Lapatinib combined with Radiotherapy

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Stomatitis Hospitalization 2/14/2007 53 Female 3/5/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Pancytopenia Life Threatening 12/1/2006 37 Female 4/12/2007 Physician United States
Primary
Secondary
Concomitant
Local Swelling Hospitalization 4/6/2007 57 Female 165 lb 6/20/2007 Physician Netherlands
Primary
Secondary
Concomitant
Sinus Tachycardia Hospitalization 7/11/2007 42 Female 144 lb 7/17/2007 Physician Peru
Primary
Secondary
Concomitant
Localised Oedema Hospitalization 6/8/2007 57 Female 165 lb 7/18/2007 Physician Netherlands
Primary
Secondary
Concomitant
Renal Failure Other Serious 7/11/2007 42 Female 7/19/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 5/1/2004 50 Female 7/24/2007 Physician Spain
Primary
Secondary
Concomitant
Sinus Tachycardia Hospitalization 7/3/2007 42 Female 144 lb 7/26/2007 Physician Peru
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 6/8/2007 57 Female 165 lb 7/27/2007 Physician Netherlands
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 6/8/2007 57 Female 165 lb 7/30/2007 Physician Netherlands
Primary
Secondary
Concomitant
Pain Hospitalization 2/13/2007 53 Female 134 lb 8/20/2007 Physician France
Primary
Secondary
Concomitant
Renal Failure Hospitalization 10/29/2007 60 Male 181 lb 11/12/2007 Physician Belgium
Primary
Secondary
Hypertension Life Threatening 11/10/2007 50 11/19/2007 Physician India
Primary
Secondary
Concomitant
Renal Failure Hospitalization 10/16/2007 60 Male 181 lb 11/21/2007 Physician Belgium
Primary
Secondary
Concomitant
Renal Failure Hospitalization 10/16/2007 60 Male 181 lb 11/29/2007 Physician Belgium
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 5/1/2004 50 Female 12/13/2007 Physician Spain
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 6/27/2007 50 Female 12/13/2007 Physician Spain
Primary
Secondary
Concomitant
Renal Failure Hospitalization 10/29/2007 60 Male 174 lb 12/19/2007 Physician Belgium
Primary
Secondary
Concomitant
Renal Failure Hospitalization 10/29/2007 60 Male 174 lb 12/27/2007 Physician Belgium
Primary
Secondary
Concomitant
Hypertension Life Threatening 11/10/2007 50 1/4/2008 Physician India
Primary
Secondary
Concomitant
Sinus Tachycardia Hospitalization 7/3/2007 42 Female 144 lb 1/25/2008 Physician Peru
Primary
Secondary
Concomitant
Renal Failure Other Serious 7/3/2007 42 Female 1/29/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Mucosal Inflammation Other Serious 2/14/2008 48 Male 2/28/2008 Consumer United Kingdom
Primary
Secondary
Mucosal Inflammation Other Serious 2/14/2008 48 Male 3/5/2008 Consumer United Kingdom
Primary
Secondary
Soft Tissue Inflammation Hospitalization 4/9/2008 66 Male 168 lb 4/18/2008 Physician Spain
Primary
Secondary
Soft Tissue Inflammation Hospitalization 4/9/2008 66 Male 4/25/2008 Consumer United Kingdom
Primary
Secondary
Blood Bilirubin Abnormal Other Serious 4/17/2008 53 Male 210 lb 5/2/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Soft Tissue Inflammation Hospitalization 4/9/2008 66 Male 168 lb 5/5/2008 Physician Spain
Primary
Secondary
Soft Tissue Inflammation Hospitalization 4/9/2008 66 Male 5/8/2008 Consumer United Kingdom
