Lantus combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Death Death 12/25/2005 57 Male 235 lb 1/13/2006 Other Health Professional United States
Primary
Concomitant
Ankle Fracture Other Serious 8/1/2005 Female 281 lb 1/24/2006 Physician United States
Primary
Concomitant
Pneumonia Death 12/25/2005 57 Male 235 lb 2/14/2006 Other Health Professional United States
Primary
Concomitant
Renal Failure Death 12/25/2005 57 Male 235 lb 2/24/2006 Other Health Professional United States
Primary
Concomitant
Urinary Retention 57 Female 4/28/2006 Consumer United States
Primary
Secondary
Concomitant
Tremor Hospitalization 1/1/2005 85 Female 5/10/2006 Consumer United States
Primary
Concomitant
Sleep Apnoea Syndrome Hospitalization Male 6/12/2006 Physician United States
Primary
Concomitant
Vomiting Other Serious 3/1/2005 Female 6/23/2006 Physician United States
Primary
Concomitant
Hypertriglyceridaemia Hospitalization 1/5/2006 50 Male 146 lb 6/30/2006 Physician France
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 3/1/2006 Female 225 lb 9/15/2006 Consumer United States
Primary
Concomitant
Sepsis Hospitalization 1/1/2006 59 Female 192 lb 9/25/2006 Physician United States
Primary
Concomitant
Sepsis Hospitalization 1/1/2006 59 Female 192 lb 9/29/2006 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 8/7/2006 48 Female 9/21/2006 Physician United States
Primary
Secondary
Concomitant
Hyperglycaemia Hospitalization 9/15/2006 Female 130 lb 10/3/2006 Physician Sweden
Primary
Concomitant
Infection Hospitalization 9/15/2006 Female 130 lb 10/13/2006 Physician Sweden
Primary
Concomitant
Sepsis Hospitalization 1/1/2006 59 Female 192 lb 11/1/2006 Physician United States
Primary
Secondary
Concomitant
Hypoglycaemia Other Serious 9/30/2006 Female 11/15/2006 Pharmacist United Kingdom
Primary
Concomitant
Hypoglycaemia Other Serious 9/30/2006 Female 12/13/2006 Pharmacist United Kingdom
Primary
Concomitant
Injection Site Pain 5/1/2006 Female 12/20/2006 Pharmacist United States
Primary
Concomitant
Paraesthesia 6/1/2006 Female 12/22/2006 Consumer United States
Primary
Concomitant
Dry Throat 59 Female 205 lb 10/24/2006 Qatar
Primary
Concomitant
Vomiting 9/5/2006 65 Female 195 lb 10/16/2006 Consumer United States
Primary
Secondary
Concomitant
Psoriasis 8/7/2006 65 Female 250 lb 10/16/2006 Consumer United States
Primary
Secondary
Concomitant
Myalgia Hospitalization 10/1/2005 52 Male 182 lb 4/2/2007 Consumer United States
Primary
Concomitant
Hyperglycaemia Other Serious 5/3/2007 46 Female 5/18/2007 Consumer United States
Primary
Secondary
Concomitant
Hyperglycaemia Other Serious 5/3/2007 46 Female 6/13/2007 Consumer United States
Primary
Secondary
Concomitant
Necrotising Fasciitis Hospitalization 4/28/2007 Female 117 lb 6/27/2007 Physician United States
Primary
Concomitant
Hyperglycaemia Other Serious 5/3/2007 46 Female 7/11/2007 Consumer United States
Primary
Secondary
Concomitant
Hyperglycaemia Other Serious 5/3/2007 Female 331 lb 7/23/2007 Consumer United States
Primary
Secondary
Concomitant
Femur Fracture Other Serious 6/26/2007 63 Female 200 lb 8/5/2007 Consumer United States
Primary
Concomitant
Arthritis Other Serious 12/9/2006 Female 195 lb 8/17/2007 Other Health Professional Netherlands
Primary
Concomitant
Vomiting Other Serious 5/28/2007 51 Male 186 lb 8/22/2007 Physician United States
Primary
Concomitant
Somnolence 3/1/2007 Female 300 lb 8/29/2007 Physician United States
Primary
Secondary
Concomitant
Pancreatitis Hospitalization 8/6/2007 Female 8/23/2007 Physician United States
Primary
Concomitant
Hyperglycaemia Other Serious 5/3/2007 Female 331 lb 9/11/2007 Consumer United States
Primary
Secondary
Concomitant
Vomiting Other Serious 5/28/2007 51 Male 186 lb 9/7/2007 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 8/4/2007 69 Male 284 lb 9/17/2007 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/1/2006 55 Female 175 lb 9/14/2007 Physician United States
