Keppra combined with Valproic Acid

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Foetal Valproate Syndrome Congenital Anomaly 2/1/2006 United Kingdom
Primary
Secondary
Thrombocytopenia Other Serious 2/23/2006 49 Female 3/7/2006 Pharmacist Canada
Primary
Secondary
Thrombocytopenia Other Serious 2/23/2006 49 Female 3/15/2006 Pharmacist Canada
Primary
Secondary
Gastritis Hospitalization Female 3/20/2006 Germany
Primary
Concomitant
Urinary Tract Infection Hospitalization 1/1/2006 20 Male 3/24/2006 Consumer United States
Primary
Concomitant
Thrombocytopenia Other Serious 2/23/2006 50 Female 4/7/2006 Pharmacist Canada
Primary
Secondary
Thrombocytopenia Other Serious 17 Female 4/12/2006 Physician Hungary
Primary
Concomitant
Thrombocytopenia Other Serious 2/23/2006 50 Female 5/2/2006 Pharmacist Canada
Primary
Secondary
Drug Toxicity Hospitalization 1/10/2006 69 Female 99 lb 5/10/2006 Pharmacist Canada
Primary
Secondary
Concomitant
Status Epilepticus Other Serious 9 Female 108 lb 5/9/2006 Physician Portugal
Primary
Concomitant
Muscle Rigidity Other Serious 22 Male 3/15/2006 United States
Primary
Concomitant
Thrombocytopenia Other Serious 2/23/2006 50 Female 5/10/2006 Pharmacist Canada
Primary
Secondary
Urinary Tract Infection Hospitalization 3/3/2006 20 Male 5/23/2006 Consumer United States
Primary
Concomitant
Lung Disorder Other Serious Male 6/28/2006 Germany
Primary
Concomitant
Thrombocytopenia Other Serious 2/23/2006 50 Female 8/1/2006 Pharmacist Canada
Primary
Secondary
Thrombocytopenia Hospitalization 1/1/2005 50 Female 8/14/2006 United States
Primary
Secondary
Thrombocytopenia Hospitalization 1/1/2005 50 Female 8/18/2006 United States
Primary
Secondary
Bone Marrow Failure Other Serious 53 Male 8/17/2006 United States
Primary
Concomitant
Thrombocytopenia Hospitalization 1/1/2005 50 Female 8/18/2006 United States
Primary
Secondary
Leukopenia Other Serious 20 Male 9/8/2006 Physician United States
Primary
Secondary
Myalgia Hospitalization 1/1/2006 55 Female 176 lb 9/29/2006 Physician Germany
Primary
Secondary
Thrombocytopenia Other Serious 1/1/2006 50 Female 10/10/2006 Pharmacist Canada
Primary
Secondary
Concomitant
Status Epilepticus Other Serious 9 Female 108 lb 11/20/2006 Physician Portugal
Primary
Concomitant
Respiratory Disorder Life Threatening Female 11/22/2006 Germany
Primary
Concomitant
Thrombocytopenia Other Serious 7/11/2006 68 Male 154 lb 12/19/2006 Germany
Primary
Concomitant
Tachycardia Death 1/28/2007 Female 2/20/2007 Other Health Professional United States
Primary
Concomitant
Anticonvulsant Drug Level Below Therapeutic Hospitalization Female 112 lb 3/12/2007 Physician Germany
Primary
Secondary
Nephritis Interstitial Hospitalization 11/1/2006 65 Male 172 lb 4/5/2007 Physician Germany
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 10/1/2006 44 Female 7/27/2007 Physician Germany
Primary
Concomitant
Ventricular Septal Defect Congenital Anomaly Male 5 lb 9/4/2007 Germany
Primary
Secondary
Hypospadias Congenital Anomaly Male 7 lb 9/4/2007 Germany
Primary
Secondary
Platelet Count Decreased Life Threatening 6/11/2006 14 Female 9/6/2007 Physician United States
Primary
Concomitant
Overdose Other Serious 1/1/2007 Male 9/21/2007 Pharmacist United States
Primary
Concomitant
Thrombocytopenia Other Serious Female 9/14/2007 Other Health Professional Germany
Primary
Secondary
Hypoxic Encephalopathy Death Male 9/17/2007 Other Health Professional Germany
Primary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/2006 14 Female 125 lb 9/26/2007 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 1/1/2006 14 Female 125 lb 10/2/2007 Physician United States
Primary
Secondary
Concomitant
Troponin Increased Death 1/28/2007 Female 10/22/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 9/2/2007 50 Female 198 lb 11/6/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Overdose Other Serious 1/1/2007 Male 154 lb 12/19/2007 Pharmacist United States
Primary
Concomitant
Unresponsive To Stimuli Hospitalization 36 Female 135 lb 1/10/2008 Other Health Professional United States
