Lacosamide combined with Levetiracetam

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vomiting Hospitalization 11/13/2008 37 Male 2/11/2009 United States
Primary
Concomitant
Chest Pain Hospitalization 6/14/2009 54 Female 155 lb 6/30/2009 Physician United States
Primary
Concomitant
Hyponatraemia Death 4/17/2009 63 Female 7/7/2009 Other Health Professional United Kingdom
Primary
Secondary
Psychotic Disorder Hospitalization 6/1/2009 32 Male 154 lb 8/7/2009 Physician Germany
Primary
Secondary
Concomitant
Grand Mal Convulsion Hospitalization Male 8/7/2009 Other Health Professional Germany
Primary
Secondary
Rash Maculo-papular 8/21/2009 Physician United States
Primary
Secondary
Concomitant
Drug Ineffective 7/1/2009 Female 85 lb 8/21/2009 Consumer United States
Primary
Secondary
Concomitant
Grand Mal Convulsion Hospitalization Male 9/3/2009 Germany
Primary
Secondary
Psychotic Disorder Hospitalization 6/1/2009 32 Male 154 lb 9/15/2009 Germany
Primary
Secondary
Concomitant
Convulsion Life Threatening 4/8/2009 Female 165 lb 9/17/2009 Germany
Primary
Concomitant
Weight Decreased Other Serious Female 168 lb 10/23/2009 Consumer United States
Primary
Secondary
Concomitant
Restlessness Other Serious 45 Female 12/3/2009 Other Health Professional United Kingdom
Primary
Concomitant
Restlessness 45 Female 12/8/2009 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Life Threatening 1/1/2004 Female 120 lb 11/30/2009 United States
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Other Serious 9 Female 12/2/2009 Physician United States
Primary
Secondary
Convulsion 6/1/2009 Male 210 lb 11/19/2009 Consumer United States
Primary
Secondary
Concomitant
Nausea 7/1/2009 Male 176 lb 11/19/2009 Consumer United States
Primary
Concomitant
Convulsion Hospitalization 7/6/2009 Male 1/8/2010 Physician Germany
Primary
Concomitant
Convulsion Hospitalization Female 79 lb 1/25/2010 Consumer United States
Primary
Secondary
Concomitant
Pneumonia Aspiration Other Serious 55 Male 2/8/2010 Germany
Primary
Secondary
Pancytopenia Life Threatening 1/2/2010 Female 198 lb 2/17/2010 Physician Germany
Primary
Secondary
Concomitant
Complex Partial Seizures Hospitalization 12/17/2009 Male 244 lb 3/10/2010 Physician United Kingdom
Primary
Concomitant
Eosinophilia Life Threatening 1/11/2010 Female 132 lb 3/29/2010 Other Health Professional Germany
Primary
Secondary
Pancreatic Enzymes Increased Other Serious 15 Female 3/29/2010 Physician United States
Primary
Secondary
Psychotic Disorder Hospitalization Male 4/9/2010 Physician Belgium
Primary
Secondary
Road Traffic Accident Other Serious Female 161 lb 4/12/2010 Physician Germany
Primary
Concomitant
Psychotic Disorder Disability Male 176 lb 4/19/2010 Physician Belgium
Primary
Secondary
Concomitant
Road Traffic Accident Other Serious Female 161 lb 4/30/2010 Physician Germany
Primary
Secondary
Eosinophilia Life Threatening 1/11/2010 57 Female 132 lb 5/6/2010 Other Health Professional Germany
Primary
Secondary
Weight Decreased Other Serious Female 168 lb 6/16/2010 United States
Primary
Secondary
Concomitant
Whiplash Injury Other Serious 2/1/2010 29 Female 161 lb 6/29/2010 Physician Germany
Primary
Secondary
Therapeutic Response Unexpected Other Serious 6/6/2010 26 Female 99 lb 7/6/2010 Physician Belgium
Primary
Concomitant
Dizziness 7/1/2010 52 Female 150 lb 8/16/2010 Consumer United States
Primary
Secondary
Concomitant
Drug Eruption Other Serious 6/24/2010 55 Male 185 lb 8/20/2010 Pharmacist United States
Primary
Concomitant
Pancreatitis Acute Other Serious 15 Female 8/17/2010 Physician United States
Primary
Secondary
Pancreatitis Acute Other Serious 15 Female 8/17/2010 Physician United States
Primary
Secondary
