Lapatinib combined with Xeloda

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pneumonia Hospitalization 10/1/2006 Female 11/6/2006 Other Health Professional United States
Primary
Concomitant
Transaminases Increased Other Serious Female 4/2/2007 Physician France
Primary
Secondary
Hepatocellular Damage Other Serious 3/7/2007 44 Female 121 lb 4/16/2007 Physician France
Primary
Secondary
Concomitant
Pulmonary Hypertension Other Serious 1/5/2007 Female 100 lb 5/16/2007 Physician United States
Primary
Secondary
Concomitant
Pulmonary Hypertension Other Serious 1/5/2007 Female 100 lb 5/16/2007 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/1/2007 75 Female 5/22/2007 Consumer United States
Primary
Secondary
Stent Occlusion Hospitalization 5/10/2007 68 Male 181 lb 5/30/2007 Physician United States
Primary
Secondary
Concomitant
Rash Hospitalization 5/1/2007 46 Female 6/11/2007 Consumer United States
Primary
Secondary
Concomitant
Nausea 4/2/2007 Female 7/6/2007 Consumer United States
Primary
Secondary
Concomitant
Vomiting 4/11/2007 59 Female 7/6/2007 Consumer United States
Primary
Secondary
Concomitant
Neutropenia Death 6/7/2007 45 Female 7/20/2007 Physician Spain
Primary
Secondary
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 5/1/2004 50 Female 7/24/2007 Physician Spain
Primary
Secondary
Concomitant
Neutropenia Death 6/7/2007 45 Female 7/24/2007 Physician Spain
Primary
Secondary
Pulmonary Hypertension Other Serious 1/5/2007 Female 100 lb 9/19/2007 Physician United States
Primary
Secondary
Concomitant
Pulmonary Hypertension Other Serious 1/5/2007 Female 100 lb 9/19/2007 Physician United States
Primary
Secondary
Concomitant
Pulmonary Hypertension Other Serious 1/5/2007 Female 100 lb 10/8/2007 Physician United States
Primary
Secondary
Concomitant
Pulmonary Hypertension Other Serious 1/5/2007 Female 100 lb 10/8/2007 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 9/18/2007 66 Female 10/9/2007 Other Health Professional Italy
Primary
Concomitant
Renal Failure Acute Hospitalization 9/18/2007 66 Female 11/1/2007 Other Health Professional Italy
Primary
Concomitant
Pulmonary Hypertension Other Serious 1/5/2007 Female 100 lb 11/13/2007 Physician United States
Primary
Secondary
Concomitant
Pulmonary Hypertension Other Serious 1/5/2007 Female 100 lb 11/13/2007 Physician United States
Primary
Secondary
Concomitant
Hepatocellular Damage Other Serious 3/7/2007 44 Female 121 lb 11/27/2007 Physician France
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 5/1/2004 50 Female 12/13/2007 Physician Spain
Primary
Secondary
Concomitant
Neutropenia Death 6/7/2007 45 Female 12/13/2007 Physician Spain
Primary
Secondary
Paresis Hospitalization 6/7/2007 45 Female 12/13/2007 Physician Spain
Primary
Secondary
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 6/27/2007 50 Female 12/13/2007 Physician Spain
Primary
Secondary
Concomitant
Vomiting Life Threatening 72 Female 134 lb 12/27/2007 Physician France
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 10/1/2007 55 Female 121 lb 12/27/2007 Physician France
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 11/28/2007 56 Female 176 lb 12/27/2007 Physician France
Primary
Secondary
Weight Decreased Hospitalization 9/1/2007 71 Female 12/28/2007 Physician France
Primary
Secondary
Concomitant
Skin Lesion Hospitalization 10/16/2007 69 Female 97 lb 1/9/2008 Physician France
Primary
Secondary
Thrombocytopenia Hospitalization 11/28/2007 56 Female 176 lb 2/29/2008 Physician France
Primary
Secondary
Death Death 5/22/2007 52 Female 4/2/2008 Consumer United States
Primary
Secondary
Swelling Hospitalization Female 4/23/2008 Physician Germany
Primary
Secondary
Vomiting Hospitalization 3/26/2008 43 Female 4/21/2008 Physician United Kingdom
Primary
Secondary
Transaminases Increased Other Serious 3/28/2008 41 Female 5/5/2008 Physician Spain
