Lamotrigine combined with Phenytoin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
International Normalised Ratio Increased 7/22/2004 9/12/2005 Physician United States
Primary
Concomitant
Tachycardia Other Serious 4/26/2004 57 Female 5/1/2006 France
Primary
Concomitant
Interacting
Vomiting Projectile Hospitalization 7/1/2005 Female 5/5/2006 Other Health Professional United Kingdom
Primary
Secondary
Vomiting Projectile Hospitalization 7/1/2005 Female 5/11/2006 Physician United Kingdom
Primary
Secondary
Tachycardia Other Serious 4/26/2004 57 Female 6/2/2006 France
Primary
Concomitant
Interacting
Vomiting Projectile Hospitalization 7/1/2005 Female 5/26/2006 Other Health Professional United Kingdom
Primary
Secondary
Lethargy Hospitalization 5/16/2006 56 Male 157 lb 7/16/2006 Pharmacist United States
Primary
Concomitant
Drug Interaction Other Serious 55 Male 9/21/2006 Other Health Professional Australia
Primary
Secondary
Concomitant
Ventricular Tachycardia Death 2/15/2006 Male 235 lb United States
Primary
Concomitant
Status Epilepticus Hospitalization 8/26/2006 29 Male 9/25/2006 Other Health Professional Ireland
Primary
Concomitant
Therapy Non-responder Other Serious 6/7/2006 42 Male 10/3/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Hospitalization 4/15/2000 Female 10/27/2006 Consumer France
Primary
Secondary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Hospitalization 4/15/2000 Female 10/31/2006 Consumer France
Primary
Secondary
Concomitant
Urine Ketone Body Present Other Serious 12/1/2005 Female 12/26/2006 Other Health Professional United Kingdom
Primary
Concomitant
Urticaria Hospitalization 6/1/2006 22 Male 2/9/2007 Consumer United States
Primary
Secondary
Tachyarrhythmia Other Serious 29 Male 154 lb 3/1/2007 Other Health Professional United Kingdom
Primary
Concomitant
Fall Death 2/20/2007 36 Female 181 lb 3/20/2007 Physician Russian Federation
Primary
Concomitant
Vomiting Projectile Other Serious 7/1/2005 1 Female 3/23/2007 United Kingdom
Primary
Secondary
Concomitant
Vomiting Projectile Hospitalization 1/1/1996 1 Female 3/27/2007 United Kingdom
Primary
Secondary
Vomiting Projectile Hospitalization 7/1/2005 1 Female 4/10/2007 Other Health Professional United Kingdom
Primary
Secondary
Fall Death 2/20/2007 36 Female 181 lb 5/2/2007 Physician Russian Federation
Primary
Concomitant
Suicide Attempt Other Serious 36 Male 6/1/2007 United States
Primary
Secondary
Concomitant
Tremor Other Serious 2/24/2001 Male 6/27/2007 Consumer United States
Primary
Concomitant
Status Epilepticus Hospitalization 8/26/2006 29 Male 8/10/2007 Other Health Professional Ireland
Primary
Concomitant
Speech Disorder Hospitalization 44 Male 8/31/2007 Germany
Primary
Concomitant
Electroencephalogram Abnormal Other Serious 16 Male 9/6/2007 Belgium
Primary
Concomitant
Interacting
Status Epilepticus Hospitalization 8/26/2006 29 Male 9/13/2007 Other Health Professional Ireland
Primary
Concomitant
Status Epilepticus Hospitalization 8/26/2006 29 Male 9/28/2007 Other Health Professional Ireland
Primary
Concomitant
Headache Other Serious 64 Female 10/17/2007 Other Health Professional Australia
Primary
Secondary
Headache Other Serious 64 Female 10/18/2007 Other Health Professional Australia
Primary
Secondary
Tremor Other Serious 2/1/2001 Male 135 lb 10/19/2007 Consumer United States
Primary
Concomitant
Myelitis Transverse Hospitalization 7/19/2007 Male 240 lb 10/31/2007 Physician
Primary
Concomitant
Tremor Other Serious 2/1/2001 Male 135 lb 11/9/2007 Consumer United States
Primary
Concomitant
Rash Generalised Other Serious 10/23/2007 67 Female 12/14/2007 Other Health Professional United Kingdom
Primary
Concomitant
Rhabdomyolysis Life Threatening 1/1/2008 37 Female 231 lb 2/8/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Life Threatening 1/1/2008 37 Female 231 lb 2/20/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 11/10/2006 75 Female 2/19/2008 Physician Turkey
Primary
Secondary
Status Epilepticus Life Threatening 1/1/2008 37 Female 231 lb 2/19/2008 United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Life Threatening 1/1/2008 37 Female 231 lb 3/7/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Somnolence 12/21/2007 Female 172 lb 3/14/2008 Consumer United States
Primary
Concomitant
Vomiting Projectile Hospitalization Female 4/30/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Grand Mal Convulsion Other Serious 3/1/1984 Female 5/30/2008 Physician France
Primary
Secondary
Concomitant
