Lactulose combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Breast Cancer Stage Iii Hospitalization 9/19/2005 Female 1/5/2006 Other Health Professional United Kingdom
Primary
Concomitant
Uterine Cancer Other Serious 11/1/2003 90 Female 121 lb 1/30/2006 United States
Primary
Secondary
Concomitant
Osteoporosis Hospitalization 2/15/2004 Female 112 lb 2/9/2006 United Kingdom
Primary
Concomitant
Paraesthesia Hospitalization 12/4/2005 21 Male 159 lb 2/17/2006 United Kingdom
Primary
Concomitant
Sepsis Hospitalization 12/15/2005 66 Male 2/14/2006 Sweden
Primary
Secondary
Concomitant
Uterine Cancer Other Serious 88 Female 121 lb 2/24/2006 United States
Primary
Secondary
Concomitant
Pyopneumothorax Other Serious 5/28/2005 Female 104 lb 3/23/2006 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 1/1/2000 70 Female 146 lb 3/28/2006 Lawyer United States
Primary
Concomitant
Renal Failure Chronic Hospitalization 1/1/2000 78 Female 150 lb 4/7/2006 Physician United States
Primary
Concomitant
Vomiting Hospitalization 1/1/2000 70 Female 146 lb 4/10/2006 Physician United States
Primary
Concomitant
Respiratory Distress Hospitalization 1/1/2000 78 Female 150 lb 5/3/2006 Physician United States
Primary
Concomitant
Osteoporosis Hospitalization 2/15/2004 Female 112 lb 5/23/2006 Consumer United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 3/1/2006 Female 8/1/2006 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 3/1/2006 Female 8/18/2006 Physician United States
Primary
Secondary
Concomitant
Chest Discomfort Disability 2/16/2006 43 Female 8/30/2006 Australia
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/1/2006 Female 9/7/2006 Physician United States
Primary
Secondary
Concomitant
Death Other Serious Female 137 lb 9/20/2006 Other Health Professional United Kingdom
Primary
Concomitant
Hyponatraemia Other Serious 7/8/2006 65 Female 9/26/2006 Consumer United States
Primary
Concomitant
Thrombosis 9/29/2006 Pharmacist United States
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2006 Female 12/5/2006 Physician United States
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 10/14/2006 11 Female 60 lb 11/30/2006 Physician Canada
Primary
Concomitant
Pneumonia Other Serious Female 137 lb 1/25/2007 Other Health Professional United Kingdom
Primary
Concomitant
Ankle Fracture Hospitalization 8/17/2004 Female 112 lb 2/6/2007 Other Health Professional United Kingdom
Primary
Concomitant
Renal Colic Hospitalization 11/5/2006 Male 176 lb 2/9/2007 Other Health Professional United Kingdom
Primary
Concomitant
Heart Rate Abnormal Disability 2/16/2006 43 Female 2/17/2007 Australia
Primary
Secondary
Concomitant
Wound Other Serious 8/14/2006 Female 137 lb 3/23/2007 Other Health Professional United Kingdom
Primary
Concomitant
Polyneuropathy Other Serious 9/30/1999 5 Female 4/5/2007 Physician Sweden
Primary
Concomitant
Interacting
Haemorrhage Hospitalization 3/27/2006 Female 130 lb 4/11/2007 Consumer United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 2/11/2007 Female 112 lb 5/10/2007 Other Health Professional United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 2/11/2007 Female 112 lb 5/18/2007 Other Health Professional United Kingdom
Primary
Concomitant
Breast Cancer Stage Iii Hospitalization 9/19/2005 Female 212 lb 6/22/2007 Physician United Kingdom
Primary
Concomitant
Vomiting Other Serious 12/25/2004 Female 110 lb 6/25/2007 Consumer United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 9 Male 7/10/2007 Other Health Professional Sweden
Primary
Concomitant
Vomiting Hospitalization 1/1/2007 Male 7/13/2007 Other Health Professional United Kingdom
Primary
Concomitant
Renal Colic Other Serious 11/5/2006 Male 176 lb 7/20/2007 Other Health Professional United Kingdom
Primary
Concomitant
Sepsis Other Serious 3/27/2006 Female 130 lb 7/20/2007 Consumer United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 2/11/2007 Female 112 lb 7/25/2007 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 9 Male 8/3/2007 Other Health Professional Sweden
Primary
Concomitant
