Lapatinib combined with Paclitaxel

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Hypotension Other Serious 11/21/2005 75 Female 10/16/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 3/15/2006 66 Female 12/1/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/10/2005 40 Female 3/14/2007 Consumer United Kingdom
Primary
Secondary
Dehydration Hospitalization 3/27/2007 55 Female 123 lb 4/4/2007 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 11/20/2006 55 Female 126 lb 4/9/2007 Physician Thailand
Primary
Secondary
Rales Hospitalization 3/20/2007 46 Female 90 lb 4/11/2007 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Pancytopenia Life Threatening 12/1/2006 37 Female 4/12/2007 Physician United States
Primary
Secondary
Concomitant
Rales Hospitalization 3/20/2007 46 Female 90 lb 4/17/2007 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Ventricular Dysfunction Other Serious 2/14/2007 47 Female 186 lb 4/19/2007 Physician United States
Primary
Secondary
Dehydration Hospitalization 3/27/2007 55 Female 123 lb 4/20/2007 Physician United States
Primary
Secondary
Concomitant
Rales Hospitalization 3/20/2007 46 Female 90 lb 4/27/2007 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Regurgitation Hospitalization 4/15/2007 82 Female 5/9/2007 Physician United States
Primary
Secondary
Concomitant
Regurgitation Hospitalization 4/15/2007 82 Female 5/18/2007 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 5/17/2007 60 Female 132 lb 6/1/2007 Physician China
Primary
Secondary
Concomitant
Rales Hospitalization 3/20/2007 46 Female 90 lb 6/1/2007 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Neutropenia Other Serious 5/25/2007 49 Female 88 lb 6/7/2007 Physician China
Primary
Secondary
Neutropenia Hospitalization 8/7/2007 59 Female 111 lb 8/17/2007 Physician China
Primary
Secondary
Neutropenia Life Threatening 1/11/2007 62 Female 137 lb 8/17/2007 Physician Thailand
Primary
Secondary
Staphylococcal Infection Hospitalization 12/4/2006 53 Female 139 lb 8/20/2007 Physician Thailand
Primary
Secondary
Hypokalaemia Hospitalization 6/6/2006 49 Female 156 lb 8/23/2007 Physician United States
Primary
Secondary
Concomitant
Neutropenia Hospitalization 8/7/2007 59 Female 111 lb 8/24/2007 Physician China
Primary
Secondary
Hypoalbuminaemia Hospitalization 7/12/2007 Male 9/5/2007 Other Health Professional Japan
Primary
Secondary
Hypoalbuminaemia Hospitalization 7/12/2007 Male 9/7/2007 Other Health Professional Japan
Primary
Secondary
Hypoalbuminaemia Hospitalization 7/12/2007 Male 9/12/2007 Other Health Professional Japan
Primary
Secondary
Hypoalbuminaemia Hospitalization 7/12/2007 Male 9/13/2007 Other Health Professional Japan
Primary
Secondary
Hypoalbuminaemia Hospitalization 7/12/2007 Male 9/27/2007 Other Health Professional Japan
Primary
Secondary
Hypoalbuminaemia Hospitalization 7/12/2007 Male 10/2/2007 Other Health Professional Japan
Primary
Secondary
Renal Failure Hospitalization 11/23/2007 72 Female 132 lb 12/4/2007 Physician United States
Primary
Secondary
Concomitant
Infection Hospitalization 11/25/2007 Female 12/18/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Hospitalization 11/23/2007 72 Female 132 lb 1/7/2008 Physician United States
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 12/26/2007 53 Female 163 lb 1/10/2008 Physician United States
Primary
Secondary
Concomitant
Infection Hospitalization 11/25/2007 Female 1/26/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 12/26/2007 53 Female 163 lb 1/29/2008 Physician United States
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 12/1/2007 53 Female 1/31/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Lethargy Hospitalization 12/26/2007 Female 2/5/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Aspartate Aminotransferase Increased Other Serious 2/22/2008 22 Female 154 lb 2/28/2008 Physician Ireland
Primary
Secondary
Concomitant
Pneumonia Hospitalization 3/3/2008 58 Male 3/12/2008 Other Health Professional Japan
Primary
Secondary
