Lansoprazole combined with Warfarin Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Liver Function Test Abnormal 11/1/2004 61 9/12/2005 Pharmacist United States
Primary
Concomitant
Pruritus Death 7/22/2004 Male 187 lb 1/25/2006 United Kingdom
Primary
Concomitant
Peripheral Embolism Other Serious 12/15/2004 Female 1/27/2006 Other Health Professional United Kingdom
Primary
Concomitant
Pneumonitis Death 6/1/2005 69 Male 1/30/2006 United Kingdom
Primary
Concomitant
Appendicitis Hospitalization 9/8/2005 68 Male 211 lb 2/1/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Pulmonary Haemorrhage Other Serious 1/11/2006 40 Male 2/6/2006 Japan
Primary
Concomitant
Pneumonitis Death 6/1/2005 69 Male 2/6/2006 United Kingdom
Primary
Concomitant
Renal Impairment Disability 2/1/1998 65 Female 2/6/2006 Physician Japan
Primary
Concomitant
Palpitations Other Serious 1/13/2006 Female 216 lb 2/16/2006 Other Health Professional United Kingdom
Primary
Concomitant
Nephritis Interstitial Other Serious 2/1/1998 65 Female 2/8/2006 Japan
Primary
Concomitant
Sinus Bradycardia Life Threatening 9/7/2005 74 Male 2/10/2006 Other Health Professional Japan
Primary
Concomitant
Oedema Peripheral Other Serious 1/1/2006 67 Male 2/3/2006 Physician Ireland
Primary
Secondary
Concomitant
Vomiting Death 72 Female 110 lb 2/24/2006 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 5/4/2005 49 Female 3/24/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Life Threatening 2/28/2006 65 Male 3/23/2006 Japan
Primary
Secondary
Lethargy Other Serious 2/10/2006 75 Male 3/28/2006 United Kingdom
Primary
Concomitant
Paraneoplastic Syndrome Hospitalization 9/19/2003 45 Female 139 lb 3/15/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Hallucination Hospitalization Female 4/12/2006 Consumer Australia
Primary
Concomitant
Gastric Cancer Other Serious 3/22/2006 65 Female 4/6/2006 Japan
Primary
Concomitant
Pulmonary Oedema Required Intervention 57 Female 3/30/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Status Epilepticus Required Intervention 3/7/2006 54 Female 180 lb 3/16/2006 United States
Primary
Concomitant
Musculoskeletal Chest Pain Hospitalization 9/3/2005 46 Male 5/8/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
International Normalised Ratio Increased Hospitalization 4/27/2006 56 Female 5/12/2006 Physician United Kingdom
Primary
Concomitant
Death Life Threatening 4/1/2006 Female 187 lb 5/30/2006 Other Health Professional United Kingdom
Primary
Concomitant
Stomach Discomfort Hospitalization 1/1/2005 87 Male 134 lb 5/31/2006 United States
Primary
Concomitant
Rash Other Serious 8/12/2005 79 Female 137 lb 6/1/2006 Physician Australia
Primary
Concomitant
Chest Pain Hospitalization 10/31/2004 89 Female 6/8/2006 Other Health Professional Sweden
Primary
Secondary
Concomitant
Pneumonia Hospitalization 4/3/2006 Female 165 lb 6/16/2006 Other Health Professional United Kingdom
Primary
Concomitant
Hallucination Hospitalization 3/1/2006 77 Female 6/28/2006 Consumer Australia
Primary
Secondary
Concomitant
International Normalised Ratio Increased Hospitalization 4/27/2006 56 Female 6/23/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Sepsis Life Threatening Female 187 lb 7/12/2006 Other Health Professional United Kingdom
Primary
Concomitant
Pulmonary Hypertension Hospitalization 7/14/2005 41 Female 143 lb 7/13/2006 Physician Japan
Primary
Concomitant
Bladder Perforation Death 5/15/2006 67 Male 7/25/2006 Consumer Japan
Primary
Secondary
Concomitant
Right Ventricular Failure Other Serious 7/31/2004 26 Female 149 lb 7/24/2006 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 61 Male 5/9/2005 Pharmacist United States
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 73 Male 8/11/2006 Brazil
Primary
Concomitant
Leukopenia Required Intervention 9/12/2005 60 Male 156 lb 1/9/2006 Consumer United States
Primary
Concomitant
Urinary Tract Infection Other Serious 11/15/2003 Female 143 lb 8/24/2006 Other Health Professional United Kingdom
