Lapatinib combined with Pazopanib

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pyrexia Hospitalization 3/7/2007 57 Male 181 lb 3/23/2007 Physician United States
Primary
Secondary
Haemorrhage Intracranial Hospitalization 4/3/2007 49 Male 175 lb 4/17/2007 Physician United States
Primary
Secondary
Muscle Spasms Hospitalization 4/24/2007 76 Male 188 lb 5/2/2007 Physician United States
Primary
Secondary
Concomitant
Muscle Spasms Hospitalization 4/24/2007 76 Male 188 lb 5/10/2007 Physician United States
Primary
Secondary
Concomitant
Syncope Hospitalization 5/6/2007 44 Female 93 lb 5/16/2007 Physician Italy
Primary
Secondary
Concomitant
Muscle Spasms Hospitalization 4/24/2007 76 Male 188 lb 5/24/2007 Physician United States
Primary
Secondary
Concomitant
Syncope Life Threatening 5/6/2007 44 Female 93 lb 5/24/2007 Physician Italy
Primary
Secondary
Concomitant
Transaminases Increased Hospitalization 5/16/2007 70 Male 190 lb 5/29/2007 Physician United States
Primary
Secondary
Concomitant
Muscle Spasms Hospitalization 4/24/2007 76 Male 188 lb 5/31/2007 Physician United States
Primary
Secondary
Concomitant
Transaminases Increased Hospitalization 5/16/2007 70 Male 190 lb 6/4/2007 Physician United States
Primary
Secondary
Concomitant
Syncope Life Threatening 5/6/2007 44 Female 93 lb 6/7/2007 Physician Italy
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 5/31/2007 50 Male 246 lb 6/15/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Left Ventricular Dysfunction Other Serious 5/29/2007 50 Female 172 lb 6/18/2007 Physician Poland
Primary
Secondary
Thrombocytopenia Hospitalization 5/31/2007 50 Male 246 lb 6/22/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 5/31/2007 50 Male 246 lb 6/28/2007 Physician United Kingdom
Primary
Secondary
Vomiting Hospitalization 6/18/2007 63 Female 6/29/2007 Physician Pakistan
Primary
Secondary
Abdominal Pain Hospitalization 6/25/2007 49 Female 112 lb 7/3/2007 Physician Belgium
Primary
Secondary
Syncope Hospitalization 5/6/2007 44 Female 93 lb 7/11/2007 Physician Italy
Primary
Secondary
Concomitant
Rhinitis Hospitalization 6/24/2007 44 Female 194 lb 7/11/2007 Physician Russian Federation
Primary
Secondary
Pollakiuria Hospitalization 7/9/2007 55 Male 7/18/2007 Physician United States
Primary
Secondary
Concomitant
Rhinitis Hospitalization 6/24/2007 44 Female 194 lb 7/20/2007 Physician Russian Federation
Primary
Secondary
Somnolence Hospitalization 5/31/2007 50 Male 246 lb 7/20/2007 Physician United Kingdom
Primary
Secondary
Pancreatitis Hospitalization 7/24/2007 51 Male 168 lb 8/8/2007 Physician United States
Primary
Secondary
Pollakiuria Hospitalization 7/9/2007 55 Male 8/9/2007 Physician United States
Primary
Secondary
Concomitant
Retroperitoneal Cancer Hospitalization 6/25/2007 49 Female 112 lb 8/10/2007 Physician Belgium
Primary
Secondary
Left Ventricular Dysfunction Other Serious 5/29/2007 50 Female 172 lb 8/15/2007 Physician Poland
Primary
Secondary
Pulmonary Embolism Life Threatening 8/9/2007 50 Male 210 lb 8/20/2007 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/17/2007 36 Female 94 lb 8/28/2007 Physician Thailand
Primary
Secondary
Intermittent Claudication Disability 8/20/2007 63 Female 128 lb 8/30/2007 Physician Belgium
Primary
Secondary
Concomitant
Left Ventricular Dysfunction Other Serious 5/29/2007 50 Female 172 lb 8/31/2007 Physician Poland
Primary
Secondary
Vomiting Hospitalization 8/17/2007 36 Female 94 lb 9/4/2007 Physician Thailand
Primary
Secondary
Pollakiuria Hospitalization 7/9/2007 55 Male 9/5/2007 Physician United States
Primary
Secondary
Concomitant
Pulmonary Embolism Life Threatening 8/9/2007 50 Male 210 lb 9/12/2007 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/17/2007 36 Female 94 lb 9/12/2007 Physician Thailand
Primary
Secondary
Intermittent Claudication Hospitalization 8/20/2007 63 Female 139 lb 9/12/2007 Physician Belgium
Primary
Secondary
Concomitant
Pneumonia Hospitalization 5/7/2007 42 Female 129 lb 9/13/2007 Physician Thailand
Primary
Secondary
