Lamotrigine combined with Valproate Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Partial Seizures Other Serious 10/15/2005 36 Female 129 lb 1/4/2006 Physician Mexico
Primary
Concomitant
Hypospadias Other Serious 1/19/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Disability 17 Female 1/19/2006 Australia
Primary
Secondary
Anger Hospitalization 8/18/2005 43 Male 1/20/2006 Australia
Primary
Secondary
Concomitant
Spina Bifida Congenital Anomaly NotSpecified 6 lb 2/3/2006 United Kingdom
Primary
Secondary
Unintended Pregnancy Other Serious 4/7/2005 21 Female 90 lb 2/28/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Placental Disorder Other Serious 4/7/2005 1 2/28/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Somnolence Other Serious 1/25/2006 38 Female 2/22/2006 Slovakia (Slovak Republic)
Primary
Secondary
Status Epilepticus Life Threatening 3/4/2005 Male 26 lb 3/24/2006 Physician Macedonia, The Former Yugoslav Republic Of
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious Male 3/27/2006 Pharmacist United Kingdom
Primary
Concomitant
Gastroschisis Death Male 4/6/2006 Physician Poland
Primary
Concomitant
Onychoclasis Other Serious 11/1/2005 60 Female 5/16/2006 Consumer Australia
Primary
Concomitant
Tachycardia Other Serious 4/26/2004 57 Female 6/2/2006 France
Primary
Concomitant
Interacting
Disorientation Other Serious 7/10/2005 77 Male 5/25/2006 Other Health Professional United Kingdom
Primary
Concomitant
Tardive Dyskinesia Other Serious 12/1/2005 Male 6/12/2006 Other Health Professional United Kingdom
Primary
Concomitant
Petit Mal Epilepsy Other Serious 15 Male 6/15/2006 Consumer United Kingdom
Primary
Secondary
Therapy Non-responder Other Serious 17 Female 6/27/2006 Physician Spain
Primary
Secondary
Concomitant
Stereotypic Movement Disorder Hospitalization 26 Male 7/6/2006 France
Primary
Secondary
Concomitant
Pericardial Effusion Other Serious 1/1/2006 48 Female 6/30/2006 Other Health Professional Netherlands
Primary
Concomitant
Therapy Regimen Changed Hospitalization 24 Male 7/17/2006 France
Primary
Interacting
Rebound Effect Other Serious 35 Female 7/18/2006 Physician United Kingdom
Primary
Concomitant
Granulocytopenia Required Intervention 12/5/2005 48 Male 6/16/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/17/2005 20 Female 1/27/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 8/15/2005 26 Male 5/17/2006 Consumer United States
Primary
Concomitant
Tonic Convulsion 29 Male 212 lb 1/30/2006 Pharmacist United States
Primary
Secondary
Concomitant
Drug Exposure During Pregnancy Other Serious Female 7/28/2006 Australia
Primary
Secondary
Concomitant
Migraine Other Serious 4/14/2006 42 Male 295 lb 7/25/2006 Consumer United States
Primary
Concomitant
Leukopenia Required Intervention 3/1/2006 60 Female 5/18/2006 Consumer United States
Primary
Concomitant
Foetal Movements Decreased Other Serious NotSpecified 8/18/2006 Mexico
Primary
Concomitant
Pancreatitis Hospitalization 14 Female 8/23/2006 United Kingdom
Primary
Secondary
Concomitant
Sudden Death Death 9/12/2000 Male 8/30/2006 United Kingdom
Primary
Concomitant
Drug Administration Error Other Serious 31 Female 9/11/2006 Other Health Professional France
Primary
Secondary
Aggression Other Serious 4 Female 9/12/2006 Pharmacist Belgium
Primary
Concomitant
Tic Other Serious 1/1/2005 7 Female 11/9/2006 Consumer United Kingdom
Primary
Concomitant
Weight Increased Other Serious 1/1/2006 26 Male 11/9/2006 Consumer Germany
Primary
Concomitant
Renal Failure Hospitalization 1/1/1997 31 Male 11/13/2006 France
Primary
Concomitant
