Lactulose combined with Nexavar

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Renal Cell Carcinoma Stage Unspecified Death 1/19/2006 55 Male 218 lb 2/28/2006 United States
Primary
Concomitant
Urinary Incontinence Other Serious 3/10/2006 Female 110 lb 3/15/2006 Pharmacist United States
Primary
Concomitant
Urinary Incontinence 3/10/2006 Female 110 lb 7/12/2006 United States
Primary
Concomitant
Flatulence 6/1/2006 54 Male 7/12/2006 United States
Primary
Concomitant
Flatulence 6/1/2006 54 Male 10/23/2006 United States
Primary
Concomitant
Thrombocytopenia Other Serious 7/8/2007 75 Male 8/7/2007 Physician United States
Primary
Concomitant
Thrombocytopenia Other Serious 7/8/2007 75 Male 10/5/2007 Physician United States
Primary
Concomitant
Weight Decreased Death 7/19/2007 75 Male 161 lb 10/11/2007 Pharmacist Canada
Primary
Concomitant
Weight Decreased Death 7/19/2007 75 Male 161 lb 12/6/2007 Pharmacist Canada
Primary
Concomitant
Hepatic Neoplasm Malignant Death 30 Male 146 lb 12/17/2007 Physician Australia
Primary
Concomitant
Vomiting 11/1/2007 58 Male 11/19/2007 Consumer United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/2007 79 Female 108 lb 3/21/2008 Consumer United States
Primary
Concomitant
Renal Cell Carcinoma Stage Iv Hospitalization 7/15/2008 54 Male 108 lb 10/17/2008 Physician Japan
Primary
Concomitant
Liver Function Test Abnormal Other Serious 68 Male 168 lb 1/13/2009 United States
Primary
Secondary
Concomitant
Left Ventricular Dysfunction Other Serious 2/1/2008 60 Male 269 lb 1/16/2009 Other Health Professional United States
Primary
Concomitant
Left Ventricular Dysfunction Other Serious 2/1/2008 60 Male 269 lb 1/19/2009 Other Health Professional United States
Primary
Concomitant
Weight Decreased Other Serious 10/10/2008 60 Male 183 lb 1/23/2009 Netherlands
Primary
Concomitant
Weight Decreased Other Serious 10/10/2008 60 Male 183 lb 2/2/2009 Netherlands
Primary
Concomitant
Weight Decreased Other Serious 10/10/2008 60 Male 183 lb 2/6/2009 Netherlands
Primary
Concomitant
Hepatic Encephalopathy Other Serious 7/25/2008 72 Male 179 lb 4/8/2009 Physician Japan
Primary
Concomitant
Skin Exfoliation Other Serious 2/9/2009 56 Male 5/5/2009 United States
Primary
Concomitant
Platelet Count Decreased Other Serious 1/9/2009 Male 7/6/2009 Physician United States
Primary
Concomitant
Nausea Other Serious 3/26/2009 52 Male 183 lb 7/7/2009 Other Health Professional United States
Primary
Concomitant
Hepatic Neoplasm Malignant Death 8/6/2009 67 Male 121 lb 8/24/2009 Physician Japan
Primary
Concomitant
Renal Failure Life Threatening 7/13/2009 66 Female 106 lb 9/3/2009 Physician Japan
Primary
Concomitant
Depressed Level Of Consciousness Other Serious 8/5/2009 75 Male 9/4/2009 Physician Iran (Islamic Republic Of)
Primary
Concomitant
Vomiting Hospitalization 5/11/2009 44 Male 176 lb 9/8/2009 Other Health Professional United States
Primary
Concomitant
Jaundice Hospitalization 7/25/2009 77 Male 132 lb 9/17/2009 Physician Japan
Primary
Concomitant
Nausea Hospitalization 3/26/2009 52 Male 183 lb 9/21/2009 Other Health Professional United States
Primary
Concomitant
Malaise Hospitalization 8/19/2009 56 Male 168 lb 9/21/2009 Physician Japan
Primary
Concomitant
Thrombocytopenia Other Serious 5/21/2009 71 Male 137 lb 9/29/2009 Korea, Republic Of
Primary
Concomitant
Platelet Count Decreased Hospitalization 7/21/2009 77 Male 104 lb 10/2/2009 Physician Japan
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 8/19/2009 69 Male 168 lb 10/7/2009 Physician Japan
Primary
Concomitant
Weight Decreased Other Serious 6/1/2009 52 Male 10/13/2009 United States
Primary
Concomitant
Renal Cell Carcinoma Other Serious 7/8/2007 66 Male 157 lb 11/18/2009 Germany
Primary
Concomitant
Liver Disorder Other Serious 9/22/2009 67 Male 126 lb 12/8/2009 Physician Japan
Primary
Concomitant
Splenomegaly Other Serious 6/1/2009 55 Male 12/15/2009 Physician United States
Primary
Concomitant