Ejection Fraction Decreased Other Serious 8/17/2007 63 Female 132 lb 9/17/2007 Physician Pakistan
Primary
Secondary
Pneumonia Hospitalization 5/7/2007 42 Female 129 lb 9/27/2007 Physician Thailand
Primary
Secondary
Concomitant
Intermittent Claudication Hospitalization 8/20/2007 63 Female 139 lb 10/3/2007 Physician Belgium
Primary
Secondary
Concomitant
Vomiting Hospitalization 9/17/2007 68 Female 137 lb 10/3/2007 Physician Singapore
Primary
Secondary
Retroperitoneal Cancer Hospitalization 6/25/2007 49 Female 112 lb 10/4/2007 Physician Belgium
Primary
Secondary
Intermittent Claudication Disability 8/20/2007 63 Female 128 lb 10/4/2007 Physician Belgium
Primary
Secondary
Concomitant
Intermittent Claudication Disability 8/20/2007 63 Female 128 lb 10/19/2007 Physician Belgium
Primary
Secondary
Concomitant
Vomiting Hospitalization 9/17/2007 68 Female 137 lb 10/30/2007 Physician Singapore
Primary
Secondary
Fatigue Hospitalization 9/28/2007 39 Female 101 lb 11/2/2007 Physician Thailand
Primary
Secondary
Ejection Fraction Decreased Life Threatening 10/25/2007 72 Female 121 lb 11/5/2007 Physician France
Primary
Secondary
Ejection Fraction Decreased Life Threatening 10/25/2007 72 Female 121 lb 11/16/2007 Physician France
Primary
Secondary
Vomiting Hospitalization 11/8/2007 57 Female 151 lb 11/19/2007 Physician United Kingdom
Primary
Secondary
Female Genital Tract Fistula Other Serious 10/15/2007 50 Female 119 lb 11/27/2007 Physician Belgium
Primary
Secondary
Diarrhoea Hospitalization 9/2/2007 56 Female 115 lb 11/30/2007 Physician Pakistan
Primary
Secondary
Vomiting Hospitalization 8/17/2007 36 Female 94 lb 12/4/2007 Physician Thailand
Primary
Secondary
Oral Intake Reduced Hospitalization 9/28/2007 39 Female 101 lb 12/5/2007 Physician Thailand
Primary
Secondary
Vomiting Hospitalization 8/17/2007 36 Female 94 lb 12/6/2007 Physician Thailand
Primary
Secondary
Vomiting Hospitalization 9/17/2007 68 Female 137 lb 12/7/2007 Physician Singapore
Primary
Secondary
Upper Gastrointestinal Haemorrhage Life Threatening 11/30/2007 53 Female 146 lb 12/13/2007 Physician France
Primary
Secondary
Female Genital Tract Fistula Other Serious 10/15/2007 50 Female 119 lb 12/14/2007 Physician Belgium
Primary
Secondary
Vomiting Death 12/8/2007 55 Female 99 lb 12/19/2007 Physician India
Primary
Secondary
Concomitant
Hyponatraemia Other Serious 12/14/2007 63 Female 123 lb 12/20/2007 Physician India
Primary
Secondary
Pulmonary Haemorrhage Life Threatening 12/14/2007 43 Female 108 lb 12/21/2007 Physician France
Primary
Secondary
Ejection Fraction Decreased Other Serious 12/12/2007 47 Female 97 lb 12/21/2007 Physician Singapore
Primary
Secondary
Hyponatraemia Other Serious 12/14/2007 63 Female 123 lb 1/4/2008 Physician India
Primary
Secondary
Hyponatraemia Other Serious 12/14/2007 63 Female 123 lb 1/16/2008 Physician India
Primary
Secondary
Ejection Fraction Decreased Other Serious 12/12/2007 47 Female 97 lb 1/16/2008 Physician Singapore
Primary
Secondary
Tachypnoea Hospitalization 1/6/2008 40 Female 137 lb 1/17/2008 Physician Mexico
Primary
Secondary
Haematuria Hospitalization 1/13/2008 38 Female 162 lb 1/23/2008 Physician Argentina
Primary
Secondary
Concomitant
Tumour Necrosis Life Threatening 12/14/2007 43 Female 108 lb 1/24/2008 Physician France
Primary
Secondary
Vomiting Death 12/8/2007 55 Female 99 lb 1/24/2008 Physician India
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/7/2008 54 Female 190 lb 1/30/2008 Physician Israel
Primary
Secondary
Rash Other Serious 1/22/2008 37 Female 209 lb 1/31/2008 Physician Israel
Primary
Secondary
Tachypnoea Hospitalization 1/6/2008 40 Female 137 lb 2/1/2008 Physician Mexico
Primary
Secondary
Tachypnoea Hospitalization 1/9/2008 40 Female 137 lb 2/11/2008 Physician Mexico
Primary
Secondary
Rash Other Serious 1/22/2008 37 Female 209 lb 2/13/2008 Physician Israel
Primary
Secondary
Tumour Necrosis Life Threatening 12/14/2007 43 Female 108 lb 2/15/2008 Physician France
Primary
Secondary
Respiratory Failure Hospitalization 9/28/2007 39 Female 101 lb 3/4/2008 Physician Thailand