Weight Decreased Other Serious 35 Female 11/15/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Sudden Death Death 9/12/2000 29 Male 11/6/2006 United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious 9/15/2006 63 Female 112 lb 11/8/2006 United Kingdom
Primary
Concomitant
Mental Impairment Hospitalization 11/7/2006 57 12/19/2006 United Kingdom
Primary
Secondary
Concomitant
Ocular Hyperaemia Hospitalization Female 12/22/2006 Consumer United Kingdom
Primary
Concomitant
Tachycardia Other Serious Female 1/4/2007 Consumer Ireland
Primary
Secondary
Petit Mal Epilepsy Other Serious 15 Male 1/22/2007 Other Health Professional United Kingdom
Primary
Secondary
Vomiting Hospitalization 23 Female 1/25/2007 France
Primary
Concomitant
Interacting
Petit Mal Epilepsy Other Serious 15 Male 1/29/2007 Other Health Professional France
Primary
Secondary
Spina Bifida Congenital Anomaly Female 6 lb 1/22/2007 United Kingdom
Primary
Secondary
Type Iv Hypersensitivity Reaction Other Serious 18 Female 2/9/2007 Consumer United States
Primary
Concomitant
Acute Hepatic Failure Death 2/23/2006 17 Female 115 lb 2/21/2007 Consumer United Kingdom
Primary
Concomitant
Urinary Incontinence Other Serious 1/1/2007 60 Male 154 lb 2/21/2007 Consumer Netherlands
Primary
Secondary
Concomitant
Spina Bifida Congenital Anomaly Female 6 lb 3/9/2007 Consumer United Kingdom
Primary
Secondary
Nystagmus Hospitalization 2/25/2007 51 Female 120 lb 3/20/2007 Physician Taiwan, Province Of China
Primary
Concomitant
Weight Decreased Other Serious 47 Male 3/23/2007 Other Health Professional United Kingdom
Primary
Concomitant
No Therapeutic Response Other Serious 7/1/2006 19 Male 3/21/2007 Physician United Kingdom
Primary
Secondary
Convulsion Other Serious 5/1/2006 51 Male 12/19/2006 Physician United States
Primary
Concomitant
Treatment Noncompliance Hospitalization 2/1/2007 16 Female 3/29/2007 Other Health Professional United States
Primary
Secondary
Vision Blurred Required Intervention 4/16/2007 United Kingdom
Primary
Concomitant
Vomiting Hospitalization 23 Female 5/4/2007 France
Primary
Concomitant
Interacting
Transplant 3/23/2007 65 Male 5/29/2007 United States
Primary
Concomitant
Uvula Aplasia Other Serious 12/28/1997 Male 6/18/2007 Lawyer France
Primary
Secondary
Uvula Aplasia Other Serious 1/4/2003 Male 6/18/2007 Lawyer France
Primary
Secondary
Mobility Decreased Hospitalization Male 7/17/2007 Consumer Ireland
Primary
Secondary
Concomitant
Rash Maculo-papular Other Serious 2/7/2007 28 Female 7/20/2007 Consumer United Kingdom
Primary
Concomitant
Mobility Decreased Hospitalization Male 7/26/2007 Consumer Ireland
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 11 Female 8/1/2007 Turkey
Primary
Concomitant
Intraventricular Haemorrhage Neonatal Other Serious Male 5 lb 8/7/2007 Physician Serbia And Montenegro
Primary
Concomitant
Puberty Hospitalization 1/1/2006 10 Female 115 lb 8/20/2007 Physician Germany
Primary
Concomitant
Electroencephalogram Abnormal Other Serious 16 Male 9/6/2007 Belgium
Primary
Concomitant
Interacting
Status Epilepticus Life Threatening 6/10/2007 19 Male 8/30/2007 Physician United Kingdom
Primary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 32 Male 9/13/2007 Bulgaria
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 5/24/2007 33 Female 187 lb 9/18/2007 Other Health Professional Poland
Primary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 32 Male 9/14/2007 Bulgaria
Primary
Concomitant
White Blood Cell Count Increased Other Serious 2/7/2007 28 Female 143 lb 9/21/2007 Consumer United Kingdom
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 5/24/2007 33 Female 187 lb 9/24/2007 Other Health Professional Poland
Primary
Concomitant
Grand Mal Convulsion Other Serious 10/9/2007 Female 10/15/2007 Pharmacist United Kingdom
Primary
Concomitant
