Lansoprazole combined with Nexavar

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Weight Decreased Hospitalization 7/10/2007 81 Female 104 lb 2/22/2008 Physician Germany
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Life Threatening 7/19/2008 77 Male 176 lb 9/9/2008 Physician Japan
Primary
Concomitant
Tuberculosis Hospitalization 9/18/2008 76 Male 132 lb 10/1/2008 Physician Japan
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Life Threatening 7/19/2008 77 Male 176 lb 10/7/2008 Physician Japan
Primary
Concomitant
Melaena Death 9/21/2008 67 Female 121 lb 10/22/2008 Physician Japan
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 9/8/2008 53 Female 97 lb 11/17/2008 Physician Japan
Primary
Concomitant
Tuberculosis Other Serious 9/18/2008 76 Male 121 lb 11/20/2008 Physician Japan
Primary
Concomitant
Pharyngeal Haemorrhage Other Serious 5/1/2008 59 Male 146 lb 11/21/2008 Physician Japan
Primary
Concomitant
Pharyngeal Haemorrhage Other Serious 5/1/2008 59 Male 146 lb 11/24/2008 Physician Japan
Primary
Concomitant
Melaena Death 9/21/2008 67 Female 121 lb 12/1/2008 Physician Japan
Primary
Concomitant
Renal Cancer Life Threatening 12/14/2008 65 Female 117 lb 2/2/2009 Physician United Kingdom
Primary
Concomitant
Rash Death 8/4/2009 76 Male 121 lb 10/29/2009 Physician Japan
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 8/26/2009 61 Male 126 lb 10/30/2009 Physician Japan
Primary
Concomitant
Red Blood Cell Count Decreased Life Threatening 9/17/2009 Male 137 lb 11/2/2009 Physician Japan
Primary
Concomitant
Red Blood Cell Count Decreased Life Threatening 9/17/2009 Male 137 lb 11/5/2009 Physician Japan
Primary
Concomitant
Platelet Count Decreased Other Serious 8/11/2009 61 Male 161 lb 11/12/2009 Physician Japan
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Other Serious 10/13/2009 66 Male 157 lb 11/13/2009 Physician Japan
Primary
Concomitant
Ventricular Tachycardia Hospitalization 2/22/2007 68 Male 12/4/2009 Physician Italy
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 7/1/2009 76 Male 220 lb 12/17/2009 Physician France
Primary
Concomitant
Confusional State Hospitalization 5/27/2009 55 Male 12/28/2009 Consumer France
Primary
Concomitant
Renal Disorder Other Serious 5/12/2008 79 Male 126 lb 3/18/2010 Physician Japan
Primary
Concomitant
Erythema Multiforme Other Serious 9/22/2008 83 Male 3/18/2010 Physician Japan
Primary
Concomitant
Platelet Count Decreased Life Threatening 1/23/2010 63 Male 3/23/2010 Physician Japan
Primary
Concomitant
Pancreatic Enzymes Increased Other Serious 7/23/2009 60 Male 146 lb 3/24/2010 Physician Japan
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 9/8/2008 53 Female 97 lb 3/24/2010 Physician Japan
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 9/8/2008 53 Female 97 lb 3/26/2010 Physician Japan
Primary
Concomitant
Rash Life Threatening 9/21/2009 71 Male 168 lb 3/26/2010 Physician Japan
Primary
Concomitant
Hyperammonaemia Hospitalization 1/4/2010 76 Male 106 lb 3/26/2010 Physician Japan
Primary
Concomitant
Rash Other Serious 11/2/2009 74 Male 148 lb 3/26/2010 Physician Japan