Primary
Secondary
Venous Thrombosis Other Serious 2/4/2008 42 Female 3/4/2008 Physician France
Primary
Secondary
Ejection Fraction Decreased Other Serious 12/12/2007 47 Female 97 lb 3/5/2008 Physician Singapore
Primary
Secondary
Large Intestine Perforation Hospitalization 3/4/2008 69 Female 178 lb 3/13/2008 Physician United States
Primary
Secondary
Vomiting Hospitalization 1/31/2008 36 Female 192 lb 3/18/2008 Physician United States
Primary
Secondary
Tumour Necrosis Life Threatening 12/14/2007 43 Female 108 lb 3/20/2008 Physician France
Primary
Secondary
Venous Thrombosis Other Serious 2/4/2008 42 Female 3/20/2008 Physician France
Primary
Secondary
Vaginal Haemorrhage Life Threatening 3/6/2008 34 Female 109 lb 3/20/2008 Physician Peru
Primary
Secondary
Parotitis Hospitalization 3/13/2008 77 Female 151 lb 3/28/2008 Physician United Kingdom
Primary
Secondary
Blood Bilirubin Increased Other Serious 5/24/2007 63 Male 170 lb 4/4/2008 Physician United States
Primary
Secondary
Vomiting Death 12/8/2007 55 Female 99 lb 4/9/2008 Physician India
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/31/2008 36 Female 192 lb 4/9/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/27/2008 37 Female 162 lb 4/9/2008 Physician Israel
Primary
Secondary
Respiratory Failure Hospitalization 9/28/2007 39 Female 101 lb 4/17/2008 Physician Thailand
Primary
Secondary
Haematuria Hospitalization 1/13/2008 38 Female 162 lb 4/24/2008 Physician Argentina
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/27/2008 37 Female 162 lb 4/30/2008 Physician Israel
Primary
Secondary
Thrombocytopenia Hospitalization 4/19/2008 Female 5/1/2008 Physician United States
Primary
Secondary
Ileus Hospitalization 4/28/2008 5/9/2008 Physician Japan
Primary
Secondary
Upper Gastrointestinal Haemorrhage Life Threatening 11/30/2007 53 Female 146 lb 5/13/2008 Physician France
Primary
Secondary
Thrombocytopenia Hospitalization 4/19/2008 Female 5/15/2008 Physician United States
Primary
Secondary
Ileus Hospitalization 4/28/2008 55 Female 5/15/2008 Physician Japan
Primary
Secondary
Concomitant
Haematuria Hospitalization 5/9/2008 40 Female 171 lb 5/21/2008 Physician United States
Primary
Secondary
Concomitant
Female Genital Tract Fistula Hospitalization 10/15/2007 50 Female 119 lb 5/22/2008 Physician Belgium
Primary
Secondary
Parotitis Hospitalization 3/13/2008 77 Female 151 lb 5/23/2008 Physician United Kingdom
Primary
Secondary
Hepatotoxicity Other Serious 6/19/2008 38 Female 108 lb 6/30/2008 Physician Spain
Primary
Secondary
Vomiting Hospitalization 9/17/2007 68 Female 137 lb 7/8/2008 Physician Singapore
Primary
Secondary
Liver Function Test Abnormal Other Serious 9/16/2007 75 Female 7/15/2008 Physician United States
Primary
Secondary
Concomitant
Transaminases Increased Hospitalization 5/16/2007 70 Male 190 lb 7/21/2008 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/25/2008 61 Female 8/1/2008 Physician United States
Primary
Secondary
Pyrexia Hospitalization 7/25/2008 61 Female 8/7/2008 Physician United States
Primary
Secondary
Concomitant
Forced Expiratory Volume Decreased Disability 2/21/2008 34 Female 109 lb 8/21/2008 Physician Peru
Primary
Secondary
Troponin Increased Hospitalization 8/12/2008 Male 210 lb 8/22/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 6/19/2008 38 Female 108 lb 8/22/2008 Physician Spain
Primary
Secondary
Troponin Increased Hospitalization 8/12/2008 Male 210 lb 8/29/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Troponin Increased Hospitalization 8/12/2008 Male 210 lb 9/4/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 3/22/2008 60 Female 97 lb 9/10/2008 Physician Belgium
Primary
Secondary
Concomitant
Wound Secretion Hospitalization 8/12/2008 Male 210 lb 9/11/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 10/7/2008 45 Female 120 lb 10/14/2008 Physician Israel
Primary
Secondary
Vomiting Hospitalization 10/7/2008 45 Female 120 lb 10/21/2008 Physician Israel
Primary
Secondary
