Lacosamide combined with Topiramate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vomiting Other Serious Female 1/21/2009 Other Health Professional Germany
Primary
Concomitant
Psychotic Disorder Hospitalization Male 2/5/2009 Germany
Primary
Concomitant
Fall Other Serious 1/29/2009 62 Male 1/30/2009 Physician Germany
Primary
Concomitant
Vomiting Other Serious 12/16/2008 Female 4/7/2009 Pharmacist Germany
Primary
Secondary
Concomitant
Pneumonia Hospitalization 6/16/2009 50 Male 6/29/2009 Physician United States
Primary
Concomitant
Hyponatraemia Death 4/17/2009 63 Female 7/7/2009 Other Health Professional United Kingdom
Primary
Secondary
Hyponatraemia Death 63 Female 7/13/2009 Other Health Professional United Kingdom
Primary
Secondary
Psychotic Disorder Hospitalization 6/1/2009 32 Male 154 lb 8/7/2009 Physician Germany
Primary
Secondary
Concomitant
Psychotic Disorder Hospitalization 6/1/2009 32 Male 154 lb 9/15/2009 Germany
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 6/22/2009 Male 150 lb 10/2/2009 Physician United States
Primary
Concomitant
Status Asthmaticus Hospitalization 7/13/2009 Male 10/2/2009 Physician United States
Primary
Concomitant
Status Asthmaticus Hospitalization 7/13/2009 Male 10/30/2009 Physician United States
Primary
Concomitant
Renal Failure Acute Other Serious 4/25/2009 Male 150 lb 11/26/2009 United States
Primary
Concomitant
Upper Respiratory Tract Infection Hospitalization 6/22/2009 Male 150 lb 11/23/2009 Physician United States
Primary
Concomitant
Nausea 7/25/2009 Female 225 lb 11/19/2009 Consumer United States
Primary
Concomitant
Female Orgasmic Disorder 20 Female 11/19/2009 Physician United States
Primary
Concomitant
Leukopenia Hospitalization 8/1/2009 Female 12/22/2009 Physician Germany
Primary
Concomitant
Leukopenia Hospitalization 8/1/2009 Female 2/16/2010 Consumer Germany
Primary
Concomitant
White Blood Cell Count Increased Life Threatening 1/16/2006 Female 172 lb 3/11/2010 Germany
Primary
Secondary
Concomitant
Vomiting Other Serious 4/1/2006 27 Female 172 lb 3/18/2010 Physician
Primary
Secondary
Pancreatic Enzymes Increased Other Serious 15 Female 3/29/2010 Physician United States
Primary
Secondary
Leukopenia Hospitalization 3/10/2009 38 Female 4/6/2010 Germany
Primary
Concomitant
Vomiting Hospitalization 4/1/2006 27 Female 172 lb 4/16/2010 Other Health Professional United Kingdom
Primary
Secondary
Leukopenia Hospitalization 8/1/2009 38 Female 4/8/2010 Consumer Germany
Primary
Concomitant
Stevens-johnson Syndrome Life Threatening 4/1/2010 48 Male 195 lb 4/22/2010 Pharmacist United States
Primary
Concomitant
Leukopenia Hospitalization 8/1/2009 38 Female 6/24/2010 Other Health Professional Germany
Primary
Concomitant
Drug Ineffective 11/1/2009 44 Female 5/20/2010 Consumer United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 27 Female 8/2/2010 Other Health Professional Germany
Primary
Secondary
Vomiting Hospitalization 27 Female 8/2/2010 Other Health Professional Germany
Primary
Secondary
Vomiting Hospitalization 27 Female 8/2/2010 Other Health Professional Germany
Primary
Secondary
Vomiting Hospitalization 27 Female 8/2/2010 Other Health Professional Germany
Primary
Secondary
Overdose Hospitalization 4/1/2006 27 Female 8/3/2010 Other Health Professional Germany
Primary
Secondary
Vomiting Hospitalization 4/1/2006 27 Female 7/30/2010 Other Health Professional Germany
Primary
Secondary
Vomiting Hospitalization 4/1/2006 27 Female 172 lb 8/25/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Pancreatitis Acute Other Serious 15 Female 8/17/2010 Physician United States
Primary
Secondary
Pancreatitis Acute Other Serious 15 Female 8/17/2010 Physician United States
Primary
Secondary
Optic Neuropathy Hospitalization 10/1/2009 22 Female 10/21/2010 Other Health Professional France
Primary
Secondary
