb 11/14/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2004 63 Female 11/19/2008 United States
Primary
Secondary
Wound Secretion Other Serious 1/1/2004 63 Female 12/1/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Wound Secretion Other Serious 1/1/2004 63 Female 12/4/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Tenosynovitis Hospitalization 6/1/2007 Female 141 lb 3/24/2009 Physician France
Primary
Secondary
Concomitant
Cerebrovascular Accident Other Serious 5/14/2006 42 Female 3/10/2009 United States
Primary
Secondary
Vaginal Haemorrhage Hospitalization 4/7/2002 Female 209 lb 4/2/2009 Physician Italy
Primary
Secondary
Venous Thrombosis Other Serious 1/1/1998 Female 235 lb 5/4/2009 Physician United States
Primary
Concomitant
Venous Thrombosis Other Serious 1/1/1998 Female 235 lb 5/14/2009 Physician United States
Primary
Concomitant
Neoplasm Malignant Death 3/3/2003 66 5/27/2009 Other Health Professional Australia
Primary
Secondary
Concomitant
Vertigo Other Serious 1/1/2004 Female 235 lb 6/26/2009 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 2/28/1995 Female 7/20/2009 Other Health Professional United States
Primary
Concomitant
Vertigo Other Serious 1/1/2004 Female 235 lb 7/28/2009 Physician United States
Primary
Concomitant
Osteonecrosis Other Serious 65 Female 10/20/2009 Other Health Professional Italy
Primary
Secondary
Concomitant
Weight Decreased Other Serious 8/3/2005 Female 154 lb 11/27/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 1/5/2010 Other Health Professional Italy
Primary
Secondary
Weight Decreased Other Serious 2/28/1995 Female 1/13/2010 Other Health Professional United States
Primary
Concomitant
Weight Decreased Other Serious 8/3/2005 Female 154 lb 1/25/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 2/28/1995 Female 136 lb 1/29/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vertigo Other Serious 1/1/2004 Female 235 lb 2/1/2010 Other Health Professional United States
Primary
Concomitant
Osteonecrosis Disability 12/1/2005 Female 2/1/2010 Other Health Professional Italy
Primary
Concomitant
Weight Decreased Other Serious 2/28/1995 Female 136 lb 2/2/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 2/28/1995 Female 136 lb 2/4/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 2/28/1995 Female 136 lb 2/11/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 7/1/2003 Female 136 lb 2/18/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 8/3/2005 Female 154 lb 2/23/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sinusitis Other Serious 12/14/2006 Female 134 lb 2/26/2010 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 8/3/2005 Female 154 lb 3/5/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 7/1/2003 Female 136 lb 3/11/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vertigo Other Serious 1/1/2004 Female 235 lb 3/12/2010 Other Health Professional United States
Primary
Concomitant
Vulvovaginal Candidiasis Other Serious 1/1/2001 Female 134 lb 3/15/2010 Physician United States
Primary
Concomitant
Acute Myelomonocytic Leukaemia Hospitalization 70 Female 3/17/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 8/3/2005 Female 154 lb 3/17/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 7/1/2003 Female 136 lb 3/18/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 6/19/2003 Female 3/23/2010 United States
Primary
Secondary
Concomitant
Neuropathy Peripheral Other Serious 48 Female 3/23/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2001 Female 134 lb 3/24/2010 Physician United States
Primary
Concomitant
Acute Myeloid Leukaemia Hospitalization 70 Female 3/25/2010 Other Health Professional United States
Primary
Secondary
Acute Myelomonocytic Leukaemia Other Serious 70 Female 3/25/2010 Physician United States
Primary
Secondary
Acute Myelomonocytic Leukaemia Other Serious 70 Female 3/25/2010 Physician United States
Primary
Secondary
Acute Myelomonocytic Leukaemia Other Serious 70 Female 3/25/2010 Physician United States
Primary
Secondary
Vertigo Other Serious 1/1/2004 Female 235 lb 3/26/2010 Other Health Professional United States
Primary
Concomitant
Weight Decreased Other Serious 7/1/2003 Female 136 lb 3/26/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 6/19/2003 Female 3/26/2010 United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 6/19/2003 Female 3/29/2010 United States