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 8/26/2009 61 Male 126 lb 4/6/2010 Physician Japan
Primary
Concomitant
Hepatic Failure Hospitalization 2/15/2010 76 Male 4/7/2010 Physician Japan
Primary
Concomitant
Malaise Hospitalization 7/2/2009 80 Male 117 lb 4/8/2010 Physician Japan
Primary
Concomitant
Hepatic Encephalopathy Hospitalization 3/30/2010 62 Male 4/22/2010 Physician Italy
Primary
Concomitant
Oesophageal Varices Haemorrhage Hospitalization 3/28/2010 60 Male 5/28/2010 Physician Italy
Primary
Concomitant
Walking Aid User 6/30/2010 93 Male 7/14/2010 Other Health Professional United States
Primary
Concomitant
Skin Burning Sensation Other Serious 6/10/2010 54 Male 146 lb 8/18/2010 Pharmacist France
Primary
Concomitant
Skin Burning Sensation Other Serious 6/10/2010 54 Male 146 lb 8/19/2010 Pharmacist France
Primary
Concomitant
Sudden Death Death 10/15/2010 75 Male 11/5/2010 Physician Japan
Primary
Concomitant
Urethritis Other Serious 3/10/2010 83 Male 11/8/2010 Physician Italy
Primary
Concomitant
Sudden Death Death 10/15/2010 75 Male 11/9/2010 Physician Japan
Primary
Concomitant
Hypertensive Crisis Hospitalization 12/11/2009 82 Male 11/10/2010 Physician Italy
Primary
Concomitant
Oesophageal Varices Haemorrhage Hospitalization 3/28/2010 60 Male 11/11/2010 Physician Italy
Primary
Concomitant
Drug Interaction Hospitalization 8/10/2010 77 Female 11/30/2010 Japan
Primary
Secondary
Concomitant
Drug Toxicity Hospitalization 8/10/2010 77 Female 11/30/2010 Japan
Primary
Secondary
Concomitant
Oesophageal Varices Haemorrhage Other Serious 2/23/2010 55 Male 126 lb 1/26/2011 Physician Japan
Primary
Concomitant
Ascites Hospitalization 1/26/2011 70 Male 2/16/2011 Other Health Professional Italy
Primary
Concomitant
Ascites Other Serious 1/26/2011 70 Male 4/7/2011 Other Health Professional Italy
Primary
Concomitant
Diarrhoea Other Serious 10/28/2010 71 143 lb 4/12/2011 Physician Japan
Primary
Concomitant
Hepatic Encephalopathy Hospitalization 1/18/2011 51 Female 5/9/2011 Physician United States
Primary
Concomitant
Duodenal Ulcer Hospitalization 2/14/2011 53 Male 130 lb 5/12/2011 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Red Blood Cell Count Decreased Hospitalization 2/14/2011 53 Male 130 lb 5/12/2011 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Renal Impairment Death 9/16/2009 66 Male 138 lb 5/20/2011 Physician Japan
Primary
Concomitant
Decreased Appetite Disability 12/12/2010 75 Male 5/23/2011 Physician Japan
Primary
Concomitant
Renal Cell Carcinoma Hospitalization 8/29/2009 63 Female 128 lb 5/21/2011 Physician Japan
Primary
Concomitant
Malaise Other Serious 7/18/2009 63 Male 111 lb 5/25/2011 Physician Japan
Primary
Concomitant
Erythema Multiforme Hospitalization 9/19/2008 82 Male 5/30/2011 Physician Japan
Primary
Concomitant
Haematemesis Other Serious 5/3/2010 57 Male 179 lb 6/2/2011 Physician Japan
Primary
Concomitant
Ascites Other Serious 8/17/2009 79 Female 6/3/2011 Physician Japan
Primary
Concomitant
Diarrhoea Life Threatening 12/3/2009 81 Male 6/3/2011 Physician Japan
Primary
Concomitant