Large Intestine Perforation Hospitalization 3/4/2008 69 Female 178 lb 3/13/2008 Physician United States
Primary
Secondary
Hepatic Enzyme Increased Other Serious 2/22/2008 22 Female 154 lb 3/17/2008 Physician Ireland
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Other Serious 2/22/2008 22 Female 154 lb 4/9/2008 Physician Ireland
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 12/26/2007 53 Female 163 lb 4/17/2008 Physician United States
Primary
Secondary
Concomitant
Neutropenia Other Serious 1/11/2007 62 Female 137 lb 4/18/2008 Physician Thailand
Primary
Secondary
Neuropathy Peripheral Hospitalization 12/1/2007 53 Female 4/21/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Granulocytopenia Hospitalization 4/14/2008 47 Female 141 lb 4/22/2008 Physician China
Primary
Secondary
Neutropenia Other Serious 8/16/2006 58 Female 121 lb 4/24/2008 Physician Thailand
Primary
Secondary
Neutropenia Other Serious 10/25/2007 48 Female 144 lb 4/28/2008 Physician Thailand
Primary
Secondary
Pyrexia Hospitalization 12/11/2007 56 Female 129 lb 4/28/2008 Physician China
Primary
Secondary
Neutropenia Hospitalization 12/29/2007 64 Female 141 lb 4/28/2008 Physician China
Primary
Secondary
Pyrexia Hospitalization 11/11/2007 61 Female 130 lb 4/28/2008 Physician China
Primary
Secondary
Pyrexia Hospitalization 11/27/2007 62 Female 130 lb 4/28/2008 Physician China
Primary
Secondary
Swelling Hospitalization 10/18/2007 53 Female 146 lb 4/29/2008 Physician China
Primary
Secondary
Neutrophil Count Other Serious 4/24/2008 27 Female 119 lb 5/1/2008 Physician Italy
Primary
Secondary
Death Death 4/29/2008 57 Female 5/5/2008 Consumer United Kingdom
Primary
Secondary
Death Death 4/29/2008 57 Female 162 lb 5/8/2008 Physician Brazil
Primary
Secondary
Neutrophil Count Other Serious 4/24/2008 27 Female 119 lb 5/15/2008 Physician Italy
Primary
Secondary
Pyrexia Hospitalization 4/14/2008 47 Female 141 lb 5/21/2008 Physician China
Primary
Secondary
Neutrophil Count Other Serious 4/24/2008 27 Female 119 lb 5/21/2008 Physician Italy
Primary
Secondary
Neutrophil Count Other Serious 4/24/2008 27 Female 119 lb 6/3/2008 Physician Italy
Primary
Secondary
Neutropenia Other Serious 4/24/2008 27 Female 119 lb 6/6/2008 Physician Italy
Primary
Secondary
Pulmonary Embolism Hospitalization 10/8/2007 51 Female 6/9/2008 Consumer United Kingdom
Primary
Secondary
Granulocytopenia Other Serious 6/4/2008 6/11/2008 Physician China
Primary
Secondary
Hypokalaemia Hospitalization 7/1/2008 50 Female 166 lb 7/3/2008 Physician Pakistan
Primary
Secondary
Neutropenia Other Serious 7/5/2008 31 Female 181 lb 7/8/2008 Physician China
Primary
Secondary
Hypokalaemia Hospitalization 7/1/2008 50 Female 166 lb 7/9/2008 Physician Pakistan
Primary
Secondary
Rash Other Serious 6/30/2008 50 Female 154 lb 7/10/2008 Physician Netherlands
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 7/8/2008 38 Female 176 lb 7/11/2008 Physician Pakistan
Primary
Secondary
Hypokalaemia Hospitalization 7/1/2008 50 Female 166 lb 7/14/2008 Physician Pakistan
Primary
Secondary
Rash Hospitalization 7/2/2008 50 Female 154 lb 7/14/2008 Physician Netherlands
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Other Serious 6/30/2008 66 Female 144 lb 7/17/2008 Physician Spain
Primary
Secondary
Mucosal Inflammation Hospitalization 7/8/2008 38 Female 176 lb 7/17/2008 Physician Pakistan
Primary
Secondary
Neutropenia Other Serious 7/1/2008 56 Female 117 lb 7/22/2008 Physician Greece
Primary
Secondary
Mucosal Inflammation Hospitalization 7/8/2008 38 Female 176 lb 7/23/2008 Physician Pakistan
Primary
Secondary
Rash Other Serious 7/1/2008 49 Female 104 lb 7/24/2008 Physician Spain
Primary
Secondary
Renal Failure Hospitalization 11/23/2007 72 Female 132 lb 7/31/2008 Physician United States
Primary
Secondary
Concomitant
Neutropenia Other Serious 5/9/2008 40 Female 121 lb 7/31/2008 Physician China
Primary
Secondary
Pyrexia Hospitalization 7/25/2008 61 Female 8/1/2008 Physician United States
Primary
Secondary