Primary
Concomitant
Respiratory Failure Death 6/27/2005 Male 176 lb 9/1/2006 United Kingdom
Primary
Secondary
Concomitant
Helicobacter Infection Hospitalization 4/27/2006 56 Female 9/7/2006 Consumer United States
Primary
Secondary
Concomitant
Urinary Tract Infection Life Threatening 2/24/2006 65 Male 9/8/2006 Pharmacist Japan
Primary
Secondary
Vertigo Hospitalization 8/2/2006 64 Female 205 lb 9/26/2006 Physician Sweden
Primary
Concomitant
Liver Disorder Hospitalization 7/6/2006 82 Female 86 lb 10/9/2006 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 1/26/2005 76 Female 110 lb 10/18/2006 Physician Japan
Primary
Secondary
Concomitant
Oesophageal Ulcer Hospitalization 4/27/2006 56 Female 10/11/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rash Other Serious 80 Female 137 lb 10/18/2006 Other Health Professional United Kingdom
Primary
Concomitant
Liver Disorder Hospitalization 7/6/2006 82 Female 86 lb 10/18/2006 Physician Japan
Primary
Secondary
Concomitant
Condition Aggravated Hospitalization 2/14/2006 69 Female 121 lb 10/11/2006 Physician Japan
Primary
Concomitant
Neutropenic Sepsis Life Threatening 9/1/2006 78 Female 10/13/2006 United Kingdom
Primary
Concomitant
Vomiting Required Intervention 8/27/2005 43 Female 10/18/2006 United States
Primary
Concomitant
Thrombocytopenia Life Threatening 9/6/2006 74 Male 10/25/2006 Physician Japan
Primary
Secondary
Renal Failure Chronic Hospitalization 11/18/2004 51 Female 10/25/2006 Physician United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 7/6/2006 82 Female 86 lb 10/26/2006 Physician Japan
Primary
Secondary
Concomitant
Oesophageal Ulcer Hospitalization 4/27/2006 56 Female 10/24/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Oesophageal Ulcer Haemorrhage Hospitalization 4/27/2006 56 Female 10/24/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Melaena Hospitalization 4/27/2006 56 Female 10/25/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 11/21/2005 80 Male 121 lb 11/1/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 11/21/2005 80 Male 121 lb 11/2/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 9/6/2006 74 Male 11/6/2006 Physician France
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 11/13/2005 62 Female 190 lb 8/11/2006 Pharmacist United States
Primary
Concomitant
Humerus Fracture Disability 8/1/2006 89 Female 11/2/2006 Consumer United Kingdom
Primary
Concomitant
Sinus Arrest Other Serious 10/12/2006 56 Female 86 lb 10/27/2006 Japan
Primary
Secondary
Concomitant
Surgery Other Serious 72 Female 11/11/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Helicobacter Infection Hospitalization 4/27/2006 56 Female 11/16/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 9/6/2006 74 Male 11/16/2006 Physician Japan
Primary
Secondary
Visual Acuity Reduced Other Serious 62 Male 11/16/2006 Consumer Japan
Primary
Concomitant
Hyperammonaemia Disability 1/1/2006 63 Female 11/16/2006 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 1/26/2005 76 Female 110 lb 11/17/2006 Physician Japan
Primary
Secondary
Concomitant
Hyperammonaemia Other Serious 1/1/2006 63 Female 11/21/2006 Physician Japan
Primary
Concomitant
Thinking Abnormal Other Serious 2/13/2005 53 Male 11/9/2006 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 7/31/2004 26 Female 149 lb 11/30/2006 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Hypertension Hospitalization 7/14/2005 41 Female 143 lb 11/30/2006 Physician Japan
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 11/27/2005 68 Male 212 lb 12/19/2006 Physician United Kingdom
Primary
Concomitant
Xanthopsia Other Serious 62 Male 12/21/2006
Primary
Concomitant
Xanthopsia Other Serious 62 Male 12/14/2006 Physician Japan
Primary
Concomitant
Pancreatitis Acute Hospitalization 6/1/2005 60 Male 11/21/2005 Physician United States
Primary
Concomitant
Overdose Other Serious 11/30/2005 69 Female 8/21/2006 Pharmacist United States
Primary
Concomitant
Pneumonia Required Intervention 7/23/2006 68 Female 148 lb 7/28/2006 Pharmacist United States
