Lanirapid combined with Warfarin Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vomiting Death 72 Female 110 lb 2/24/2006 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/7/2006 71 Female 4/12/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Hyperlipidaemia 2/14/2006 73 Female 106 lb 4/6/2006 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 66 Female 4/24/2006 Physician Japan
Primary
Concomitant
Shock Life Threatening 6/22/2005 78 Female 4/26/2006 Japan
Primary
Secondary
Concomitant
Pancytopenia Other Serious 2/10/2006 66 Female 5/16/2006 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/1/2006 71 Female 6/12/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Postoperative Wound Infection Life Threatening 6/2/2006 74 Male 6/16/2006 Pharmacist Japan
Primary
Secondary
Concomitant
Pancytopenia Other Serious 2/10/2006 66 Female 6/19/2006 Physician Japan
Primary
Concomitant
Pancytopenia Other Serious 2/10/2006 66 Female 6/19/2006 Physician Japan
Primary
Concomitant
Platelet Count Decreased Other Serious 2/10/2006 66 Female 6/27/2006 Physician Japan
Primary
Concomitant
Hypoglycaemic Coma Life Threatening 6/2/2006 74 Male 7/10/2006 Pharmacist Japan
Primary
Secondary
Concomitant
Proctalgia Life Threatening 71 Female 85 lb 7/24/2006 Physician Japan
Primary
Concomitant
Shock Life Threatening 6/22/2005 78 Female 8/2/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Shock Life Threatening 6/22/2005 78 Female 8/10/2006 Japan
Primary
Secondary
Concomitant
Pneumatosis Intestinalis Hospitalization 6/1/2004 72 Male 168 lb 8/25/2006 Physician Japan
Primary
Concomitant
Pulmonary Congestion Hospitalization 3/19/2005 76 Female 99 lb 9/16/2006 Physician Japan
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 7/22/2006 67 Female 9/28/2006 Physician Japan
Primary
Secondary
Concomitant
Atrioventricular Block Third Degree Life Threatening 6/15/2006 63 Male 104 lb 9/29/2006 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Congestion Hospitalization 3/19/2005 76 Female 99 lb 10/10/2006 Physician Japan
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 7/24/2006 67 Female 99 lb 10/18/2006 Physician Japan
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 7/24/2006 67 Female 99 lb 11/3/2006 Physician Japan
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 7/24/2006 67 Female 11/6/2006 Pharmacist Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Life Threatening 8/30/2006 62 Male 11/8/2006 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Life Threatening 8/30/2006 62 Male 11/14/2006 Physician Japan
Primary
Secondary
Concomitant
Cerebral Haemorrhage Hospitalization 10/30/2006 Male 115 lb 11/21/2006 Physician Japan
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 7/24/2006 67 Female 11/22/2006 Pharmacist Japan
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 7/24/2006 67 Female 12/22/2006 Pharmacist Japan
Primary
Concomitant
Oxygen Saturation Decreased Life Threatening 7/12/2001 Female 1/8/2007 Physician Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 6/7/2006 Male 1/19/2007 Physician Japan
Primary
Concomitant
Cerebral Haemorrhage Hospitalization 10/30/2006 54 Male 115 lb 2/1/2007 Physician Japan
Primary
Secondary
Concomitant
Respiratory Arrest Life Threatening 7/12/2001 Female 2/19/2007 Physician Japan
Primary
Secondary
Concomitant
Serotonin Syndrome Other Serious 3/8/2007 85 Female 3/21/2007 Pharmacist Japan
Primary
Secondary
Concomitant
Serotonin Syndrome Other Serious 3/8/2007 85 Female 3/25/2007 Pharmacist Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 3/8/2007 85 Female 4/13/2007 Pharmacist Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/13/2005 71 Female 5/17/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Cardiac Failure Acute Hospitalization 6/15/2007 Female 101 lb 6/27/2007 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 7/11/2007 Female 143 lb 7/24/2007 Physician Japan