Optic Neuropathy Hospitalization 10/1/2009 22 Female 11/10/2010 Other Health Professional France
Primary
Secondary
Concomitant
Tongue Biting Hospitalization 10/13/2010 26 Male 182 lb 10/28/2010 United Kingdom
Primary
Concomitant
Status Epilepticus Other Serious 38 Female 11/4/2010 Italy
Primary
Concomitant
Treatment Noncompliance Hospitalization 10/13/2010 26 Male 182 lb 11/8/2010 Physician United Kingdom
Primary
Concomitant
Lennox-gastaut Syndrome Other Serious 38 Female 11/4/2010 Italy
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 10/13/2010 26 Male 182 lb 11/19/2010 United Kingdom
Primary
Concomitant
Loss Of Consciousness Other Serious 1/1/2010 46 Female 200 lb 12/1/2010 Consumer United States
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious 6/20/2009 32 Male 12/1/2010 Germany
Primary
Secondary
Concomitant
Pancreatitis Acute Other Serious 15 Female 11/10/2010 Physician United States
Primary
Secondary
Epilepsy Hospitalization 12/10/2010 12/20/2010 Australia
Primary
Concomitant
Electroencephalogram Abnormal Hospitalization Male 12/23/2010 Consumer United States
Primary
Secondary
Concomitant
No Adverse Event 1/12/2009 48 Male 196 lb 1/21/2011 Other Health Professional Germany
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 1/31/2011 52 Female 163 lb 2/7/2011 Consumer United States
Primary
Concomitant
Convulsion Hospitalization 36 Female 3/3/2011 Other Health Professional United Kingdom
Primary
Secondary
Diplopia Other Serious 36 Female 3/9/2011 Consumer United Kingdom
Primary
Secondary
Drug Interaction Other Serious 36 Female 3/9/2011 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Diplopia Hospitalization 36 Female 3/11/2011 Other Health Professional United Kingdom
Primary
Secondary
Inhibitory Drug Interaction Other Serious 36 Female 3/1/2011 Other Health Professional United Kingdom
Primary
Secondary
Persecutory Delusion Other Serious 40 Female 3/1/2011 Physician France
Primary
Secondary
Concomitant
Lethargy 11/1/2010 67 Male 153 lb 2/4/2011 Consumer United States
Primary
Concomitant
Weight Increased Female 2/4/2011 Physician United States
Primary
Concomitant
Quadriparesis Other Serious 74 Female 3/14/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 36 Female 3/17/2011 Consumer United Kingdom
Primary
Secondary
Balance Disorder Other Serious 36 Female 3/4/2011 Other Health Professional United Kingdom
Primary
Secondary
Diplopia Other Serious 36 Female 3/23/2011 Other Health Professional United Kingdom
Primary
Interacting
Drug Interaction Other Serious 36 Female 3/23/2011 Other Health Professional United Kingdom
Primary
Interacting
Off Label Use Other Serious 77 Male 3/14/2011 Physician Germany
Primary
Secondary
Concomitant
Anticonvulsant Drug Level Decreased Hospitalization 36 Female 3/21/2011 Other Health Professional United Kingdom
Primary
Secondary
Balance Disorder Other Serious 37 Female 3/21/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Hospitalization 36 Female 4/7/2011 Other Health Professional United Kingdom
Primary
Secondary
Condition Aggravated Other Serious 36 Female 3/25/2011 United Kingdom
Primary
Secondary
Concomitant
Incorrect Route Of Drug Administration Death 52 Female 4/12/2011 Other Health Professional United Kingdom
Primary
Secondary
Drug Interaction Hospitalization 36 Female 4/14/2011 Physician United Kingdom
Primary
Interacting
Convulsion Hospitalization 36 Female 4/15/2011 Other Health Professional United Kingdom
Primary
Secondary
Dyskinesia Other Serious 1/1/2011 16 Male 114 lb 4/12/2011 Other Health Professional United States
Primary
Concomitant
Glioblastoma Death Male 4/11/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Neurotoxicity Hospitalization 36 Female 4/7/2011 Other Health Professional United Kingdom
Primary
Secondary
Drug Interaction Other Serious 36 Female 4/15/2011 Other Health Professional
