Lapatinib combined with Vinorelbine

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pain Other Serious 10/31/2006 47 Male 11/1/2006 United States
Primary
Secondary
Pancytopenia Life Threatening 12/1/2006 37 Female 4/12/2007 Physician United States
Primary
Secondary
Concomitant
Wound Dehiscence Hospitalization 9/19/2007 Male 183 lb 9/24/2007 United States
Primary
Secondary
Concomitant
Wound Dehiscence Hospitalization 9/19/2007 Male 183 lb 10/2/2007 United States
Primary
Secondary
Concomitant
Treatment Noncompliance Other Serious 2/7/2008 36 Female 3/10/2008 United States
Primary
Secondary
Concomitant
Urinary Incontinence Death 2/19/2008 Female 126 lb 5/6/2008 Other Health Professional United States
Primary
Secondary
Pulmonary Mass Death 6/8/2008 Male 174 lb 6/12/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 6/21/2008 53 Male 80 lb 7/2/2008 Physician United States
Primary
Secondary
Pyrexia Hospitalization 7/16/2008 76 Female 170 lb 7/25/2008 Physician United States
Primary
Secondary
Pyrexia Hospitalization 7/16/2008 76 Female 170 lb 8/7/2008 Physician United States
Primary
Secondary
Vomiting Death 8/10/2008 Female 9/30/2008 Physician Italy
Primary
Secondary
Thrombocytopenia Hospitalization 9/18/2008 10/1/2008 Physician Italy
Primary
Secondary
Vomiting Hospitalization 12/22/2007 62 Female 10/10/2008 Physician France
Primary
Secondary
Vomiting Death 8/10/2008 65 Female 10/14/2008 Physician Italy
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 9/18/2008 58 Female 128 lb 10/29/2008 Physician Italy
Primary
Secondary
Thrombocytopenia Hospitalization 9/18/2008 58 Female 128 lb 11/5/2008 Physician Italy
Primary
Secondary
Thrombocytopenia Hospitalization 9/18/2008 58 Female 128 lb 11/10/2008 Physician Italy
Primary
Secondary
Thrombocytopenia Hospitalization 9/18/2008 58 Female 128 lb 11/12/2008 Physician Italy
Primary
Secondary
Thrombocytopenia Hospitalization 9/18/2008 58 Female 128 lb 11/24/2008 Physician Italy
Primary
Secondary
Thrombocytopenia Hospitalization 9/18/2008 58 Female 128 lb 12/1/2008 Physician Italy
Primary
Secondary
Vomiting Death 8/10/2008 65 Female 12/2/2008 Physician Italy
Primary
Secondary
Concomitant
Vomiting Death 8/10/2008 65 Female 12/9/2008 Physician Italy
Primary
Secondary
Concomitant
Stomatitis Hospitalization 12/14/2008 56 Female 157 lb 12/29/2008 Physician France
Primary
Secondary
Stomatitis Hospitalization 12/14/2008 56 Female 157 lb 1/15/2009 Physician France
Primary
Secondary
Febrile Neutropenia Other Serious 7/16/2008 76 Female 157 lb 3/13/2009 Physician United States
Primary
Secondary
Abdominal Pain Hospitalization 3/13/2009 70 Female 142 lb 3/19/2009 Physician United States
Primary
Secondary
Constipation Hospitalization 3/13/2009 70 Female 142 lb 4/2/2009 Physician United States
Primary
Secondary
Abdominal Pain Hospitalization 3/13/2009 70 Female 142 lb 4/14/2009 Physician United States
Primary
Secondary
Stomatitis Other Serious 5/11/2009 54 Female 200 lb 5/18/2009 Physician United States
Primary
Secondary
Duodenal Ulcer Hospitalization 5/25/2009 54 Female 200 lb 6/2/2009 Physician United States
Primary
Secondary
Stomatitis Hospitalization 5/11/2009 57 Female 184 lb 6/2/2009 Physician United States
Primary
Secondary
Stomatitis Other Serious 5/11/2009 54 Female 200 lb 6/9/2009 Physician United States
Primary
Secondary
Neutropenia Other Serious 4/29/2009 Female 174 lb 7/13/2009 Physician France
Primary
Secondary
Concomitant
Neutropenia Other Serious 10/30/2008 Female 137 lb 7/13/2009 Physician France
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Other Serious 64 Female 8/28/2009 Other Health Professional France
Primary
Secondary
Stomatitis Hospitalization 5/11/2009 57 Female 184 lb 9/28/2009 Physician United States
Primary
Secondary
Abdominal Pain Hospitalization 10/10/2009 64 Female 185 lb 10/21/2009 Physician United States
Primary
Secondary
Concomitant