Radiation Mucositis Other Serious 6/1/2007 Male 126 lb 8/31/2007 Germany
Primary
Concomitant
Swelling Face Other Serious 6/2/2007 Male 174 lb 9/7/2007 Other Health Professional United Kingdom
Primary
Concomitant
Toxic Epidermal Necrolysis Required Intervention 10 Male 9/17/2007 Other Health Professional Sweden
Primary
Secondary
Concomitant
Swelling Face Other Serious 6/2/2007 Male 174 lb 10/31/2007 Other Health Professional United Kingdom
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 10/14/2006 11 Female 60 lb 11/8/2007 Physician Canada
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 10 Male 11/8/2007 Sweden
Primary
Secondary
Concomitant
Syncope Life Threatening 7/11/2007 Female 190 lb 11/21/2007 Physician United States
Primary
Concomitant
Toxic Epidermal Necrolysis Other Serious 10 Male 12/14/2007 Sweden
Primary
Secondary
Concomitant
Vomiting Other Serious 12/25/2004 Female 110 lb 1/15/2008 Consumer United States
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 9/27/2004 67 Male 2/8/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Other Serious 9/27/2004 67 Male 2/15/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 2/5/2008 3 Male 29 lb 2/26/2008 Other Health Professional Canada
Primary
Concomitant
Surgery Hospitalization 9/27/2004 29 Male 2/26/2008 Germany
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Hospitalization 9/27/2004 Male 2/29/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Sepsis Death 7/11/2007 Female 154 lb 3/31/2008 United Kingdom
Primary
Concomitant
Sepsis Death 7/11/2007 Female 154 lb 4/8/2008 United Kingdom
Primary
Concomitant
Urinary Tract Infection Staphylococcal Other Serious 8/2/2007 50 Female 6/23/2008 Physician United Kingdom
Primary
Concomitant
Death Other Serious Female 119 lb 7/18/2008 Other Health Professional United Kingdom
Primary
Concomitant
Carcinoma In Situ Of Skin Other Serious 4/4/2007 Female 137 lb 7/29/2008 Other Health Professional United Kingdom
Primary
Concomitant
Liver Function Test Abnormal Other Serious 9/2/2007 Male 212 lb 8/4/2008 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Staphylococcal Other Serious 8/2/2007 50 Female 8/7/2008 Physician United Kingdom
Primary
Concomitant
Death Other Serious 65 Female 163 lb 8/18/2008 Other Health Professional United Kingdom
Primary
Concomitant
Varices Oesophageal 9/20/2006 53 Male 2/21/2008 Physician United States
Primary
Concomitant
Myocardial Ischaemia Other Serious 65 Female 163 lb 9/5/2008 Other Health Professional United Kingdom
Primary
Concomitant
Post Procedural Pneumonia Other Serious 10/9/2007 Male 238 lb 10/3/2008 Other Health Professional United Kingdom
Primary
Concomitant
Ventricular Dysfunction Hospitalization 9/28/2008 Male 200 lb 10/6/2008 Consumer United States
Primary
Secondary
Concomitant
Joint Dislocation Other Serious 5/8/2008 73 Female 128 lb 10/13/2008 Consumer United Kingdom
Primary
Concomitant
Myocardial Ischaemia Other Serious 65 Female 163 lb 10/28/2008 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Other Serious 6/21/2008 78 Female 119 lb 10/31/2008 Other Health Professional United Kingdom
Primary
Concomitant
Nephrotic Syndrome Hospitalization Male 216 lb 11/14/2008 Physician Belgium
Primary
Concomitant
Tympanic Membrane Perforation Hospitalization 2/15/2007 15 Male 11/14/2008 United Kingdom
Primary
Concomitant
Nephrotic Syndrome Hospitalization 10/14/2008 Male 216 lb 12/12/2008 Belgium
Primary
Secondary
Concomitant
Fall Hospitalization 6/1/2008 Female 119 lb 1/22/2009 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 1/26/2009 25 Female 159 lb 2/5/2009 Pharmacist Canada
Primary
Secondary
Concomitant
Ulcer Hospitalization 12/21/2008 Male 170 lb 2/26/2009 United Kingdom
Primary
Concomitant
Pneumonia Other Serious 1/1/2008 Female 128 lb 3/13/2009 Other Health Professional United Kingdom
Primary
Concomitant
Gastric Ulcer Hospitalization 12/21/2008 Male 170 lb 3/20/2009 United Kingdom
Primary
Concomitant
Glomerulonephritis Proliferative Hospitalization 2/9/2007 Female 130 lb 4/3/2009 Physician United Kingdom
Primary
Concomitant