Primary
Concomitant
Cardiac Failure Acute Hospitalization 6/15/2007 Female 101 lb 7/31/2007 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 7/11/2007 Female 143 lb 8/7/2007 Physician Japan
Primary
Concomitant
Ventricular Tachycardia Other Serious 9/14/2006 78 Male 8/30/2007 Physician Japan
Primary
Secondary
Concomitant
Ventricular Tachycardia Other Serious 9/14/2006 78 Male 9/7/2007 Physician United States
Primary
Secondary
Concomitant
Ventricular Tachycardia Other Serious 9/14/2006 78 Male 9/10/2007 Physician United States
Primary
Secondary
Concomitant
Ventricular Tachycardia Other Serious 9/14/2006 78 Male 9/12/2007 Physician United States
Primary
Secondary
Concomitant
Fall Hospitalization 10/30/2006 54 Male 115 lb 10/4/2007 Physician Japan
Primary
Secondary
Concomitant
Nervous System Disorder Hospitalization 5/1/2006 75 Male 10/6/2007 Physician Japan
Primary
Concomitant
Nervous System Disorder Hospitalization 5/1/2006 75 Male 10/27/2007 Physician Japan
Primary
Concomitant
Idiopathic Thrombocytopenic Purpura Other Serious 7/11/2007 Female 143 lb 1/23/2008 Physician Japan
Primary
Concomitant
Dementia Other Serious 79 Female 2/19/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Injection Site Induration Hospitalization 4/1/2007 73 Female 95 lb 3/17/2008 Pharmacist Japan
Primary
Secondary
Concomitant
Pneumonia Aspiration Other Serious 1/21/2008 Male 104 lb 3/27/2008 Physician Japan
Primary
Concomitant
Sudden Death Hospitalization 5/1/2007 Female 4/17/2008 Japan
Primary
Concomitant
Sudden Death Hospitalization 5/1/2007 Female 4/23/2008 Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/28/2008 Male 5/9/2008 Physician Japan
Primary
Concomitant
Hepatic Function Abnormal Life Threatening 12/6/2007 82 Male 128 lb 5/15/2008 Other Health Professional Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/28/2008 Male 5/16/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/28/2008 Male 112 lb 5/19/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Cardiac Failure Other Serious 5/23/2008 44 Male 6/20/2008 Other Health Professional Japan
Primary
Concomitant
Myelodysplastic Syndrome Other Serious 1/1/2005 77 Male 7/15/2008 Consumer Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 6/7/2006 Male 161 lb 7/15/2008 Physician Japan
Primary
Concomitant
Ventricular Fibrillation Death 5/23/2008 Male 121 lb 7/18/2008 Other Health Professional Japan
Primary
Concomitant
Cardiac Failure Life Threatening 10/6/2007 81 Male 132 lb 7/29/2008 Other Health Professional Japan
Primary
Concomitant
Cardiac Failure Life Threatening 10/6/2007 81 Male 132 lb 8/13/2008 Other Health Professional Japan
Primary
Concomitant
Unevaluable Event Hospitalization 84 Male 8/19/2008 Pharmacist Japan
Primary
Concomitant
Unevaluable Event Hospitalization 8/5/2008 84 Male 9/2/2008 Pharmacist Japan
Primary
Concomitant
Cardiac Failure Life Threatening 10/6/2007 81 Male 132 lb 9/3/2008 Other Health Professional Japan
Primary
Concomitant
Upper Respiratory Tract Inflammation Hospitalization 7/29/2008 76 Female 104 lb 9/5/2008 Physician Japan
Primary
Concomitant
Shock Life Threatening 8/18/2008 Female 10/7/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Cerebral Haemorrhage Hospitalization 10/30/2006 Male 115 lb 10/10/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 5/10/2004 59 Male 123 lb 10/17/2008 Japan
Primary
Concomitant
Renal Failure Life Threatening 11/15/2007 86 Male 123 lb 11/5/2008 Other Health Professional Japan
Primary
Concomitant
Cardiac Failure Other Serious Male 176 lb 11/10/2008
Primary
Concomitant
Cardiac Failure Other Serious Male 176 lb 11/12/2008
Primary
Concomitant
Myocardial Infarction Hospitalization 3/31/2007 Female 11/12/2008
Primary
Concomitant
Hepatitis Hospitalization 10/16/2008 Male 141 lb 11/18/2008 Physician
Primary
Concomitant
Renal Failure Life Threatening 1/22/2008 86 Male 123 lb 12/1/2008 Other Health Professional Japan
