Lactulose combined with Metformin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Headache Hospitalization 3/3/2004 Male 1/4/2006 France
Primary
Concomitant
Death Death 3/2/2006 Female 3/15/2006 Physician Canada
Primary
Concomitant
Pain Death 75 Female 4/5/2006 Physician Canada
Primary
Concomitant
Hypoglycaemia Hospitalization 1/16/2006 62 Male Pharmacist United States
Primary
Secondary
Concomitant
Multiple Myeloma Death 10/12/2004 67 Male 250 lb 5/31/2006 Physician Canada
Primary
Concomitant
Disease Progression Death 10/12/2004 67 Male 250 lb 6/21/2006 Physician Canada
Primary
Concomitant
Weight Decreased 1/6/2006 65 Male 230 lb 4/17/2006 Consumer United States
Primary
Secondary
Concomitant
Somnolence Life Threatening 2/24/2006 68 Male 153 lb 6/30/2006 Physician France
Primary
Concomitant
Rash Other Serious 53 Female 10/10/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Pain In Extremity Life Threatening 1/26/2006 69 Male 12/1/2006 Consumer United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 77 Male 4/2/2007 Physician Sweden
Primary
Concomitant
Haemorrhage Hospitalization 3/27/2006 Female 130 lb 4/11/2007 Consumer United Kingdom
Primary
Concomitant
Treatment Noncompliance 6/8/2006 69 Male 10/25/2007 Consumer United States
Primary
Concomitant
Hepatic Encephalopathy Life Threatening 11/18/2007 62 Male 12/5/2007 Physician United States
Primary
Concomitant
Hepatic Encephalopathy Life Threatening 11/18/2007 62 Male 12/7/2007 Physician United States
Primary
Concomitant
Hepatic Encephalopathy Life Threatening 11/18/2007 62 Male 12/11/2007 Physician United States
Primary
Concomitant
Somnolence Life Threatening 2/24/2006 Male 152 lb 6/23/2008 France
Primary
Concomitant
Platelet Count Decreased Other Serious 1/1/2008 Male 195 lb 12/19/2008 Consumer United States
Primary
Concomitant
Left Ventricular Dysfunction Other Serious 2/1/2008 60 Male 269 lb 1/16/2009 Other Health Professional United States
Primary
Concomitant
Platelet Count Decreased Other Serious 1/1/2008 Male 195 lb 1/20/2009 Other Health Professional United States
Primary
Concomitant
Urticaria 1/20/2009 65 Male 190 lb 2/26/2009 Other Health Professional United States
Primary
Concomitant
Tachycardia Hospitalization 63 Male 7/23/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 59 Female 157 lb 10/7/2009 United States
Primary
Concomitant
Thrombocytopenia Hospitalization 6/25/2009 Female 10/8/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/13/2008 Male 10/22/2009 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/1/2008 Male 11/6/2009 Physician United States
Primary
Concomitant
Thrombocytopenia Hospitalization 6/25/2009 Female 11/24/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Wrist Fracture Hospitalization 1/1/2008 51 Female 12/29/2009 Other Health Professional United States
Primary
Concomitant
Renal Failure Acute Hospitalization 68 Male 1/4/2010 Other Health Professional United Kingdom
Primary
Concomitant
Neoplasm Progression Other Serious 12/5/2009 Male 1/4/2010 Physician Canada
Primary
Concomitant
Wrist Fracture Hospitalization 1/1/2008 51 Female 1/25/2010 Other Health Professional United States
Primary
Concomitant
Pneumonia Hospitalization 2/3/2010 63 Male 2/12/2010 Physician Germany
Primary
Concomitant
Thrombocytopenia Hospitalization 2/4/2010 63 Male 2/25/2010 Physician Germany
Primary
Concomitant
Wheelchair User Other Serious 1/1/2004 Male 174 lb 3/22/2010 United States
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 4/14/2009 66 Male 3/29/2010 Physician United States
Primary
Secondary
Concomitant
Neurological Symptom Disability 1/1/2008 66 Male 209 lb 4/19/2010 Pharmacist United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious 5/21/2009 71 Male 143 lb 4/26/2010 Korea, Republic Of
Primary
Concomitant
Subarachnoid Haemorrhage Life Threatening 4/23/2010 77 Female 106 lb 4/29/2010 Physician United States