Stomatitis Hospitalization 5/11/2009 57 Female 184 lb 10/27/2009 Physician United States
Primary
Secondary
Oesophagitis Hospitalization 5/25/2009 54 Female 200 lb 11/5/2009 Physician United States
Primary
Secondary
Concomitant
Stomatitis Hospitalization 10/24/2009 Female 11/6/2009 Physician Turkey
Primary
Secondary
Concomitant
Vomiting Other Serious 48 Female 11/13/2009 Physician United Kingdom
Primary
Secondary
Vomiting Other Serious 48 Female 11/23/2009 Consumer United Kingdom
Primary
Secondary
Stomatitis Hospitalization 10/24/2009 Female 168 lb 11/25/2009 Physician Turkey
Primary
Secondary
Concomitant
Oesophagitis Hospitalization 5/25/2009 54 Female 200 lb 11/25/2009 Physician United States
Primary
Secondary
Concomitant
Abdominal Pain Hospitalization 10/10/2009 64 Female 185 lb 11/25/2009 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 48 Female 11/26/2009 Other Health Professional United Kingdom
Primary
Secondary
Vomiting Other Serious 48 Female 12/7/2009 Other Health Professional United Kingdom
Primary
Secondary
Stomatitis Hospitalization 10/24/2009 Female 168 lb 12/11/2009 Physician Turkey
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 12/3/2009 60 Female 183 lb 12/15/2009 Physician United States
Primary
Secondary
Hyponatraemia Hospitalization 12/3/2009 64 Female 183 lb 12/16/2009 Physician United States
Primary
Secondary
Vomiting Other Serious 48 Female 12/28/2009 Physician United Kingdom
Primary
Secondary
Vomiting Hospitalization 48 Female 12/30/2009 Other Health Professional United Kingdom
Primary
Secondary
Vomiting Other Serious 48 Female 1/4/2010 Physician United Kingdom
Primary
Secondary
Vomiting Other Serious 48 Female 1/7/2010 Physician United Kingdom
Primary
Secondary
Hyponatraemia Hospitalization 12/3/2009 64 Female 183 lb 1/28/2010 Physician United States
Primary
Secondary
Hyperbilirubinaemia Life Threatening 1/25/2010 Female 150 lb 1/29/2010 Physician Peru
Primary
Secondary
Concomitant
Vomiting Other Serious 48 Female 2/1/2010 Other Health Professional United Kingdom
Primary
Secondary
Febrile Neutropenia Other Serious 7/16/2008 76 Female 157 lb 2/9/2010 Physician United States
Primary
Secondary
Hyperbilirubinaemia Life Threatening 1/25/2010 Female 150 lb 2/19/2010 Physician Peru
Primary
Secondary
Concomitant
Vomiting Hospitalization 48 Female 2/25/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 12/3/2009 64 Female 183 lb 2/26/2010 Physician United States
Primary
Secondary
Oedema Peripheral Hospitalization 10/10/2009 64 Female 185 lb 3/2/2010 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 48 Female 3/2/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 48 Female 3/4/2010 Other Health Professional United Kingdom
Primary
Secondary
Abdominal Pain Hospitalization 10/10/2009 64 Female 185 lb 3/11/2010 Physician United States
Primary
Secondary
Concomitant
Vomiting Life Threatening 3/8/2010 Female 95 lb 3/15/2010 Physician France
Primary
Secondary
Concomitant
Neuropathy Peripheral Other Serious 48 Female 3/23/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Vomiting Life Threatening 3/8/2010 73 Female 95 lb 3/22/2010 France
Primary
Secondary
Concomitant
Vomiting Life Threatening 3/8/2010 73 Female 95 lb 4/1/2010 Physician France
Primary
Secondary
Concomitant
Vomiting Life Threatening 3/8/2010 73 Female 95 lb 3/22/2010 Other Health Professional France
Primary
Secondary
Concomitant
Vomiting Life Threatening 3/8/2010 73 Female 95 lb 4/9/2010 Physician France
Primary
Secondary
Concomitant
Vomiting Life Threatening 3/8/2010 73 Female 95 lb 4/7/2010 Physician France
Primary
Secondary
Concomitant
Tachycardia Life Threatening 3/8/2010 73 Female 95 lb 4/8/2010 Physician France
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/22/2010 74 Female 220 lb 5/7/2010 Physician Turkey
Primary
Secondary
Abdominal Pain Hospitalization 3/13/2009 70 Female 142 lb 5/25/2010 Physician United States