Primary
Concomitant
Tooth Abscess Hospitalization 1/1/2002 58 Female 132 lb 10/22/2007 Physician United States
Primary
Concomitant
Depressed Level Of Consciousness 10/16/2007 Female 114 lb 10/22/2007 United States
Primary
Secondary
Concomitant
Visual Acuity Reduced Other Serious 10/5/2007 68 Male 11/6/2007 Consumer United States
Primary
Concomitant
Pancreatitis Hospitalization 8/6/2007 54 Female 150 lb 11/9/2007 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 8/1/2007 Male 560 lb 11/20/2007 Physician United States
Primary
Concomitant
Pancreatitis Hospitalization 8/6/2007 54 Female 150 lb 11/20/2007 United States
Primary
Concomitant
Weight Increased Required Intervention 1/1/2007 70 Female 145 lb 11/26/2007 Consumer United States
Primary
Concomitant
Vulvovaginal Mycotic Infection Hospitalization 10/1/2005 Female 206 lb 12/6/2007 Physician United States
Primary
Concomitant
Myalgia Other Serious 2/28/2007 60 Female 114 lb 4/27/2007 Consumer United States
Primary
Concomitant
Drug Ineffective 5/1/2007 Female 12/12/2007 Other Health Professional United States
Primary
Concomitant
Staphylococcal Infection 7/1/2007 Female 129 lb 12/14/2007 United States
Primary
Concomitant
Tooth Abscess Hospitalization 1/1/2002 58 Female 132 lb 12/18/2007 Physician United States
Primary
Concomitant
Skin Hyperpigmentation 10/1/2007 48 Male 209 lb 12/21/2007 Consumer United States
Primary
Concomitant
Urticaria 10/16/2007 48 Male 209 lb 12/21/2007 Consumer United States
Primary
Concomitant
Rectal Cancer Life Threatening 6/19/2007 78 Female 1/14/2008
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 1/17/2008 Physician United States
Primary
Secondary
Concomitant
Hospitalisation Hospitalization 1/1/2008 74 Female 1/22/2008 Consumer United States
Primary
Secondary
Concomitant
Tooth Abscess Hospitalization 1/1/2002 57 Female 132 lb 1/24/2008 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 1/25/2008 Physician United States
Primary
Secondary
Concomitant
Pyelonephritis Life Threatening 6/19/2007 Female 1/31/2008 Other Health Professional France
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 2/12/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 9/1/2006 Female 224 lb 2/13/2008 Consumer United States
Primary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 2/14/2008 Physician United States
Primary
Secondary
Concomitant
Colorectal Cancer Metastatic Life Threatening 6/19/2007 Female 2/21/2008 Other Health Professional France
Primary
Secondary
Concomitant
Tooth Abscess Hospitalization 1/1/2002 57 Female 132 lb 2/28/2008 Physician United States
Primary
Concomitant
Urticaria 10/16/2007 48 Male 209 lb 3/27/2008 Consumer United States
Primary
Concomitant
Respiratory Failure Other Serious 12/27/2007 58 Male 3/28/2008 Physician France
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 4/25/2008 60 Male 5/8/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Septic Shock Hospitalization Male 5/28/2008 Other Health Professional United Kingdom
Primary
Concomitant
Rectal Neoplasm Life Threatening 10/1/2005 Female 6/9/2008 Other Health Professional France
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 3/25/2008 60 Male 6/3/2008 Physician United States
Primary
Secondary
Concomitant
Visual Disturbance 1/1/2008 Male 190 lb 6/12/2008 Physician United States
Primary
Concomitant
Weight Decreased 6/1/2005 61 Female 222 lb 4/10/2008 Consumer United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 6/25/2008 Physician United States
Primary
Secondary
Concomitant
Stomatitis Hospitalization 6/3/2008 27 Male 88 lb 6/30/2008 Physician United States
Primary
Secondary
Concomitant
Hyperglycaemia Other Serious 1/1/2007 84 Female 4/30/2008 United States
Primary
