Lapatinib combined with Taxotere

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Febrile Neutropenia Hospitalization 9/25/2007 65 Female 155 lb 10/17/2007 Physician Ireland
Primary
Secondary
Vomiting Hospitalization 2/25/2008 61 Female 117 lb 3/10/2008 Physician United States
Primary
Secondary
Vomiting Hospitalization 2/25/2008 61 Female 117 lb 3/20/2008 Physician United States
Primary
Secondary
Vomiting Hospitalization 2/25/2008 61 Female 117 lb 4/28/2008 Physician United States
Primary
Secondary
Vomiting Hospitalization 2/25/2008 61 Female 117 lb 5/1/2008 Physician United States
Primary
Secondary
Anaemia Life Threatening 11/6/2008 77 Female 3/25/2009 Physician France
Primary
Secondary
Concomitant
No Therapeutic Response Other Serious 4/1/2009 48 Female 5/13/2009 Consumer Greece
Primary
Concomitant
Febrile Neutropenia Hospitalization 7/18/2009 Female 143 lb 7/28/2009 Physician Australia
Primary
Secondary
Febrile Neutropenia Hospitalization 7/18/2009 Female 143 lb 8/3/2009 Physician Australia
Primary
Secondary
Mucosal Inflammation Hospitalization 8/16/2009 54 Female 142 lb 8/24/2009 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/25/2008 61 Female 117 lb 8/31/2009 Physician United States
Primary
Secondary
Neutropenia Hospitalization 8/18/2009 Female 128 lb 10/1/2009 Physician France
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Other Serious Female 10/15/2009 Physician United States
Primary
Secondary
Neutropenia Hospitalization 10/3/2009 Female 104 lb 10/26/2009 Physician Taiwan, Province Of China
Primary
Secondary
Pericardial Effusion Other Serious 10/22/2009 Female 126 lb 11/23/2009 Physician Germany
Primary
Secondary
Concomitant
Neutropenia Hospitalization 10/29/2009 Female 104 lb 11/25/2009 Physician Taiwan, Province Of China
Primary
Secondary
Pericardial Effusion Other Serious 10/22/2009 Female 126 lb 12/9/2009 Physician Germany
Primary
Secondary
Concomitant
Stomatitis Hospitalization 2/11/2010 Female 128 lb 2/22/2010 Physician France
Primary
Secondary
Concomitant
Stomatitis Hospitalization 2/11/2010 Female 128 lb 3/31/2010 Physician France
Primary
Secondary
Concomitant
Metastases To Central Nervous System Hospitalization 4/7/2010 77 Female 4/19/2010 Physician France
Primary
Secondary
Concomitant
Metastases To Central Nervous System Hospitalization 4/7/2010 77 Female 4/27/2010 Physician France
Primary
Secondary
Concomitant
Metastases To Central Nervous System Hospitalization 4/7/2010 77 Female 4/29/2010 Physician France
Primary
Secondary
Concomitant
Electrocardiogram Abnormal Other Serious 6/25/2010 36 Female 134 lb 7/13/2010 Physician Philippines
Primary
Secondary
Concomitant
Fatigue Other Serious 6/25/2010 36 Female 134 lb 8/2/2010 Physician Philippines
Primary
Secondary
Concomitant
Stomatitis Other Serious 1/21/2010 77 Female 115 lb 8/9/2010 Physician France
Primary
Secondary
Concomitant
Fatigue Other Serious 6/25/2010 36 Female 134 lb 8/23/2010 Physician Philippines
Primary
Secondary
Concomitant
Polyneuropathy Hospitalization 10/20/2008 58 Female 185 lb 9/28/2010 Physician Denmark
Primary
Secondary
Concomitant
Stomatitis Other Serious 1/21/2010 77 Female 115 lb 9/28/2010 Physician France
Primary
Secondary
Concomitant
Vomiting Hospitalization 11/11/2010 47 Female 136 lb 11/19/2010 Physician United States
Primary
Secondary
Pneumomediastinum Death 48 Female 1/21/2011 Physician Ireland
Primary
Secondary
Neutropenia Other Serious 2/16/2011 39 Female 130 lb 4/5/2011 Physician France
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 6/21/2011 72 Female 139 lb 6/30/2011 Physician France
Primary
Secondary
Febrile Neutropenia Hospitalization 6/21/2011 72 Female 139 lb 7/19/2011 Physician France
Primary
Secondary
Gastritis Hospitalization 10/12/2011 40 Female 119 lb 10/24/2011 Physician Ireland