Pulmonary Embolism Death 5/29/2010 57 Male 6/3/2011 Physician Japan
Primary
Concomitant
Face Oedema Other Serious 8/5/2010 69 Male 152 lb 6/3/2011 Physician Japan
Primary
Concomitant
Alopecia Death 10/20/2009 75 Male 6/3/2011 Physician Japan
Primary
Concomitant
Hypertension Disability 9/6/2010 74 Male 137 lb 6/3/2011 Physician Japan
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 7/15/2009 80 Male 6/5/2011 Physician Japan
Primary
Concomitant
Rash Generalised Death 5/3/2010 57 Male 179 lb 6/6/2011 Physician Japan
Primary
Concomitant
Hepatic Function Abnormal Death 1/17/2011 97 Male 123 lb 6/6/2011 Physician Japan
Primary
Concomitant
Diarrhoea Other Serious 5/16/2011 77 Female 137 lb 6/8/2011 Physician Japan
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 2/1/2011 79 Female 6/10/2011 Physician Japan
Primary
Concomitant
Platelet Count Decreased Other Serious 1/1/2009 81 Male 6/15/2011 Physician Japan
Primary
Concomitant
Oedema Peripheral Other Serious 8/5/2010 69 Male 152 lb 6/17/2011 Physician Japan
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Death 7/24/2009 83 Male 114 lb 7/7/2011 Physician Japan
Primary
Concomitant
Hypophosphataemia Hospitalization 2/1/2011 79 Female 7/11/2011 Physician Japan
Primary
Concomitant
Hepatic Encephalopathy Hospitalization 4/27/2011 64 Female 84 lb 7/12/2011 Physician Japan
Primary
Concomitant
Abdominal Pain Hospitalization 7/2/2009 68 Male 126 lb 7/12/2011 Physician Japan
Primary
Concomitant
Constipation Death 5/14/2011 65 Male 84 lb 7/13/2011 Physician Japan
Primary
Concomitant
Hepatic Function Abnormal Hospitalization 4/20/2011 77 Male 97 lb 7/15/2011 Physician Japan
Primary
Concomitant
Melaena Death 9/8/2008 67 Female 121 lb 7/21/2011 Physician Japan
Primary
Concomitant
Ascites Death 1/26/2011 70 Male 7/27/2011 Other Health Professional Italy
Primary
Concomitant
Multi-organ Failure Death 11/1/2010 49 Female 8/1/2011 Physician Japan
Primary
Concomitant
Hepatic Function Abnormal Other Serious 6/30/2009 68 Female 106 lb 8/1/2011 Physician Japan
Primary
Secondary
Concomitant
Rash Other Serious 8/5/2010 69 Male 152 lb 8/2/2011 Physician Japan
Primary
Concomitant
Dysarthria Hospitalization 6/7/2011 67 Male 8/4/2011 Physician Japan
Primary
Concomitant
Liver Disorder Hospitalization 8/28/2009 65 Male 128 lb 8/8/2011 Physician Japan
Primary
Concomitant
Hepatorenal Syndrome Hospitalization 7/23/2009 68 Male 140 lb 8/5/2011 Physician Japan
Primary
Concomitant
Diarrhoea Other Serious 8/23/2009 74 Male 181 lb 8/16/2011 Physician Japan
Primary
Concomitant
Hepatic Neoplasm Malignant Other Serious 2/1/2011 79 Female 8/17/2011 Physician Japan
Primary
Concomitant
Cleft Lip Congenital Anomaly 6/24/2010 64 Male 134 lb 8/18/2011 Physician Japan
Primary
Concomitant
Gamma-glutamyltransferase Increased Other Serious 5/27/2009 66 Male 126 lb 8/19/2011 Physician Japan
Primary
Concomitant
Gastrointestinal Haemorrhage Death 6/24/2010 64 Male 134 lb 8/23/2011 Physician Japan
Primary
Concomitant
Gastrointestinal Erosion Other Serious 9/1/2008 60 Male 141 lb 8/25/2011 Physician Japan
Primary
Concomitant
