Kytril combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Venoocclusive Liver Disease Life Threatening 6/6/2005 2 Male 26 lb 1/3/2006 Physician Japan
Primary
Secondary
Concomitant
Visual Disturbance Other Serious 2/20/2006 Male 134 lb 4/7/2006 Physician United States
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1997 59 Female 157 lb 5/6/2006 United States
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1997 59 Female 157 lb 5/31/2006 United States
Primary
Secondary
Concomitant
Drug Clearance Decreased Required Intervention 2/24/2004 17 Male 152 lb 7/12/2006 Pharmacist United States
Primary
Concomitant
Mucous Membrane Disorder Hospitalization 8/26/2004 8 Male 51 lb 7/21/2006 Physician Japan
Primary
Concomitant
Renal Disorder Other Serious 1/1/2002 16 Female 95 lb 7/21/2006 Physician Japan
Primary
Secondary
Concomitant
Renal Tubular Acidosis Other Serious 5/5/2005 20 Male 8/3/2006 Consumer United States
Primary
Secondary
Concomitant
Renal Tubular Acidosis Other Serious 5/5/2005 20 Male 8/30/2006 Consumer United States
Primary
Secondary
Concomitant
Oral Mucosal Disorder Hospitalization 2/9/2006 10 Male 8/30/2006 Consumer United States
Primary
Secondary
Concomitant
Hyponatraemia Other Serious 7/8/2006 65 Female 9/26/2006 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 10/17/2006 61 Female 11/2/2006 Consumer United States
Primary
Secondary
Concomitant
Visual Acuity Reduced Other Serious 2/25/2006 42 Male 165 lb 10/24/2006 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 2/4/2002 56 Female 11/20/2006 Consumer United States
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1997 59 Female 157 lb 1/23/2007 United States
Primary
Secondary
Concomitant
Pneumothorax Other Serious 5/31/2006 54 Male 123 lb 2/26/2007 Physician Japan
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1997 59 Female 157 lb 3/17/2007 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/27/2007 35 Female 3/22/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 5/30/2005 48 Male 4/2/2007 Pharmacist Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 1/27/2007 35 Female 4/4/2007 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/27/2007 35 Female 4/19/2007 Physician Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Life Threatening 12/18/2006 20 Male 115 lb 8/2/2007 Physician Japan
Primary
Concomitant
Leukoencephalopathy Other Serious Female 124 lb 10/15/2007 Physician Japan
Primary
Secondary
Cardiac Failure Other Serious 6/29/2006 2 Male 10/18/2007 Consumer United States
Primary
Secondary
Concomitant
Cardiac Failure Other Serious 6/29/2006 2 Male 12/7/2007 Consumer United States
Primary
Secondary
Concomitant
Metastases To Skin Life Threatening 12/18/2006 20 Male 115 lb 1/4/2008 Physician Japan
Primary
Concomitant
Pneumothorax Other Serious 5/31/2006 54 Male 123 lb 2/29/2008 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Congestive Disability 4/16/2007 46 Female 108 lb 4/17/2008 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Congestive Disability 4/16/2007 46 Female 108 lb 4/22/2008 Physician Japan
Primary
Concomitant
Pneumothorax Other Serious 5/31/2006 54 Male 123 lb 5/9/2008 Physician Japan
Primary
Secondary
Concomitant
Muscle Spasms 5/1/2008 58 Female 240 lb 6/30/2008 Other Health Professional United States
Primary
Concomitant
Cardiomegaly Disability 4/16/2007 46 Female 108 lb 7/15/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/2/2008 19 Male 110 lb 7/16/2008 Physician Japan
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Death 3/21/2008 71 Male 9/8/2008 Physician Japan
Primary
Concomitant
Cardiomegaly Disability 4/16/2007 46 Female 108 lb 9/19/2008 Physician Japan
Primary
Secondary
Concomitant
Muscle Spasms 5/15/2008 58 Female 240 lb 9/25/2008 Other Health Professional United States
Primary
Concomitant
Venoocclusive Disease Death 8/7/2008 Female 12/18/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Life Threatening 11/24/2008 55 Male 123 lb 12/30/2008 Physician Ecuador