Primary
Secondary
Mucosal Inflammation Other Serious 1/21/2008 48 Male 5/29/2008 Consumer United Kingdom
Primary
Secondary
Thrombophlebitis Hospitalization 41 Female 6/18/2008 Physician France
Primary
Secondary
Concomitant
Pyrexia Hospitalization 4/21/2008 51 Female 115 lb 6/19/2008 Physician Taiwan, Province Of China
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 8/5/2008 51 Male 183 lb 8/13/2008 Physician Austria
Primary
Secondary
Renal Failure Hospitalization 10/29/2007 60 Male 174 lb 8/14/2008 Physician Belgium
Primary
Secondary
Concomitant
Dysphagia Hospitalization 8/3/2008 48 Male 149 lb 8/15/2008 Physician Philippines
Primary
Secondary
Mucosal Inflammation Hospitalization 8/5/2008 51 Male 183 lb 8/28/2008 Physician Austria
Primary
Secondary
Mucosal Inflammation Hospitalization 8/5/2008 51 Male 183 lb 9/2/2008 Physician Austria
Primary
Secondary
Hypertension Life Threatening 11/10/2007 50 9/12/2008 Physician India
Primary
Secondary
Concomitant
Blood Creatinine Increased Other Serious 9/1/2008 59 Male 115 lb 9/16/2008 Physician Thailand
Primary
Secondary
Concomitant
Gastrointestinal Fistula Hospitalization 9/13/2008 48 Male 149 lb 9/25/2008 Physician Philippines
Primary
Secondary
Hypertension Hospitalization 11/10/2007 50 9/25/2008 Physician India
Primary
Secondary
Concomitant
Septic Shock Life Threatening 9/25/2008 58 Male 151 lb 10/6/2008 Physician Belgium
Primary
Secondary
Concomitant
Dysphagia Hospitalization 8/3/2008 48 Male 149 lb 10/8/2008 Physician Philippines
Primary
Secondary
Gastrointestinal Fistula Hospitalization 9/13/2008 48 Male 149 lb 10/9/2008 Physician Philippines
Primary
Secondary
Blood Creatinine Increased Other Serious 9/1/2008 59 Male 115 lb 10/15/2008 Physician Thailand
Primary
Secondary
Concomitant
Gastrointestinal Fistula Hospitalization 9/13/2008 48 Male 149 lb 10/20/2008 Physician Philippines
Primary
Secondary
Hyponatraemia Hospitalization 8/27/2008 51 Male 108 lb 10/22/2008 Physician India
Primary
Secondary
Metabolic Disorder Death 10/8/2008 48 Male 149 lb 10/23/2008 Physician Philippines
Primary
Secondary
Metabolic Disorder Death 10/8/2008 48 Male 149 lb 10/30/2008 Physician Philippines
Primary
Secondary
Blood Creatinine Increased Other Serious 9/1/2008 59 Male 115 lb 10/31/2008 Physician Thailand
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 11/11/2008 51 Male 183 lb 11/21/2008 Physician Austria
Primary
Secondary
Tracheostomy Hospitalization 11/19/2008 54 Male 137 lb 11/26/2008 Physician Spain
Primary
Secondary
Acute Respiratory Failure Hospitalization 11/19/2008 54 Male 137 lb 12/10/2008 Physician Spain
Primary
Secondary
Sepsis Life Threatening 3/23/2008 59 Male 207 lb 12/15/2008 Physician Austria
Primary
Secondary
Dehydration Hospitalization 12/3/2008 56 Male 163 lb 12/15/2008 Physician Czech Republic
Primary
Secondary
Pharyngeal Oedema Hospitalization 11/19/2008 54 Male 137 lb 12/19/2008 Physician Spain
Primary
Secondary
Concomitant
Dehydration Hospitalization 12/3/2008 56 Male 163 lb 12/22/2008 Physician Czech Republic
Primary
Secondary
Pneumonitis Other Serious 12/10/2008 63 Female 143 lb 1/7/2009 Physician Romania
Primary
Secondary