Status Epilepticus Other Serious 6/8/2006 42 Male 7/7/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vagus Nerve Disorder Other Serious 1/1/1998 Female 7/21/2008 Consumer United States
Primary
Secondary
Concomitant
Vesicoureteric Reflux Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Vesicoureteric Reflux Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Vesicoureteric Reflux Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Vesicoureteric Reflux Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Vesicoureteric Reflux Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Vesicoureteric Reflux Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Vesicoureteric Reflux Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Vesicoureteric Reflux Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Vesicoureteric Reflux Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Vesicoureteric Reflux Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Tracheo-oesophageal Fistula Congenital Anomaly 8/5/2008 Other Health Professional Ireland
Primary
Concomitant
Vomiting Life Threatening 5/12/2008 46 Female 8/12/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Life Threatening 46 Female 8/18/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Troponin Increased Hospitalization 8/12/2008 Male 210 lb 8/22/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Hospitalization 8/7/2008 25 Female 8/25/2008 Consumer United Kingdom
Primary
Secondary
Drug Interaction Hospitalization 8/7/2008 25 Female 8/26/2008 Other Health Professional United Kingdom
Primary
Interacting
Drug Interaction Hospitalization 8/7/2008 25 Female 8/28/2008 Other Health Professional United Kingdom
Primary
Interacting
Troponin Increased Hospitalization 8/12/2008 Male 210 lb 8/29/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Other Serious 25 Female 9/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Postictal State Hospitalization 8/7/2008 25 Female 8/27/2008 Other Health Professional United Kingdom
Primary
Concomitant
Troponin Increased Hospitalization 8/12/2008 Male 210 lb 9/4/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Convulsion Hospitalization 8/7/2008 25 Female 8/28/2008 Other Health Professional United Kingdom
Primary
Secondary
Wound Secretion Hospitalization 8/12/2008 Male 210 lb 9/11/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Stomach Discomfort Other Serious 2/1/2001 Male 130 lb 9/15/2008 Consumer United States
Primary
Secondary
Concomitant
Status Epilepticus Other Serious 4 Female 9/19/2008 United States
Primary
Secondary
Hepatotoxicity Other Serious 4 9/23/2008 Consumer United States
Primary
Secondary
Concomitant
Parainfluenzae Virus Infection Other Serious 4 Female 9/22/2008 Other Health Professional United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 3 Female 9/29/2008 United States
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Other Serious 50 Female 10/9/2008 Norway
Primary
Secondary
Drug Eruption Other Serious 17 Female 10/9/2008 Norway
Primary
Secondary
Vomiting Hospitalization 6/4/2003 12 Female 10/16/2008 France
Primary
Concomitant
Vomiting Projectile Other Serious 7/1/2005 Female 10/22/2008 Denmark
Primary
Concomitant
Paraesthesia Other Serious 2/24/2001 60 Male 130 lb 11/26/2008 Consumer United States
Primary
Concomitant
Interacting
Brugada Syndrome Other Serious 67 Male 1/2/2009 Other Health Professional Italy
Primary
Concomitant
Ventricular Fibrillation Life Threatening 67 Male 12/22/2008 Physician Italy
Primary
Concomitant
Ventricular Fibrillation Other Serious 67 Male 1/5/2009 Physician Italy
Primary
Concomitant
Brugada Syndrome Other Serious 67 Male 1/2/2008 Italy
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 11/1/2000 59 Male 2/6/2009 Physician New Zealand
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 11/1/2000 59 Male 2/10/2009 Physician New Zealand
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 50 Female 2/17/2009 Germany
Primary
Secondary
Concomitant
Convulsion 6/1/2006 39 Female 3/25/2009 United Kingdom
Primary
Secondary
Concomitant
Product Quality Issue Other Serious 3/27/2009 23 Male 180 lb 3/27/2009 Pharmacist United States
Primary
Concomitant
Convulsion 6/1/2006 39 Female 5/4/2009 United Kingdom
Primary
Secondary
Concomitant
Vith Nerve Paralysis Hospitalization 25 Female 5/11/2009 Australia
Primary
Concomitant
Vith Nerve Paralysis Other Serious 25 Female 5/28/2009
Primary
Secondary
Concomitant
Vith Nerve Paralysis Other Serious 25 Female 5/22/2009 Physician Australia
Primary
Concomitant
Meningitis Aseptic Hospitalization 25 Female 6/1/2009 Other Health Professional Australia