Type Iv Hypersensitivity Reaction Other Serious Female 8/24/2010 Physician United States
Primary
Secondary
Renal Failure Acute Hospitalization Male 141 lb 9/3/2010 Physician United States
Primary
Concomitant
Suicide Attempt Other Serious 6/17/2010 25 Female 8/19/2010 Physician United States
Primary
Concomitant
Angioedema Other Serious Female 9/17/2010 Physician United States
Primary
Concomitant
Paraesthesia Hospitalization 8/6/2010 25 Female 148 lb 9/20/2010 Physician United Kingdom
Primary
Concomitant
Product Formulation Issue Other Serious Female 150 lb 10/5/2010 Consumer United States
Primary
Secondary
Concomitant
Product Formulation Issue Other Serious Female 150 lb 10/5/2010 Consumer United States
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Other Serious Female 150 lb 10/8/2010 Physician United States
Primary
Secondary
Concomitant
Generalised Anxiety Disorder Hospitalization 7/1/2009 24 Female 11/23/2010 Other Health Professional United Kingdom
Primary
Concomitant
Psychotic Disorder Other Serious 6/20/2009 32 Male 12/1/2010 Germany
Primary
Secondary
Concomitant
Hallucination, Auditory Hospitalization 6/18/2009 32 Male 154 lb 12/3/2010 Germany
Primary
Secondary
Concomitant
Visual Impairment 3/1/2010 65 Female 220 lb 11/10/2010 Consumer United States
Primary
Secondary
Concomitant
Diarrhoea 9/4/2010 11 Male 65 lb 11/10/2010 Consumer United States
Primary
Concomitant
Pancreatitis Acute Other Serious 15 Female 11/10/2010 Physician United States
Primary
Secondary
Vision Blurred Other Serious 1/1/2009 43 Female 212 lb 12/15/2010 Consumer United States
Primary
Concomitant
Bradycardia Other Serious 2/20/2010 13 Female 130 lb 1/5/2011 Physician United States
Primary
Concomitant
Status Epilepticus Hospitalization 137 lb 2/2/2011 Physician United States
Primary
Secondary
Concomitant
Concussion Other Serious 2/1/2010 29 Female 161 lb 2/8/2011 Other Health Professional Germany
Primary
Secondary
Off Label Use Other Serious 49 Female 2/10/2011 United States
Primary
Secondary
Concomitant
Treatment Failure Other Serious 73 Female 115 lb 2/8/2011 Physician United States
Primary
Secondary
Concomitant
Epilepsy Hospitalization 4/14/2010 30 Male 148 lb 2/28/2011 Other Health Professional Germany
Primary
Concomitant
Balance Disorder Other Serious 24 Female 3/11/2011 Other Health Professional United Kingdom
Primary
Interacting
Facial Bones Fracture Hospitalization 19 Female 2/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Diplopia Female 2/4/2011 Consumer United States
Primary
Secondary
Oedema Peripheral 3/1/2010 65 Female 220 lb 2/4/2011 Consumer United States
Primary
Secondary
Concomitant
Dysarthria Other Serious 24 Female 3/14/2011 Other Health Professional United Kingdom
Primary
Interacting
Quadriparesis Other Serious 74 Female 3/14/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Off Label Use Other Serious 77 Male 3/14/2011 Physician Germany
Primary
Secondary
Concomitant
Grand Mal Convulsion Hospitalization 19 Female 3/15/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Other Serious 24 Female 3/24/2011 Other Health Professional United Kingdom
Primary
Interacting
Mechanical Ventilation Other Serious 80 Male 3/14/2011 Physician Germany
Primary
Secondary
Concomitant
Diplopia Other Serious 47 Female 3/25/2011 Other Health Professional United Kingdom
Primary
Interacting
Partial Seizures Hospitalization 83 Female 3/16/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Balance Disorder Other Serious 24 Female 3/29/2011 Other Health Professional United Kingdom
Primary
Interacting
Vertigo Other Serious 47 Female 3/30/2011 Other Health Professional United Kingdom
Primary
Secondary
Ataxia Other Serious 26 Female 3/30/2011 Consumer United Kingdom
Primary
Secondary
Interacting