Secondary
Concomitant
Hypoaesthesia Hospitalization Male 7/18/2008 Consumer United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 12/25/2006 70 183 lb 8/5/2008
Primary
Concomitant
Rash 5/15/2008 58 Female 226 lb 7/30/2008 Other Health Professional United States
Primary
Concomitant
Lymphoma Hospitalization 7/3/2008 80 Male 168 lb 8/1/2008 Physician France
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 6/25/2008 Female 8/7/2008 Other Health Professional Italy
Primary
Concomitant
Pain 10/1/2007 69 Female 7/7/2008 Consumer United States
Primary
Concomitant
Colorectal Cancer Metastatic Life Threatening 6/19/2007 Female 8/15/2008 Other Health Professional France
Primary
Secondary
Concomitant
Infusion Related Reaction Hospitalization 11/12/2007 Male 275 lb 9/22/2008 Physician United States
Primary
Concomitant
Neoplasm Recurrence Hospitalization 7/30/2008 80 Male 168 lb 9/17/2008 Physician France
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 12/10/2008 Physician United States
Primary
Secondary
Concomitant
Haematochezia Hospitalization 11/22/2008 Male 12/29/2008 Pharmacist United States
Primary
Concomitant
Rhabdomyolysis Other Serious 5/1/2008 1/23/2009 France
Primary
Concomitant
Interacting
Psoriasis Hospitalization 1/1/2009 Female 177 lb 2/9/2009 Physician United States
Primary
Concomitant
Hypoglycaemic Unconsciousness Required Intervention 2/18/2008 74 Female 11/21/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2006 Male 2/20/2009 Physician Canada
Primary
Concomitant
Weight Increased Hospitalization 2/2/2009 73 Female 146 lb 2/23/2009 Physician France
Primary
Secondary
Concomitant
Dizziness Other Serious 12/23/2008 65 Female 3/11/2009 Consumer United States
Primary
Secondary
Concomitant
Urinary Tract Infection 7/1/2008 Female 154 lb 3/14/2009 United States
Primary
Concomitant
Vomiting Other Serious 11/9/2008 85 Female 3/19/2009 Other Health Professional France
Primary
Secondary
Concomitant
Skin Cancer Other Serious 1/1/2004 75 Female 3/20/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Pleural Effusion Female 287 lb 3/20/2009 United States
Primary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 3/26/2009 Physician United States
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 4/6/2009 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2004 75 Female 119 lb 4/13/2009 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 4/16/2009 Physician United States
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 4/16/2009 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 11/9/2008 85 Female 4/21/2009 Other Health Professional France
Primary
Secondary
Concomitant
Skin Ulcer Other Serious 10/29/2008 Male 265 lb 4/24/2009 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2004 75 Female 119 lb 4/27/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 5/1/2009 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 5/4/2009 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2004 75 Female 119 lb 5/22/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Insulin-requiring Type 2 Diabetes Mellitus Other Serious 4/29/2002 50 Female 388 lb 6/1/2009 United States
Primary
Concomitant
Injection Site Pain 1/1/2008 Male 289 lb 6/11/2009 Consumer United States
Primary
Concomitant
Vertigo Hospitalization 6/5/2009 53 Female 208 lb 6/18/2009 Consumer Israel
Primary
Concomitant
Wound Hospitalization 6/5/2009 53 Female 208 lb 6/26/2009 Other Health Professional Israel
Primary
Concomitant
Generalised Oedema Hospitalization 6/23/2009 Female 316 lb 7/21/2009 Physician United States
Primary
Secondary
Concomitant
Hyperglycaemic Hyperosmolar Nonketotic Syndrome Other Serious 4/5/2004 60 Female 180 lb 7/22/2009 United States
Primary
Secondary
Concomitant
Generalised Oedema Life Threatening 6/23/2009 Female 316 lb 7/24/2009 Physician United States
