Lapatinib combined with Trastuzumab

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Febrile Neutropenia Hospitalization 2/19/2007 76 Female 170 lb 3/27/2007 Physician United States
Primary
Secondary
Neutropenia Other Serious 10/26/2006 44 Female 123 lb 4/4/2007 Physician France
Primary
Secondary
Dehydration Hospitalization 3/27/2007 55 Female 123 lb 4/4/2007 Physician United States
Primary
Secondary
Concomitant
Rales Hospitalization 3/20/2007 46 Female 90 lb 4/11/2007 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Neutropenia Other Serious 10/26/2006 44 Female 123 lb 4/17/2007 Physician France
Primary
Secondary
Rales Hospitalization 3/20/2007 46 Female 90 lb 4/17/2007 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Ejection Fraction Decreased Death 1/19/2007 Female 4/17/2007 Physician United Kingdom
Primary
Secondary
Ventricular Dysfunction Other Serious 2/14/2007 47 Female 186 lb 4/19/2007 Physician United States
Primary
Secondary
Dehydration Hospitalization 3/27/2007 55 Female 123 lb 4/20/2007 Physician United States
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 12/4/2006 Female 4/20/2007 Physician United Kingdom
Primary
Secondary
Rales Hospitalization 3/20/2007 46 Female 90 lb 4/27/2007 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Ejection Fraction Decreased Other Serious 5/23/2007 42 Female 148 lb 6/1/2007 Physician Ireland
Primary
Secondary
Rales Hospitalization 3/20/2007 46 Female 90 lb 6/1/2007 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Ejection Fraction Decreased Other Serious 5/23/2007 42 Female 148 lb 6/11/2007 Physician Ireland
Primary
Secondary
Neutropenia Other Serious 10/26/2006 44 Female 123 lb 6/20/2007 Physician France
Primary
Secondary
Weight Decreased Hospitalization 8/30/2006 51 Female 137 lb 6/22/2007 Physician United States
Primary
Secondary
Ejection Fraction Decreased Other Serious 5/23/2007 42 Female 148 lb 7/3/2007 Physician Ireland
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 2/19/2007 76 Female 170 lb 7/25/2007 Physician United States
Primary
Secondary
Weight Decreased Hospitalization 8/30/2006 51 Female 137 lb 8/3/2007 Physician United States
Primary
Secondary
Hypokalaemia Hospitalization 6/6/2006 49 Female 156 lb 8/23/2007 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/23/2006 37 Female 138 lb 8/24/2007 Physician United States
Primary
Secondary
Vomiting Other Serious 6/27/2007 56 Female 148 lb 8/28/2007 Physician Australia
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/31/2006 37 Female 138 lb 9/4/2007 Physician United States
Primary
Secondary
Ejection Fraction Decreased Death 1/19/2007 Female 9/11/2007 Physician United Kingdom
Primary
Secondary
Tachycardia Life Threatening 7/20/2007 26 Female 150 lb 9/17/2007 Physician Italy
Primary
Secondary
Vomiting Hospitalization 10/31/2006 36 Female 138 lb 10/5/2007 Physician United States
Primary
Secondary
Febrile Neutropenia Hospitalization 9/25/2007 65 Female 155 lb 10/17/2007 Physician Ireland
Primary
Secondary
Pruritus Hospitalization 8/18/2007 74 Female 168 lb 10/26/2007 Physician Germany
Primary
Secondary
Concomitant
Skin Reaction Hospitalization 8/18/2007 74 Female 168 lb 11/8/2007 Physician Germany
Primary
Secondary
Concomitant