Primary
Concomitant
Hepatitis Hospitalization 10/16/2008 Male 141 lb 12/3/2008 Physician
Primary
Concomitant
Tricuspid Valve Incompetence Other Serious 4/5/2000 Female 86 lb 12/17/2008 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Acute Disability 11/22/2008 85 Male 1/28/2009 Physician Japan
Primary
Concomitant
Renal Failure Acute Disability 11/22/2008 85 Male 2/12/2009 Physician Japan
Primary
Concomitant
Tricuspid Valve Incompetence Life Threatening 9/15/2007 Female 86 lb 2/13/2009 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Acute Disability 11/22/2008 85 Male 2/16/2009 Physician Japan
Primary
Concomitant
Pneumonia Other Serious 2/21/2009 83 Male 3/18/2009
Primary
Secondary
Concomitant
Ventricular Fibrillation Death 5/23/2008 Male 121 lb 4/3/2009 Other Health Professional France
Primary
Concomitant
Myocardial Infarction Other Serious 5/20/2009 79 Female 6/27/2009 Physician Japan
Primary
Secondary
Concomitant
Vitreous Haemorrhage Other Serious 6/20/2009 Male 9/3/2009 Physician Switzerland
Primary
Secondary
Concomitant
Vitreous Haemorrhage Other Serious 6/20/2009 Male 9/9/2009 Physician Switzerland
Primary
Secondary
Concomitant
Hyperglycaemia Hospitalization 3/9/2008 77 Male 10/2/2009 Japan
Primary
Concomitant
Lung Disorder Hospitalization 4/21/2009 Female 11/3/2009 Other Health Professional France
Primary
Concomitant
Hyperglycaemia Hospitalization 3/9/2008 77 Male 11/6/2009 Japan
Primary
Concomitant
Organising Pneumonia Hospitalization 4/21/2009 Female 12/4/2009 Other Health Professional France
Primary
Concomitant
Vitreous Haemorrhage Other Serious 6/20/2009 Male 1/5/2010 Physician Switzerland
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 12/26/2008 Male 128 lb 3/11/2010 Physician Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 12/26/2008 80 Male 128 lb 4/9/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 2/24/2010 65 Male 6/4/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Rash Generalised Other Serious 3/1/2010 81 Male 6/30/2010 Physician Japan
Primary
Concomitant
Subarachnoid Haemorrhage Death 1/28/2010 81 Male 7/15/2010 Physician Japan
Primary
Secondary
Concomitant
Stent Placement Other Serious 12/14/2007 82 Male 130 lb 8/4/2010 Physician Japan
Primary
Concomitant
Sciatica Other Serious 7/3/2010 96 Female 8/11/2010 Pharmacist Japan
Primary
Concomitant
Pyrexia Hospitalization 3/9/2010 49 Male 152 lb 8/26/2010 Physician Japan
Primary
Secondary
Concomitant
Sciatica Other Serious 4/24/2010 96 Female 79 lb 8/31/2010 Pharmacist Japan
Primary
Concomitant
Retinal Detachment Hospitalization 8/3/2010 75 Male 9/8/2010 Physician Switzerland
Primary
Concomitant
Kidney Transplant Rejection Other Serious 10/25/2006 54 Male 9/23/2010 Physician Japan
Primary
Secondary
Concomitant
Torsade De Pointes Life Threatening 5/5/2010 75 Female 9/10/2010 Japan
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 3/9/2010 49 Male 152 lb 10/11/2010 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 8/29/2010 63 Male 190 lb 10/15/2010 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Hospitalization 8/29/2010 62 Male 190 lb 10/21/2010 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Hospitalization 8/29/2010 63 Male 190 lb 10/28/2010 Physician Japan
Primary
Concomitant
Rash Hospitalization 11/25/2010 65 Male 99 lb 12/9/2010 Physician Japan
Primary
Concomitant
Kidney Transplant Rejection Other Serious 10/25/2006 54 Male 12/23/2010 Physician Japan
Primary
Secondary
Concomitant
International Normalised Ratio Increased Life Threatening 7/20/2010 80 Female 88 lb 2/7/2011 Pharmacist Japan
Primary
Secondary
Concomitant
Neuropathy Peripheral Life Threatening 7/20/2010 80 Female 88 lb 2/11/2011 Pharmacist Japan
Primary
Secondary
Concomitant
Lumbar Vertebral Fracture Hospitalization 2/22/2011 84 Female 5/25/2011 Other Health Professional Japan
Primary
Concomitant
