Klonopin combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Intervertebral Disc Protrusion Hospitalization 9/1/2005 63 Female 1/5/2006 Consumer United States
Primary
Concomitant
Sciatica Hospitalization 9/1/2005 63 Female 1/17/2006 United States
Primary
Concomitant
Neuropathy Hospitalization 12/2/2005 Female 146 lb 3/3/2006 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/20/2006 57 Female 128 lb 3/6/2006 Consumer United States
Primary
Concomitant
Restless Legs Syndrome Hospitalization 11/2/2005 Female 170 lb 3/15/2006 Other Health Professional United States
Primary
Concomitant
Thrombosis Other Serious 11/1/2002 24 Female 165 lb 4/7/2006 Lawyer United States
Primary
Concomitant
Weight Increased Other Serious 11/1/2005 Female 4/27/2006 Other Health Professional United States
Primary
Concomitant
Weight Increased Other Serious 11/1/2005 60 Female 5/11/2006 Other Health Professional United States
Primary
Concomitant
Bladder Cancer Hospitalization 9/1/2005 Male 5/26/2006 Physician United States
Primary
Concomitant
Prostate Cancer Other Serious 8/1/2005 Male 5/26/2006 Physician United States
Primary
Concomitant
Basal Cell Carcinoma Other Serious 7/1/2005 Male 6/9/2006 Physician United States
Primary
Concomitant
Depression 4/1/2006 45 Female 183 lb 6/30/2006 Consumer United States
Primary
Concomitant
Toxic Induced Encephalopathy Hospitalization 6/30/2006 59 Male 8/8/2006 Physician United States
Primary
Secondary
Concomitant
Toxic Induced Encephalopathy Other Serious 6/1/2006 59 Male 8/8/2006 Other Health Professional United States
Primary
Concomitant
Toxic Induced Encephalopathy Other Serious 6/1/2006 59 Male 8/14/2006 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 7/1/2006 46 Female 9/20/2006 Physician United States
Primary
Concomitant
Refusal Of Treatment By Patient Other Serious 1/1/2006 73 Female 9/18/2006 Consumer United States
Primary
Concomitant
Skin Infection Hospitalization 5/1/2005 Female 305 lb 10/19/2006 Physician United States
Primary
Concomitant
Pneumonia Aspiration Hospitalization 1/1/2002 73 Female 10/11/2006 Consumer United States
Primary
Concomitant
Facial Palsy Disability 1/1/2006 60 Female 12/8/2006 Consumer United States
Primary
Concomitant
Pyrexia Hospitalization 8/25/2006 Female 213 lb 12/13/2006 Physician United States
Primary
Concomitant
Arthralgia 4/21/2006 Female 12/13/2006 Consumer United States
Primary
Concomitant
Paraesthesia 4/12/2006 Female 12/20/2006 Other Health Professional United States
Primary
Concomitant
Weight Increased 11/1/2006 63 Female 118 lb 2/14/2007 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/1/2002 Female 252 lb 3/20/2007 Physician United States
Primary
Secondary
Concomitant
Haemorrhage Hospitalization 5/30/2006 55 Female 116 lb 12/4/2006 United States
Primary
Concomitant
Gait Disturbance Other Serious 4/1/2007 70 Female 220 lb 5/1/2007 Consumer United States
Primary
Concomitant
Fall Hospitalization 1/26/2007 Male 229 lb 5/15/2007 Consumer United States
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 1/1/2007 Female 5/15/2007 Physician United States
Primary
Secondary
Concomitant
Malaise Other Serious 1/1/2007 70 Female 220 lb 6/27/2007 Consumer United States
Primary
Concomitant
Pneumonia Hospitalization 10/1/2006 Female 109 lb 7/11/2007 Physician United States
Primary
Concomitant
Insomnia 9/9/2007 51 Male 177 lb 10/5/2007 Consumer United States
Primary
Secondary
Concomitant
Meningitis Hospitalization 1/1/2007 Female 160 lb 10/1/2007 Physician United States
Primary
Concomitant
Rash Macular Hospitalization 11/5/2007 Female 190 lb 11/6/2007 United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 3/1/2007 Female 12/6/2007 Physician United States
Primary
Secondary
Concomitant
Sinus Disorder 1/1/2006 57 Female 214 lb 12/21/2007 Consumer United States
Primary
Concomitant