International Normalised Ratio Increased Other Serious 10/21/2008 57 Male 174 lb 12/28/2009 Pharmacist United States
Primary
Concomitant
Diarrhoea Male 1/5/2010 Consumer United States
Primary
Concomitant
Hepatic Failure Death 11/21/2009 71 Male 1/25/2010 Physician Japan
Primary
Concomitant
Wound Dehiscence Other Serious 1/1/2007 Male 222 lb 2/11/2010 Physician United States
Primary
Concomitant
Wound Dehiscence Other Serious 1/1/2007 Male 222 lb 2/18/2010 Physician United States
Primary
Concomitant
Wound Dehiscence Other Serious 1/1/2007 Male 222 lb 2/26/2010 Physician United States
Primary
Concomitant
Wound Dehiscence Other Serious 1/1/2007 Male 222 lb 3/2/2010 Physician United States
Primary
Concomitant
Liver Function Test Abnormal 68 Male 168 lb 8/7/2009 United States
Primary
Secondary
Concomitant
Wound Dehiscence Other Serious 1/1/2007 Male 222 lb 3/11/2010 Physician United States
Primary
Concomitant
Wound Dehiscence Other Serious 1/1/2007 Male 222 lb 3/18/2010 Physician United States
Primary
Concomitant
Pain Death 1/1/2010 63 Male 150 lb 3/24/2010 Germany
Primary
Concomitant
Rash Other Serious 11/2/2009 74 Male 148 lb 3/26/2010 Physician Japan
Primary
Secondary
Concomitant
Wound Dehiscence Other Serious 1/1/2007 Male 222 lb 3/30/2010 Physician United States
Primary
Concomitant
Nausea Hospitalization 3/26/2009 52 Male 183 lb 4/7/2010 Other Health Professional United States
Primary
Concomitant
Unevaluable Event Other Serious 1/1/2009 64 Male 4/13/2010 United States
Primary
Concomitant
Renal Cell Carcinoma Hospitalization 7/15/2008 54 Male 108 lb 4/14/2010 Physician Japan
Primary
Concomitant
Hepatic Encephalopathy Other Serious 7/25/2008 72 Male 179 lb 4/14/2010 Physician Japan
Primary
Concomitant
Jaundice Other Serious 2/2/2010 72 Male 187 lb 4/16/2010 Physician United States
Primary
Concomitant
Renal Failure Life Threatening 7/13/2009 66 Female 106 lb 4/20/2010 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 9/16/2009 61 Male 159 lb 4/20/2010 Physician Japan
Primary
Concomitant
Thrombocytopenia Other Serious 5/21/2009 71 Male 143 lb 4/26/2010 Korea, Republic Of
Primary
Concomitant
Nausea Hospitalization 3/26/2009 52 Male 183 lb 4/30/2010 Other Health Professional Germany
Primary
Concomitant
Jaundice Other Serious 2/2/2010 72 Male 187 lb 5/7/2010 Physician United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 3/1/2010 62 Female 5/7/2010 United States
Primary
Concomitant
Rash Other Serious 11/2/2009 74 Male 148 lb 6/1/2010 Physician Japan
Primary
Secondary
Concomitant
Splenomegaly Other Serious 6/1/2009 55 Male 6/3/2010 Physician United States
Primary
Concomitant
Encephalopathy Hospitalization Female 6/4/2010 Physician United States
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 8/31/2009 67 Female 123 lb 6/9/2010 Physician Japan
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Death 2/16/2010 76 Male 137 lb 7/12/2010 Physician Japan
Primary
Concomitant
Liver Disorder Other Serious 9/22/2009 67 Male 126 lb 7/27/2010 Physician Japan
Primary
Concomitant
Liver Disorder Other Serious 9/22/2009 67 Male 126 lb 7/29/2010 Physician Japan
Primary
Concomitant
Pyrexia Life Threatening 9/15/2009 61 Male 159 lb 7/30/2010 Physician Japan
Primary
Concomitant
Renal Failure Life Threatening 7/13/2009 66 Female 106 lb 8/13/2010 Physician Japan
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Death 2/16/2010 76 Male 137 lb 8/26/2010 Physician Japan
Primary
Concomitant
Somnolence Other Serious 1/4/2010 71 Male 8/27/2010 Physician United States
Primary
Concomitant
Somnolence Other Serious 1/4/2010 71 Male 9/3/2010 Physician United States
Primary
Concomitant
Jaundice Hospitalization 7/25/2009 77 Male 132 lb 9/16/2010 Physician Japan
Primary
Concomitant
Somnolence Other Serious 1/4/2010 71 Male 9/20/2010 Physician United States
Primary
Concomitant
Renal Failure Life Threatening 7/13/2009 66 Female 106 lb 10/12/2010 Other Health Professional Japan
