Lacosamide combined with Lamotrigine

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Renal Failure Male 2/3/2009 Physician Germany
Primary
Concomitant
Visual Impairment Hospitalization 1/30/2009 Female 141 lb 2/24/2009 Physician Germany
Primary
Concomitant
Mental Disorder Hospitalization 16 Female 2/27/2009 Germany
Primary
Secondary
Pregnancy On Contraceptive Other Serious Female 292 lb 3/5/2009 Germany
Primary
Concomitant
Somatoform Disorder Hospitalization 2/5/2009 Female 110 lb 3/6/2009 Germany
Primary
Secondary
Grand Mal Convulsion Hospitalization 3/3/2009 42 Female 6/2/2009 United Kingdom
Primary
Concomitant
Visual Impairment Hospitalization 1/30/2009 Female 141 lb 7/14/2009 Germany
Primary
Concomitant
Partial Seizures 9/21/2009 Germany
Primary
Concomitant
Bradycardia 9/28/2009 Physician Germany
Primary
Concomitant
Drug Level Decreased 9/1/2009 21 Male 11/19/2009 Pharmacist United States
Primary
Secondary
Female Orgasmic Disorder 20 Female 11/19/2009 Physician United States
Primary
Concomitant
Vomiting Other Serious 35 Female 12/23/2009 Physician Germany
Primary
Concomitant
Ventricular Tachycardia Life Threatening 11/5/2009 48 Male 12/29/2009 Physician United States
Primary
Secondary
Concomitant
Convulsion Hospitalization 7/6/2009 Male 1/8/2010 Physician Germany
Primary
Concomitant
Stevens-johnson Syndrome Life Threatening 4/1/2010 48 Male 195 lb 4/22/2010 Pharmacist United States
Primary
Concomitant
Tremor Hospitalization 4/21/2010 27 Female 126 lb 5/3/2010 Other Health Professional United States
Primary
Concomitant
Heart Rate Increased Other Serious 10/28/2009 37 Female 112 lb 6/16/2010 Other Health Professional United States
Primary
Concomitant
Atrial Fibrillation Hospitalization 3/10/2009 48 6/25/2010 Germany
Primary
Concomitant
Ventricular Tachycardia Life Threatening 12/1/2009 48 Male 6/9/2010 Physician United States
Primary
Secondary
Concomitant
Weight Increased 47 Female 5/20/2010 Physician United States
Primary
Concomitant
Cardiomegaly Hospitalization 3/10/2009 46 Male 185 lb 7/13/2010 Physician Germany
Primary
Concomitant
Paranoia Female 5/20/2010 Physician United States
Primary
Secondary
Concomitant
Drug Ineffective 11/1/2009 44 Female 5/20/2010 Consumer United States
Primary
Secondary
Concomitant
Condition Aggravated Hospitalization 3/10/2009 48 Male 185 lb 7/15/2010 Physician Germany
Primary
Concomitant
Pregnancy Hospitalization 19 Female 7/27/2010 Consumer United States
Primary
Concomitant
Disease Recurrence Life Threatening 1/1/2009 47 Male 190 lb 8/6/2010 Physician Germany
Primary
Concomitant
Drug Eruption Other Serious 6/24/2010 55 Male 185 lb 8/20/2010 Pharmacist United States
Primary
Concomitant
Ventricular Fibrillation Hospitalization 37 Male 9/8/2010 Physician Austria
Primary
Secondary
Vomiting Other Serious 29 Female 8/31/2010 Physician United States
Primary
Secondary
Anger Female 8/19/2010 Physician United States
Primary
Concomitant
Rash Female 170 lb 8/19/2010 United States
Primary
Concomitant
Paraesthesia Hospitalization 8/6/2010 25 Female 148 lb 9/20/2010 Physician United Kingdom
Primary
Concomitant
Treatment Noncompliance Hospitalization 19 Female 9/30/2010 Consumer United States
Primary
Concomitant
Tremor Other Serious 1/1/2009 52 Male 190 lb 10/27/2010 Consumer United States
Primary
Concomitant
Fall Other Serious Male 11/23/2010 Other Health Professional United Kingdom
Primary
Concomitant
Vision Blurred Hospitalization Male 209 lb 12/6/2010 Other Health Professional Germany
Primary
Concomitant
Product Substitution Issue Other Serious Female 12/9/2010 Consumer United States
Primary
Secondary
Pregnancy Female 11/10/2010 Physician United States
Primary
Concomitant
Thinking Abnormal Other Serious 7/31/2005 52 Male 146 lb 12/7/2010 United Kingdom