Overdose Other Serious 2/17/2011 86 Female 90 lb 5/31/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Hypothyroidism Other Serious 1/11/2011 68 Male 6/10/2011 Consumer Japan
Primary
Secondary
Concomitant
Epistaxis Hospitalization 1/22/2003 66 Male 134 lb 6/11/2011 Physician Japan
Primary
Concomitant
Chest Discomfort Death 5/1/2003 87 Female 97 lb 6/11/2011 Physician Japan
Primary
Concomitant
Cardiac Failure Congestive Other Serious 11/15/2010 51 Male 6/14/2011 Physician Japan
Primary
Concomitant
Loss Of Consciousness Other Serious 5/31/2011 79 Male 6/14/2011 Pharmacist Japan
Primary
Secondary
Concomitant
Chills Hospitalization 8/5/2004 71 Female 309 lb 6/16/2011 Physician Japan
Primary
Concomitant
Atrial Fibrillation Other Serious 2/18/2009 91 Male 101 lb 6/22/2011 Physician Japan
Primary
Concomitant
Drug Interaction Hospitalization 9/27/2010 70 Male 150 lb 6/23/2011 Physician Japan
Primary
Concomitant
Interacting
Retinal Detachment Disability 8/3/2009 74 Male 7/7/2011 Consumer Switzerland
Primary
Concomitant
Depressed Level Of Consciousness Hospitalization 6/24/2011 78 Male 132 lb 7/21/2011 Physician Japan
Primary
Concomitant
Off Label Use Hospitalization 12/1/2007 58 Female 88 lb 8/8/2011 Pharmacist Japan
Primary
Concomitant
Blood Urea Increased Other Serious 5/9/2011 75 Male 8/11/2011 Physician Japan
Primary
Concomitant
Altered State Of Consciousness Death 7/29/2011 79 Female 97 lb 8/25/2011 Physician Japan
Primary
Secondary
Haemorrhagic Disorder Hospitalization 11/21/2010 84 Male 9/12/2011 Physician Japan
Primary
Secondary
Concomitant
Cerebral Infarction Disability 8/23/2011 74 Male 139 lb 10/5/2011 Physician Japan
Primary
Secondary
Concomitant
Neuralgia Hospitalization 9/16/2010 81 Male 132 lb 10/10/2011 Physician Japan
Primary
Concomitant
Muscular Weakness Hospitalization 9/28/2011 76 Male 139 lb 10/13/2011 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 12/1/2010 79 Male 110 lb 10/17/2011 Physician Japan
Primary
Secondary
Concomitant
Embolic Cerebral Infarction Hospitalization 9/22/2011 72 Female 10/17/2011 Physician Japan
Primary
Concomitant
Anaemia Other Serious 1/11/2011 68 Male 10/19/2011 Consumer Japan
Primary
Secondary
Concomitant
Neutrophil Count Decreased Death 5/12/2011 65 Male 10/19/2011 Physician Japan
Primary
Secondary
Concomitant
Condition Aggravated Hospitalization 9/28/2011 76 Male 139 lb 10/20/2011 Physician Japan
Primary
Secondary
Concomitant
Cerebral Infarction Hospitalization 8/23/2011 74 Male 139 lb 11/8/2011 Physician Japan
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 10/3/2011 70 Male 11/16/2011 Physician Japan
Primary
Concomitant
Anaemia Other Serious 1/11/2011 68 Male 11/24/2011 Consumer Japan
Primary
Secondary
Concomitant
C-reactive Protein Increased Other Serious 2/3/2011 91 Male 117 lb 12/2/2011 Other Health Professional Japan
Primary
Concomitant
Gastrooesophageal Reflux Disease Other Serious 5/12/2008 67 Male 121 lb 12/5/2011 Physician Japan
Primary
Concomitant
Blast Cell Count Increased Other Serious 11/15/2010 51 Male 12/6/2011 Physician Japan
Primary
Concomitant
Oedema Peripheral Other Serious 5/12/2008 67 Male 121 lb 12/12/2011 Physician Japan
Primary
Concomitant
Multiple Myeloma Disability 5/12/2011 65 Male 12/29/2011 Physician Japan
Primary
Secondary
Concomitant
Blast Cell Count Increased Hospitalization 11/15/2010 51 Male 1/26/2012 Physician Japan
Primary
Concomitant
Diabetes Mellitus Other Serious 2/2/2011 66 Female 139 lb 2/22/2012 Physician Japan
Primary
Concomitant
Ventricular Tachycardia Hospitalization 1/18/2012 82 Female 2/27/2012 Consumer Germany
Primary
Secondary
Concomitant
Pneumonia Other Serious Male 3/5/2012 Other Health Professional Switzerland
Primary
Concomitant
Cerebral Infarction Disability 2/28/2012 78 Male 109 lb 3/12/2012 Physician Japan
Primary
Secondary
Cerebral Infarction Hospitalization 2/28/2012 78 Male 109 lb 3/19/2012 Physician Japan
Primary
Secondary

Drug Data