Primary
Concomitant
Psychiatric Symptom Hospitalization 12/16/2008 Female 46 lb 3/9/2009 Physician Japan
Primary
Concomitant
Sepsis Other Serious 10/3/2008 60 Female 106 lb 3/12/2009 Physician Japan
Primary
Concomitant
Nausea Life Threatening 9/28/2008 59 Female 123 lb 3/16/2009 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 4/2/2008 19 Male 110 lb 3/20/2009 Physician Japan
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 21 Male 5/11/2009 Physician Spain
Primary
Secondary
Sepsis Death 9/18/2008 64 Male 117 lb 5/26/2009 Physician Japan
Primary
Concomitant
Vomiting Other Serious 3/1/2008 6 Male 60 lb 6/5/2009 Physician Japan
Primary
Concomitant
Psychiatric Symptom Hospitalization 12/16/2008 Female 46 lb 6/12/2009 Physician Japan
Primary
Concomitant
Drug Effect Prolonged Hospitalization 4/2/2009 56 6/19/2009 Other Health Professional France
Primary
Secondary
Concomitant
Urticaria Other Serious 12/9/2008 7 Female 7/13/2009 Other Health Professional Japan
Primary
Concomitant
Vomiting Other Serious 3/1/2008 6 Male 60 lb 7/31/2009 Physician Japan
Primary
Concomitant
Stomatitis Life Threatening 9/23/2008 59 Female 123 lb 8/6/2009 Physician Japan
Primary
Secondary
Concomitant
Stomatitis Life Threatening 9/28/2008 59 Female 123 lb 9/15/2009 Physician Japan
Primary
Secondary
Concomitant
Trisomy 21 Required Intervention 8/3/2009 14 Male 103 lb 9/17/2009 Pharmacist United States
Primary
Concomitant
Electrolyte Imbalance Hospitalization 3/15/2008 Female 10/2/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Urticaria Other Serious 12/9/2008 7 Female 10/15/2009 Physician Japan
Primary
Concomitant
Sepsis Life Threatening 9/18/2008 64 Male 117 lb 11/2/2009 Physician Japan
Primary
Concomitant
Electrolyte Imbalance Hospitalization 3/15/2008 Female 11/5/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Respiratory Distress Life Threatening 1/17/2010 Female 2/4/2010 Physician France
Primary
Concomitant
Respiratory Distress Life Threatening 8/16/2009 Female 192 lb 2/22/2010 Physician France
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/3/2010 Female 90 lb 3/12/2010 Physician Japan
Primary
Secondary
Concomitant
Interacting
Pyrexia Hospitalization 3/14/2010 Male 180 lb 3/18/2010 United States
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1997 3/26/2010 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/3/2010 61 Female 90 lb 4/6/2010 Physician Japan
Primary
Secondary
Concomitant
Interacting
Wound Treatment Other Serious 1/1/1997 4/8/2010 Pharmacist United States
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1997 4/15/2010 United States
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1997 51 Female 157 lb 4/22/2010 United States
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1997 51 Female 157 lb 4/29/2010 United States
Primary
Secondary
Concomitant
Pulmonary Mycosis Death 3/1/2007 14 Female 86 lb 4/27/2010 Physician Japan
Primary
Concomitant
Wound Treatment Other Serious 1/1/1997 51 Female 157 lb 5/6/2010 United States
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1997 51 Female 157 lb 5/17/2010 United States
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1997 51 Female 157 lb 5/19/2010 United States
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1997 51 Female 157 lb 6/8/2010 United States
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1997 51 Female 157 lb 6/18/2010 United States
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1997 51 Female 157 lb 6/24/2010 United States
Primary
Secondary
Concomitant
Syncope Other Serious 10/6/2007 50 Male 194 lb 6/30/2010 Lawyer United States
Primary
Concomitant
Wound Treatment Other Serious 1/1/1997 51 Female 157 lb 7/7/2010 United States
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1997 51 Female 157 lb 7/19/2010 United States
Primary
Secondary
Concomitant