Myoclonus Other Serious 10/18/2007 Other Health Professional France
Primary
Interacting
Myoclonus Other Serious 10/25/2007 Other Health Professional Australia
Primary
Secondary
Weight Decreased Hospitalization 11/1/2007 Physician United Kingdom
Primary
Concomitant
Myoclonus Other Serious 11/1/2006 11/1/2007 Other Health Professional France
Primary
Interacting
Tremor Other Serious 10/9/2007 Female 11/16/2007 Pharmacist United Kingdom
Primary
Concomitant
Tremor Other Serious 10/9/2007 Female 11/28/2007 Pharmacist United Kingdom
Primary
Concomitant
Interacting
Tremor Other Serious 10/9/2007 Female 12/7/2007 Pharmacist United Kingdom
Primary
Concomitant
Interacting
Septic Shock Life Threatening 11 Female 79 lb 12/12/2007 Consumer United Kingdom
Primary
Concomitant
Gingival Hypertrophy Disability 1/1/2004 5 Female 12/14/2007 Other Health Professional France
Primary
Concomitant
Encephalopathy Other Serious 1/1/2006 28 Male 1/18/2008 France
Primary
Secondary
Concomitant
Pneumonia Hospitalization Male 12/7/2007 Physician United States
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 5/14/2007 56 Female 154 lb 1/28/2008 Physician Austria
Primary
Concomitant
Weight Decreased Hospitalization 35 Male 1/28/2008 Physician Germany
Primary
Secondary
Concomitant
Myoclonic Epilepsy Other Serious 0 Female 2/15/2008 France
Primary
Secondary
White Blood Cell Count Increased Other Serious 2/7/2007 28 Female 143 lb 2/29/2008 Consumer United Kingdom
Primary
Concomitant
Thrombocytopenic Purpura Other Serious 7/1/2006 19 Male 3/3/2008 Consumer United Kingdom
Primary
Secondary
Withdrawal Syndrome Other Serious 45 Male 2/29/2008 United States
Primary
Concomitant
Thrombocytopenic Purpura Other Serious 7/1/2006 19 Male 3/7/2008 Physician United Kingdom
Primary
Secondary
Rash Generalised Other Serious 20 Male 3/9/2008 Consumer
Primary
Secondary
Concomitant
Thrombocytopenic Purpura Other Serious 7/1/2006 19 Male 3/14/2008 Other Health Professional France
Primary
Secondary
Liver Injury Other Serious 3/25/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Toxic Shock Syndrome Staphylococcal Life Threatening 10/1/2007 11 Female 3/26/2008 Pharmacist France
Primary
Concomitant
Interacting
Tremor Disability 14 Male 4/3/2008 France
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2008 20 Male 4/9/2008 Consumer United States
Primary
Secondary
Concomitant
Crohn's Disease Hospitalization 10/10/2007 Female 123 lb 5/2/2008 Physician United Kingdom
Primary
Concomitant
Grand Mal Convulsion Other Serious 3/1/1984 Female 5/30/2008 Physician France
Primary
Secondary
Concomitant
Hepatic Encephalopathy Other Serious 71 Female 5/30/2008 France
Primary
Concomitant
Withdrawal Syndrome Other Serious 45 Male 6/27/2008 United States
Primary
Concomitant
Tendonitis Other Serious 16 Male 7/9/2008 France
Primary
Secondary
Metabolic Encephalopathy Other Serious 71 Female 7/10/2008 France
Primary
Concomitant
Osteoporosis Hospitalization 7 Male 7/11/2008 France
Primary
Secondary
Rash Other Serious 5/20/2008 17 Female 137 lb 7/9/2008 Physician Poland
Primary
Concomitant
Vomiting Hospitalization 2/23/2006 17 Female 115 lb 8/5/2008 Consumer United Kingdom
Primary
Concomitant
Uvula Aplasia Other Serious 12/28/1997 Male 8/19/2008 Lawyer France
Primary
Secondary
Troponin Increased Hospitalization 8/12/2008 Male 210 lb 8/22/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Hypospadias Congenital Anomaly Male 8/27/2008 Other Health Professional United Kingdom
Primary
Secondary
Troponin Increased Hospitalization 8/12/2008 Male 210 lb 8/29/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Maternal Drugs Affecting Foetus Congenital Anomaly Male 6 lb 9/4/2008 Other Health Professional United Kingdom