Primary
Concomitant
Psychotic Disorder Other Serious 7/31/2005 52 Male 146 lb 12/7/2010 United Kingdom
Primary
Concomitant
Atrial Flutter Hospitalization 12/8/2010 55 Male 293 lb 1/4/2011 United Kingdom
Primary
Concomitant
Dizziness Hospitalization 2/3/2010 53 Male 209 lb 1/27/2011 Other Health Professional Germany
Primary
Concomitant
Diplopia Other Serious 37 Female 3/9/2011 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Diplopia Other Serious 37 Female 3/9/2011 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Diplopia Other Serious 37 Female 3/9/2011 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Dizziness Other Serious 37 Female 3/8/2011 Other Health Professional United Kingdom
Primary
Secondary
Epilepsy Hospitalization 4/14/2010 30 Male 148 lb 2/28/2011 Other Health Professional Germany
Primary
Concomitant
Facial Bones Fracture Hospitalization 19 Female 2/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Fumbling Other Serious Male 3/2/2011 Other Health Professional Germany
Primary
Concomitant
Balance Disorder Hospitalization 37 Female 3/14/2011 Other Health Professional United Kingdom
Primary
Interacting
Dizziness Other Serious 37 Female 3/16/2011 Other Health Professional United Kingdom
Primary
Secondary
Interacting
Dizziness Other Serious 37 Female 3/17/2011 Other Health Professional United Kingdom
Primary
Secondary
Dizziness Other Serious 37 Female 3/18/2011 Physician United Kingdom
Primary
Concomitant
Interacting
Treatment Noncompliance Hospitalization Female 3/7/2011 Consumer United States
Primary
Concomitant
Grand Mal Convulsion Hospitalization 19 Female 3/15/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Drug Level Below Therapeutic Other Serious 37 Female 3/21/2011 Other Health Professional United Kingdom
Primary
Secondary
Drug Interaction Other Serious 37 Female 3/21/2011 Other Health Professional
Primary
Secondary
Balance Disorder Other Serious 37 Female 3/21/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Condition Aggravated Other Serious 36 Female 3/25/2011 United Kingdom
Primary
Secondary
Concomitant
Diplopia Other Serious 37 Female 3/28/2011 United Kingdom
Primary
Secondary
Concomitant
Status Epilepticus Hospitalization Female 132 lb 4/1/2011 Physician Germany
Primary
Concomitant
Anticonvulsant Drug Level Decreased Death 4/26/2010 31 Male 224 lb 4/7/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Vision Blurred Disability 2/20/2011 Male 172 lb 4/18/2011 Consumer Germany
Primary
Concomitant
Fatigue Other Serious 30 Male 4/15/2011 Other Health Professional Germany
Primary
Concomitant
Drug Exposure During Pregnancy Other Serious 3/8/2011 35 Female 187 lb 4/22/2011 Other Health Professional Bulgaria
Primary
Concomitant
Complex Partial Seizures Other Serious Male 5/5/2011 Consumer Germany
Primary
Secondary
Asphyxia Death 4/26/2010 31 Male 224 lb 4/25/2011 Other Health Professional
Primary
Secondary
Concomitant
Pyrexia Hospitalization 4/15/2011 5 Male 46 lb 4/28/2011 Other Health Professional United States
Primary
Concomitant
Condition Aggravated Other Serious 7 Male 5/4/2011 Physician Germany
Primary
Concomitant
Off Label Use Other Serious 12 Female 5/5/2011 Germany
Primary
Concomitant
Partial Seizures Other Serious 1/1/2007 19 Male 5/5/2011 Physician Germany
Primary
Secondary
Concomitant
Fatigue Other Serious Male 175 lb 5/10/2011 Physician Germany
Primary
Concomitant
Respiratory Distress Hospitalization 4/15/2011 5 Male 46 lb 5/13/2011 Other Health Professional United States
Primary
Concomitant
Weight Increased 6/21/2010 20 Female 5/3/2011 Physician United States
Primary
Concomitant
Vomiting Hospitalization 5/31/2011 5 Female 51 lb 6/14/2011 Physician Colombia
Primary
Concomitant
Death Death 3/12/2011 37 Male 6/20/2011 Other Health Professional United States