Primary
Concomitant
Paraesthesia Hospitalization 4/25/2008 47 Female 172 lb 5/7/2008 Physician Germany
Primary
Secondary
Concomitant
Gastroenteritis Hospitalization 2/23/2008 80 Female 91 lb 5/8/2008 Physician Singapore
Primary
Secondary
Vaginal Haemorrhage Hospitalization 4/11/2008 56 Female 112 lb 5/8/2008 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/5/2008 38 Female 5/9/2008 Physician Austria
Primary
Secondary
Ocular Icterus Other Serious 4/7/2008 38 Female 150 lb 5/9/2008 Physician Belgium
Primary
Secondary
Concomitant
Septic Shock Hospitalization 4/28/2008 45 Female 5/9/2008 Physician Israel
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 1/11/2008 49 Female 266 lb 5/10/2008 Other Health Professional United States
Primary
Concomitant
Hepatocellular Injury Other Serious 3/7/2007 44 Female 121 lb 5/12/2008 Physician France
Primary
Secondary
Concomitant
Rash Hospitalization 4/1/2008 28 Female 5/12/2008 Physician Australia
Primary
Secondary
Concomitant
Swelling Face Hospitalization 3/20/2008 52 Female 146 lb 5/12/2008 Physician Germany
Primary
Secondary
Transaminases Increased Hospitalization 6/19/2007 53 Female 141 lb 5/13/2008 Physician Austria
Primary
Secondary
Paraesthesia Hospitalization 4/25/2008 47 Female 172 lb 5/19/2008 Physician Germany
Primary
Secondary
Concomitant
Lymphoedema Hospitalization 4/22/2008 33 Female 198 lb 5/19/2008 Physician Denmark
Primary
Secondary
Respiratory Tract Infection Hospitalization 5/2/2008 58 Female 216 lb 5/19/2008 Physician Netherlands
Primary
Secondary
Muscle Spasms Hospitalization 4/25/2008 Female 5/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Skin Ulcer Disability 4/30/2008 62 Female 170 lb 5/20/2008 Physician Italy
Primary
Secondary
Pyrexia Hospitalization 5/12/2008 64 Female 135 lb 5/21/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/5/2008 38 Female 5/21/2008 Physician Austria
Primary
Secondary
Hypokalaemia Hospitalization 5/11/2008 50 Female 183 lb 5/21/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/25/2008 50 Female 5/21/2008 Physician Spain
Primary
Secondary
Pleural Infection Hospitalization 11/17/2006 54 Female 5/22/2008 Physician United States
Primary
Secondary
Paronychia Hospitalization 57 Female 5/27/2008 Physician France
Primary
Secondary
Diarrhoea Other Serious 51 Female 5/27/2008 Physician France
Primary
Secondary
Vomiting Hospitalization 4/25/2008 50 Female 225 lb 5/27/2008 Physician Spain
Primary
Secondary
Concomitant
Rash Hospitalization 4/23/2008 46 Female 137 lb 5/29/2008 Physician Korea, Republic Of
Primary
Secondary
Dehydration Hospitalization 4/1/2008 Female 5/29/2008 Physician Germany
Primary
Secondary
Hypokalaemia Hospitalization 4/25/2008 Female 5/30/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Ocular Icterus Other Serious 4/7/2008 38 Female 150 lb 6/3/2008 Physician Belgium
Primary
Secondary
Concomitant
Respiratory Tract Infection Hospitalization 5/2/2008 58 Female 216 lb 6/3/2008 Physician Netherlands
Primary
Secondary
Vomiting Hospitalization 2/18/2008 53 Female 130 lb 6/3/2008 Physician Israel
Primary
Secondary
Concomitant
Skin Laceration Disability 3/31/2008 Female 6/16/2008 Other Health Professional Italy
Primary
Concomitant
Hepatocellular Injury Other Serious 3/7/2007 44 Female 121 lb 6/24/2008 Physician France
Primary
Secondary
Concomitant
Blood Lactate Dehydrogenase Increased Other Serious 5/30/2008 38 Female 176 lb 7/2/2008 Other Health Professional Germany
Primary
Concomitant
Femur Fracture Hospitalization 3/23/2008 Female 7/17/2008 Physician France
Primary
Secondary
Subileus Life Threatening 2/23/2007 65 Female 9/25/2008 Other Health Professional Czech Republic
Primary
Secondary
Concomitant
Skin Laceration Disability 3/31/2008 Female 9/29/2008 Other Health Professional Italy
Primary
Concomitant
Subileus Life Threatening 2/23/2007 65 Female 10/14/2008 Other Health Professional Czech Republic