Right Ventricular Failure Hospitalization 11/19/2007 64 Female 11/30/2007 Physician Germany
Primary
Secondary
Renal Failure Hospitalization 11/23/2007 72 Female 132 lb 12/4/2007 Physician United States
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 11/19/2007 64 Female 172 lb 12/17/2007 Physician Germany
Primary
Secondary
Infection Hospitalization 11/25/2007 Female 12/18/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Hospitalization 11/23/2007 72 Female 132 lb 1/7/2008 Physician United States
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 12/26/2007 53 Female 163 lb 1/10/2008 Physician United States
Primary
Secondary
Concomitant
Tachycardia Hospitalization 11/19/2007 64 Female 161 lb 1/21/2008 Physician Germany
Primary
Secondary
Infection Hospitalization 11/25/2007 Female 1/26/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Skin Reaction Disability 8/18/2007 74 Female 168 lb 1/28/2008 Physician Germany
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 12/26/2007 53 Female 163 lb 1/29/2008 Physician United States
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 12/1/2007 53 Female 1/31/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Lethargy Hospitalization 12/26/2007 Female 2/5/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Tachycardia Hospitalization 11/19/2007 64 Female 161 lb 2/6/2008 Physician Germany
Primary
Secondary
Acne Hospitalization 1/28/2008 33 Female 218 lb 2/12/2008 Physician Czech Republic
Primary
Secondary
Concomitant
Aspartate Aminotransferase Increased Other Serious 2/22/2008 22 Female 154 lb 2/28/2008 Physician Ireland
Primary
Secondary
Concomitant
Diarrhoea Other Serious 1/23/2008 44 Female 107 lb 3/4/2008 Physician Philippines
Primary
Secondary
Hepatic Enzyme Increased Other Serious 2/22/2008 22 Female 154 lb 3/17/2008 Physician Ireland
Primary
Secondary
Concomitant
Diarrhoea Other Serious 1/23/2008 44 Female 107 lb 4/3/2008 Physician Philippines
Primary
Secondary
Hepatic Enzyme Increased Other Serious 2/22/2008 22 Female 154 lb 4/9/2008 Physician Ireland
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 12/26/2007 53 Female 163 lb 4/17/2008 Physician United States
Primary
Secondary
Concomitant
Thrombosis Hospitalization 3/21/2008 41 Female 154 lb 4/17/2008 Physician Germany
Primary
Secondary
Concomitant
Urticaria Hospitalization 3/21/2008 41 Female 154 lb 4/18/2008 Physician Germany
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 12/1/2007 53 Female 4/21/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tachycardia Hospitalization 11/19/2007 64 Female 161 lb 5/29/2008 Physician Germany
Primary
Secondary
Neutropenia Other Serious 7/1/2008 56 Female 117 lb 7/22/2008 Physician Greece
Primary
Secondary
Hepatic Function Abnormal Other Serious 7/18/2008 41 Female 7/23/2008 Physician Pakistan
Primary
Secondary
Pulmonary Congestion Life Threatening Female 141 lb 7/24/2008 Physician Philippines
Primary
Secondary
Alanine Aminotransferase Increased Other Serious 6/30/2008 52 Female 172 lb 7/25/2008 Physician Germany
Primary
Secondary
Aspartate Aminotransferase Increased Other Serious 7/14/2008 54 Female 163 lb 7/25/2008 Physician Germany
Primary
Secondary
Pulmonary Hypertension Life Threatening 6/1/2008 Female 141 lb 7/29/2008 Physician Philippines
Primary
Secondary