Primary
Concomitant
Convulsion Hospitalization 6/2/2011 29 Male 163 lb 6/20/2011 Physician Australia
Primary
Concomitant
Chest Pain Other Serious 5/29/2011 57 Male 198 lb 7/1/2011 Physician United Kingdom
Primary
Concomitant
Dysarthria Hospitalization 6/28/2011 43 Female 118 lb 7/13/2011 Physician United States
Primary
Concomitant
Communication Disorder Other Serious 15 Male 8/15/2011 Physician Germany
Primary
Secondary
Concomitant
Memory Impairment Hospitalization 1/10/2007 15 Female 8/29/2011 Consumer United States
Primary
Concomitant
Weight Increased 8/31/2010 8 Female 71 lb 8/8/2011 Physician United States
Primary
Concomitant
Major Depression Hospitalization 11/10/2008 46 Female 8/8/2011 Consumer United States
Primary
Secondary
Concomitant
Fatigue Hospitalization 9/3/2010 48 Male 212 lb 8/8/2011 Consumer United States
Primary
Secondary
Concomitant
Suicidal Ideation Other Serious 17 Male 8/8/2011 Other Health Professional United States
Primary
Concomitant
Depression Other Serious 8/8/2011 Other Health Professional United States
Primary
Concomitant
Weight Increased 8/1/2010 20 Female 96 lb 8/8/2011 Physician United States
Primary
Concomitant
Heart Rate Irregular 1/1/2011 49 Male 8/8/2011 Consumer United States
Primary
Concomitant
Febrile Neutropenia Hospitalization 9/20/2011 25 Male 198 lb 10/4/2011 Physician Spain
Primary
Concomitant
Somatoform Disorder Hospitalization 2/11/2009 54 Female 141 lb 10/11/2011 Physician Germany
Primary
Concomitant
Epilepsy Hospitalization 1/1/2011 54 Male 11/7/2011 Consumer United States
Primary
Concomitant
Viral Upper Respiratory Tract Infection Hospitalization 4/15/2011 5 Male 46 lb 11/11/2011 Physician United States
Primary
Concomitant
Maternal Exposure During Pregnancy Other Serious Female 11/28/2011 Physician Netherlands
Primary
Concomitant
Foetal Exposure During Pregnancy Congenital Anomaly 11/28/2011 Physician Netherlands
Primary
Concomitant
Drug Ineffective Other Serious 1/1/2008 44 Female 1/30/2012 Physician Germany
Primary
Secondary
Concomitant
Death Death 1/6/2012 50 Male 190 lb 1/31/2012 Physician United States
Primary
Concomitant
Dizziness Other Serious 1/1/2008 44 Female 2/1/2012 Physician Germany
Primary
Secondary
Concomitant
Eye Infection Hospitalization 1/1/2012 12 Male 1/27/2012 Consumer United States
Primary
Concomitant
Bradycardia Hospitalization 5/3/2011 74 Female 2/22/2012 Physician France
Primary
Concomitant
Atrial Flutter Hospitalization 5/3/2011 74 Female 3/13/2012 Physician France
Primary
Concomitant
Pyrexia Hospitalization 3/11/2012 4 Male 41 lb 3/21/2012 Physician United States
Primary
Concomitant
Death Death 1/6/2012 50 Male 190 lb 3/23/2012 Physician United States
Primary
Concomitant
Fall Hospitalization 3/6/2012 20 Male 3/26/2012 Consumer United States
Primary
Concomitant
Status Epilepticus Hospitalization 3/11/2012 4 Male 41 lb 6/8/2012 Physician United States
Primary
Concomitant
Partial Seizures Other Serious 31 Female 6/20/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Protrusion Tongue Other Serious 31 Female 7/9/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Gait Disturbance Other Serious 31 Female 7/13/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cardiac Arrest Death 1/6/2012 50 Male 190 lb 7/20/2012 Physician United States
Primary
Concomitant
Pneumonia Hospitalization 40 Male 7/20/2012 Physician Germany
Primary
Secondary
Partial Seizures Other Serious 31 Female 7/10/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Movement Disorder Other Serious 31 Female 7/10/2012 Consumer United Kingdom
Primary
Secondary
Concomitant
Mobility Decreased Other Serious 31 Female 7/10/2012 Consumer United Kingdom
Primary
Secondary
Concomitant