Death Death 80 Male 214 lb 4/17/2009 Other Health Professional United Kingdom
Primary
Concomitant
Small Cell Lung Cancer Stage Unspecified Other Serious 3/1/2009 54 Female 4/20/2009 Other Health Professional United Kingdom
Primary
Concomitant
Pulmonary Fibrosis Other Serious 80 Male 214 lb 5/21/2009 Other Health Professional United Kingdom
Primary
Concomitant
Injection Site Rash 1/22/2009 19 Female 135 lb 5/15/2009 Consumer United States
Primary
Concomitant
Transaminases Increased Other Serious 1/22/2009 Female 165 lb 6/5/2009 Germany
Primary
Concomitant
Transaminases Increased Other Serious 1/22/2009 Female 165 lb 6/8/2009 Germany
Primary
Concomitant
Gastric Ulcer Other Serious 9/11/2008 Female 130 lb 6/12/2009 United Kingdom
Primary
Concomitant
Small Cell Lung Cancer Extensive Stage Other Serious 1/1/2008 Female 6/16/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 1/22/2009 Female 165 lb 6/16/2009 Germany
Primary
Concomitant
Urinary Tract Infection Other Serious 1/1/2008 80 Male 214 lb 7/16/2009 Other Health Professional United Kingdom
Primary
Concomitant
Transaminases Increased Other Serious 1/22/2009 Female 165 lb 8/17/2009 Germany
Primary
Concomitant
Vomiting Hospitalization 8/1/2009 Female 162 lb 9/4/2009 Canada
Primary
Concomitant
Respiratory Failure Hospitalization 9/4/2009 Male 9/11/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Lymphoma Other Serious 6/15/2007 69 Male 126 lb 9/28/2009 Other Health Professional United Kingdom
Primary
Concomitant
Respiratory Failure Hospitalization 9/4/2009 Male 9/30/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 9/4/2009 Male 10/8/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Wrist Fracture Hospitalization 9/2/2009 75 Female 130 lb 10/13/2009 Physician New Zealand
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 8/24/2009 69 Female 10/21/2009 United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/1/2009 Female 162 lb 10/27/2009 Canada
Primary
Concomitant
Drug Interaction Hospitalization 10/6/2009 15 Male 11/5/2009 Physician France
Primary
Concomitant
Interacting
Drug Interaction Hospitalization 10/6/2009 Male 11/6/2009 Other Health Professional France
Primary
Secondary
Concomitant
Wrist Fracture Hospitalization 9/2/2009 75 Female 130 lb 11/4/2009 Physician New Zealand
Primary
Concomitant
Somnambulism Other Serious 10/29/2009 10 Male 11/11/2009 Pharmacist United Kingdom
Primary
Concomitant
Respiratory Failure Hospitalization 9/4/2009 Male 11/12/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Hodgkin's Disease Nodular Sclerosis Stage Unspecified Other Serious 5/1/2008 69 Male 126 lb 12/18/2009 Other Health Professional United Kingdom
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 11/12/2009 Female 15 lb 12/30/2009 United States
Primary
Secondary
Concomitant
Tachypnoea Hospitalization 11/12/2009 Female 15 lb 1/12/2010 United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Death 11/6/2009 Female 163 lb 2/12/2010 United Kingdom
Primary
Concomitant
Hyperammonaemic Encephalopathy Life Threatening 1 Male 2/24/2010
Primary
Secondary
Concomitant
Wrist Fracture Hospitalization 9/2/2009 Female 130 lb 3/25/2010 Physician New Zealand
Primary
Concomitant
Red Blood Cell Sedimentation Rate Increased 10/6/2009 15 Male 5/13/2010 Other Health Professional France
Primary
Concomitant
Interacting
Pyrexia Hospitalization 36 Male 5/27/2010 Physician United States
Primary
Concomitant
Vomiting Other Serious 36 Male 5/27/2010
Primary
Secondary
Drug Interaction Hospitalization 10/6/2009 15 Male 6/1/2010 Other Health Professional France
Primary
Concomitant
Interacting
Wound Other Serious 5/23/2007 2 lb 7/9/2010 Other Health Professional Sweden
Primary
Concomitant
Premature Rupture Of Membranes Other Serious 1/1/2006 37 Female 7/9/2010 Other Health Professional Sweden
Primary
Concomitant
Small Intestinal Perforation Hospitalization 7/4/2010 5 Male 37 lb 7/5/2010 Canada
Primary
Secondary
Concomitant
Neck Pain 6/1/2006 67 Female 174 lb 7/31/2010 Consumer United States
Primary
Concomitant
Tinea Versicolour Hospitalization 3/28/2010 82 Male 8/13/2010 Physician United States