Primary
Secondary
Concomitant
Suicidal Ideation Hospitalization Male 5/6/2010 Physician United Kingdom
Primary
Concomitant
Tricuspid Valve Incompetence Other Serious 4/23/2010 77 Female 106 lb 5/6/2010 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious Female 5/7/2010 Physician Canada
Primary
Secondary
Concomitant
Surgery Other Serious 1/1/2009 Male 6/4/2010 Pharmacist Germany
Primary
Concomitant
Hepatic Cirrhosis Hospitalization 41 Male 6/7/2010 Physician United States
Primary
Secondary
Concomitant
Tendon Rupture Hospitalization Male 260 lb 7/21/2010 Other Health Professional United States
Primary
Concomitant
Wrong Technique In Drug Usage Process 3/1/2008 68 Male 120 lb 7/21/2010 Consumer United States
Primary
Concomitant
Hepatitis B Other Serious 45 Male 8/18/2010 Consumer United States
Primary
Concomitant
Wheelchair User Other Serious 1/1/2004 57 Male 174 lb 9/3/2010 United States
Primary
Secondary
Concomitant
Tendon Rupture Hospitalization Male 260 lb 9/7/2010 Other Health Professional United States
Primary
Concomitant
Self Injurious Behaviour Hospitalization 74 Female 9/10/2010 Physician United Kingdom
Primary
Concomitant
Traumatic Lung Injury Hospitalization 6/30/2010 61 Male 155 lb 9/17/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Disseminated Intravascular Coagulation Life Threatening 9/8/2010 89 Female 9/22/2010 Other Health Professional United Kingdom
Primary
Concomitant
Nervousness 9/19/2010 51 Female 200 lb 9/26/2010 Consumer United States
Primary
Concomitant
Rash Erythematous Other Serious 9/13/2010 60 Female 220 lb 9/30/2010 Other Health Professional United Kingdom
Primary
Concomitant
Wheelchair User Other Serious 1/1/2004 57 Male 174 lb 9/30/2010 United States
Primary
Secondary
Concomitant
Nervousness 9/19/2010 51 Female 200 lb 10/4/2010 Consumer United States
Primary
Concomitant
Sepsis Death 9/13/2010 10/4/2010 Other Health Professional United Kingdom
Primary
Concomitant
Wheelchair User Other Serious 1/1/2004 57 Male 174 lb 10/14/2010 United States
Primary
Secondary
Concomitant
Traumatic Lung Injury Hospitalization 6/30/2010 61 Male 155 lb 10/15/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Other Serious 7/1/2009 10/21/2010 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 5/7/2005 58 Male 174 lb 10/27/2010 United States
Primary
Secondary
Concomitant
Escherichia Infection Hospitalization 10/17/2010 78 Female 148 lb 12/3/2010 Consumer United Kingdom
Primary
Concomitant
Neuroleptic Malignant Syndrome Other Serious Male 159 lb 12/8/2010 Pharmacist Canada
Primary
Concomitant
Syncope Hospitalization 9/20/2010 45 Male 12/6/2010 Physician United Kingdom
Primary
Concomitant
Treatment Noncompliance Hospitalization 9/20/2010 45 Male 12/9/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 9/20/2010 45 Male 12/9/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 9/20/2010 45 Male 12/10/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Neuroleptic Malignant Syndrome Other Serious Male 159 lb 12/14/2010 Pharmacist Canada
Primary
Concomitant
Multiple Drug Overdose Death 63 Female 265 lb 12/14/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Life Threatening 12/9/2010 75 Male 130 lb 12/21/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 5/7/2005 58 Male 174 lb 12/24/2010 United States
Primary
Secondary
Concomitant
Serotonin Syndrome Death 63 Female 265 lb 12/16/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Life Threatening 12/9/2010 75 Male 130 lb 1/19/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
No Adverse Event 45 Male 1/26/2011 Consumer United States
Primary
Concomitant
Hyperbilirubinaemia Hospitalization 12/19/2010 70 Male 500 lb 1/28/2011 Consumer United States
Primary
Secondary
Concomitant
Hepatic Cirrhosis Hospitalization 1/9/2011 59 Female 2/3/2011 Physician United States
Primary
Concomitant