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1998 Female 150 lb 3/31/2010 Lawyer United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 8/3/2005 Female 154 lb 3/31/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 7/1/2003 57 Female 136 lb 4/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 7/1/2003 57 Female 136 lb 4/9/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2001 44 Female 134 lb 4/12/2010 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 6/19/2003 81 Female 4/12/2010 United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 1/1/2003 56 Female 155 lb 4/14/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 1/1/2003 56 Female 155 lb 4/23/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 1/1/2003 56 Female 155 lb 4/26/2010 United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2001 44 Female 134 lb 5/4/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 6/19/2003 81 Female 5/12/2010 United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 6/19/2003 81 Female 5/18/2010 United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 1/1/2003 56 Female 155 lb 5/20/2010 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 6/19/2003 81 Female 5/26/2010 United States
Primary
Secondary
Concomitant
Colorectal Cancer Other Serious 62 Female 5/27/2010 Physician United States
Primary
Secondary
Colorectal Cancer Other Serious 62 Female 5/27/2010 Physician United States
Primary
Secondary
Wound Infection Staphylococcal Other Serious 1/1/2003 56 Female 155 lb 5/27/2010 United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 1/1/2003 56 Female 155 lb 6/3/2010 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 6/19/2003 81 Female 6/3/2010 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 6/19/2003 81 Female 6/8/2010 United States
Primary
Secondary
Concomitant
Vertigo Other Serious 1/1/2004 43 Female 235 lb 7/6/2010 Other Health Professional United States
Primary
Concomitant
Wound Infection Staphylococcal Other Serious 1/1/2003 56 Female 155 lb 7/7/2010 United States
Primary
Secondary
Concomitant
Vomiting Other Serious 75 Female 7/12/2010 Physician Australia
Primary
Secondary
Wound Infection Staphylococcal Other Serious 1/1/2003 56 Female 155 lb 8/2/2010 United States
Primary
Secondary
Concomitant
Vertigo Other Serious 1/1/2004 43 Female 235 lb 8/27/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2001 44 Female 134 lb 8/29/2010 United States
Primary
Concomitant
Wound Infection Staphylococcal Other Serious 1/1/2003 56 Female 155 lb 9/30/2010 United States
Primary
Secondary
Concomitant
Swelling Death 10/15/2006 72 Female 1/12/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Fatigue Hospitalization 78 Female 2/8/2011 Other Health Professional United States
Primary
Concomitant
Bone Lesion Other Serious 31 Female 4/21/2011 Physician Denmark
Primary
Secondary
Concomitant
Endometrial Disorder Other Serious 3/15/2011 59 Female 5/16/2011 Physician Belgium
Primary
Concomitant
Insomnia Other Serious 8/25/2002 68 Female 5/16/2011 Lawyer United States
Primary
Secondary
Concomitant
Vitamin D Deficiency Hospitalization 1/1/2001 44 Female 134 lb 6/6/2011 Other Health Professional United States
Primary
Concomitant
Hypoaesthesia Other Serious 1/1/2006 42 Female 6/10/2011 Physician United States
Primary
Concomitant
Fatigue Other Serious 1/1/2006 42 Female 6/15/2011 Physician United States
Primary
Concomitant
Abdominal Distension Other Serious 4/1/2002 38 Female 6/30/2011 Physician United States
Primary
Concomitant
Lichenoid Keratosis Other Serious 1/1/2003 56 Female 155 lb 7/7/2011 Pharmacist United States
Primary
Secondary
Concomitant
Dementia Other Serious Female 194 lb 7/21/2011 Physician Syrian Arab Republic
Primary
Secondary
Concomitant
Hiatus Hernia Death 10/1/2007 62 Female 136 lb 7/25/2011 Lawyer United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/1/2006 42 Female 7/26/2011 Lawyer United States
Primary
Concomitant
Dizziness Other Serious 8/25/2002 68 Female 8/1/2011 Physician United States
Primary
Secondary
Concomitant