Primary
Secondary
Concomitant
Occult Blood Positive 10/21/2006 78 Female 10/24/2006 United States
Primary
Concomitant
General Physical Health Deterioration Other Serious 1/1/2006 74 Female 99 lb 1/12/2007 Other Health Professional United Kingdom
Primary
Concomitant
Respiratory Distress Hospitalization 5/10/2005 63 Male 138 lb 1/19/2007 Physician United Kingdom
Primary
Concomitant
Drug Level Increased Other Serious 12/1/2006 65 Male 1/19/2007 United Kingdom
Primary
Secondary
Concomitant
Retinal Haemorrhage Other Serious 9/1/2006 60 Male 280 lb 1/29/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Retinal Haemorrhage Other Serious 9/1/2006 60 Male 280 lb 1/23/2007 United Kingdom
Primary
Secondary
Concomitant
Retinal Haemorrhage Other Serious 9/1/2006 60 Male 280 lb 1/30/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vasculitis Other Serious 12/17/2006 64 Male 1/23/2007 United Kingdom
Primary
Secondary
Concomitant
Vasculitis Other Serious 12/17/2006 64 Male 1/29/2007 United Kingdom
Primary
Secondary
Concomitant
Vasculitis Disability 12/17/2006 64 Male 1/29/2007 United Kingdom
Primary
Secondary
Concomitant
Vasculitis Other Serious 12/17/2006 64 Male 1/26/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/30/2003 56 Female 173 lb 2/15/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Urinary Retention Hospitalization 1/12/2007 71 Female 2/19/2007 Physician Japan
Primary
Concomitant
Peritonitis Hospitalization 11/27/2005 68 Male 212 lb 3/5/2007 Physician United Kingdom
Primary
Concomitant
Urinary Retention Hospitalization 1/12/2007 71 Female 3/5/2007 Physician Japan
Primary
Concomitant
Urinary Retention Hospitalization 1/12/2007 71 Female 3/16/2007 Physician Japan
Primary
Concomitant
International Normalised Ratio Increased Other Serious 9/1/2006 46 Male 344 lb 3/27/2007 Physician United Kingdom
Primary
Concomitant
External Ear Disorder Other Serious 6/1/2006 84 Male 176 lb 4/2/2007 Other Health Professional United Kingdom
Primary
Concomitant
Renal Disorder Hospitalization 3/20/2006 60 Male 3/29/2007 Other Health Professional Japan
Primary
Concomitant
Vomiting Hospitalization 8/12/2006 39 Male 186 lb 8/31/2006 Pharmacist United States
Primary
Concomitant
External Ear Disorder Other Serious 6/1/2006 84 Male 176 lb 4/2/2007 Other Health Professional United Kingdom
Primary
Concomitant
External Ear Disorder Other Serious 6/1/2006 84 Male 176 lb 4/2/2007 United Kingdom
Primary
Concomitant
Swelling Face Other Serious 10/26/2006 64 Female 4/9/2007 United Kingdom
Primary
Concomitant
Pulmonary Embolism Death 11/24/2006 39 Male 179 lb 4/19/2007 Consumer United Kingdom
Primary
Concomitant
Cardiac Arrest Life Threatening 1/27/2007 51 Female 463 lb 5/10/2007 Consumer United States
Primary
Concomitant
Ulcer Hospitalization 3/1/2007 61 Female 5/16/2007 United Kingdom
Primary
Secondary
Concomitant
Vasculitis Hospitalization 2/2/2007 76 Male 5/25/2007 Japan
Primary
Secondary
Concomitant
Myalgia Hospitalization 12/31/2006 32 Male 226 lb 4/30/2007 Pharmacist United States
Primary
Concomitant
Hypergammaglobulinaemia Benign Monoclonal Other Serious 4/10/2007 Female 110 lb 6/11/2007 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 1/7/2007 74 Female 6/20/2007 Other Health Professional Ireland
Primary
Concomitant
Intracardiac Thrombus Life Threatening 67 Female 117 lb 6/26/2007 Other Health Professional Canada
Primary
Secondary
Concomitant
Pulmonary Hypertension Hospitalization 1/23/2006 55 Female 7/12/2007 Physician Japan
Primary
Concomitant
Right Ventricular Failure Hospitalization 5/31/2007 Male 189 lb 7/12/2007 United States
Primary
Concomitant
Ventricular Extrasystoles Hospitalization 4/10/2007 74 Female 7/13/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Weight Fluctuation Hospitalization 1/7/2007 74 Female 7/10/2007 Other Health Professional Denmark
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 7/11/2007 Female 143 lb 7/24/2007 Physician Japan