Hepatic Cirrhosis 1/25/2011 59 Female 1/28/2011 Pharmacist United States
Primary
Concomitant
C-reactive Protein Increased Hospitalization 11/6/2010 78 Male 218 lb 2/10/2011 Physician Sweden
Primary
Secondary
Concomitant
Intervertebral Disc Degeneration Hospitalization 5/7/2005 58 Male 174 lb 2/18/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastric Haemorrhage Hospitalization 11/21/2010 67 Male 132 lb 2/21/2011 Consumer United States
Primary
Secondary
Concomitant
Neutropenic Sepsis Hospitalization 12/9/2010 75 Male 130 lb 3/14/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Oral Herpes Hospitalization 3/1/2011 69 Male 3/22/2011 Other Health Professional Netherlands
Primary
Concomitant
Haemoglobin Decreased Other Serious 10/1/2010 65 Female 139 lb 3/28/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Haemoglobin Decreased Other Serious 10/1/2010 65 Female 139 lb 4/3/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Herpes Simplex Serology Positive Other Serious 5/7/2005 58 Male 174 lb 4/5/2011 Lawyer United States
Primary
Secondary
Concomitant
Diabetic Ketoacidosis Hospitalization 44 Female 243 lb 4/14/2011 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Diabetic Ketoacidosis Hospitalization 44 Female 243 lb 4/14/2011 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Diabetic Ketoacidosis Hospitalization 44 Female 243 lb 4/14/2011 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Syncope Other Serious 3/1/2011 54 Female 154 lb 4/20/2011 Consumer Brazil
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Life Threatening 2/15/2011 70 Male 156 lb 4/25/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Death 12/9/2010 75 Male 130 lb 4/27/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Platelet Count Decreased Hospitalization 4/17/2011 48 Female 147 lb 4/22/2011 Pharmacist United States
Primary
Concomitant
Hepatic Encephalopathy Hospitalization 11/21/2010 67 Male 132 lb 4/28/2011 Physician United States
Primary
Secondary
Concomitant
Skin Disorder Other Serious 12/1/2010 79 Male 176 lb 5/4/2011 Other Health Professional United Kingdom
Primary
Concomitant
Skin Disorder Other Serious 12/1/2010 79 Male 176 lb 5/6/2011 Other Health Professional United Kingdom
Primary
Concomitant
Pancreatic Carcinoma Other Serious 4/1/2011 82 Male 5/13/2011 Physician France
Primary
Concomitant
Large Intestinal Obstruction Death Male 5/23/2011 Other Health Professional United Kingdom
Primary
Concomitant
Hyperkalaemia Hospitalization 5/10/2011 59 Male 7/21/2011 Other Health Professional France
Primary
Secondary
Concomitant
Balance Disorder Hospitalization Male 8/18/2011 Consumer Canada
Primary
Concomitant
Hepatic Neoplasm Malignant Hospitalization Male 260 lb 9/2/2011 Other Health Professional United States
Primary
Concomitant
Diabetes Mellitus Inadequate Control Hospitalization 90 Female 158 lb 6/13/2012 Consumer United Kingdom
Primary
Concomitant
Antipsychotic Drug Level Increased Other Serious 2/20/2012 40 Female 8/22/2012 Pharmacist United Kingdom
Primary
Concomitant
Parkinson's Disease Other Serious Male 8/23/2012 Consumer Ireland
Primary
Concomitant
Renal Impairment Hospitalization 7/1/2012 71 Male 8/24/2012 Physician United States
Primary
Concomitant
Somnolence Death 2/24/2006 68 Male 152 lb 3/22/2013 Physician Fr
Primary
Concomitant
Tricuspid Valve Incompetence Death 4/23/2010 77 Female 107 lb 3/27/2013 Physician Us
Primary
Secondary
Concomitant
Tendon Rupture Death Male 260 lb 3/1/2013 Consumer Us
Primary
Secondary
Concomitant
Tremor Other Serious Female 10/5/2012 Lawyer Us
Primary
Concomitant
Tenderness Other Serious 7/11/2005 56 Male 6/3/2013 Other Health Professional Ie
Primary
Concomitant
Vomiting Other Serious Female 117 lb 10/19/2012 Lawyer Us
Primary
Concomitant
Suicide Attempt Hospitalization 12/25/2011 NotSpecified 4/8/2013 Consumer De
Primary
Secondary
Concomitant