Primary
Concomitant
Muscle Spasms Disability 4/30/2009 6/1/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Virus Culture Positive Hospitalization 4 Female 5/29/2009 Physician United States
Primary
Concomitant
Malabsorption Other Serious 41 Female 6/3/2009 Pharmacist France
Primary
Concomitant
Vomiting Hospitalization 25 Female 5/29/2009 Australia
Primary
Concomitant
Malabsorption Other Serious 41 Female 6/12/2009 Pharmacist France
Primary
Secondary
Vith Nerve Paralysis Other Serious 25 Female 6/4/2009 Other Health Professional
Primary
Concomitant
Unevaluable Event Disability 1/1/1968 Male 155 lb 6/8/2009 Consumer United States
Primary
Secondary
Vith Nerve Paralysis Hospitalization 25 Female 6/19/2009 Australia
Primary
Concomitant
Rash Hospitalization 3/1/2008 81 6/29/2009 United Kingdom
Primary
Concomitant
Vith Nerve Paralysis Other Serious 25 Female 7/3/2009 United Kingdom
Primary
Concomitant
Impaired Driving Ability Other Serious 4/1/2009 Male 6/23/2009 Physician United States
Primary
Concomitant
Rash Other Serious 37 Female 7/17/2009 Norway
Primary
Concomitant
Drug Interaction Other Serious Male 7/22/2009 Other Health Professional Germany
Primary
Secondary
Vomiting Other Serious 25 Female 7/29/2009 United Kingdom
Primary
Concomitant
Suicidal Ideation Other Serious 8/1/2005 38 Male 139 lb 7/30/2009 Consumer Germany
Primary
Secondary
Concomitant
Gastrooesophageal Reflux Disease Male 140 lb 8/6/2009 Consumer United States
Primary
Concomitant
Vith Nerve Paralysis Other Serious 25 Female 8/14/2009 United Kingdom
Primary
Concomitant
Tonic Convulsion Other Serious 8/28/2009 Physician Japan
Primary
Concomitant
Drug Interaction Other Serious Female 8/25/2009 Denmark
Primary
Secondary
Rash Other Serious 17 Female 8/31/2009 Germany
Primary
Secondary
Concomitant
Idiosyncratic Drug Reaction Other Serious 26 Female 8/31/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Rash Other Serious 40 Female 8/31/2009 Germany
Primary
Secondary
Concomitant
Rash Other Serious 37 Male 8/31/2009 Other Health Professional Germany
Primary
Concomitant
Rash Other Serious 37 Female 8/31/2009 Germany
Primary
Secondary
Concomitant
Rash Other Serious 31 Female 8/31/2009 Germany
Primary
Secondary
Concomitant
Rash Other Serious 53 Male 8/31/2009 Germany
Primary
Secondary
Concomitant
Vith Nerve Paralysis Hospitalization 25 Female 8/31/2009 United States
Primary
Secondary
Concomitant
Completed Suicide Death 31 Female 9/7/2009 Physician United States
Primary
Secondary
Concomitant
Malabsorption Other Serious 41 Female 9/9/2009 Pharmacist France
Primary
Secondary
Vomiting Projectile Hospitalization 1/7/2005 1 Female 9/22/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Ventricular Tachycardia Other Serious 2/24/2009 Female 9/23/2009 Consumer United States
Primary
Secondary
Vomiting Projectile Hospitalization 1/7/2005 1 Female 9/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Projectile Other Serious 1/6/1996 1 Female 9/18/2009 Other Health Professional United Kingdom
Primary
Secondary
Vomiting Projectile Other Serious 1/6/1996 16 Female 9/18/2009 United Kingdom
Primary
Concomitant
Vomiting Projectile Other Serious 1/6/1996 16 Female 9/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Projectile Other Serious 1 Female 9/22/2009
Primary
Secondary
Concomitant
Vomiting Projectile Other Serious 1 Female 9/26/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Confusional State Hospitalization 11/25/2008 48 Male 9/18/2009 Pharmacist United States
Primary
Secondary
Concomitant
Ventricular Tachycardia Other Serious 2/24/2009 Female 11/11/2009 Physician United States
Primary
Secondary
Drug Ineffective Other Serious 23 Female 11/5/2009 Spain
Primary
Concomitant
Memory Impairment Other Serious 32 Male 12/14/2009 Other Health Professional United States
Primary
Concomitant
Drug Rash With Eosinophilia And Systemic Symptoms Hospitalization 70 Female 12/21/2009 Other Health Professional France
Primary
Secondary
Concomitant
Poisoning Hospitalization 12/1/2009 48 Male 12/22/2009 Physician Germany
Primary
Concomitant
Interacting
Drug Toxicity Hospitalization 12/1/2009 48 Female 12/30/2009 Physician Germany
Primary
Secondary
Concomitant
Sweat Gland Disorder Other Serious 9 Male 1/18/2010 United Kingdom
Primary
Secondary
Concomitant
Visual Impairment Other Serious 48 Female 2/2/2010 Other Health Professional New Zealand
Primary
Secondary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Hospitalization 4/15/2000 Female 2/3/2010 France
Primary
Secondary
Concomitant

Drug Data