Primary
Secondary
Stomatitis Hospitalization 5/11/2009 57 Female 184 lb 5/25/2010 Physician United States
Primary
Secondary
Disease Progression Other Serious 36 Female 6/9/2010 Consumer Canada
Primary
Secondary
Concomitant
Vomiting Life Threatening 3/8/2010 73 Female 95 lb 6/22/2010 Physician France
Primary
Secondary
Concomitant
Vomiting Life Threatening 3/8/2010 73 Female 95 lb 6/29/2010 Physician France
Primary
Secondary
Concomitant
Stomatitis Hospitalization 5/11/2009 57 Female 184 lb 6/28/2010 Physician United States
Primary
Secondary
Metastases To Central Nervous System Other Serious Female 6/28/2010 Physician United States
Primary
Secondary
Concomitant
Hepatic Pain Hospitalization 6/6/2010 44 Female 225 lb 6/24/2010 Physician France
Primary
Secondary
Concomitant
Vomiting Life Threatening 3/8/2010 73 Female 95 lb 6/23/2010 Other Health Professional France
Primary
Secondary
Concomitant
Stomatitis Hospitalization 5/11/2009 57 Female 184 lb 7/12/2010 Physician United States
Primary
Secondary
Neutropenia Hospitalization 12/3/2009 64 Female 183 lb 7/12/2010 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/16/2010 74 Female 220 lb 7/20/2010 Physician Turkey
Primary
Secondary
Neutropenia Other Serious 2/27/2009 53 Female 186 lb 7/23/2010 Physician United States
Primary
Secondary
Vomiting Life Threatening 3/8/2010 73 Female 95 lb 7/27/2010 Physician France
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/16/2010 74 Female 220 lb 7/28/2010 Physician Turkey
Primary
Secondary
Neutropenia Hospitalization 12/3/2009 64 Female 183 lb 8/23/2010 Physician United States
Primary
Secondary
Concomitant
Neutropenia Other Serious 7/23/2009 38 Female 158 lb 10/18/2010 Physician United States
Primary
Secondary
Malignant Neoplasm Progression Death Female 117 lb 12/3/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Gamma-glutamyltransferase Increased Hospitalization 6/6/2010 44 Female 225 lb 11/17/2010 Consumer France
Primary
Secondary
Concomitant
Neutropenia Other Serious 2/27/2009 53 Female 186 lb 12/20/2010 Physician United States
Primary
Secondary
Febrile Infection Hospitalization 12/30/2010 79 Female 143 lb 1/5/2011 Physician Germany
Primary
Secondary
Infection Hospitalization 12/30/2010 79 Female 143 lb 1/12/2011 Physician Germany
Primary
Secondary
Cough Hospitalization 12/29/2010 79 Female 143 lb 1/25/2011 Physician Germany
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 11/1/2010 64 Female 2/4/2011 Other Health Professional Poland
Primary
Secondary
Concomitant
Cough Hospitalization 12/29/2010 79 Female 143 lb 2/4/2011 Physician Germany
Primary
Secondary
Concomitant
Infection Hospitalization 12/29/2010 79 Female 143 lb 3/16/2011 Physician Germany
Primary
Secondary
Concomitant
Neutropenia Hospitalization 12/29/2010 79 Female 143 lb 3/24/2011 Physician Germany
Primary
Secondary
Dehydration Hospitalization 4/20/2011 49 Female 233 lb 4/25/2011 Physician United States
Primary
Secondary
Dehydration Hospitalization 4/20/2011 49 Female 233 lb 4/27/2011 Physician United States
Primary
Secondary
Neutropenia Other Serious 5/5/2011 50 Female 175 lb 5/18/2011 Physician Poland
Primary
Secondary
Neutropenia Other Serious 5/10/2011 54 Female 187 lb 5/18/2011 Physician Poland
Primary
Secondary
Dehydration Hospitalization 4/20/2011 49 Female 233 lb 5/19/2011 Physician United States
Primary
Secondary
Neutropenia Other Serious 5/5/2011 50 Female 175 lb 5/25/2011 Physician Poland
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 59 Female 6/24/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Osteonecrosis Of Jaw Other Serious 59 Female 6/24/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Neutropenia Other Serious 5/10/2011 54 Female 187 lb 7/5/2011 Physician Poland
Primary
Secondary
Neutropenia Other Serious 10/27/2008 49 Female 112 lb 7/13/2011 Physician United States
Primary
Secondary
Disease Progression Death Female 7/28/2011 Physician Algeria