Primary
Secondary
Concomitant
Generalised Oedema Life Threatening 6/23/2009 Female 316 lb 7/31/2009 Physician United States
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 68 Female 8/10/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 68 Female 8/13/2009 Consumer United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2004 75 Female 119 lb 9/1/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Hospitalization 68 Female 8/23/2009 Lawyer United States
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 1/1/2004 Female 220 lb 9/4/2009 Consumer United States
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 1/1/2004 Female 220 lb 9/9/2009 Consumer United States
Primary
Concomitant
Injection Site Pain 11/1/2006 Female 140 lb 9/11/2009 Consumer United States
Primary
Concomitant
Incorrect Dose Administered 8/9/2007 Female 114 lb 9/12/2009 Consumer United States
Primary
Concomitant
Incorrect Dose Administered 1/25/2008 Male 185 lb 9/12/2009 Consumer United States
Primary
Concomitant
Injection Site Haemorrhage 7/14/2008 163 lb 9/12/2009 Consumer United States
Primary
Concomitant
Injection Site Pain 7/25/2009 Female 250 lb 9/19/2009 Consumer United States
Primary
Concomitant
Vomiting 6/1/2009 Female 240 lb 9/19/2009 United States
Primary
Secondary
Concomitant
Suicide Attempt Other Serious 2/2/2001 30 Female 273 lb 9/23/2009 United States
Primary
Concomitant
Generalised Oedema Life Threatening 6/23/2009 Female 316 lb 9/25/2009 Physician United States
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Hospitalization 4/1/2009 Female 260 lb 9/25/2009 United States
Primary
Secondary
Concomitant
Hyperglycaemia Hospitalization 9/13/2009 45 Female 9/28/2009 Other Health Professional United Kingdom
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 68 Female 9/17/2009 United States
Primary
Concomitant
Hyperglycaemia Hospitalization 9/13/2009 45 Female 10/1/2009 Consumer United Kingdom
Primary
Concomitant
Hyperglycaemia Hospitalization 9/13/2009 45 Female 10/14/2009 Consumer United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 12/28/2008 Male 10/16/2009 United Kingdom
Primary
Concomitant
Pneumonia Hospitalization 5/1/2009 57 Female 10/23/2009 Physician Netherlands
Primary
Secondary
Concomitant
Weight Bearing Difficulty Hospitalization 1/1/2009 Female 251 lb 10/30/2009 Consumer United States
Primary
Concomitant
Generalised Oedema Life Threatening 6/23/2009 Female 316 lb 11/6/2009 Physician United States
Primary
Secondary
Concomitant
Pulmonary Oedema Other Serious 6/12/2007 Male 210 lb 11/25/2009 Canada
Primary
Concomitant
Pulmonary Oedema Other Serious 6/12/2009 Male 210 lb 11/30/2009 Canada
Primary
Concomitant
Tongue Injury Other Serious 10/13/2008 Female 11/30/2009 Physician United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2006 Male 12/1/2009 Physician Canada
Primary
Concomitant
Respiratory Failure Hospitalization 8/1/2009 Male 119 lb 12/4/2009 Physician Netherlands
Primary
Secondary
Concomitant
Pneumonia Legionella Hospitalization 11/17/2009 51 Male 12/4/2009 Physician Italy
Primary
Concomitant
Generalised Oedema Life Threatening 6/23/2009 Female 316 lb 12/23/2009 Physician United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 8/1/2009 Male 119 lb 1/4/2010 Physician Netherlands
Primary
Secondary
Concomitant
Tremor Other Serious 12/31/2009 Male 194 lb 1/15/2010 Other Health Professional United States
Primary
Concomitant
Pain In Jaw 8/19/2009 Male 235 lb 1/29/2010 Consumer United States
Primary
Concomitant
Sinusitis 8/1/2009 Male 155 lb 1/30/2010 Other Health Professional United States
Primary
Concomitant
Wound Infection Other Serious 10/1/2007 Male 210 lb 2/10/2010 United States
Primary
Concomitant
Death Death Male 190 lb 2/15/2010 Consumer United States
Primary
Concomitant

Drug Data