Myocardial Infarction Other Serious 4/21/2008 41 Female 119 lb 8/5/2008 Physician Switzerland
Primary
Secondary
Hepatic Enzyme Increased Other Serious 7/4/2008 59 Female 159 lb 8/6/2008 Physician Ireland
Primary
Secondary
Hypokalaemia Hospitalization 4/30/2008 58 Female 113 lb 8/6/2008 Physician France
Primary
Secondary
Neuropathy Peripheral Hospitalization 12/26/2007 53 Female 163 lb 8/7/2008 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/25/2008 61 Female 8/7/2008 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/30/2008 54 Female 155 lb 8/8/2008 Physician Netherlands
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/30/2008 Female 8/18/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Liver Function Test Abnormal Other Serious 8/12/2008 56 Female 119 lb 8/21/2008 Physician Greece
Primary
Secondary
Gamma-glutamyltransferase Increased Other Serious 8/19/2008 50 Female 132 lb 8/21/2008 Physician Belgium
Primary
Secondary
Concomitant
Guillain-barre Syndrome Hospitalization 12/26/2007 Female 8/21/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Neutropenia Other Serious 8/20/2008 56 Female 148 lb 8/25/2008 Physician Taiwan, Province Of China
Primary
Secondary
Concomitant
Liver Function Test Abnormal Other Serious 8/12/2008 56 Female 119 lb 8/27/2008 Physician Greece
Primary
Secondary
Alanine Aminotransferase Increased Other Serious 8/19/2008 50 Female 132 lb 8/27/2008 Physician Belgium
Primary
Secondary
Concomitant
Infection Hospitalization 3/17/2008 70 Female 123 lb 8/28/2008 Physician Germany
Primary
Secondary
Rash Other Serious 7/1/2008 49 Female 104 lb 8/28/2008 Physician Spain
Primary
Secondary
Hepatic Function Abnormal Other Serious 8/21/2008 53 Female 161 lb 8/28/2008 Physician Czech Republic
Primary
Secondary
Concomitant
Pyrexia Hospitalization 8/20/2008 58 Female 154 lb 8/29/2008 Physician Thailand
Primary
Secondary
Vomiting Hospitalization 8/18/2008 64 Female 198 lb 9/2/2008 Physician Hungary
Primary
Secondary
Alanine Aminotransferase Increased Other Serious 8/21/2008 40 Female 161 lb 9/3/2008 Physician Spain
Primary
Secondary
Myocardial Infarction Other Serious 4/21/2008 41 Female 119 lb 9/4/2008 Physician Switzerland
Primary
Secondary
Perihepatic Discomfort Other Serious 8/25/2008 47 Female 218 lb 9/4/2008 Physician South Africa
Primary
Secondary
Concomitant
Multi-organ Failure Death 4/29/2008 57 Female 162 lb 9/5/2008 Physician Brazil
Primary
Secondary
Neutropenia Hospitalization 9/1/2008 55 Female 9/8/2008 Physician China
Primary
Secondary
Concomitant
Neutropenia Hospitalization 9/1/2008 55 Female 9/17/2008 Physician China
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Other Serious 8/21/2008 40 Female 161 lb 9/17/2008 Physician Spain
Primary
Secondary
Perihepatic Discomfort Other Serious 8/25/2008 47 Female 218 lb 9/17/2008 Physician South Africa
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 8/21/2008 53 Female 161 lb 9/18/2008 Physician Czech Republic
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Other Serious 8/21/2008 40 Female 161 lb 9/18/2008 Physician Spain
Primary
Secondary
Hepatic Function Abnormal Other Serious 9/10/2008 55 Female 139 lb 9/18/2008 Physician Czech Republic
Primary
Secondary
Pyrexia Hospitalization 9/4/2008 60 Female 121 lb 9/19/2008 Physician New Zealand
Primary
Secondary
Hepatic Function Abnormal Other Serious 9/10/2008 55 Female 139 lb 9/22/2008 Physician Czech Republic
Primary
Secondary
Neutropenia Other Serious 3/5/2007 40 Female 126 lb 9/25/2008 Physician United States
Primary
Secondary
Neutropenia Hospitalization 9/1/2008 55 Female 9/26/2008 Physician China
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Other Serious 7/4/2008 59 Female 159 lb 9/26/2008 Physician Ireland
Primary
Secondary
Neutropenia Other Serious 9/24/2008 43 Female 123 lb 9/30/2008 Physician China
Primary
Secondary
Gamma-glutamyltransferase Increased Other Serious 9/23/2008 64 Female 198 lb 10/2/2008 Physician Hungary
Primary
Secondary
Pyrexia Hospitalization 9/9/2008 60 Female 121 lb 10/2/2008 Physician New Zealand