Renal Failure Hospitalization 11/23/2007 72 Female 132 lb 7/31/2008 Physician United States
Primary
Secondary
Concomitant
Neutropenia Other Serious 5/9/2008 54 Female 278 lb 8/4/2008 Physician France
Primary
Secondary
Pulmonary Hypertension Life Threatening 6/1/2008 57 Female 141 lb 8/5/2008 Physician Philippines
Primary
Secondary
Myocardial Infarction Other Serious 4/21/2008 41 Female 119 lb 8/5/2008 Physician Switzerland
Primary
Secondary
Hepatic Enzyme Increased Other Serious 7/4/2008 59 Female 159 lb 8/6/2008 Physician Ireland
Primary
Secondary
Alanine Aminotransferase Increased Other Serious 6/30/2008 52 Female 172 lb 8/6/2008 Physician Germany
Primary
Secondary
Hypokalaemia Hospitalization 4/30/2008 58 Female 113 lb 8/6/2008 Physician France
Primary
Secondary
Neuropathy Peripheral Hospitalization 12/26/2007 53 Female 163 lb 8/7/2008 Physician United States
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Other Serious 6/30/2008 52 Female 172 lb 8/8/2008 Physician Germany
Primary
Secondary
Pyrexia Hospitalization 7/30/2008 54 Female 155 lb 8/8/2008 Physician Netherlands
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 7/18/2008 41 Female 8/11/2008 Physician Pakistan
Primary
Secondary
Hepatic Function Abnormal Other Serious 7/18/2008 41 Female 8/14/2008 Physician Pakistan
Primary
Secondary
Cardiac Failure Other Serious 8/5/2008 73 Female 127 lb 8/14/2008 Physician South Africa
Primary
Secondary
Pyrexia Hospitalization 7/30/2008 Female 8/18/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Aspartate Aminotransferase Increased Other Serious 8/14/2008 39 Female 123 lb 8/20/2008 Physician China
Primary
Secondary
Liver Function Test Abnormal Other Serious 8/12/2008 56 Female 119 lb 8/21/2008 Physician Greece
Primary
Secondary
Venous Pressure Jugular Increased Other Serious 8/5/2008 73 Female 127 lb 8/21/2008 Physician South Africa
Primary
Secondary
Cardiac Failure Congestive Other Serious 8/5/2008 57 Female 137 lb 8/21/2008 Physician Germany
Primary
Secondary
Guillain-barre Syndrome Hospitalization 12/26/2007 Female 8/21/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Oedema Other Serious 8/13/2008 38 Female 187 lb 8/25/2008 Physician Belgium
Primary
Secondary
Concomitant
Neutropenia Other Serious 5/9/2008 54 Female 278 lb 8/26/2008 Physician France
Primary
Secondary
Liver Function Test Abnormal Other Serious 8/12/2008 56 Female 119 lb 8/27/2008 Physician Greece
Primary
Secondary
Hypertension Hospitalization 8/14/2008 71 Female 163 lb 8/28/2008 Physician Poland
Primary
Secondary
Dizziness Hospitalization 8/18/2008 52 Female 187 lb 8/28/2008 Physician Germany
Primary
Secondary
Concomitant
Myocardial Infarction Other Serious 4/21/2008 41 Female 119 lb 9/4/2008 Physician Switzerland
Primary
Secondary
Aspartate Aminotransferase Increased Other Serious 7/14/2008 54 Female 163 lb 9/4/2008 Physician Germany
Primary
Secondary
Perihepatic Discomfort Other Serious 8/25/2008 47 Female 218 lb 9/4/2008 Physician South Africa
Primary
Secondary
Concomitant
Vertigo Hospitalization 8/19/2008 52 Female 187 lb 9/11/2008 Physician Germany
Primary
Secondary
Concomitant
Cardiac Failure Congestive Other Serious 8/5/2008 57 Female 137 lb 9/12/2008 Physician Germany
Primary
Secondary
Hepatitis A Antibody Positive Other Serious 8/14/2008 39 Female 123 lb 9/12/2008 Physician China