Hyponatraemia Hospitalization 8/27/2008 51 Male 108 lb 1/19/2009 Physician India
Primary
Secondary
Blood Creatinine Increased Hospitalization 1/14/2009 54 Female 124 lb 1/21/2009 Physician Spain
Primary
Secondary
Blood Bilirubin Abnormal Other Serious 4/17/2008 53 Male 210 lb 1/27/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 11/11/2008 51 Male 183 lb 1/27/2009 Physician Austria
Primary
Secondary
Blood Bilirubin Abnormal Other Serious 4/17/2008 53 Male 210 lb 1/30/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pyrexia Other Serious 1/31/2009 53 Male 148 lb 2/5/2009 Physician France
Primary
Secondary
Hepatic Enzyme Increased Hospitalization 12/20/2007 54 Male 182 lb 2/11/2009 Physician Germany
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 8/27/2008 51 Male 108 lb 2/12/2009 Physician India
Primary
Secondary
Septic Shock Life Threatening 9/25/2008 58 Male 151 lb 2/12/2009 Physician Belgium
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 8/27/2008 51 Male 108 lb 2/13/2009 Physician India
Primary
Secondary
Septic Shock Life Threatening 9/25/2008 58 Male 151 lb 2/13/2009 Physician Belgium
Primary
Secondary
Concomitant
Pyrexia Other Serious 1/31/2009 53 Male 148 lb 3/2/2009 Physician France
Primary
Secondary
Mucosal Inflammation Hospitalization 2/28/2009 63 Male 121 lb 3/5/2009 Physician India
Primary
Secondary
Stomatitis Haemorrhagic Hospitalization 2/17/2009 63 Male 121 lb 3/16/2009 Physician India
Primary
Secondary
Dysphagia Hospitalization 8/3/2008 48 Male 149 lb 3/18/2009 Physician Philippines
Primary
Secondary
Hypertension Hospitalization 11/10/2007 50 3/18/2009 Physician India
Primary
Secondary
Concomitant
Pyrexia Other Serious 1/31/2009 53 Male 148 lb 3/18/2009 Physician France
Primary
Secondary
Gastrointestinal Fistula Hospitalization 9/13/2008 48 Male 149 lb 3/19/2009 Physician Philippines
Primary
Secondary
Polyneuropathy Hospitalization 3/11/2009 58 Female 185 lb 3/23/2009 Physician Denmark
Primary
Secondary
Concomitant
Blood Bilirubin Abnormal Other Serious 4/17/2008 Male 210 lb 4/1/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Blood Bilirubin Abnormal Other Serious 4/17/2008 Male 210 lb 4/3/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Respiratory Tract Infection Hospitalization 3/29/2009 Male 128 lb 4/9/2009 Physician Spain
Primary
Secondary
Concomitant
Metabolic Disorder Death 10/8/2008 Male 149 lb 4/10/2009 Physician Philippines
Primary
Secondary
Syncope Hospitalization 5/6/2008 Male 210 lb 4/10/2009 Physician United Kingdom
Primary
Secondary
Palpitations Hospitalization 4/2/2009 Female 143 lb 4/10/2009 Physician United Kingdom
Primary
Secondary
Polyneuropathy Hospitalization 3/11/2009 Female 185 lb 4/16/2009 Physician Denmark
Primary
Secondary
Concomitant
Renal Failure Hospitalization 5/27/2007 Male 172 lb 4/17/2009 Physician France
Primary
Secondary
Hyponatraemia Hospitalization 8/27/2008 Male 108 lb 4/22/2009 Physician India
Primary
Secondary
Respiratory Tract Infection Hospitalization 3/29/2009 Male 128 lb 5/7/2009 Physician Spain
Primary
Secondary
Concomitant
Fistula Hospitalization 2/24/2009 Male 165 lb 5/15/2009 Physician Spain
Primary
Secondary