Hypertension Death 6/25/2009 65 Male 119 lb 8/29/2011 Physician Japan
Primary
Concomitant
Hepatic Encephalopathy Death 7/27/2009 73 Female 77 lb 9/1/2011 Physician Japan
Primary
Concomitant
Duodenal Ulcer Hospitalization 2/12/2011 53 Male 130 lb 9/2/2011 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Hepatic Failure Death 6/24/2011 66 Female 150 lb 9/5/2011 Physician Korea, Republic Of
Primary
Concomitant
Decreased Appetite Other Serious 6/20/2010 60 Male 154 lb 9/13/2011 Physician Japan
Primary
Concomitant
Rash Generalised Other Serious 5/3/2010 57 Male 179 lb 9/16/2011 Physician Japan
Primary
Concomitant
Blood Uric Acid Increased Death 7/21/2009 79 Male 139 lb 9/20/2011 Physician Japan
Primary
Concomitant
Alopecia Death 10/20/2009 75 Male 9/28/2011 Physician Japan
Primary
Concomitant
Diarrhoea Hospitalization 11/7/2010 61 Male 134 lb 9/30/2011 Physician Japan
Primary
Concomitant
Blood Bilirubin Increased Life Threatening 8/13/2009 54 Male 89 lb 10/4/2011 Physician Japan
Primary
Concomitant
Hepatic Function Abnormal Death 9/17/2010 53 Male 174 lb 10/5/2011 Physician Japan
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 6/30/2011 80 Male 10/6/2011 Physician Japan
Primary
Concomitant
Hepatic Failure Death 9/1/2010 74 Male 88 lb 10/14/2011 Physician Japan
Primary
Concomitant
Myoglobin Blood Increased Hospitalization 3/24/2011 74 Male 10/21/2011 Physician Italy
Primary
Concomitant
Malaise Death 7/21/2009 79 Male 139 lb 10/24/2011 Physician Japan
Primary
Concomitant
Ascites Hospitalization 8/5/2010 69 Male 152 lb 10/26/2011 Physician Japan
Primary
Concomitant
C-reactive Protein Increased 9/12/2011 78 Male 128 lb 10/27/2011 Physician Japan
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 6/30/2011 80 Male 163 lb 10/28/2011 Physician Japan
Primary
Concomitant
Depressed Level Of Consciousness Hospitalization 10/20/2011 69 Female 11/10/2011 Pharmacist Japan
Primary
Concomitant
Henoch-schonlein Purpura Other Serious 9/28/2011 72 Male 11/16/2011 Physician Japan
Primary
Concomitant
Henoch-schonlein Purpura Other Serious 9/28/2011 72 Male 11/22/2011 Physician Japan
Primary
Concomitant
Infection Other Serious 5/27/2010 63 Male 247 lb 11/22/2011 Physician Japan
Primary
Secondary
Concomitant
Hepatic Cirrhosis Death 9/11/2011 52 Male 130 lb 11/24/2011 Physician Japan
Primary
Concomitant
Encephalopathy Other Serious 1/31/2011 77 Female 302 lb 11/30/2011 Physician Japan
Primary
Concomitant
Hypertension Hospitalization 11/17/2009 60 Male 139 lb 11/29/2011 Pharmacist Japan
Primary
Concomitant
Pleurisy 10/30/2011 80 Male 106 lb 11/30/2011 Physician Japan
Primary
Concomitant
Gastrointestinal Haemorrhage Other Serious 6/24/2010 63 Male 134 lb 12/15/2011 Physician Japan
Primary
Concomitant
Decreased Appetite Other Serious 7/28/2010 76 Male 132 lb 12/16/2011 Physician Japan
Primary
Concomitant
Oesophageal Varices Haemorrhage Hospitalization 10/3/2011 75 Male 112 lb 12/20/2011 Physician Japan
Primary
Concomitant
Renal Impairment Other Serious 7/21/2009 79 Male 139 lb 12/21/2011 Physician Japan
Primary
Concomitant
Visual Field Defect Hospitalization 10/20/2011 69 Male 12/28/2011 Physician Japan