Primary
Secondary
Pyrexia Hospitalization 9/6/2008 41 Female 196 lb 9/12/2008 Physician Germany
Primary
Secondary
Hepatic Enzyme Increased Other Serious 6/11/2008 62 Female 165 lb 9/17/2008 Physician Switzerland
Primary
Secondary
Concomitant
Perihepatic Discomfort Other Serious 8/25/2008 47 Female 218 lb 9/17/2008 Physician South Africa
Primary
Secondary
Concomitant
Skin Toxicity Hospitalization 9/6/2008 41 Female 196 lb 9/18/2008 Physician Germany
Primary
Secondary
Pyrexia Hospitalization 9/4/2008 60 Female 121 lb 9/19/2008 Physician New Zealand
Primary
Secondary
Hepatic Enzyme Increased Other Serious 7/4/2008 59 Female 159 lb 9/26/2008 Physician Ireland
Primary
Secondary
Swelling Hospitalization 9/6/2008 41 Female 196 lb 9/26/2008 Physician Germany
Primary
Secondary
Pneumonia Hospitalization 9/19/2008 71 Female 132 lb 9/26/2008 Physician Germany
Primary
Secondary
Rash Other Serious 9/19/2008 43 Female 141 lb 9/26/2008 Physician Pakistan
Primary
Secondary
Swelling Hospitalization 9/6/2008 41 Female 196 lb 9/30/2008 Physician Germany
Primary
Secondary
Pleural Effusion Hospitalization 9/19/2008 71 Female 132 lb 10/1/2008 Physician Germany
Primary
Secondary
Pyrexia Hospitalization 9/9/2008 60 Female 121 lb 10/2/2008 Physician New Zealand
Primary
Secondary
Rash Other Serious 7/10/2008 65 Female 227 lb 10/6/2008 Physician Belgium
Primary
Secondary
Blood Bilirubin Increased Other Serious 7/17/2008 54 Female 130 lb 10/14/2008 Physician Romania
Primary
Secondary
Aspartate Aminotransferase Increased Other Serious 7/14/2008 54 Female 163 lb 10/14/2008 Physician Germany
Primary
Secondary
Rash Other Serious 9/19/2008 43 Female 141 lb 10/14/2008 Physician Pakistan
Primary
Secondary
Perihepatic Discomfort Other Serious 8/25/2008 47 Female 218 lb 10/17/2008 Physician South Africa
Primary
Secondary
Concomitant
Rash Other Serious 9/19/2008 43 Female 141 lb 10/23/2008 Physician Pakistan
Primary
Secondary
Urinary Tract Infection Hospitalization 10/16/2008 45 Female 166 lb 10/27/2008 Physician United States
Primary
Secondary
Blood Bilirubin Increased Other Serious 7/17/2008 54 Female 130 lb 10/27/2008 Physician Romania
Primary
Secondary
Aspartate Aminotransferase Increased Other Serious 8/14/2008 39 Female 123 lb 10/27/2008 Physician China
Primary
Secondary
Electrocardiogram Abnormal Hospitalization 9/30/2008 44 Female 138 lb 10/27/2008 Physician Belgium
Primary
Secondary
Concomitant
Pneumonia Life Threatening 9/19/2008 71 Female 132 lb 10/29/2008 Physician Germany
Primary
Secondary
Concomitant
Electrocardiogram Abnormal Hospitalization 9/30/2008 44 Female 138 lb 10/30/2008 Physician Belgium
Primary
Secondary
Concomitant
Rash Other Serious 9/19/2008 43 Female 141 lb 10/31/2008 Physician Pakistan
Primary
Secondary
Neutropenia Other Serious 8/11/2008 72 Female 201 lb 10/31/2008 Physician Spain
Primary
Secondary
Urinary Tract Infection Hospitalization 10/16/2008 45 Female 11/3/2008 Other Health Professional United Kingdom
Primary
Secondary
Neutropenia Other Serious 8/11/2008 72 Female 201 lb 11/3/2008 Physician Spain
Primary
Secondary
Rash Other Serious 9/19/2008 43 Female 141 lb 11/5/2008 Physician Pakistan
Primary
Secondary
Oedema Other Serious 8/13/2008 38 Female 187 lb 11/6/2008 Physician Belgium