Drug Interaction Other Serious 24 Female 3/18/2011 Other Health Professional United Kingdom
Primary
Secondary
Diplopia Other Serious 26 Female 3/21/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Balance Disorder Other Serious 37 Female 3/21/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Neurotoxicity Other Serious 26 Female 3/24/2011 United Kingdom
Primary
Secondary
Pneumonia Aspiration Death 10/1/2010 89 Female 154 lb 3/24/2011 Other Health Professional Germany
Primary
Concomitant
Diplopia Other Serious 37 Female 3/28/2011 United Kingdom
Primary
Secondary
Concomitant
Convulsion Hospitalization 9/20/2009 56 Male 3/30/2011 Other Health Professional Germany
Primary
Concomitant
Convulsion Hospitalization 4/14/2010 30 Male 148 lb 4/4/2011 Physician Germany
Primary
Concomitant
Dyskinesia Other Serious 1/1/2011 16 Male 114 lb 4/12/2011 Other Health Professional United States
Primary
Concomitant
Complex Partial Seizures Other Serious Male 5/5/2011 Consumer Germany
Primary
Secondary
Status Epilepticus Other Serious 1/1/2011 16 Male 114 lb 4/29/2011 Other Health Professional United States
Primary
Concomitant
Off Label Use Other Serious 9 Female 5/4/2011 Physician Germany
Primary
Concomitant
Off Label Use Other Serious 2 Male 5/4/2011 Other Health Professional Germany
Primary
Concomitant
Off Label Use Other Serious 10 Female 5/5/2011 Germany
Primary
Concomitant
Hypertension Other Serious 1/1/2011 59 Female 178 lb 5/9/2011 United States
Primary
Concomitant
Status Epilepticus Death 10 Female 5/19/2011 Physician Germany
Primary
Concomitant
Convulsion Other Serious 39 Male 156 lb 5/19/2011 Consumer United States
Primary
Concomitant
Fall Hospitalization 1/30/2011 35 Male 165 lb 5/24/2011 Physician Belgium
Primary
Secondary
Angioedema Other Serious 73 Female 115 lb 5/26/2011 Pharmacist United States
Primary
Secondary
Concomitant
Convulsion 8 Male 5/3/2011 Other Health Professional United States
Primary
Secondary
Dizziness Male 5/3/2011 Other Health Professional United States
Primary
Concomitant
Off Label Use 57 Male 5/3/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 11/7/2010 60 Female 105 lb 6/15/2011 Consumer United States
Primary
Secondary
Concomitant
Convulsion Hospitalization 4 Male 6/15/2011 Physician Germany
Primary
Concomitant
Pollakiuria Hospitalization 4 Male 6/16/2011 Physician Germany
Primary
Concomitant
Chest Pain Other Serious 5/29/2011 57 Male 198 lb 7/1/2011 Physician United Kingdom
Primary
Concomitant
Dysarthria Hospitalization 6/28/2011 43 Female 118 lb 7/13/2011 Physician United States
Primary
Concomitant
Communication Disorder Other Serious 15 Male 8/15/2011 Physician Germany
Primary
Secondary
Concomitant
Petit Mal Epilepsy Other Serious 8/9/2011 31 Female 181 lb 8/19/2011 Physician United States
Primary
Concomitant
Memory Impairment Hospitalization 1/10/2007 15 Female 8/29/2011 Consumer United States
Primary
Concomitant
Drug Administration Error Hospitalization 68 Male 9/6/2011 Physician Germany
Primary
Concomitant
Petit Mal Epilepsy Other Serious 8/9/2011 31 Female 181 lb 9/12/2011 Physician United States
Primary
Concomitant
Convulsion 6/22/2011 44 Female 8/8/2011 Consumer United States
Primary
Secondary
Major Depression Hospitalization 11/10/2008 46 Female 8/8/2011 Consumer United States
Primary
Secondary
Concomitant
Fatigue Hospitalization 9/3/2010 48 Male 212 lb 8/8/2011 Consumer United States
Primary
Secondary
Concomitant
Suicidal Ideation Other Serious 17 Male 8/8/2011 Other Health Professional United States
Primary
Concomitant
Depression Other Serious 8/8/2011 Other Health Professional United States
Primary
Concomitant
Abasia Other Serious 11/1/2010 51 Male 9/29/2011 Physician Germany