Tachycardia Other Serious 9/20/2007 50 Male 194 lb 8/27/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Toothache Hospitalization 3/23/2008 19 Female 143 lb 9/28/2010 Consumer
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1997 51 Female 157 lb 10/4/2010 United States
Primary
Secondary
Concomitant
Shock Life Threatening 11/11/2007 12 Female 80 lb 11/15/2010 Physician Japan
Primary
Secondary
Concomitant
Encephalitis Fungal Death Male 139 lb 11/15/2010 Physician Japan
Primary
Secondary
Concomitant
Shock Life Threatening 11/11/2007 12 Female 80 lb 12/6/2010 Physician Japan
Primary
Secondary
Concomitant
Mouth Haemorrhage Death 4/25/2009 4 Female 32 lb 12/8/2010 Physician Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Hospitalization 9/18/2010 5 Female 53 lb 12/21/2010 Physician Japan
Primary
Concomitant
Acute Respiratory Distress Syndrome Life Threatening 11/11/2007 12 Female 80 lb 1/6/2011 Physician Japan
Primary
Secondary
Concomitant
Headache Other Serious 9/1/2007 50 Male 194 lb 1/12/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Infection Death 4/25/2009 4 Female 32 lb 1/24/2011 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Life Threatening 2/14/2008 17 Female 134 lb 2/9/2011 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Death 7/25/2010 60 Female 93 lb 2/14/2011 Physician Japan
Primary
Secondary
Concomitant
Human Herpesvirus 6 Infection Hospitalization 3/27/2010 23 Male 117 lb 2/14/2011 Physician Japan
Primary
Secondary
Concomitant
Back Pain Hospitalization 1/1/2003 52 Male 2/14/2011 Other Health Professional United States
Primary
Concomitant
Thrombotic Microangiopathy Hospitalization 9/18/2010 5 Female 53 lb 2/23/2011 Physician Japan
Primary
Concomitant
Febrile Neutropenia Hospitalization 9/15/2008 20 Male 115 lb 3/10/2011 Physician Japan
Primary
Secondary
Concomitant
Gamma-glutamyltransferase Increased Life Threatening 11/7/2008 59 Male 148 lb 3/11/2011 Physician Japan
Primary
Concomitant
Renal Failure Death 72 Female 174 lb 3/9/2011 Other Health Professional Canada
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 9/22/2007 Male 19 lb 3/24/2011 Physician Japan
Primary
Secondary
Concomitant
Blood Creatinine Increased Death 6/30/2002 16 Female 73 lb 4/6/2011 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 8/24/2008 9 Male 64 lb 4/6/2011 Physician Japan
Primary
Secondary
Concomitant
Pseudomonas Infection Hospitalization 8/4/2006 48 Male 165 lb 4/12/2011 Physician Japan
Primary
Concomitant
Diarrhoea Disability 11/17/2009 Female 104 lb 4/12/2011 Physician Japan
Primary
Secondary
Concomitant
Mucous Membrane Disorder Disability 8/1/2009 20 Male 110 lb 4/13/2011 Physician Japan
Primary
Secondary
Concomitant
Abdominal Pain Disability 10/4/2010 20 Female 106 lb 4/13/2011 Physician Japan
Primary
Secondary
Concomitant
Diarrhoea Disability 11/24/2008 11 Male 93 lb 4/13/2011 Physician Japan
Primary
Secondary
Concomitant
Sepsis Death 8/19/2009 55 Female 121 lb 4/13/2011 Physician Japan
Primary
Concomitant
Sepsis Disability 7/25/2009 11 Male 93 lb 4/14/2011 Physician Japan
Primary
Secondary
Concomitant
Febrile Neutropenia Death 2/18/2009 56 Female 128 lb 4/14/2011 Physician Japan
Primary
Secondary
Concomitant
Melaena Other Serious 10/18/2009 48 Female 97 lb 4/15/2011 Physician Japan
Primary
Secondary
Concomitant
Bronchitis Other Serious 1/1/2003 52 Male 4/15/2011 Lawyer United States
Primary
Concomitant
Thrombotic Microangiopathy Life Threatening 12/7/2009 1 Female 22 lb 4/19/2011 Physician Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Life Threatening 12/7/2009 1 Female 22 lb 4/19/2011 Physician Japan
Primary
Secondary
Concomitant
Renal Disorder Hospitalization 7/25/2010 60 Female 93 lb 4/20/2011 Physician Japan
Primary
Secondary
Concomitant
Febrile Neutropenia Other Serious 9/4/2010 Male 33 lb 4/20/2011 Physician Japan
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 1/1/2003 52 Male 4/25/2011 Other Health Professional United States
Primary
Concomitant