Primary
Secondary
Stomatitis Hospitalization 10/12/2011 40 Female 119 lb 11/1/2011 Physician Ireland
Primary
Secondary
Neutropenic Sepsis Hospitalization 11/3/2011 45 Female 159 lb 11/18/2011 Physician Ireland
Primary
Secondary
Concomitant
Neutropenic Sepsis Hospitalization 11/3/2011 45 Female 159 lb 11/22/2011 Physician Ireland
Primary
Secondary
Concomitant
Cytolytic Hepatitis Other Serious 9/23/2011 52 Female 152 lb 11/28/2011 Physician France
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 11/3/2011 45 Female 159 lb 11/28/2011 Physician Ireland
Primary
Secondary
Concomitant
Folliculitis Hospitalization 11/23/2011 40 Female 119 lb 12/5/2011 Physician Ireland
Primary
Secondary
Concomitant
Cytolytic Hepatitis Other Serious 9/23/2011 52 Female 152 lb 12/13/2011 Physician France
Primary
Secondary
Concomitant
Syncope Hospitalization 12/7/2011 52 Male 209 lb 12/8/2011 Consumer United States
Primary
Secondary
Concomitant
Folliculitis Hospitalization 11/23/2011 40 Female 119 lb 12/15/2011 Physician Ireland
Primary
Secondary
Concomitant
Neutropenic Sepsis Hospitalization 11/3/2011 45 Female 159 lb 2/3/2012 Physician Ireland
Primary
Secondary
Concomitant
Confusional State Death 4/16/2012 57 Male 398 lb 4/18/2012 Other Health Professional United States
Primary
Secondary
Nausea Hospitalization 4/27/2012 77 Male 145 lb 4/30/2012 Other Health Professional United States
Primary
Secondary
Breast Cancer Other Serious Female 6/13/2012 Physician United States
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 6/13/2012 29 Female 146 lb 6/21/2012 Physician Belgium
Primary
Secondary
Drug Ineffective Other Serious 4/1/2012 46 Female 7/3/2012 Consumer United States
Primary
Secondary
Alanine Aminotransferase Increased Other Serious 5/21/2012 60 Female 154 lb 7/11/2012 Physician United States
Primary
Concomitant
Neutropenia Hospitalization 6/13/2012 29 Female 146 lb 7/19/2012 Physician Belgium
Primary
Secondary
Pain In Jaw Other Serious 2/1/2010 Male 8/24/2012 Consumer United States
Primary
Concomitant
Wound Other Serious 6/9/2005 59 Female 5/8/2013 Consumer Us
Primary
Secondary
Concomitant
Drug-induced Liver Injury Other Serious 9/23/2011 52 Female 152 lb 12/6/2013 Physician Fr
Primary
Secondary
Concomitant
Rash Maculo-papular Hospitalization 10/11/2012 53 Female 110 lb 10/15/2013 Physician Ie
Primary
Secondary
Vomiting Other Serious 10/26/2012 70 Female 176 lb 11/12/2012 Physician Ie
Primary
Secondary
Concomitant
Tenderness Other Serious Female 2/11/2013 Physician Dk
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 2/2011 68 Female 119 lb 11/20/2012 Physician Be
Primary
Secondary
Concomitant
Superior Vena Cava Syndrome Other Serious 7/2011 Female 1/24/2013 Other Health Professional Dk
Primary
Secondary
Concomitant
Metastases To Central Nervous System Other Serious 11/30/2012 Physician Au
Primary
Secondary
Concomitant
Disease Progression Other Serious 10/26/2010 57 Female 1/29/2013 Physician Dk
Primary
Secondary
Tenderness Other Serious 2010 Female 2/17/2013 Physician Dk
Primary
Secondary
Concomitant
Liver Disorder Other Serious 58 Female 12/6/2012 Physician Ca
Primary
Secondary
Concomitant
Vomiting Other Serious Female 132 lb 12/10/2012 Physician Be
Primary
Secondary
Superior Vena Cava Syndrome Other Serious 64 Female 2/11/2013 Physician Dk
Primary
Secondary
Concomitant
Superior Vena Cava Syndrome Other Serious 64 Female 2/6/2013 Other Health Professional Dk
Primary
Secondary
Concomitant
Disease Progression Other Serious 59 Female 12/11/2012 Physician Dk
Primary
Secondary
Rash Other Serious 3/19/2010 44 Female 3/12/2013 Consumer Dk
Primary
Secondary
Concomitant
Metastases To Skin Other Serious 10/2005 Female 1/9/2013 Physician Dk
Primary
Secondary
Concomitant
Haematuria Hospitalization 1/3/2013 32 Female 134 lb 1/24/2013 Physician Ie