Primary
Concomitant
Pulmonary Hypertension Hospitalization 1/23/2006 55 Female 7/27/2007 Physician Japan
Primary
Secondary
Concomitant
Haemoglobin Decreased Hospitalization 6/18/2007 46 Male 7/26/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Sepsis Hospitalization 5/21/2007 73 Male 7/25/2007 Physician United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious 7/11/2007 Female 143 lb 8/7/2007 Physician Japan
Primary
Concomitant
Death Other Serious Male 185 lb 8/14/2007 Other Health Professional United Kingdom
Primary
Concomitant
Thrombocytopenia Life Threatening 6/4/2007 31 Female 139 lb 8/9/2007 Physician Japan
Primary
Secondary
Concomitant
Swelling Hospitalization 8/1/2007 Female 184 lb 8/30/2007 Consumer United States
Primary
Concomitant
Somnolence Life Threatening 7/27/2007 58 Male 119 lb 8/31/2007 Physician Japan
Primary
Secondary
Concomitant
Mouth Ulceration Disability 5/8/2007 89 Female 9/10/2007 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 1/7/2007 74 Female 9/6/2007 Other Health Professional Ireland
Primary
Secondary
Concomitant
Sepsis Disability 1/1/2007 Male 9/14/2007 Physician Japan
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 2/1/2007 53 Male 220 lb 9/17/2007 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Myocardial Ischaemia Other Serious Male 185 lb 9/21/2007 Other Health Professional United Kingdom
Primary
Concomitant
Systemic Inflammatory Response Syndrome Other Serious 2/1/2007 53 Male 220 lb 9/15/2007
Primary
Secondary
Concomitant
Somnolence Life Threatening 7/27/2007 58 Male 119 lb 9/25/2007 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Other Serious 3/29/2007 69 Male 135 lb 9/21/2007 Other Health Professional Japan
Primary
Concomitant
Muscular Weakness Hospitalization 8/6/2007 61 Male 143 lb 9/26/2007 Pharmacist Japan
Primary
Secondary
Concomitant
Oesophageal Ulcer Hospitalization 4/27/2006 Female 9/26/2007 United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Life Threatening 2/1/2007 53 Male 9/21/2007 United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 6/11/2007 31 Female 139 lb 9/18/2007 Physician Japan
Primary
Secondary
Concomitant
Intra-abdominal Haematoma Other Serious 1/1/2007 58 Male 10/8/2007 Other Health Professional United Kingdom
Primary
Concomitant
Respiratory Arrest Life Threatening 9/4/2007 77 Male 53 lb 10/2/2007 Other Health Professional Japan
Primary
Concomitant
Intra-abdominal Haematoma Other Serious 8/14/2007 58 Male 280 lb 10/3/2007 United Kingdom
Primary
Secondary
Concomitant
Intra-abdominal Haematoma Other Serious 1/1/2007 Male 281 lb 10/12/2007 Physician United Kingdom
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 10/5/2004 73 Male 187 lb 10/16/2007 Other Health Professional France
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 84 Female 10/16/2007
Primary
Secondary
Concomitant
Intra-abdominal Haematoma Other Serious 58 Male 10/15/2007 United Kingdom
Primary
Secondary
Concomitant
Encephalopathy Hospitalization 7/19/2007 66 Male 123 lb 10/22/2007 Physician Japan
Primary
Concomitant
International Normalised Ratio Increased Other Serious 6/23/2007 67 Male 223 lb 10/23/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Haemorrhage Subcutaneous Hospitalization 8/1/2007 75 Female 10/25/2007 Japan
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 10/2/2007 Female 107 lb 11/1/2007 Physician Japan
Primary
Secondary
Concomitant
Prothrombin Time Prolonged Hospitalization 10/8/2007 Male 11/5/2007 Physician Japan
Primary
Secondary
Concomitant
Photosensitivity Reaction Other Serious 50 Male 209 lb 11/5/2007 Other Health Professional United Kingdom
Primary
Concomitant
Left Ventricular Dysfunction Hospitalization 4/27/2007 74 Male 241 lb 11/7/2007 Other Health Professional Ireland
Primary
Secondary
Concomitant
Burning Sensation Other Serious 3/1/2006 65 Female 11/15/2007 United Kingdom
Primary
Concomitant
Melaena Life Threatening 5/17/2007 57 Female 11/16/2007 United Kingdom
Primary
Concomitant

Drug Data