Primary
Concomitant
Renal Failure Death 10/29/2011 74 Male 93 lb 12/28/2011 Physician Japan
Primary
Concomitant
Hypoalbuminaemia Other Serious 11/15/2011 70 Male 150 lb 1/3/2012 Physician Japan
Primary
Concomitant
Cerebral Infarction Hospitalization 10/20/2011 69 Male 1/9/2012 Physician Japan
Primary
Concomitant
Abdominal Pain Hospitalization 1/3/2012 1/16/2012 Other Health Professional Italy
Primary
Concomitant
Aspartate Aminotransferase Increased Hospitalization 6/28/2011 69 Female 157 lb 1/16/2012 Physician Japan
Primary
Concomitant
Constipation Other Serious 11/1/2011 54 Male 139 lb 1/24/2012 Physician Japan
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 11/15/2011 70 Male 150 lb 1/31/2012 Physician Japan
Primary
Concomitant
Malaise Other Serious 9/10/2009 62 Male 142 lb 2/6/2012 Physician Japan
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 10/1/2010 63 Male 119 lb 2/9/2012 Physician Japan
Primary
Concomitant
Hepatic Failure Death 11/8/2011 70 Female 101 lb 2/15/2012 Physician Japan
Primary
Concomitant
Hepatic Encephalopathy Hospitalization 1/1/2012 80 Male 115 lb 2/15/2012 Physician Japan
Primary
Concomitant
Angina Pectoris Hospitalization 1/13/2012 68 Male 203 lb 2/21/2012 Physician Japan
Primary
Concomitant
Oedema Peripheral Hospitalization 2/7/2011 77 Male 110 lb 2/22/2012 Physician Japan
Primary
Concomitant
Angina Pectoris Life Threatening 1/13/2012 68 Male 203 lb 2/23/2012 Physician Japan
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 10/21/2010 76 Male 141 lb 2/23/2012 Physician Japan
Primary
Concomitant
Blood Bilirubin Increased Death 9/27/2010 61 Male 106 lb 2/27/2012 Other Health Professional Japan
Primary
Concomitant
Coronary Artery Restenosis Hospitalization 1/13/2012 68 Male 203 lb 3/2/2012 Physician Japan
Primary
Concomitant
Pulmonary Tuberculosis Death 11/2/2009 76 Male 112 lb 3/6/2012 Physician Japan
Primary
Secondary
Concomitant
Hepatic Encephalopathy Hospitalization 1/1/2012 80 Male 115 lb 3/9/2012 Physician Japan
Primary
Concomitant
Hyponatraemia Death 11/8/2011 69 Female 101 lb 3/12/2012 Physician Japan
Primary
Concomitant
Cardiac Failure Chronic Other Serious 2/7/2012 78 Male 112 lb 3/13/2012 Physician Japan
Primary
Concomitant
Hepatic Failure Death 11/8/2011 69 Female 101 lb 3/13/2012 Pharmacist Japan
Primary
Concomitant
Pyrexia Hospitalization 3/1/2012 3/14/2012 Other Health Professional Italy
Primary
Concomitant
Hypoxia Other Serious 1/21/2012 80 Male 132 lb 3/20/2012 Physician Japan
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Life Threatening 7/13/2010 68 Male 143 lb 3/20/2012 Physician Japan
Primary
Secondary
Concomitant
Renal Cell Carcinoma Death 8/29/2009 63 Female 128 lb 3/29/2012 Physician Japan
Primary
Concomitant
Henoch-schonlein Purpura Hospitalization 3/15/2012 72 Male 150 lb 4/10/2012 Physician Japan
Primary
Concomitant
Pulmonary Alveolar Haemorrhage Death 1/21/2012 80 Male 132 lb 4/11/2012 Physician Japan
Primary
Secondary
Concomitant
Multi-organ Failure Hospitalization 11/1/2010 49 Female 130 lb 4/12/2012 Physician Japan
Primary
Concomitant

Drug Data