Primary
Secondary
Concomitant
Neutropenia Other Serious 7/26/2011 32 Female 115 lb 8/18/2011 Physician Poland
Primary
Secondary
Neutropenia Other Serious 7/26/2011 32 Female 115 lb 8/24/2011 Physician Poland
Primary
Secondary
Dermatitis Acneiform Other Serious 9/26/2011 Other Health Professional Australia
Primary
Concomitant
Ejection Fraction Decreased Other Serious 47 Female 10/20/2011 Consumer United States
Primary
Secondary
Concomitant
Hypotension Other Serious 47 Female 10/21/2011 Consumer United States
Primary
Secondary
Concomitant
Dehydration Hospitalization 10/18/2011 48 Female 150 lb 10/24/2011 Physician Brazil
Primary
Secondary
Dehydration Hospitalization 10/18/2011 48 Female 150 lb 11/1/2011 Physician Brazil
Primary
Secondary
Dehydration Hospitalization 10/18/2011 48 Female 150 lb 11/14/2011 Physician Brazil
Primary
Secondary
Febrile Neutropenia Hospitalization 11/22/2011 40 Female 112 lb 11/30/2011 Physician Poland
Primary
Secondary
Concomitant
Neutropenia Other Serious 6/25/2010 56 Female 147 lb 12/6/2011 Physician Poland
Primary
Secondary
Diarrhoea Other Serious 11/22/2011 40 Female 112 lb 12/9/2011 Physician Poland
Primary
Secondary
Concomitant
Dehydration Hospitalization 4/20/2011 49 Female 233 lb 1/9/2012 Physician United States
Primary
Secondary
Anaemia Hospitalization 1/23/2012 53 Female 132 lb 1/27/2012 Physician Poland
Primary
Secondary
Anaemia Hospitalization 2/1/2012 62 Female 132 lb 2/3/2012 Physician Poland
Primary
Secondary
Anaemia Hospitalization 3/14/2012 62 Female 132 lb 3/20/2012 Physician Poland
Primary
Secondary
Electrocardiogram Pr Prolongation Other Serious 3/27/2012 Other Health Professional Turkey
Primary
Concomitant
Febrile Neutropenia Hospitalization 4/15/2012 36 Female 153 lb 4/23/2012 Physician Peru
Primary
Secondary
Febrile Neutropenia Other Serious 4/20/2012 63 Female 172 lb 5/7/2012 Physician Chile
Primary
Secondary
Febrile Neutropenia Hospitalization 4/15/2012 36 Female 153 lb 5/9/2012 Physician Peru
Primary
Secondary
Neutropenia Other Serious 2/9/2012 60 Female 164 lb 6/29/2012 Physician Chile
Primary
Secondary
Febrile Neutropenia Other Serious 4/19/2012 63 Female 172 lb 6/29/2012 Physician Chile
Primary
Secondary
Anaemia Hospitalization 7/4/2012 62 Female 132 lb 7/9/2012 Physician Poland
Primary
Secondary
Alanine Aminotransferase Increased Other Serious 5/21/2012 60 Female 154 lb 7/11/2012 Physician United States
Primary
Concomitant
Anaemia Hospitalization 7/4/2012 62 Female 132 lb 7/25/2012 Physician Poland
Primary
Secondary
Disease Recurrence Other Serious 1/1/2006 45 Female 8/3/2012 Physician Australia
Primary
Secondary
Concomitant
Anaemia Hospitalization 1/23/2012 53 Female 132 lb 8/8/2012 Physician Poland
Primary
Secondary
Disease Progression Other Serious 43 148 lb 8/14/2012 Physician Australia
Primary
Secondary
Concomitant
Neutropenia Other Serious 6/25/2010 56 Female 147 lb 10/4/2012 Physician Pl
Primary
Secondary
Neutropenia Other Serious 2/9/2012 61 Female 164 lb 9/17/2012 Physician Cl
Primary
Secondary
Neutropenia Other Serious 8/6/2012 55 Female 110 lb 9/17/2012 Physician Pl
Primary
Secondary
Vomiting Other Serious 5/2011 62 Female 117 lb 9/27/2012 Physician Be
Primary
Secondary
Disease Progression Other Serious Female 143 lb 3/22/2013 Physician Au
Primary
Secondary
Concomitant
Liver Disorder Other Serious 5/20/2008 72 Female 12/14/2012 Physician Be
Primary
Secondary
Concomitant
Disease Progression Other Serious Female 11/7/2012 Physician Dk
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious 5/1/2011 46 Female 150 lb 11/26/2012 Physician Be
Primary
Secondary
Disease Progression Other Serious Female 11/30/2012 Physician Dk
Primary
Secondary
Concomitant
Vomiting Other Serious Female 132 lb 12/10/2012 Physician Be
Primary
Secondary
Disease Progression Other Serious 59 Female 12/11/2012 Physician Dk
Primary
Secondary

Drug Data