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/30/2008 54 Female 155 lb 11/10/2008 Physician Netherlands
Primary
Secondary
Concomitant
Rash Other Serious 9/19/2008 43 Female 141 lb 11/12/2008 Physician Pakistan
Primary
Secondary
Hypothyroidism Hospitalization 11/4/2008 57 Female 203 lb 11/14/2008 Physician Israel
Primary
Secondary
Neutropenia Other Serious 10/28/2008 57 Female 203 lb 11/14/2008 Physician Israel
Primary
Secondary
Hypothyroidism Hospitalization 11/4/2008 57 Female 203 lb 11/14/2008 Physician Israel
Primary
Secondary
Transaminases Increased Other Serious Female 11/18/2008 Physician France
Primary
Concomitant
Chills Hospitalization 7/30/2008 Female 11/18/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Somnolence Hospitalization 10/21/2008 71 Female 132 lb 11/19/2008 Physician Germany
Primary
Secondary
Concomitant
Neutropenia Other Serious 8/11/2008 72 Female 201 lb 11/20/2008 Physician Spain
Primary
Secondary
Aspartate Aminotransferase Increased Other Serious 8/14/2008 39 Female 123 lb 11/21/2008 Physician China
Primary
Secondary
Tachycardia Hospitalization 11/4/2008 57 Female 203 lb 11/21/2008 Physician Israel
Primary
Secondary
Neutropenia Other Serious 10/28/2008 57 Female 203 lb 11/24/2008 Physician Israel
Primary
Secondary
Tachycardia Hospitalization 11/4/2008 57 Female 203 lb 12/2/2008 Physician Israel
Primary
Secondary
Tachycardia Hospitalization 11/19/2007 64 Female 161 lb 12/5/2008 Physician Germany
Primary
Secondary
Hypokalaemia Hospitalization 10/27/2008 45 Female 163 lb 12/5/2008 Physician Belgium
Primary
Secondary
White Blood Cell Count Decreased Other Serious 11/18/2008 Female 168 lb 12/9/2008 Physician United States
Primary
Secondary
Neutropenia Other Serious 12/3/2008 50 Female 194 lb 12/12/2008 Physician France
Primary
Secondary
Hypokalaemia Hospitalization 10/22/2008 45 Female 163 lb 12/12/2008 Physician Belgium
Primary
Secondary
Pyrexia Hospitalization 12/12/2008 54 Female 182 lb 12/19/2008 Physician United States
Primary
Secondary
Nausea Hospitalization 12/9/2008 52 Female 12/23/2008 Physician Germany
Primary
Secondary
Nausea Hospitalization 12/9/2008 52 Female 12/30/2008 Physician Germany
Primary
Secondary
Loss Of Consciousness Hospitalization 12/15/2008 56 Female 12/30/2008 Physician United Kingdom
Primary
Secondary
Aspartate Aminotransferase Increased Other Serious 8/14/2008 39 Female 123 lb 1/6/2009 Physician China
Primary
Secondary
Pneumonitis Other Serious 12/10/2008 63 Female 143 lb 1/7/2009 Physician Romania
Primary
Secondary
Rash Erythematous Hospitalization 1/3/2009 52 Female 161 lb 1/7/2009 Physician India
Primary
Secondary
Transfusion Reaction Hospitalization 12/12/2008 54 Female 182 lb 1/12/2009 Physician United States
Primary
Secondary
Neutropenia Other Serious 8/16/2006 33 Female 131 lb 1/15/2009 Physician Ireland
Primary
Secondary
Vomiting Hospitalization 11/9/2008 67 Female 157 lb 1/15/2009 Physician India
Primary
Secondary
Jaundice Other Serious 12/1/2008 47 Female 99 lb 1/16/2009 Physician India
Primary
Secondary
Rash Erythematous Hospitalization 1/3/2009 52 Female 161 lb 1/19/2009 Physician India
Primary
Secondary
Loss Of Consciousness Hospitalization 12/15/2008 56 Female 1/20/2009 Physician United Kingdom
Primary
Secondary

Drug Data