Hypothyroidism Other Serious 11/19/2008 47 Female 122 lb 12/12/2008 Physician United States
Primary
Secondary
Vomiting Hospitalization 10/7/2008 45 Female 120 lb 12/16/2008 Physician Israel
Primary
Secondary
Vomiting Hospitalization 3/17/2008 37 Female 162 lb 12/19/2008 Physician Israel
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/12/2008 49 Male 178 lb 12/22/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Thyroiditis Other Serious 10/8/2008 47 Female 122 lb 12/29/2008 Physician United States
Primary
Secondary
Diarrhoea Hospitalization 12/21/2008 58 Male 196 lb 1/5/2009 Physician United States
Primary
Secondary
Hypotension Hospitalization 1/5/2009 Male 1/12/2009
Primary
Secondary
Concomitant
Sudden Death Death 12/25/2008 76 Female 137 lb 1/15/2009 Physician France
Primary
Secondary
Thrombosis Hospitalization 1/8/2009 61 Male 164 lb 1/16/2009 Physician United States
Primary
Secondary
Respiratory Failure Life Threatening 1/3/2009 53 Female 187 lb 1/29/2009 Physician Russian Federation
Primary
Secondary
Hepatotoxicity Other Serious 6/19/2008 38 Female 108 lb 1/30/2009 Physician Spain
Primary
Secondary
Respiratory Failure Life Threatening 1/3/2009 53 Female 187 lb 2/5/2009 Physician Russian Federation
Primary
Secondary
Vomiting Hospitalization 12/12/2008 49 Male 178 lb 2/25/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 2/19/2009 57 Male 194 lb 3/5/2009 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 2/19/2009 57 Male 194 lb 3/12/2009 Physician United States
Primary
Secondary
Concomitant
Tumour Haemorrhage Life Threatening Male 210 lb 4/3/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Tumour Haemorrhage Life Threatening 3/16/2009 Male 210 lb 4/16/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Tumour Haemorrhage Life Threatening 3/16/2009 Male 210 lb 4/24/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pneumonia Hospitalization Female 7/24/2009 Physician Japan
Primary
Secondary
Vomiting Hospitalization 3/17/2008 Female 162 lb 7/27/2009 Physician Israel
Primary
Secondary
Concomitant
Large Intestine Perforation Hospitalization 3/4/2008 69 Female 178 lb 7/28/2009 Physician United States
Primary
Secondary
Thrombosis Hospitalization 1/8/2009 61 Male 164 lb 8/7/2009 Physician United States
Primary
Secondary
Concomitant
Pneumonia Disability 7/16/2009 Female 8/11/2009 Physician Japan
Primary
Secondary
Concomitant
Thrombosis Hospitalization 1/8/2009 61 Male 164 lb 8/12/2009 Physician United States
Primary
Secondary
Concomitant
Osteonecrosis Disability 8/13/2009 Female 203 lb 8/20/2009 Physician Argentina
Primary
Secondary
Concomitant
Pneumonia Hospitalization 7/16/2009 Female 9/14/2009 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 7/16/2009 Female 9/22/2009 Physician Japan
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 9/28/2009 Female 130 lb 10/6/2009 Physician Korea, Republic Of
Primary
Secondary
Diarrhoea Hospitalization 9/28/2009 Female 130 lb 10/19/2009 Physician Korea, Republic Of
Primary
Secondary
Osteonecrosis Disability 8/6/2009 Female 203 lb 11/18/2009 Physician Argentina
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 4/17/2008 Female 2/10/2010 Physician United States
Primary
Secondary
Vomiting Hospitalization 3/17/2008 37 Female 162 lb 5/14/2010 Physician Israel
Primary
Secondary
Concomitant
Subarachnoid Haemorrhage Life Threatening 6/6/2010 61 Female 99 lb 6/14/2010 Physician United Kingdom
Primary
Secondary
Pyrexia Hospitalization 3/7/2007 57 Male 181 lb 7/20/2010 Physician United States
Primary
Secondary
Muscle Spasms Hospitalization 4/24/2007 76 Male 188 lb 7/20/2010 Physician United States
Primary
Secondary
Concomitant
Subarachnoid Haemorrhage Life Threatening 6/6/2010 61 Female 99 lb 7/21/2010 Physician United Kingdom
Primary
Secondary
Wound Secretion Hospitalization 8/12/2008 Male 210 lb 7/23/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Tumour Haemorrhage Life Threatening 3/16/2009 38 Male 210 lb 7/23/2010 Physician United Kingdom
Primary
Secondary
Concomitant

Drug Data