Blood Bilirubin Abnormal Other Serious 4/17/2008 Male 210 lb 6/23/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Stomatitis Other Serious 6/17/2009 Female 126 lb 7/1/2009 Physician Austria
Primary
Secondary
Hepatic Enzyme Increased Hospitalization 12/20/2007 Male 182 lb 7/2/2009 Physician Germany
Primary
Secondary
Concomitant
Syncope Hospitalization 5/6/2008 Male 210 lb 7/6/2009 Physician United Kingdom
Primary
Secondary
Death Death 6/30/2009 Female 153 lb 7/8/2009 Physician United Kingdom
Primary
Secondary
Radiation Mucositis Other Serious 4/27/2009 Male 168 lb 7/17/2009 Physician France
Primary
Secondary
Swelling Face Other Serious 6/14/2009 Female 143 lb 7/20/2009 Physician United Kingdom
Primary
Secondary
Stomatitis Other Serious 6/17/2009 Female 126 lb 8/5/2009 Physician Austria
Primary
Secondary
Mucosal Inflammation Hospitalization 7/12/2009 Female 141 lb 8/20/2009 Physician Spain
Primary
Secondary
Palpitations Hospitalization 4/2/2009 Female 143 lb 9/2/2009 Physician United Kingdom
Primary
Secondary
Uterine Haemorrhage Hospitalization 8/17/2009 Female 190 lb 9/14/2009 Physician Russian Federation
Primary
Secondary
Concomitant
Tachypnoea Hospitalization 9/2/2009 79 Male 182 lb 9/17/2009 Physician United States
Primary
Secondary
Concomitant
Mucosal Inflammation Other Serious 7/12/2009 Female 141 lb 9/18/2009 Physician Spain
Primary
Secondary
Uterine Haemorrhage Hospitalization 8/17/2009 Female 190 lb 9/24/2009 Physician Russian Federation
Primary
Secondary
Concomitant
Mucosal Inflammation Other Serious 7/12/2009 Female 141 lb 9/28/2009 Physician Spain
Primary
Secondary
Tachypnoea Hospitalization 9/2/2009 79 Male 182 lb 9/29/2009 Physician United States
Primary
Secondary
Concomitant
Radiation Mucositis Other Serious 4/27/2009 Male 168 lb 10/1/2009 Physician France
Primary
Secondary
Uterine Haemorrhage Hospitalization 8/17/2009 Female 190 lb 10/5/2009 Physician Russian Federation
Primary
Secondary
Concomitant
Disease Progression Death 6/30/2009 Female 153 lb 10/6/2009 Physician United Kingdom
Primary
Secondary
Uterine Haemorrhage Hospitalization 8/17/2009 Female 190 lb 10/15/2009 Physician Russian Federation
Primary
Secondary
Concomitant
Gastrointestinal Infection Hospitalization 4/21/2009 Male 185 lb 12/2/2009 Physician Peru
Primary
Secondary
Lymphopenia Other Serious 11/3/2009 Male 117 lb 12/8/2009 Physician France
Primary
Secondary
Lymphopenia Other Serious Female 235 lb 12/18/2009 Physician France
Primary
Secondary
Lymphopenia Other Serious 11/3/2009 Male 117 lb 1/4/2010 Physician France
Primary
Secondary
Vomiting Hospitalization 1/6/2010 Male 130 lb 1/20/2010 Physician India
Primary
Secondary
Vomiting Hospitalization 11/9/2007 1/29/2010 Physician India
Primary
Secondary
Concomitant
Palpitations Hospitalization 4/2/2009 Female 143 lb 1/29/2010 Physician United Kingdom
Primary
Secondary
Palpitations Hospitalization 4/2/2009 Female 143 lb 2/11/2010 Physician United Kingdom
Primary
Secondary
Lymphopenia Other Serious 10/27/2009 Male 117 lb 2/11/2010 Physician France
Primary
Secondary
Neutropenia Other Serious 12/17/2009 Male 121 lb 2/11/2010 Physician France
Primary
Secondary
Lymphopenia Other Serious Female 235 lb 2/15/2010 Physician France