Primary
Secondary
Troponin Increased Hospitalization 8/12/2008 Male 210 lb 9/4/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Vitamin D Deficiency Other Serious 11 Male 8/29/2008 Physician Greece
Primary
Secondary
Vitamin D Deficiency Other Serious 11 Male 9/8/2008 Other Health Professional Greece
Primary
Secondary
Unintended Pregnancy Other Serious 31 Female 9/2/2008 Other Health Professional Germany
Primary
Secondary
Maternal Drugs Affecting Foetus Other Serious 6/16/2008 Male 1 lb 9/2/2008 Other Health Professional Germany
Primary
Secondary
Suicidal Ideation Hospitalization 8/10/2008 Male 209 lb 9/10/2008 Germany
Primary
Concomitant
Wound Secretion Hospitalization 8/12/2008 Male 210 lb 9/11/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Vitamin D Deficiency Other Serious 11 Male 9/11/2008 Greece
Primary
Secondary
Treatment Noncompliance Other Serious 11 Male 9/8/2008 Physician Greece
Primary
Secondary
Maternal Drugs Affecting Foetus Congenital Anomaly Male 6 lb 9/12/2008 Other Health Professional United Kingdom
Primary
Secondary
Rickets Other Serious 11 Male 9/12/2008 France
Primary
Secondary
Photosensitivity Reaction Disability 55 Female 9/15/2008 Consumer United Kingdom
Primary
Concomitant
Posture Abnormal 7/7/2008 45 Female 9/22/2008 Physician United Kingdom
Primary
Concomitant
Weight Increased Other Serious 8/1/2007 22 Male 9/24/2008 Consumer United States
Primary
Concomitant
Strabismus Congenital Anomaly 12/28/1997 Male 9/26/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Maternal Drugs Affecting Foetus Other Serious Male 9/22/2008 United Kingdom
Primary
Secondary
Bone Marrow Failure Other Serious 10/28/2008 32 Female 11/6/2008 Physician South Africa
Primary
Concomitant
Tremor Hospitalization 72 Female 11/14/2008 France
Primary
Concomitant
Interacting
Rickets Other Serious 11 Male 11/24/2008 Consumer Greece
Primary
Secondary
Bone Marrow Failure Other Serious 10/28/2008 32 Female 12/23/2008 Physician South Africa
Primary
Secondary
Concomitant
Varicose Vein Hospitalization 12/16/2008 Female 1/2/2009 Physician New Zealand
Primary
Concomitant
Drug Ineffective Other Serious 12/10/2008 Other Health Professional United States
Primary
Secondary
Rash Generalised Hospitalization 1/16/2009 29 Male 187 lb 1/28/2009 Physician Portugal
Primary
Concomitant
Sweat Gland Disorder Other Serious 9 Male 2/4/2009
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 12 Female 2/6/2009 Consumer Iran (Islamic Republic Of)
Primary
Concomitant
Sweat Gland Disorder Other Serious 9 Male 2/11/2009 United Kingdom
Primary
Interacting
Rash Hospitalization 1/1/2005 16 Female 2/6/2009 Physician New Zealand
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 11/1/2000 59 Male 2/6/2009 Physician New Zealand
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 11/1/2000 59 Male 2/10/2009 Physician New Zealand
Primary
Concomitant
Rash Macular Hospitalization 1/1/2005 16 Female 2/10/2009 Physician New Zealand
Primary
Concomitant
Increased Tendency To Bruise Other Serious 10/7/2008 79 Female 2/13/2009 United Kingdom
Primary
Concomitant
Psychiatric Symptom Life Threatening Female 2/25/2009 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 2 Female 33 lb 3/3/2009 Pharmacist United Kingdom
Primary
Concomitant
Hallucination Other Serious 5/1/2006 60 Male 3/11/2009 France
Primary
Interacting
Hallucination Other Serious 5/1/2006 60 Male 3/26/2009 France
Primary
Interacting
Sudden Unexplained Death In Epilepsy Death 3/9/2009 Female 3/23/2009 Germany
Primary
Concomitant
Panic Reaction Other Serious 5/1/2006 Male 3/27/2009 Consumer Germany
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 44 Female 4/2/2009 France
Primary
Secondary

Drug Data