General Physical Health Deterioration Other Serious 31 Female 7/10/2012 Other Health Professional
Primary
Secondary
Concomitant
Convulsion Death 8/3/2012 21 Male 302 lb 8/9/2012 Physician Canada
Primary
Concomitant
Convulsion Death 8/3/2012 21 Male 302 lb 8/14/2012 Physician Canada
Primary
Concomitant
Convulsion Hospitalization 6/2/2011 29 Male 163 lb 7/22/2013 Physician Au
Primary
Concomitant
Headache Hospitalization 6/28/2011 43 Female 118 lb 3/6/2013 Physician Us
Primary
Concomitant
Sudden Unexplained Death In Epilepsy Death 1/6/2012 50 Male 190 lb 2/26/2013 Physician Us
Primary
Concomitant
Sudden Unexplained Death In Epilepsy Death 8/3/2012 21 Male 302 lb 11/12/2013 Physician Ca
Primary
Concomitant
Small For Dates Baby Congenital Anomaly Female 7 lb 9/21/2012 Consumer De
Primary
Secondary
Concomitant
Grand Mal Convulsion Other Serious 5/24/2011 25 Male 12/20/2012 Physician De
Primary
Secondary
Concomitant
Pregnancy Other Serious 9/2011 Female 10/4/2012 Physician Nl
Primary
Concomitant
Foetal Exposure During Pregnancy Other Serious 10/4/2012 Physician Nl
Primary
Concomitant
Renal Impairment Other Serious 23 Male 266 lb 11/9/2012 Physician Gb
Primary
Concomitant
Haematemesis Hospitalization 2012 10 Male 11/17/2012 Physician Gb
Primary
Concomitant
Tension Other Serious 47 Male 11/21/2012 Physician De
Primary
Concomitant
Neuroleptic Malignant Syndrome Hospitalization 8/10/2012 59 Female 1/28/2013 Consumer Au
Primary
Concomitant
Interacting
Urinary Tract Infection Hospitalization 7/26/2012 72 Female 95 lb 8/19/2013 Physician Dk
Primary
Concomitant
Somnolence Other Serious Male 353 lb 3/8/2013 Consumer Gb
Primary
Concomitant
Weight Decreased Other Serious NotSpecified 2/22/2013 Other Health Professional De
Primary
Concomitant
Status Epilepticus Other Serious 7/2012 42 Male 3/28/2013 Physician De
Primary
Secondary
Concomitant
Schizophrenia Other Serious 7/31/2012 59 Female 3/29/2013 Consumer Au
Primary
Concomitant
Urinary Tract Infection Other Serious 42 Male 5/14/2013 Physician Es
Primary
Concomitant
Toxicity To Various Agents Death 56 Male 5/29/2013 Other Health Professional Fr
Primary
Concomitant
Interacting
Partial Seizures Other Serious 10/2012 51 Female 5/16/2013 Physician De
Primary
Concomitant
Vomiting Other Serious 53 Female 6/19/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Ventricular Tachycardia Other Serious 49 Male 5/29/2013 Physician Us
Primary
Secondary
Concomitant
Poisoning Death 40 Female 104 lb 6/4/2013 Country Not Specified
Primary
Secondary
Toxicity To Various Agents Other Serious 56 Male 5/30/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Toxicity To Various Agents Death 56 Male 5/30/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Toxicity To Various Agents Death 40 Female 104 lb 6/7/2013 Other Health Professional De
Primary
Secondary
Vomiting Other Serious 53 Female 6/19/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Red Blood Cell Count Decreased Other Serious 6/28/2013 52 Female 7/23/2013 Other Health Professional Ar
Primary
Concomitant
Sudden Unexplained Death In Epilepsy Death 2/6/2011 36 Female 9/11/2013 Physician Gb
Primary
Concomitant
Visual Field Defect Other Serious 12/2011 Male 9/25/2013 Other Health Professional Us
Primary
Concomitant
Hypotension Other Serious 24 Male 8/27/2013 Other Health Professional Country Not Specified
Primary
Concomitant
Hypoaesthesia Other Serious 32 Male 8/28/2013 Other Health Professional Pl
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 10 Male 10/8/2013 Physician Us
Primary
Secondary
Concomitant
Grand Mal Convulsion Other Serious 2011 35 Female 10/11/2013 Other Health Professional Pl
Primary
Secondary
Concomitant
Status Epilepticus Hospitalization 5/2012 42 NotSpecified 10/24/2013 Physician De
Primary
Secondary
Concomitant

Drug Data