Osteonecrosis Other Serious 3/1/2007 53 Female 250 lb 11/28/2007 Other Health Professional United States
Primary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 1/19/2007 Female 1/7/2008 United States
Primary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 1/19/2007 Female 1/8/2008 Physician United States
Primary
Concomitant
Throat Tightness 11/23/2007 Female 180 lb 3/14/2008 United States
Primary
Concomitant
Withdrawal Syndrome Other Serious Female 151 lb 5/12/2008 Physician United States
Primary
Secondary
Concomitant
Withdrawal Syndrome Other Serious Female 151 lb 5/30/2008 Physician United States
Primary
Secondary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 151 lb 6/4/2008 Physician United States
Primary
Secondary
Concomitant
Paranasal Sinus Hypersecretion 1/1/2007 57 Female 214 lb 6/30/2008 Physician United States
Primary
Concomitant
Stomatitis Hospitalization 6/3/2008 27 Male 88 lb 6/30/2008 Physician United States
Primary
Secondary
Concomitant
Lymphoma Life Threatening 6/17/2008 Male 185 lb 7/7/2008 Physician United States
Primary
Secondary
Concomitant
Withdrawal Syndrome Other Serious Female 151 lb 8/1/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Life Threatening 1/19/2008 71 Female 151 lb 7/9/2008 Physician United States
Primary
Secondary
Concomitant
Diffuse Large B-cell Lymphoma Life Threatening 5/24/2008 Male 185 lb 8/11/2008 Physician United States
Primary
Secondary
Concomitant
Serotonin Syndrome Other Serious 1/14/2008 71 Female 151 lb 8/22/2008 Physician United States
Primary
Secondary
Concomitant
Vaginal Haemorrhage Hospitalization 5/1/2006 Female 250 lb 9/11/2008 United States
Primary
Concomitant
Photosensitivity Reaction 1/1/2008 75 Male 194 lb 9/25/2008 Consumer United States
Primary
Concomitant
Wound Infection Hospitalization Female 10/22/2008 Consumer United States
Primary
Concomitant
Rash Macular Hospitalization 11/5/2007 Female 190 lb 11/10/2008 United States
Primary
Secondary
Concomitant
Urticaria 9/18/2008 Female 180 lb 11/25/2008 Physician United States
Primary
Concomitant
Swelling Face 7/28/2008 Female 148 lb 12/13/2008 Physician United States
Primary
Concomitant
Spinal Fracture Other Serious 7/1/2008 Female 177 lb 12/17/2008 Physician United States
Primary
Concomitant
Photosensitivity Reaction 6/15/2008 75 Male 194 lb 12/31/2008 Consumer United States
Primary
Concomitant
Blood Pressure Increased 71 Female 12/31/2008 Physician United States
Primary
Secondary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 1/19/2007 Female 1/29/2009 Physician United States
Primary
Concomitant
Tricuspid Valve Incompetence Other Serious 1/1/2008 Male 185 lb 2/9/2009 Physician United States
Primary
Concomitant
Tricuspid Valve Incompetence Other Serious 1/1/2008 Male 185 lb 2/20/2009 Physician United States
Primary
Concomitant
Vision Blurred 3/25/2008 40 Female 2/27/2009 Consumer United States
Primary
Concomitant
Upper Respiratory Tract Infection 1/1/2008 Female 3/14/2009 United States
Primary
Secondary
Concomitant
Macular Degeneration Hospitalization 1/1/2008 Female 134 lb 3/14/2009 Consumer United States
Primary
Concomitant
Aggression Other Serious 1/1/2008 Female 120 lb 5/5/2009 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 12/22/2008 Male 5/18/2009 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 12/22/2008 Male 5/19/2009 Physician United States
Primary
Secondary
Concomitant
Insulin-requiring Type 2 Diabetes Mellitus Other Serious 4/29/2002 50 Female 388 lb 6/1/2009 United States
Primary
Concomitant
Supraventricular Tachycardia Female 127 lb 6/11/2009 United States
Primary
Concomitant
Psoriasis Male 302 lb 6/12/2009 United States
Primary
Concomitant
Vomiting 5/13/2009 Female 118 lb 6/12/2009 Consumer United States
Primary
Concomitant
Migraine 3/1/2009 54 Female 6/22/2009 Consumer United States
Primary
Concomitant
Vomiting Other Serious 1/1/2007 32 Female 119 lb 6/23/2009 Physician United States