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 9/20/2011 25 Male 198 lb 10/4/2011 Physician Spain
Primary
Concomitant
Pregnancy Other Serious 2/1/2010 29 Female 161 lb 10/10/2011 Physician Germany
Primary
Secondary
Neurotoxicity Other Serious 52 Female 11/11/2011 Other Health Professional United Kingdom
Primary
Concomitant
Gait Disturbance Hospitalization 11/1/2010 51 Male 11/30/2011 Physician Germany
Primary
Secondary
Concomitant
Convulsion Hospitalization 11/1/2010 51 Male 12/12/2011 Physician Germany
Primary
Secondary
Concomitant
Post-traumatic Neck Syndrome Hospitalization 2/1/2010 29 Female 161 lb 12/14/2011 Physician Germany
Primary
Secondary
Aggression Other Serious 11/1/2010 51 Male 12/16/2011 Physician Germany
Primary
Secondary
Concomitant
Petit Mal Epilepsy Other Serious 8/9/2011 31 Female 181 lb 12/20/2011 Physician United States
Primary
Concomitant
Partial Seizures Other Serious 5/4/2009 26 1/30/2012 Physician Germany
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 1/1/2008 44 Female 1/30/2012 Physician Germany
Primary
Secondary
Concomitant
Convulsion Other Serious 10/1/2008 75 Female 1/30/2012 Physician Germany
Primary
Secondary
Concomitant
Dizziness Other Serious 1/1/2008 44 Female 2/1/2012 Physician Germany
Primary
Secondary
Concomitant
Bradycardia Hospitalization 5/3/2011 74 Female 2/22/2012 Physician France
Primary
Concomitant
No Adverse Event 60 Male 2/2/2012 Physician United States
Primary
Concomitant
Convulsion 11/1/2011 33 Female 2/2/2012 Consumer United States
Primary
Secondary
Concomitant
Tremor 1/1/2011 26 Female 144 lb 2/2/2012 Consumer United States
Primary
Concomitant
Pregnancy 10/1/2011 26 105 lb 2/2/2012 Other Health Professional United States
Primary
Concomitant
Weight Increased 11/19/2009 20 Female 185 lb 2/2/2012 Other Health Professional United States
Primary
Concomitant
Convulsion 84 Male 2/2/2012 Physician United States
Primary
Concomitant
Atrial Flutter Hospitalization 5/3/2011 74 Female 3/13/2012 Physician France
Primary
Concomitant
Post Procedural Infection Death 60 Female 3/21/2012 Other Health Professional Switzerland
Primary
Concomitant
Fall Hospitalization 3/6/2012 20 Male 3/26/2012 Consumer United States
Primary
Concomitant
Atrial Flutter Hospitalization 5/3/2011 74 Female 4/9/2012 Physician France
Primary
Concomitant
Status Epilepticus Death 10 Female 4/10/2012 Physician Germany
Primary
Concomitant
Convulsion Other Serious 2/1/2010 29 Female 161 lb 4/11/2012 Physician Germany
Primary
Secondary
Status Epilepticus Other Serious 10 Female 4/20/2012 Physician Germany
Primary
Concomitant
Hypernatraemia 1/21/2012 54 Male 212 lb 2/17/2012 Pharmacist United States
Primary
Concomitant
Sepsis Death 78 Male 4/25/2012 Physician Germany
Primary
Concomitant
Pneumonia Death 84 Female 4/25/2012 Physician Germany
Primary
Concomitant
Pneumonia Death 81 Female 4/25/2012 Physician Germany
Primary
Concomitant
Ataxia Other Serious 4/26/2012 Physician United States
Primary
Secondary
Concomitant
Sepsis Death 78 Male 4/27/2012 Physician Germany
Primary
Concomitant
Pneumonia Death 84 Female 4/27/2012 Physician Germany
Primary
Concomitant
Sepsis Death 78 Male 4/27/2012 Physician Germany
Primary
Concomitant
Pneumonia Death 81 Female 4/27/2012 Physician Germany
Primary
Concomitant
Status Epilepticus Other Serious Female 4/27/2012 Physician Germany
Primary
Concomitant
Convulsion Hospitalization 10/1/2008 75 Female 5/1/2012 Physician Germany
Primary
Secondary
Concomitant
Fatigue 9 Female 5/2/2012 Physician Germany
Primary
Concomitant
Convulsion Other Serious 59 Female 5/14/2012 Other Health Professional United States
Primary
Secondary
Oculogyric Crisis Hospitalization 17 Female 88 lb 5/21/2012 Physician Australia
Primary
Concomitant

Drug Data