Excessive Granulation Tissue Hospitalization 1/1/2003 56 Female 155 lb 8/4/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Dysplastic Naevus Other Serious 1/1/2003 56 Female 155 lb 8/11/2011 United States
Primary
Secondary
Concomitant
Fatigue Other Serious 1/1/2003 56 Female 155 lb 8/20/2011 Consumer United States
Primary
Secondary
Concomitant
Exposed Bone In Jaw Hospitalization 1/1/2006 42 Female 8/26/2011 Physician United States
Primary
Concomitant
Tendon Disorder Other Serious 1/1/2003 56 Female 155 lb 8/26/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Folliculitis Other Serious 50 Female 8/29/2011 Canada
Primary
Secondary
Concomitant
Folliculitis Death 5/1/2010 50 Female 9/23/2011 Other Health Professional Canada
Primary
Secondary
Breast Cancer Metastatic Other Serious 6/1/2002 30 Female 9/23/2011 Physician Canada
Primary
Secondary
Lymphadenopathy Death 10/1/2007 62 Female 136 lb 9/23/2011 Physician United States
Primary
Secondary
Concomitant
Metastases To Bone Death Female 9/30/2011 Physician United States
Primary
Concomitant
Cerebral Small Vessel Ischaemic Disease Other Serious 8/25/2002 68 Female 10/6/2011 Lawyer United States
Primary
Secondary
Concomitant
Aneurysm Hospitalization 10/5/2010 67 Female 187 lb 10/17/2011 Physician France
Primary
Concomitant
Flank Pain Other Serious 8/25/2002 68 Female 11/1/2011 Lawyer United States
Primary
Secondary
Concomitant
Hepatic Failure Other Serious 53 Female 11/9/2011 Other Health Professional Israel
Primary
Secondary
Alanine Aminotransferase Increased Other Serious 53 Female 11/14/2011 Physician Israel
Primary
Secondary
Concomitant
Hepatic Failure Death Female 11/17/2011 Physician Israel
Primary
Secondary
Concomitant
Thyroid Disorder Other Serious Female 11/17/2011 Physician United States
Primary
Concomitant
Hepatic Failure Other Serious 53 Female 11/20/2011 Other Health Professional Israel
Primary
Secondary
Cardiac Cirrhosis Other Serious 51 Female 11/20/2011 Other Health Professional Israel
Primary
Secondary
Cerebral Ischaemia Hospitalization 1/28/2005 45 11/21/2011 United States
Primary
Secondary
Bone Lesion Other Serious 8/25/2002 68 Female 11/28/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Hepatic Failure Death 51 Female 11/18/2011 Israel
Primary
Secondary
Concomitant
Hepatic Failure Death 53 Female 11/18/2011 Israel
Primary
Secondary
Hepatic Failure Death 51 Female 12/1/2011 Other Health Professional Israel
Primary
Secondary
Flank Pain Death 8/25/2002 68 Female 108 lb 12/1/2011 Consumer United States
Primary
Secondary
Concomitant
Facial Nerve Disorder Other Serious Female 12/31/2011 Lawyer United States
Primary
Concomitant
Lymphadenopathy Death 10/1/2007 62 Female 136 lb 1/1/2012 Lawyer United States
Primary
Secondary
Concomitant
Intracranial Aneurysm Life Threatening 10/5/2010 67 Female 187 lb 1/4/2012 Physician France
Primary
Concomitant
Tinnitus Hospitalization 1/1/2003 56 Female 155 lb 1/5/2012 Pharmacist United States
Primary
Secondary
Concomitant
Pain In Jaw Other Serious 1/1/2003 56 Female 155 lb 1/14/2012 Consumer United States
Primary
Secondary
Concomitant
Intracranial Aneurysm Hospitalization 10/5/2010 67 Female 187 lb 1/27/2012 Physician France
Primary
Concomitant
Contusion Death 8/25/2002 68 Female 108 lb 1/31/2012 Physician United States
Primary
Secondary
Concomitant
Hand Fracture Other Serious 1/1/2003 56 Female 155 lb 2/8/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Breast Cancer Recurrent Other Serious 1/1/2004 57 Female 99 lb 3/8/2012 Physician Japan
Primary
Secondary
Hot Flush Other Serious 1/1/2006 42 Female 3/9/2012 Lawyer United States
Primary
Concomitant
Nasal Congestion Death Female 3/16/2012 Consumer United States
Primary
Concomitant
Headache Hospitalization 3/6/2012 45 Female 143 lb 3/21/2012 Physician Germany
Primary
Secondary
Monoplegia Hospitalization 3/6/2012 45 Female 143 lb 3/25/2012 Physician Germany
Primary
Secondary
Neoplasm Malignant Other Serious Female 150 lb 4/16/2012 Physician Germany
Primary
Secondary
Colorectal Cancer Other Serious 1/25/2011 58 Female 220 lb 4/17/2012 Physician Belgium
Primary
Secondary
Concomitant
Colorectal Cancer Other Serious 1/25/2011 58 Female 220 lb 4/23/2012 Physician Belgium
Primary
Secondary
Acute Myeloid Leukaemia Other Serious 70 Female 5/7/2012 Other Health Professional United States
Primary
Secondary

Drug Data