Primary
Concomitant
Encephalopathy Hospitalization Female 10/20/2010 Physician United States
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Other Serious 8/1/2010 76 Male 123 lb 10/25/2010 Libyan Arab Jamahiriya
Primary
Concomitant
Renal Failure Life Threatening 7/13/2009 66 Female 106 lb 11/1/2010 Physician Japan
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Other Serious 7/25/2010 76 Male 123 lb 11/10/2010 Libyan Arab Jamahiriya
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Other Serious 7/25/2010 76 Male 123 lb 11/18/2010 Libyan Arab Jamahiriya
Primary
Concomitant
Multi-organ Failure Hospitalization 11/14/2010 73 Female 11/23/2010 Physician United States
Primary
Concomitant
Encephalopathy Death 1/4/2010 71 Male 1/14/2011 Physician United States
Primary
Concomitant
Gastrointestinal Erosion Other Serious 9/1/2008 60 Male 141 lb 2/7/2011 Other Health Professional Japan
Primary
Concomitant
Sepsis Hospitalization 9/10/2010 56 Male 3/14/2011 Physician Italy
Primary
Concomitant
Pyrexia Hospitalization 1/29/2010 75 Male 115 lb 3/24/2011 Pharmacist Japan
Primary
Concomitant
General Physical Health Deterioration Death 7/23/2010 73 Male 150 lb 5/2/2011 Physician Japan
Primary
Concomitant
Fatigue Other Serious Male 5/7/2011 Consumer United States
Primary
Concomitant
Pneumonia Death 2/1/2011 53 Male 136 lb 5/7/2011 Physician United States
Primary
Concomitant
Hepatic Encephalopathy Hospitalization 1/18/2011 51 Female 5/9/2011 Physician United States
Primary
Concomitant
Vertigo Other Serious 10/25/2010 73 Male 5/11/2011 Consumer Germany
Primary
Concomitant
Thrombocytopenia Hospitalization 2/8/2011 56 Male 173 lb 5/13/2011 Physician United States
Primary
Concomitant
Coma Hospitalization 5/10/2011 57 Male 5/16/2011 Consumer United States
Primary
Concomitant
Diarrhoea Hospitalization 4/1/2011 53 Female 5/21/2011 Physician United States
Primary
Concomitant
Face Oedema Other Serious 8/5/2010 69 Male 152 lb 6/3/2011 Physician Japan
Primary
Concomitant
Loss Of Consciousness Hospitalization 5/1/2011 83 Female 6/13/2011 Consumer United States
Primary
Concomitant
Hepatic Encephalopathy Hospitalization 1/29/2010 75 Male 115 lb 6/14/2011 Pharmacist Japan
Primary
Concomitant
Hepatic Encephalopathy Hospitalization 1/29/2010 75 Male 115 lb 6/17/2011 Pharmacist Japan
Primary
Concomitant
Oedema Peripheral Other Serious 8/5/2010 69 Male 152 lb 6/17/2011 Physician Japan
Primary
Concomitant
Fatigue Life Threatening 7/23/2010 73 Male 150 lb 7/26/2011 Physician Japan
Primary
Concomitant
Rash Other Serious 8/5/2010 69 Male 152 lb 8/2/2011 Physician Japan
Primary
Concomitant
Oculogyric Crisis Other Serious 7/28/2011 71 Male 8/4/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Atrial Fibrillation Other Serious 1/4/2010 71 Male 8/5/2011 Consumer United States
Primary
Secondary
Concomitant
Gastrointestinal Erosion Other Serious 9/1/2008 60 Male 141 lb 8/25/2011 Physician Japan
Primary
Concomitant
Retinal Vascular Thrombosis Other Serious 6/7/2011 62 Male 148 lb 8/31/2011 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Ascites Hospitalization 6/21/2011 66 Male 9/7/2011 Consumer United States
Primary
Concomitant
Abdominal Pain Upper Other Serious 4/1/2011 54 Male 9/8/2011 Physician United States
Primary
Concomitant
Decreased Appetite Other Serious 6/20/2010 60 Male 154 lb 9/13/2011 Physician Japan
Primary
Concomitant
Chronic Hepatic Failure Death 3/30/2011 60 Female 9/22/2011 Other Health Professional United States
Primary
Concomitant
Blister Hospitalization 8/1/2011 54 Male 9/24/2011 Other Health Professional United States
Primary
Concomitant
Consciousness Fluctuating Other Serious Female 9/26/2011 Consumer United States
Primary
Concomitant
Hyperkeratosis Hospitalization 8/1/2011 54 Male 9/29/2011 Other Health Professional United States
Primary
Concomitant
Dyspnoea Other Serious 4/1/2011 54 Male 10/1/2011 Consumer United States
Primary
Concomitant