Primary
Secondary
Concomitant
Rash Other Serious Female 1/29/2013 Other Health Professional Dk
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 2/2008 Female 2/11/2013 Physician Dk
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 2/2008 Female 2/13/2013 Consumer Dk
Primary
Secondary
Concomitant
Rash Other Serious Female 1/25/2013 Physician Dk
Primary
Secondary
Tenderness Other Serious 2010 64 Female 2/14/2013 Physician Dk
Primary
Secondary
Concomitant
Rash Other Serious 2/2008 Female 3/14/2013 Physician Dk
Primary
Secondary
Concomitant
Metastases To Skin Other Serious 10/2005 Female 1/21/2013 Physician Dk
Primary
Secondary
Concomitant
Disease Progression Other Serious Female 2/7/2013 Physician Dk
Primary
Secondary
Fatigue Other Serious 6/25/2010 Female 134 lb 2/7/2013 Physician Ph
Primary
Secondary
Concomitant
Disease Progression Other Serious 10/26/2010 Female 2/8/2013 Physician Dk
Primary
Secondary
Disease Progression Other Serious 1/25/2013 Female 2/6/2013 Physician Dk
Primary
Secondary
Rash Other Serious Female 1/22/2013 Physician Dk
Primary
Secondary
Disease Progression Other Serious 3/2008 44 Female 3/7/2013 Physician At
Primary
Secondary
Concomitant
Metastatic Neoplasm Other Serious 2/2011 36 Female 6/17/2013 Physician Au
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious 47 Female 115 lb 1/28/2013 Physician Be
Primary
Secondary
Disease Progression Other Serious 1/25/2013 56 Female 2/15/2013 Physician Dk
Primary
Secondary
Rash Other Serious Female 2/15/2013 Physician Dk
Primary
Secondary
Concomitant
Rash Other Serious Female 1/16/2013 Other Health Professional Dk
Primary
Secondary
Disease Progression Other Serious 7/2011 49 Female 115 lb 2/21/2013 Physician Be
Primary
Secondary
Metastases To Skin Other Serious 57 Female 1/31/2013 Other Health Professional Dk
Primary
Secondary
Concomitant
Haematotoxicity Other Serious Female 2/21/2013 Physician Dk
Primary
Secondary
Disease Progression Other Serious Female 2/22/2013 Physician Dk
Primary
Secondary
Metastases To Bone Other Serious 12/22/2009 69 Female 8/21/2013 Physician At
Primary
Secondary
Concomitant
Haematotoxicity Other Serious Female 3/27/2013 Physician Dk
Primary
Secondary
Tenderness Other Serious 2010 Female 2/26/2013 Physician Dk
Primary
Secondary
Concomitant
Death Death 49 Female 115 lb 2/25/2013 Physician Be
Primary
Secondary
Haematotoxicity Other Serious Female 2/27/2013 Other Health Professional Dk
Primary
Secondary
Haematotoxicity Other Serious Female 2/27/2013 Other Health Professional Dk
Primary
Secondary
Cardiac Failure Congestive Hospitalization 8/16/2009 40 Female 231 lb 2/28/2013 Physician Us
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Other Serious Female 3/1/2013 Country Not Specified
Primary
Secondary
Haematotoxicity Other Serious Female 3/6/2013 Physician Dk
Primary
Secondary
Wound Other Serious 10/26/2010 57 Female 2/13/2013 Other Health Professional Dk
Primary
Secondary
Malignant Neoplasm Progression Other Serious 52 Female 2/28/2013 Dk
Primary
Secondary
Disease Progression Death Female 3/20/2013 Physician Au
Primary
Secondary
Concomitant
Metastasis Other Serious 6/2009 30 Female 4/18/2013 Physician Au
Primary
Secondary
Concomitant
Hypertension Other Serious 9/13/2010 71 Female 4/29/2013 Physician Dk
Primary
Secondary
Disease Progression Other Serious Female 7/1/2013 Physician Dk
Primary
Secondary
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 53 Female 4/11/2013 Physician Pl
Primary
Secondary
Concomitant
Disease Progression Other Serious NotSpecified 4/18/2013 Physician Au
Primary
Secondary
Concomitant
Hypertension Other Serious 9/13/2010 71 Female 5/8/2013 Physician Dk
Primary
Secondary
Hypertension Other Serious Female 5/15/2013 Physician Dk
Primary
Secondary