Primary
Concomitant
Withdrawal Syndrome 1/1/2008 43 Female 145 lb 7/15/2009 Consumer United States
Primary
Concomitant
Rotator Cuff Syndrome Other Serious 7/1/2009 Female 122 lb 7/17/2009 United States
Primary
Concomitant
Rotator Cuff Syndrome Other Serious 7/1/2009 Female 122 lb 7/20/2009 United States
Primary
Concomitant
Weight Increased Other Serious 57 Female 135 lb 7/21/2009 United States
Primary
Concomitant
Upper Respiratory Tract Infection Hospitalization 10/13/2008 Female 254 lb 8/18/2009 Physician United States
Primary
Secondary
Concomitant
Stress Hospitalization 6/1/2008 Female 160 lb 8/20/2009 Physician United States
Primary
Concomitant
Spinal Disorder Other Serious 12/1/2008 Female 9/2/2009 Consumer United States
Primary
Concomitant
Urticaria 5/13/2009 32 Female 8/1/2009 Physician United States
Primary
Concomitant
Panic Reaction 7/30/2009 Female 138 lb 9/19/2009 United States
Primary
Concomitant
Suicide Attempt Other Serious 2/2/2001 30 Female 273 lb 9/23/2009 United States
Primary
Concomitant
Spinal Disorder Other Serious 6/1/2008 Female 192 lb 11/19/2009 Physician United States
Primary
Concomitant
Thoracic Outlet Syndrome 5/10/2008 Female 12/1/2009 Physician United States
Primary
Concomitant
Urticaria 10/2/2009 47 Female 185 lb 12/2/2009 Other Health Professional United States
Primary
Concomitant
Injection Site Reaction Female 230 lb 1/29/2010 United States
Primary
Concomitant
Sinusitis 6/1/2009 Female 174 lb 1/30/2010 United States
Primary
Concomitant
Drug Ineffective Female 215 lb 1/30/2010 United States
Primary
Concomitant
Rheumatoid Arthritis 11/2/2009 Female 132 lb 1/30/2010 Consumer United States
Primary
Concomitant
Sinusitis 8/1/2009 Male 155 lb 1/30/2010 Other Health Professional United States
Primary
Concomitant
Suicidal Ideation Life Threatening 10/23/2009 Female 208 lb 2/5/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Pain 4/1/2009 37 Female 302 lb 2/22/2010 Consumer United States
Primary
Concomitant
Urinary Tract Infection 63 Female 209 lb 2/22/2010 Consumer United States
Primary
Concomitant
Rhabdomyolysis Other Serious 11/1/2009 57 Female 150 lb 3/10/2010 Consumer United States
Primary
Concomitant
Red Blood Cell Sedimentation Rate Increased Hospitalization 1/1/2007 Female 210 lb 3/26/2010 Consumer United States
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 3/19/2010 60 Male 267 lb 4/1/2010 Physician United States
Primary
Secondary
Concomitant
Benign Ovarian Tumour Other Serious 3/1/2010 29 4/6/2010 United States
Primary
Concomitant
Neuropathy Peripheral Hospitalization 12/2/2005 47 Female 146 lb 4/16/2010 Physician United States
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 3/21/2010 60 Male 267 lb 4/16/2010 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Disability 6/1/2007 70 Female 219 lb 4/15/2010 United States
Primary
Concomitant
Renal Failure Acute Hospitalization 7/19/2008 76 Male 199 lb 4/21/2010 Physician United States
Primary
Secondary
Concomitant
Tremor Hospitalization 1/1/2007 70 Female 200 lb 4/23/2010 Consumer United States
Primary
Concomitant
Weight Increased Other Serious 4/23/2010 57 Female 135 lb 4/29/2010 United States
Primary
Concomitant
Sepsis Hospitalization 7/13/2008 76 Male 199 lb 5/3/2010 Physician United States
Primary
Secondary
Concomitant
Sjogren's Syndrome Other Serious 1/1/2005 68 Female 200 lb 5/12/2010 Consumer United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 7/13/2008 76 Male 156 lb 5/14/2010 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 7/13/2008 76 Male 156 lb 5/18/2010 Physician United States
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 11/1/2009 57 Female 150 lb 5/21/2010 Physician United States
Primary
Concomitant
Renal Failure Acute Hospitalization 7/13/2008 76 Male 156 lb 6/8/2010 Physician United States
Primary
Secondary
Concomitant