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious Female 2/17/2009 Physician Belgium
Primary
Concomitant
Metastases To Liver Hospitalization Female 4/28/2009 Consumer United States
Primary
Concomitant
Ocular Neoplasm Other Serious 34 Female 5/13/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Metastases To Liver Hospitalization Female 5/26/2009 Consumer United States
Primary
Concomitant
Hypoglycaemia Hospitalization 7/6/2009 Male 7/15/2009 Physician Ireland
Primary
Secondary
Concomitant
Hypotension Hospitalization 7/6/2009 Male 7/28/2009 Physician Ireland
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/25/2009 Female 117 lb 8/4/2009 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Hypotension Hospitalization 7/6/2009 Male 8/14/2009 Physician Ireland
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/25/2009 Female 117 lb 9/3/2009 Physician Korea, Republic Of
Primary
Secondary
Weight Decreased Hospitalization 3/5/2009 74 Female 9/4/2009 Other Health Professional France
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 34 Female 9/30/2009 Physician Poland
Primary
Secondary
Concomitant
Infection Hospitalization 9/14/2009 Female 154 lb 10/5/2009 Physician Ireland
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Other Serious Female 10/15/2009 Physician United States
Primary
Secondary
Confusional State Hospitalization 49 Female 10/21/2009 Physician France
Primary
Concomitant
Infection Hospitalization 9/14/2009 Female 154 lb 10/22/2009 Physician Ireland
Primary
Secondary
Concomitant
Skin Fissures Other Serious 11/1/2006 Female 10/30/2009 Consumer United States
Primary
Secondary
Concomitant
Post Procedural Haemorrhage Hospitalization 10/1/2009 Female 10/30/2009 Physician Germany
Primary
Secondary
Pyrexia Hospitalization 7/25/2009 Female 117 lb 11/4/2009 Physician Korea, Republic Of
Primary
Secondary
Skin Fissures Other Serious 1/1/2008 Female 11/11/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Arrhythmia Hospitalization Female 11/16/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Arrhythmia Hospitalization 10/24/2009 Female 11/19/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Infection Hospitalization 9/14/2009 Female 154 lb 12/4/2009 Physician Ireland
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 10/13/2009 Female 12/28/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Metastatic Gastric Cancer Death 1/1/2009 1/27/2010 Physician Netherlands
Primary
Secondary
Ventricular Fibrillation Life Threatening 2/1/2010 45 Female 2/18/2010 Physician Belgium
Primary
Concomitant
Metastases To Central Nervous System Other Serious Female 2/22/2010 Pharmacist Canada
Primary
Secondary
Ventricular Fibrillation Life Threatening 12/1/2009 45 Female 2/24/2010 Physician Belgium
Primary
Concomitant
Vomiting Hospitalization 48 Female 2/25/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 10/13/2009 Female 2/26/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 48 Female 3/2/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Other Serious 2/1/2010 65 Female 3/5/2010 Physician Venezuela
Primary
Concomitant
Loss Of Consciousness Death 49 Female 176 lb 3/10/2010 Physician Poland
Primary
Concomitant
Tooth Loss Other Serious Female 3/11/2010 Physician Portugal
Primary
Secondary
Vomiting Hospitalization 48 Female 3/16/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/4/2009 Female 121 lb 3/23/2010 Physician France
Primary
Secondary
Concomitant
Ventricular Fibrillation Life Threatening 45 Female 176 lb 3/24/2010 Physician Belgium
Primary
Secondary
Concomitant
Disease Progression Death 1/1/2008 Female 3/31/2010 Physician Netherlands
Primary
Secondary
Disease Progression Death 1/1/2008 51 Female 4/1/2010 Physician Netherlands
Primary
Secondary
Dyspnoea Other Serious Female 4/13/2010 Consumer United States