Primary
Secondary
Anticonvulsant Drug Level Decreased Hospitalization 36 Female 4/15/2011
Primary
Secondary
Death Death 52 Female 4/15/2011 Physician United Kingdom
Primary
Secondary
Optic Neuropathy Hospitalization 10/1/2009 22 Female 5/4/2011 Other Health Professional France
Primary
Secondary
Concomitant
Status Epilepticus Other Serious 1/1/2011 16 Male 114 lb 4/29/2011 Other Health Professional United States
Primary
Concomitant
Off Label Use Other Serious 2 Male 5/4/2011 Other Health Professional Germany
Primary
Concomitant
Partial Seizures Other Serious 1/1/2007 19 Male 5/5/2011 Physician Germany
Primary
Secondary
Concomitant
Fatigue Other Serious Male 175 lb 5/10/2011 Physician Germany
Primary
Concomitant
Arthralgia Disability 9/16/2010 24 Female 130 lb 5/19/2011 Consumer United States
Primary
Concomitant
Dermatitis Contact Female 5/3/2011 Physician United States
Primary
Concomitant
Weight Increased 6/21/2010 20 Female 5/3/2011 Physician United States
Primary
Concomitant
Sinus Bradycardia 12/17/2010 51 Female 5/3/2011 Other Health Professional United States
Primary
Concomitant
Suicidal Ideation Other Serious 27 Female 172 lb 6/6/2011 Other Health Professional Germany
Primary
Concomitant
Myalgia Disability 9/16/2010 24 Female 130 lb 6/21/2011 Consumer United States
Primary
Concomitant
Acute Psychosis Hospitalization 7/22/2011 33 Male 154 lb 8/17/2011 Physician Poland
Primary
Concomitant
Petit Mal Epilepsy Other Serious 8/9/2011 31 Female 181 lb 8/19/2011 Physician United States
Primary
Concomitant
Memory Impairment Hospitalization 1/10/2007 15 Female 8/29/2011 Consumer United States
Primary
Concomitant
Acute Psychosis Hospitalization 7/22/2011 33 Male 154 lb 9/2/2011 Physician Poland
Primary
Concomitant
Petit Mal Epilepsy Other Serious 8/9/2011 31 Female 181 lb 9/12/2011 Physician United States
Primary
Concomitant
Fatigue Hospitalization 9/3/2010 48 Male 212 lb 8/8/2011 Consumer United States
Primary
Secondary
Concomitant
Weight Increased 8/1/2010 20 Female 96 lb 8/8/2011 Physician United States
Primary
Concomitant
Balance Disorder Other Serious 36 Female 9/15/2011 Other Health Professional United Kingdom
Primary
Secondary
Anticonvulsant Drug Level Decreased Hospitalization 36 Female 9/8/2011 Other Health Professional United Kingdom
Primary
Interacting
Acute Psychosis Hospitalization 7/22/2011 33 Male 154 lb 9/22/2011 Physician Poland
Primary
Concomitant
Anticonvulsant Drug Level Decreased Other Serious 36 Female 9/22/2011 Physician United Kingdom
Primary
Interacting
Diplopia Other Serious 36 Female 9/26/2011 Other Health Professional United Kingdom
Primary
Interacting
Balance Disorder Hospitalization 36 Female 9/22/2011 United Kingdom
Primary
Secondary
Neurotoxicity Hospitalization 36 Female 9/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Drug Level Decreased Other Serious 36 Female 9/26/2011 Other Health Professional United Kingdom
Primary
Secondary
Drug Interaction Hospitalization 12/16/2008 38 Female 10/7/2011 Physician Germany
Primary
Concomitant
Interacting
Diplopia Hospitalization 36 Female 10/7/2011 Other Health Professional United Kingdom
Primary
Interacting
Convulsion Other Serious 36 Female 10/7/2011 Other Health Professional United Kingdom
Primary
Interacting
Drug Interaction Other Serious 36 Female 10/11/2011 Other Health Professional United Kingdom
Primary
Interacting
Neurotoxicity Other Serious 36 Female 10/24/2011 Other Health Professional United Kingdom
Primary
Interacting
Epilepsy Hospitalization 1/1/2011 54 Male 11/7/2011 Consumer United States
Primary
Concomitant
Petit Mal Epilepsy Other Serious 8/9/2011 31 Female 181 lb 12/20/2011 Physician United States
Primary
Concomitant
Diplopia Other Serious 35 Female 12/22/2011 Other Health Professional United Kingdom
Primary
Secondary