Disease Progression Other Serious 1/2011 55 Female 7/9/2013 Physician Dk
Primary
Secondary
Metastasis Other Serious 34 Female 5/16/2013 Physician Au
Primary
Secondary
Concomitant
Metastatic Neoplasm Other Serious Female 5/20/2013 Physician Dk
Primary
Secondary
Enteritis Hospitalization 5/9/2013 45 Female 6/7/2013 Physician Ie
Primary
Secondary
Concomitant
Metastatic Neoplasm Other Serious 6/2011 69 Female 5/30/2013 Consumer Dk
Primary
Secondary
Off Label Use Other Serious 69 Female 6/3/2013 Physician Dk
Primary
Secondary
Metastatic Neoplasm Other Serious Female 6/3/2013 Physician Dk
Primary
Secondary
Metastatic Neoplasm Other Serious Female 6/3/2013 Other Health Professional Dk
Primary
Secondary
Metastatic Neoplasm Other Serious 69 Female 6/4/2013 Physician Dk
Primary
Secondary
Metastases To Lung Other Serious 2011 Female 6/5/2013 Physician Au
Primary
Secondary
Concomitant
Femoral Neck Fracture Other Serious 8/24/2011 47 Female 6/7/2013 Physician Dz
Primary
Secondary
Metastases To Liver Other Serious 69 Female 6/3/2013 Other Health Professional Dk
Primary
Secondary
Concomitant
Skin Lesion Other Serious 10/26/2009 36 Female 258 lb 7/18/2013 Physician Be
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious 1/2009 76 Female 141 lb 7/1/2013 Physician Be
Primary
Secondary
Concomitant
Metastases To Central Nervous System Other Serious Female 7/30/2013 Physician Dk
Primary
Secondary
Concomitant
Disease Progression Death Female 8/27/2013 Physician Ie
Primary
Secondary
Concomitant
Disease Progression Other Serious Female 8/6/2013 Physician Dk
Primary
Secondary
Concomitant
Disease Progression Other Serious 62 Female 8/6/2013 Physician Dk
Primary
Secondary
Concomitant
Disease Progression Other Serious Female 8/2/2013 Physician Dk
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Other Serious Female 8/21/2013 Other Health Professional Dk
Primary
Secondary
Concomitant
Disease Progression Other Serious Female 7/25/2013 Physician Dk
Primary
Secondary
Concomitant
Off Label Use Other Serious 62 Female 8/27/2013 Physician Dk
Primary
Secondary
Concomitant
Disease Progression Hospitalization Female 8/23/2013 Physician Dk
Primary
Secondary
Concomitant
Disease Progression Hospitalization 62 Female 8/7/2013 Dk
Primary
Secondary
Concomitant
Disease Progression Other Serious Female 8/29/2013 Other Health Professional Dk
Primary
Secondary
Concomitant
Metastases To Central Nervous System Other Serious Female 8/12/2013 Physician Dk
Primary
Secondary
Concomitant
Non-hodgkin's Lymphoma Hospitalization 2004 Female 8/15/2013 Physician Au
Primary
Secondary
Concomitant
Metastases To Central Nervous System Other Serious Female 8/19/2013 Physician Dk
Primary
Secondary
Concomitant
Metastases To Central Nervous System Other Serious Female 8/28/2013 Physician Dk
Primary
Secondary
Concomitant
Metastases To Central Nervous System Other Serious Female 8/20/2013 Other Health Professional Dk
Primary
Secondary
Concomitant
Pain In Extremity Other Serious Female 134 lb 9/10/2013 Physician Us
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 10/2009 37 Female 156 lb 8/30/2013 Physician Us
Primary
Concomitant
Rash Other Serious 11/24/2010 59 Female 204 lb 9/4/2013 Physician Us
Primary
Concomitant
Skin Ulcer Death 2/2012 51 Female 137 lb 10/22/2013 Physician Us
Primary
Secondary
Concomitant
Weight Decreased Hospitalization Female 9/30/2013 Physician Us
Primary
Secondary
Concomitant
Peripheral Motor Neuropathy Hospitalization Female 10/4/2013 Physician Aw
Primary
Secondary
Concomitant
Stomatitis Hospitalization Female 11/21/2013 Physician Us
Primary
Secondary
Concomitant
Neutropenia Other Serious 2/16/2011 39 Female 130 lb 10/11/2013 Physician Fr
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 79 Female 134 lb 10/31/2013 Physician Us
Primary
Secondary

Drug Data