Urosepsis Hospitalization 4/2011 54 Male 12/31/2012 Physician De
Primary
Concomitant
Sudden Cardiac Death Hospitalization 7/2/2011 60 Male 9/12/2012 Physician Se
Primary
Secondary
Concomitant
Suicide Attempt Hospitalization 12/25/2011 74 Male 174 lb 1/22/2013 Consumer Us
Primary
Secondary
Concomitant
Weight Bearing Difficulty Hospitalization 2011 Female 12/11/2012 Other Health Professional Country Not Specified
Primary
Concomitant
Thrombocytopenia Other Serious 6/2012 Male 227 lb 9/10/2012 Other Health Professional Us
Primary
Secondary
Concomitant
Weight Increased Other Serious 1994 32 Female 5/13/2013 Us
Primary
Secondary
Concomitant
Wheezing Other Serious 8/6/2012 84 Male 8/30/2012 Other Health Professional Gb
Primary
Concomitant
Vomiting Hospitalization 2012 72 Female 9/5/2012 Physician Us
Primary
Concomitant
Muscle Spasms 2012 75 Female 191 lb 9/13/2012 Consumer Us
Primary
Secondary
Concomitant
Partial Seizures Other Serious 8/1/2012 66 Female 163 lb 9/13/2012 Physician Gb
Primary
Concomitant
Dizziness 49 Female 3/13/2013 Consumer Us
Primary
Secondary
Concomitant
Chapped Lips Hospitalization 8/15/2012 50 9/25/2012 Other Health Professional Gb
Primary
Concomitant
Chapped Lips Other Serious 8/15/2012 50 9/27/2012 Other Health Professional Gb
Primary
Concomitant
Chapped Lips Hospitalization 8/15/2012 50 10/2/2012 Pharmacist Gb
Primary
Concomitant
Chapped Lips Hospitalization 8/15/2012 50 10/4/2012 Other Health Professional Gb
Primary
Concomitant
Respiratory Failure Death 9/21/2012 75 Female 123 lb 11/5/2012 Physician Hk
Primary
Concomitant
Lip Pain Hospitalization 8/15/2012 50 10/2/2012 Gb
Primary
Concomitant
Lip Pain Hospitalization 8/15/2012 50 10/2/2012 Gb
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 9/17/2012 76 Male 146 lb 10/19/2012 Pharmacist Gb
Primary
Concomitant
Gastric Haemorrhage Hospitalization 10/15/2012 70 Male 243 lb 6/6/2013 Physician Za
Primary
Secondary
Concomitant
Superinfection Hospitalization 8/28/2012 69 Male 10/23/2012 Consumer Us
Primary
Concomitant
Pleural Effusion Hospitalization 9/20/2012 57 Female 11/9/2012 Pharmacist Gb
Primary
Concomitant
Renal Failure Acute Hospitalization 7/2/2012 64 Male 6/17/2013 Physician Us
Primary
Secondary
Concomitant
Glossitis 57 Female 115 lb 11/12/2012 Consumer Us
Primary
Concomitant
Nausea Hospitalization 3/2012 49 Male 223 lb 11/26/2012 Other Health Professional Gb
Primary
Concomitant
Testicular Pain Other Serious 62 Male 11/29/2012 Consumer Dk
Primary
Secondary
Concomitant
Sedation Other Serious 9/25/2012 58 Female 167 lb 2/14/2013 Pharmacist Us
Primary
Concomitant
Aspiration Death Female 2/7/2013 Pharmacist Ca
Primary
Concomitant
Vomiting Hospitalization 12/7/2012 63 Male 1/4/2013 Pharmacist Gb
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/7/2012 63 Male 1/2/2013 Pharmacist Gb
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 12/9/2012 53 Female 216 lb 12/19/2012 Pharmacist Us
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/25/2012 71 Female 5/14/2013 Physician Ca
Primary
Secondary
Concomitant
Leukocyturia Hospitalization 8/2010 54 Female 223 lb 3/1/2013 Physician Fr
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 2004 34 Male 441 lb 5/17/2013 Physician Nz
Primary
Concomitant
Respiratory Depression Other Serious 2/19/2013 66 Female 4/5/2013 Physician Nl
Primary
Concomitant
Thrombocytopenia Hospitalization 3/13/2013 68 Male 240 lb 3/25/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Pyrexia Hospitalization 2/15/2013 79 Male 139 lb 4/26/2013 Physician Gb
Primary
Secondary
Concomitant
Benign Gastric Neoplasm Hospitalization 2/10/2013 58 Male 195 lb 5/10/2013 Consumer Us
Primary
Secondary
Concomitant
Psychotic Disorder Life Threatening 8/14/2012 58 Female 170 lb 4/24/2013 Pharmacist Us
Primary
Concomitant
Sudden Cardiac Death Hospitalization 7/2/2011 60 Male 9/10/2012 Physician Se
Primary
Secondary
Concomitant

Drug Data