Primary
Secondary
Concomitant
Weight Bearing Difficulty Other Serious 4/1/2010 63 Female 128 lb 8/25/2010 Other Health Professional Canada
Primary
Concomitant
Pneumonia Other Serious 1/1/2008 72 Female 128 lb 9/14/2010 Other Health Professional United Kingdom
Primary
Concomitant
Chest Discomfort Hospitalization 9/12/2010 53 Female 170 lb 9/23/2010 Other Health Professional Canada
Primary
Concomitant
Sepsis Other Serious 12/27/2007 61 Female 163 lb 12/2/2010 Consumer United States
Primary
Secondary
Concomitant
Nausea Hospitalization 1/22/2009 43 Female 165 lb 1/3/2011 Physician Germany
Primary
Concomitant
Hydronephrosis Other Serious 5/30/1996 48 Female 1/11/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Oxygen Saturation Decreased Other Serious 1/7/2011 49 Female 146 lb 1/28/2011 Other Health Professional Canada
Primary
Concomitant
Injection Site Pain 11/5/2010 41 Female 200 lb 1/30/2011 Consumer United States
Primary
Concomitant
Dysphagia Hospitalization 12/25/2010 82 Female 95 lb 2/7/2011 Other Health Professional Canada
Primary
Concomitant
Local Swelling Hospitalization 12/25/2010 82 Female 95 lb 2/8/2011 Other Health Professional Canada
Primary
Concomitant
Renal Atrophy Other Serious 5/30/1996 48 Female 2/10/2011 United States
Primary
Secondary
Concomitant
Anxiety Other Serious 5/30/1996 48 Female 2/14/2011 Physician United States
Primary
Secondary
Concomitant
Mobility Decreased Hospitalization 10/26/2010 75 Female 5/19/2011 Other Health Professional United Kingdom
Primary
Concomitant
Skin Ulcer Hospitalization 10/26/2010 75 Female 5/23/2011 Other Health Professional United Kingdom
Primary
Concomitant
Rash Other Serious 1/6/2011 49 Female 146 lb 6/29/2011 Other Health Professional Canada
Primary
Concomitant
Vertigo Hospitalization 6/1/2011 61 Female 7/8/2011 Other Health Professional Canada
Primary
Concomitant
Colitis Other Serious 7/25/2011 67 Male 182 lb 8/5/2011 Physician United States
Primary
Concomitant
Failure To Thrive Other Serious 7/25/2011 67 Male 182 lb 8/8/2011 Physician United States
Primary
Concomitant
Penis Carcinoma Other Serious 6/1/2011 54 Male 181 lb 8/23/2011 Other Health Professional United Kingdom
Primary
Concomitant
Pleural Effusion Hospitalization 11/1/2009 61 Female 8/26/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Dyspnoea Other Serious 7/25/2011 67 Male 182 lb 8/28/2011 Physician United States
Primary
Concomitant
Colitis Other Serious 7/25/2011 67 Male 182 lb 8/30/2011 Physician United States
Primary
Concomitant
Failure To Thrive Other Serious 7/25/2011 67 Male 182 lb 9/2/2011 Physician United States
Primary
Concomitant
Bacterial Sepsis Death 5/12/2011 62 Male 9/9/2011 Other Health Professional France
Primary
Secondary
Concomitant
Metastases To Peritoneum Other Serious 11/1/2009 61 Female 9/29/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Ileal Perforation Hospitalization 10/7/2011 4 Female 36 lb 10/10/2011 Physician United States
Primary
Secondary
Concomitant
Appendicectomy Other Serious 11/5/2010 41 Female 194 lb 11/3/2011 Consumer United States
Primary
Concomitant
Gastrointestinal Necrosis Hospitalization 10/7/2011 4 Female 36 lb 11/4/2011 Physician United States
Primary
Secondary
Concomitant
Blood Pressure Systolic Increased Other Serious 5/5/2009 80 Female 163 lb 12/12/2011 Physician Canada
Primary
Concomitant
Rib Fracture Other Serious 12/18/2010 82 Female 163 lb 12/15/2011 Consumer Canada
Primary
Concomitant
Nodular Regenerative Hyperplasia Other Serious 1/1/2007 Male 12/20/2011 Other Health Professional United Kingdom
Primary
Concomitant
Intra-abdominal Haematoma Other Serious 11/1/2009 61 Female 12/21/2011 Physician United States
Primary
Secondary
Concomitant
Injection Site Haematoma Hospitalization 11/9/2011 38 Female 1/3/2012 Consumer United States
Primary
Secondary
Concomitant
Injection Site Haematoma Hospitalization 11/9/2011 38 Female 1/9/2012 Consumer United States
Primary
Secondary
Concomitant
Pneumothorax Hospitalization 9/18/2011 56 Female 1/17/2012 Physician Belgium
Primary
Secondary
Concomitant

Drug Data