Cerebral Haemorrhage Death 5/1/2011 83 Female 10/5/2011 Consumer United States
Primary
Concomitant
Fall Hospitalization 6/20/2011 66 Male 10/12/2011 Physician United States
Primary
Concomitant
Hepatic Failure Death 9/1/2010 74 Male 88 lb 10/14/2011 Physician Japan
Primary
Concomitant
Hyperkeratosis Hospitalization 9/26/2011 54 Male 10/17/2011 Other Health Professional United States
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 2/19/2011 77 Female 150 lb 10/17/2011 Physician Japan
Primary
Concomitant
Depressed Mood Other Serious 9/1/2011 74 Female 10/19/2011 Consumer United States
Primary
Concomitant
Somnolence Life Threatening 1/4/2010 71 Male 10/20/2011 Physician United States
Primary
Secondary
Concomitant
Blood Pressure Increased Other Serious 9/1/2011 74 Female 10/24/2011 Other Health Professional United States
Primary
Concomitant
Hepatic Encephalopathy Life Threatening 9/16/2011 76 Male 128 lb 10/26/2011 Physician Japan
Primary
Concomitant
Ascites Hospitalization 8/5/2010 69 Male 152 lb 10/26/2011 Physician Japan
Primary
Concomitant
Jaundice Hospitalization 8/19/2011 63 Male 121 lb 11/10/2011 Physician Japan
Primary
Secondary
Concomitant
Blood Pressure Increased Other Serious 9/1/2011 74 Female 11/22/2011 Other Health Professional United States
Primary
Concomitant
Diarrhoea Death 7/23/2010 73 Male 150 lb 11/28/2011 Physician Japan
Primary
Concomitant
Respiratory Distress Other Serious 3/30/2011 60 Female 12/8/2011 Other Health Professional United States
Primary
Concomitant
Chromaturia Other Serious 12/1/2011 57 Male 12/16/2011 Physician United States
Primary
Concomitant
Blood Uric Acid Increased Other Serious 7/23/2010 73 Male 150 lb 12/16/2011 Physician Japan
Primary
Concomitant
Ammonia Increased Other Serious 12/1/2011 57 Male 12/19/2011 Other Health Professional United States
Primary
Concomitant
Renal Failure Death 10/29/2011 74 Male 93 lb 12/28/2011 Physician Japan
Primary
Concomitant
Haematochezia Other Serious 8/1/2011 60 Male 12/30/2011 Physician United States
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 8/19/2009 68 Male 167 lb 1/17/2012 Physician Japan
Primary
Concomitant
Diarrhoea Hospitalization 1/18/2009 1/18/2012 Other Health Professional Italy
Primary
Concomitant
Hepatic Encephalopathy Hospitalization 1/18/2009 68 Female 1/30/2012 Physician Italy
Primary
Concomitant
Diarrhoea Other Serious 12/1/2011 57 Male 2/3/2012 Physician United States
Primary
Concomitant
Hepatic Encephalopathy Hospitalization 3/16/2010 57 Male 2/6/2012 Consumer United States
Primary
Concomitant
Chromaturia Other Serious 12/1/2011 57 Male 2/7/2012 Other Health Professional United States
Primary
Concomitant
Hepatic Failure Death 1/1/2012 57 Male 194 lb 2/10/2012 Physician Austria
Primary
Concomitant
Diarrhoea Other Serious 12/1/2011 57 Male 2/14/2012 Consumer United States
Primary
Concomitant
Confusional State Hospitalization 11/26/2011 65 Male 209 lb 2/23/2012 Consumer United Kingdom
Primary
Concomitant
Confusional State Hospitalization 11/24/2011 Male 3/8/2012 Other Health Professional United Kingdom
Primary
Concomitant
Fatigue Other Serious 2/1/2012 63 Male 3/14/2012 Physician United States
Primary
Concomitant
Death Death 2/1/2012 63 Male 3/16/2012 Physician United States
Primary
Concomitant
Confusional State Hospitalization 11/26/2011 65 Male 209 lb 3/19/2012 Consumer United Kingdom
Primary
Concomitant
Fatigue Hospitalization 4/1/2012 59 Male 4/5/2012 Consumer United States
Primary
Concomitant
Unresponsive To Stimuli Hospitalization 4/15/2012 55 Male 136 lb 4/18/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Dehydration Other Serious 4/1/2012 72 Male 6/12/2012 Consumer United States
Primary
Concomitant
Tumour Haemorrhage Other Serious 7/23/2010 73 Male 150 lb 6/18/2012 Physician Japan
Primary
Concomitant
Ammonia Increased Hospitalization 4/1/2012 59 Male 172 lb 6/25/2012 Physician United States
Primary
Concomitant

Drug Data