Primary
Secondary
Hyponatraemia Hospitalization 4/6/2010 61 Male 169 lb 4/16/2010 Physician China
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 4/6/2010 61 Male 169 lb 4/27/2010 Physician China
Primary
Secondary
Concomitant
Disease Progression Death 1/1/2008 51 Female 4/28/2010 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Performance Status Decreased Hospitalization 4/18/2010 71 Female 4/29/2010 Physician France
Primary
Secondary
Weight Decreased Other Serious 3/13/2010 33 Female 5/14/2010 Consumer United States
Primary
Secondary
Disease Progression Other Serious 36 Female 6/9/2010 Consumer Canada
Primary
Secondary
Concomitant
Metastases To Central Nervous System Other Serious Female 6/28/2010 Physician United States
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 4/18/2010 71 Female 7/28/2010 Physician France
Primary
Secondary
Diarrhoea Hospitalization 4/18/2010 71 Female 8/12/2010 Physician France
Primary
Secondary
Diarrhoea Hospitalization 4/18/2010 71 Female 9/13/2010 Physician France
Primary
Secondary
Urinary Tract Infection Other Serious Male 9/28/2010 United States
Primary
Secondary
Concomitant
Skin Ulcer Other Serious Female 10/4/2010 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/1995 47 Male 10/5/2010 United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 7/26/2006 59 Male 10/13/2010 United States
Primary
Secondary
Concomitant
Transaminases Increased Female 10/29/2010 Physician United States
Primary
Secondary
Concomitant
Toxic Skin Eruption Other Serious 1/1/2007 52 Female 11/5/2010 Consumer Spain
Primary
Secondary
Disease Progression Other Serious 1/1/2008 11/18/2010 Consumer Finland
Primary
Secondary
Concomitant
Weight Decreased Other Serious 7/26/2006 59 Male 11/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Skin Nodule Other Serious 1/1/2008 65 Female 11/22/2010 Physician Brazil
Primary
Secondary
Malignant Neoplasm Progression Other Serious Female 11/24/2010 Consumer Spain
Primary
Secondary
Concomitant
Drug Toxicity Other Serious Female 12/1/2010 Other Health Professional Australia
Primary
Secondary
Weight Decreased Other Serious 7/26/2006 59 Male 12/14/2010 United States
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Other Serious 72 Female 106 lb 1/14/2011 Physician Japan
Primary
Secondary
Concomitant
Infection Hospitalization 10/19/2010 48 Female 143 lb 2/2/2011 Physician Spain
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 11/1/2010 64 Female 2/4/2011 Other Health Professional Poland
Primary
Secondary
Concomitant
Renal Mass Other Serious Male 2/4/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Acute Respiratory Failure Hospitalization 10/1/2010 48 Female 143 lb 2/7/2011 Physician Spain
Primary
Concomitant
Diarrhoea Other Serious 9/1/2009 60 Female 2/25/2011 Physician Czech Republic
Primary
Concomitant
Ataxia Hospitalization 4/11/2011 80 Male 4/22/2011 Physician United States
Primary
Secondary
Concomitant
Skin Toxicity Other Serious 1/24/2011 62 Female 5/9/2011 Consumer Italy
Primary
Concomitant
Cough Life Threatening 1/20/2011 67 Female 5/13/2011 Consumer Germany
Primary
Concomitant
Erythema Multiforme Hospitalization 1/24/2011 47 Female 5/19/2011 Consumer Greece
Primary
Secondary
Erythema Multiforme Hospitalization 1/24/2011 47 Female 209 lb 5/20/2011 Other Health Professional Greece
Primary
Secondary
Asthma Life Threatening 1/20/2011 67 Female 5/25/2011 Consumer Germany
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 8/1/2007 49 Female 5/26/2011 Consumer United States
Primary
Secondary
Asthma Life Threatening 1/20/2011 67 Female 5/31/2011 Physician Germany
Primary
Secondary
Concomitant
Disease Progression Other Serious Female 177 lb 6/8/2011 Pharmacist Ireland
Primary
Secondary
Mouth Ulceration Other Serious Female 6/9/2011 Pharmacist Ireland
Primary
Concomitant

Drug Data