Primary
Secondary
Febrile Neutropenia Hospitalization 9/6/2008 50 Female 106 lb 10/2/2008 Physician Hong Kong
Primary
Secondary
Neutropenia Other Serious 9/24/2008 43 Female 123 lb 10/6/2008 Physician China
Primary
Secondary
Syncope Hospitalization 9/19/2008 56 Female 143 lb 10/10/2008 Physician United States
Primary
Secondary
Pyrexia Other Serious 9/30/2008 52 Female 196 lb 10/14/2008 Physician New Zealand
Primary
Secondary
Concomitant
Neutropenia Hospitalization 10/9/2008 60 Female 172 lb 10/15/2008 Physician Pakistan
Primary
Secondary
Perihepatic Discomfort Other Serious 8/25/2008 47 Female 218 lb 10/17/2008 Physician South Africa
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 9/10/2008 55 Female 139 lb 10/17/2008 Physician Czech Republic
Primary
Secondary
Concomitant
Pyrexia Hospitalization 9/6/2008 50 Female 106 lb 10/17/2008 Physician Hong Kong
Primary
Secondary
Pyrexia Other Serious 9/30/2008 52 Female 196 lb 10/17/2008 Physician New Zealand
Primary
Secondary
Concomitant
Pyrexia Hospitalization 5/2/2008 Female 150 lb 10/17/2008 Physician Germany
Primary
Secondary
Platelet Count Decreased Hospitalization 5/30/2008 Female 10/17/2008 Physician Germany
Primary
Secondary
Neutropenia Other Serious 10/8/2008 50 Female 128 lb 10/17/2008 Physician China
Primary
Secondary
Tonsillitis Hospitalization 6/20/2008 63 Female 128 lb 10/17/2008 Physician Germany
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 7/8/2008 Female 119 lb 10/17/2008 Physician Germany
Primary
Secondary
Concomitant
Leukocytosis Hospitalization 6/2/2008 Female 130 lb 10/17/2008 Physician Germany
Primary
Secondary
Gamma-glutamyltransferase Increased Other Serious 9/23/2008 64 Female 198 lb 10/20/2008 Physician Hungary
Primary
Secondary
Pyrexia Hospitalization 9/3/2008 51 Female 139 lb 10/20/2008 Physician Germany
Primary
Secondary
Concomitant
Pyrexia Other Serious 9/30/2008 52 Female 196 lb 10/22/2008 Physician New Zealand
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 10/8/2008 50 Female 128 lb 10/23/2008 Physician China
Primary
Secondary
Urinary Tract Infection Hospitalization 10/16/2008 45 Female 166 lb 10/27/2008 Physician United States
Primary
Secondary
Tonsillitis Hospitalization 6/20/2008 63 Female 128 lb 10/27/2008 Physician Germany
Primary
Secondary
Concomitant
Leukocytosis Hospitalization 6/2/2008 Female 130 lb 10/27/2008 Physician Germany
Primary
Secondary
Pyrexia Hospitalization 9/3/2008 51 Female 139 lb 10/29/2008 Physician Germany
Primary
Secondary
Concomitant
Syncope Hospitalization 9/19/2008 56 Female 143 lb 10/30/2008 Physician United States
Primary
Secondary
Gamma-glutamyltransferase Increased Other Serious 10/22/2008 34 Female 152 lb 10/30/2008 Physician Hungary
Primary
Secondary
Pyrexia Hospitalization 9/6/2008 50 Female 106 lb 10/31/2008 Physician Hong Kong
Primary
Secondary
Leukocytosis Hospitalization 6/2/2008 Female 130 lb 10/31/2008 Physician Germany
Primary
Secondary
Neutropenia Other Serious 8/11/2008 72 Female 201 lb 10/31/2008 Physician Spain
Primary
Secondary
Urinary Tract Infection Hospitalization 10/16/2008 45 Female 11/3/2008 Other Health Professional United Kingdom
Primary
Secondary
Neutropenia Other Serious 8/11/2008 72 Female 201 lb 11/3/2008 Physician Spain
Primary
Secondary
Neutropenia Hospitalization 10/9/2008 60 Female 172 lb 11/4/2008 Physician Pakistan
Primary
Secondary
Pyrexia Hospitalization 9/6/2008 50 Female 106 lb 11/5/2008 Physician Hong Kong
Primary
Secondary
Pyrexia Hospitalization 7/30/2008 54 Female 155 lb 11/10/2008 Physician Netherlands
Primary
Secondary
Concomitant
Hepatomegaly Other Serious 10/22/2008 34 Female 152 lb 11/14/2008 Physician Hungary
Primary
Secondary
Hypothyroidism Hospitalization 11/4/2008 57 Female 203 lb 11/14/2008 Physician Israel
Primary
Secondary
Neutropenia Other Serious 10/28/2008 57 Female 203 lb 11/14/2008 Physician Israel
Primary
Secondary
Hypothyroidism Hospitalization 11/4/2008 57 Female 203 lb 11/14/2008 Physician Israel
Primary
Secondary

Drug Data