Primary
Secondary
Swelling Face Other Serious 6/14/2009 Female 143 lb 2/16/2010 Physician United Kingdom
Primary
Secondary
Hyperkalaemia Other Serious 7/23/2008 Male 150 lb 2/17/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 11/11/2008 Male 183 lb 2/18/2010 Physician Austria
Primary
Secondary
Respiratory Tract Infection Hospitalization 3/29/2009 Male 128 lb 2/18/2010 Physician Spain
Primary
Secondary
Concomitant
Dysphagia Hospitalization 2/2/2010 Male 187 lb 2/18/2010 Physician France
Primary
Secondary
Sepsis Life Threatening 3/23/2008 Male 207 lb 2/24/2010 Physician Austria
Primary
Secondary
Pulmonary Embolism Death Male 161 lb 2/26/2010 Physician Hungary
Primary
Secondary
Pulmonary Embolism Death 2/19/2010 Male 161 lb 3/8/2010 Physician Hungary
Primary
Secondary
Mucosal Inflammation Hospitalization 3/8/2010 Female 163 lb 3/16/2010 Physician France
Primary
Secondary
Mucosal Inflammation Hospitalization 3/8/2010 Female 163 lb 3/23/2010 Physician France
Primary
Secondary
Vomiting Other Serious 3/10/2010 Male 130 lb 3/25/2010 Physician India
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 3/8/2010 Female 163 lb 3/26/2010 Physician France
Primary
Secondary
Blood Uric Acid Increased Other Serious 6/30/2009 62 Male 146 lb 4/1/2010 Physician Russian Federation
Primary
Secondary
Blood Uric Acid Increased Other Serious 6/30/2009 62 Male 146 lb 4/9/2010 Physician Russian Federation
Primary
Secondary
Blood Uric Acid Increased Other Serious 6/30/2009 62 Male 146 lb 4/29/2010 Physician Russian Federation
Primary
Secondary
Tracheitis Hospitalization 4/6/2010 57 Male 139 lb 4/30/2010 Physician France
Primary
Secondary
Malaise Hospitalization 4/27/2010 51 Male 135 lb 5/3/2010 Physician United Kingdom
Primary
Secondary
Tracheitis Hospitalization 4/6/2010 57 Male 139 lb 5/14/2010 Physician France
Primary
Secondary
Tracheitis Hospitalization 4/6/2010 57 Male 139 lb 5/21/2010 Physician France
Primary
Secondary
Pyrexia Hospitalization 3/20/2010 46 Female 190 lb 5/28/2010 Physician Poland
Primary
Secondary
Lymphopenia Other Serious 11/19/2009 57 Male 139 lb 7/1/2010 Physician France
Primary
Secondary
Lymphopenia Other Serious 11/19/2009 57 Male 139 lb 7/13/2010 Physician France
Primary
Secondary
Polyneuropathy Hospitalization 10/1/2008 58 Female 185 lb 7/14/2010 Physician Denmark
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 7/3/2010 56 Female 181 lb 8/4/2010 Physician France
Primary
Secondary
Neutropenia Hospitalization 3/2/2010 51 Female 163 lb 8/5/2010 Physician France
Primary
Secondary
Blood Uric Acid Increased Other Serious 6/30/2009 62 Male 146 lb 8/5/2010 Physician Russian Federation
Primary
Secondary
Malaise Hospitalization 4/27/2010 51 Male 135 lb 8/10/2010 Physician United Kingdom
Primary
Secondary
Pneumonia Hospitalization 5/12/2010 44 8/12/2010 Physician Poland
Primary
Secondary
Neutropenic Sepsis Hospitalization 4/27/2010 51 Male 135 lb 8/24/2010 Physician United Kingdom
Primary
Secondary
Mucosal Inflammation Hospitalization 7/3/2010 56 Female 181 lb 8/26/2010 Physician France
Primary
Secondary
Pneumonia Hospitalization 4/19/2010 44 Female 148 lb 9/3/2010 Physician Poland
Primary
Secondary
Concomitant

Drug Data