Spinal Osteoarthritis Other Serious 11/1/2009 57 Female 154 lb 6/9/2010 Physician United States
Primary
Concomitant
Suicidal Ideation Life Threatening 10/23/2009 30 Female 208 lb 2/5/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Spinal Osteoarthritis Other Serious 11/1/2009 57 Female 154 lb 6/22/2010 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 44 Male 152 lb 6/24/2010 United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 7/13/2008 76 Male 156 lb 7/1/2010 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/1999 44 Male 152 lb 7/22/2010 United States
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 2/9/2009 57 Female 154 lb 7/23/2010 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 44 Male 152 lb 7/26/2010 United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 4/1/2008 56 Female 154 lb 8/12/2010 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 44 Male 152 lb 8/25/2010 United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/17/2010 39 Female 9/10/2010 Physician United States
Primary
Concomitant
Wheezing Other Serious 4/1/2008 56 Female 154 lb 9/16/2010 Physician United States
Primary
Secondary
Concomitant
Grand Mal Convulsion Other Serious 11/28/2009 45 Male 138 lb 9/22/2010 Other Health Professional United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 54 Female 241 lb 10/6/2010 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/1999 44 Male 152 lb 10/7/2010 United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/1999 44 Male 152 lb 10/7/2010 United States
Primary
Secondary
Concomitant
Open Wound Hospitalization 9/1/2010 71 Female 10/25/2010 Consumer United States
Primary
Concomitant
Myalgia 51 Female 10/13/2010 Consumer United States
Primary
Concomitant
Wheezing Other Serious 4/1/2008 56 Female 154 lb 11/1/2010 Physician United States
Primary
Secondary
Concomitant
Wheezing Other Serious 4/1/2008 56 Female 154 lb 11/3/2010 Physician United States
Primary
Secondary
Concomitant
Vulvovaginal Mycotic Infection Other Serious 8/1/2010 11/23/2010 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 44 Male 152 lb 11/24/2010 United States
Primary
Secondary
Concomitant
Vulvovaginal Mycotic Infection Other Serious 8/1/2010 12/3/2010 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 44 Male 152 lb 12/13/2010 United States
Primary
Secondary
Concomitant
Walking Aid User Other Serious 8/30/2010 43 Female 12/15/2010 United States
Primary
Concomitant
Tardive Dyskinesia Disability 11/29/2010 60 Female 204 lb 12/8/2010 Physician United States
Primary
Concomitant
Sjogren's Syndrome Other Serious 1/1/2005 68 Female 200 lb 12/20/2010 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/1999 44 Male 152 lb 12/20/2010 United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 11/1/2005 60 Female 245 lb 12/23/2010 United States
Primary
Secondary
Concomitant
Open Wound Hospitalization 9/1/2010 71 Female 112 lb 1/10/2011 Physician United States
Primary
Concomitant
Hydronephrosis Other Serious 5/30/1996 48 Female 1/11/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Spleen Disorder Other Serious 11/1/2005 60 Female 245 lb 1/18/2011 Lawyer United States
Primary
Secondary
Concomitant
Goitre Other Serious 5/1/2010 66 Female 118 lb 1/20/2011 Consumer United States
Primary
Concomitant
Injection Site Pain 2/1/2008 12 Male 190 lb 1/28/2011 Consumer United States
Primary
Concomitant
Weight Decreased 11/1/2009 73 Female 1/28/2011 Consumer United States
Primary
Concomitant
Injection Site Reaction 6/11/2010 42 Female 204 lb 1/29/2011 Consumer Puerto Rico
Primary
Concomitant
Skin Exfoliation 3/1/2010 Female 1/29/2011 Consumer United States
Primary
Concomitant
Device Malfunction 6/1/2010 56 Female 215 lb 1/29/2011 Consumer United States
Primary
Concomitant
Injection Site Pain 7/1/2010 57 Female 1/29/2011 Consumer United States
Primary
Concomitant

Drug Data