Drug Ineffective Other Serious 10/10/2011 31 Female 240 lb 12/27/2011 Other Health Professional United Kingdom
Primary
Concomitant
Drug Hypersensitivity Other Serious 35 Female 12/27/2011 Other Health Professional Denmark
Primary
Secondary
Concomitant
Petit Mal Epilepsy Hospitalization 8/9/2011 31 Female 181 lb 1/5/2012 Physician United States
Primary
Concomitant
Self Esteem Decreased Other Serious 35 Female 1/17/2012 Other Health Professional United Kingdom
Primary
Secondary
Drug Ineffective Other Serious 1/1/2008 44 Female 1/30/2012 Physician Germany
Primary
Secondary
Concomitant
Convulsion Other Serious 10/1/2008 75 Female 1/30/2012 Physician Germany
Primary
Secondary
Concomitant
Dizziness Other Serious 1/1/2008 44 Female 2/1/2012 Physician Germany
Primary
Secondary
Concomitant
Diplopia Disability 6/12/2011 32 Female 128 lb 2/3/2012 Physician France
Primary
Concomitant
Vomiting Hospitalization 12/16/2008 38 Female 2/21/2012 Physician Germany
Primary
Concomitant
Interacting
Post Procedural Infection Death 60 Female 3/21/2012 Other Health Professional Switzerland
Primary
Concomitant
Convulsion Other Serious 36 Female 3/29/2012
Primary
Secondary
Partial Seizures Other Serious 1/1/2011 35 Female 4/27/2012 Physician United Kingdom
Primary
Concomitant
Convulsion Hospitalization 10/1/2008 75 Female 5/1/2012 Physician Germany
Primary
Secondary
Concomitant
Convulsion Other Serious 59 Female 5/14/2012 Other Health Professional United States
Primary
Secondary
Disease Recurrence Other Serious 59 Female 5/17/2012 Other Health Professional United States
Primary
Secondary
Death Death 27 Female 6/12/2012 Other Health Professional Canada
Primary
Secondary
Death Death 27 Female 6/12/2012 Other Health Professional Canada
Primary
Secondary
Partial Seizures Other Serious 31 Female 6/20/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Death Death 27 Female 7/2/2012 Other Health Professional Canada
Primary
Secondary
Death Death 27 Female 7/2/2012 Other Health Professional Canada
Primary
Secondary
Protrusion Tongue Other Serious 31 Female 7/9/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Death Other Serious 1/1/2010 29 Male 7/13/2012 Physician United States
Primary
Secondary
Gait Disturbance Other Serious 31 Female 7/13/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Acute Hepatic Failure Other Serious 1/1/2011 38 Male 7/19/2012 Physician Germany
Primary
Concomitant
Partial Seizures Other Serious 31 Female 7/10/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Movement Disorder Other Serious 31 Female 7/10/2012 Consumer United Kingdom
Primary
Secondary
Concomitant
Mobility Decreased Other Serious 31 Female 7/10/2012 Consumer United Kingdom
Primary
Secondary
Concomitant
General Physical Health Deterioration Other Serious 31 Female 7/10/2012 Other Health Professional
Primary
Secondary
Concomitant
Death Other Serious 1/1/2010 29 Male 8/3/2012 Physician United States
Primary
Secondary
Neurotoxicity Hospitalization 36 Female 2/7/2013 Other Health Professional Gb
Primary
Interacting
Acute Psychosis Hospitalization 7/23/2011 33 Male 154 lb 3/8/2013 Physician Pl
Primary
Concomitant
Toxicity To Various Agents Other Serious 20 Male 8/31/2012 Other Health Professional Country Not Specified
Primary
Secondary
Death Death 80 Male 9/17/2012 Physician Ch
Primary
Secondary
Death Death 63 Female 9/17/2012 Physician Ch
Primary
Secondary
Death Death 64 Male 9/17/2012 Physician Ch
Primary
Secondary
Rash 7/2012 Female 10/25/2012 Physician Us
Primary
Concomitant
Drug Ineffective Other Serious 2012 41 Male 12/11/2012 Physician Es
Primary
Concomitant
Weight Decreased Other Serious NotSpecified 2/22/2013 Other Health Professional De
Primary
Concomitant
Ventricular Tachycardia Life Threatening 2/12/2013 4 Male 36 lb 2/19/2013 Pharmacist Us
Primary
Secondary
Concomitant

Drug Data