Cardiac Failure Disability 10/26/2001 16 Female 79 lb 4/27/2011 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Acute Death 6/30/2002 16 Female 73 lb 4/28/2011 Physician Japan
Primary
Secondary
Concomitant
Cystitis Disability 1/11/2005 7 Male 55 lb 4/28/2011 Physician Japan
Primary
Secondary
Concomitant
Mucous Membrane Disorder Disability 11/16/2004 2 Female 19 lb 4/28/2011 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Disability 12/31/2004 3 Female 31 lb 4/28/2011 Physician Japan
Primary
Concomitant
Febrile Neutropenia Hospitalization 3/10/2007 40 Male 126 lb 4/29/2011 Physician Japan
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 3/20/2008 58 Male 119 lb 4/29/2011 Physician Japan
Primary
Secondary
Concomitant
Sepsis Death 8/19/2009 55 Female 121 lb 5/2/2011 Physician Japan
Primary
Concomitant
Renal Impairment Hospitalization 5/2/2007 56 Female 95 lb 5/2/2011 Physician Japan
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 11/8/2010 2 Male 31 lb 5/4/2011 Physician Japan
Primary
Concomitant
Anaphylactic Reaction Hospitalization 4/3/2010 16 Female 95 lb 5/4/2011 Physician Japan
Primary
Secondary
Concomitant
Sepsis Death 6/30/2002 16 Female 73 lb 5/5/2011 Physician Japan
Primary
Secondary
Concomitant
Cytomegalovirus Viraemia Hospitalization 4/28/2010 56 Male 139 lb 5/5/2011 Physician Japan
Primary
Concomitant
Pancreatitis Disability 7/27/2005 13 Male 115 lb 5/5/2011 Physician Japan
Primary
Secondary
Concomitant
Sepsis Death 2/18/2009 56 Female 128 lb 5/6/2011 Physician Japan
Primary
Secondary
Concomitant
Systemic Candida Death 8/7/2009 12 Male 95 lb 5/6/2011 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Hospitalization 7/25/2010 12 Female 80 lb 5/13/2011 Physician Japan
Primary
Secondary
Concomitant
Insomnia Death 1/1/2003 52 Male 5/19/2011 Physician United States
Primary
Concomitant
Pneumonia Life Threatening 4/28/2010 56 Male 139 lb 5/23/2011 Physician Japan
Primary
Concomitant
Renal Disorder Life Threatening 7/25/2010 60 Female 93 lb 5/24/2011 Physician Japan
Primary
Secondary
Concomitant
C-reactive Protein Increased Disability 11/26/2009 11 Female 65 lb 5/24/2011 Physician Japan
Primary
Secondary
Concomitant
Cytomegalovirus Infection Disability 10/14/2005 8 Male 55 lb 5/26/2011 Physician Japan
Primary
Secondary
Concomitant
Gamma-glutamyltransferase Increased Life Threatening 12/6/2010 53 Male 165 lb 5/27/2011 Physician Japan
Primary
Concomitant
Bacterial Infection Life Threatening 11/29/2008 8 Male 46 lb 6/2/2011 Physician Japan
Primary
Concomitant
Dyspnoea Hospitalization 5/4/2011 67 Female 6/7/2011 Physician France
Primary
Secondary
Concomitant
Angioedema 6/3/2011 14 Female 96 lb 6/6/2011 United States
Primary
Secondary
Concomitant
Pruritus Hospitalization 5/4/2011 67 Female 6/10/2011 Other Health Professional France
Primary
Secondary
Concomitant
Aspartate Aminotransferase Increased Hospitalization 12/20/2003 27 Female 108 lb 6/16/2011 Physician Japan
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 1/1/2003 52 Male 6/17/2011 Lawyer United States
Primary
Concomitant
Constipation Hospitalization 12/10/2003 27 Female 108 lb 6/24/2011 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Disability 12/31/2004 3 Female 31 lb 6/27/2011 Physician Japan
Primary
Concomitant
Blood Creatinine Increased Hospitalization 9/22/2007 Male 19 lb 6/28/2011 Physician Japan
Primary
Secondary
Concomitant
C-reactive Protein Increased Death 6/30/2002 16 Female 73 lb 6/28/2011 Physician Japan
Primary
Secondary
Concomitant
Abdominal Pain Hospitalization 8/24/2008 9 Male 64 lb 6/28/2011 Physician Japan
Primary
Secondary
Concomitant
Stomatitis Disability 11/24/2008 11 Male 93 lb 6/28/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Respiratory Distress Syndrome Life Threatening 11/11/2007 12 Female 80 lb 7/5/2011 Physician Japan
Primary
Secondary
Concomitant
Arrhythmia Life Threatening 2/14/2008 17 Female 134 lb 7/5/2011 Physician Japan
Primary
Secondary
Concomitant

Drug Data