Primary
Concomitant
Tic Life Threatening 1/10/2007 Male 44 lb 1/29/2008 Germany
Primary
Concomitant
Pneumonia Death 2 Female 2/4/2008 Physician Germany
Primary
Concomitant
Vision Blurred Other Serious 3/1/2007 23 Female 4/8/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Vision Blurred Hospitalization 3/1/2007 23 Female 4/21/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Hospitalization 1/20/2007 Male 5/1/2008 Physician Ireland
Primary
Secondary
Concomitant
Leukopenia Other Serious 33 Male 4/25/2008 Germany
Primary
Secondary
Transmission Of Drug Via Semen Other Serious Male 4/30/2008 Physician Germany
Primary
Secondary
Convulsion Hospitalization Female 4/30/2008 Other Health Professional United Kingdom
Primary
Concomitant
Vision Blurred Other Serious 3/1/2007 23 Female 5/17/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Vision Blurred Other Serious 3/1/2007 23 Female 7/25/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 7 Female 7/24/2008 Germany
Primary
Concomitant
Wrong Technique In Drug Usage Process Hospitalization 8/10/2008 4 Male 39 lb 8/19/2008 Pharmacist United States
Primary
Concomitant
Petit Mal Epilepsy Disability 7/2/2008 22 Female 119 lb 9/3/2008 Other Health Professional United Kingdom
Primary
Concomitant
Convulsion Hospitalization 8/1/2008 5 Male 44 lb 9/5/2008 Other Health Professional Germany
Primary
Concomitant
Somnolence Other Serious 9/28/2008 67 Female 10/10/2008 Physician Germany
Primary
Secondary
Peripheral Coldness Other Serious 11/4/2008 3 Female 24 lb 11/24/2008 Physician Mexico
Primary
Concomitant
Proteinuria Other Serious Male 137 lb 12/2/2008 Physician Germany
Primary
Concomitant
Convulsion Other Serious 52 Male 12/8/2008 Pharmacist United States
Primary
Concomitant
Convulsion Other Serious 51 Female 12/8/2008 Pharmacist United States
Primary
Concomitant
Convulsion Other Serious 57 Female 12/8/2008 Pharmacist United States
Primary
Concomitant
Convulsion Other Serious 55 Female 12/8/2008 Pharmacist United States
Primary
Concomitant
Vision Blurred Hospitalization 3/1/2007 23 Female 12/15/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Proteinuria Other Serious Male 137 lb 12/22/2008 Physician Germany
Primary
Concomitant
Vision Blurred Other Serious 3/1/2007 23 Female 1/16/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Vision Blurred Hospitalization 3/1/2007 23 Female 1/30/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Tinnitus Other Serious 1/15/2007 Male 2/6/2009 Consumer Mexico
Primary
Concomitant
No Therapeutic Response Hospitalization 10/21/2008 36 Female 2/19/2009 United Kingdom
Primary
Secondary
Concomitant
Meniere's Disease Other Serious 12/1/2004 53 Female 115 lb 2/23/2009 Consumer Germany
Primary
Concomitant
Vision Blurred Other Serious 23 Female 4/3/2009 United Kingdom
Primary
Secondary
Concomitant
Vision Blurred Other Serious 23 Female 4/3/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Electrocardiogram T Wave Inversion Other Serious 20 Male 4/8/2009 Germany
Primary
Concomitant
Tachycardia Other Serious 6/16/2009 23 Male 6/23/2009 Physician Germany
Primary
Secondary
Pancytopenia Hospitalization 10/4/2008 16 Female 6/25/2009 Italy
Primary
Concomitant
Tachycardia Hospitalization 6/16/2009 23 Male 141 lb 7/16/2009 Physician Germany
Primary
Secondary
Somnolence 5/9/2009 14 Female 119 lb 7/27/2009 Physician United States
Primary
Concomitant
Tachycardia Other Serious 7/15/2009 29 Female 198 lb 7/24/2009 Germany
Primary
Secondary
Convulsion Other Serious 1/1/2005 Female 144 lb 8/6/2009 Consumer United States
Primary
Secondary
Concomitant
Intestinal Haemorrhage Hospitalization 10/4/2008 16 Female 7/30/2009 Italy
Primary
Concomitant
Tachycardia Other Serious 7/15/2009 29 Female 198 lb 8/13/2009 Germany
Primary
Secondary
Product Substitution Issue Hospitalization 6/9/2009 24 Female 9/21/2009 Other Health Professional France
Primary
Secondary
Drug Interaction Other Serious 9/25/2009 55 Male 165 lb 10/5/2009 Pharmacist Canada
Primary
Concomitant
Interacting
Somnolence Other Serious 10/1/2009 Male 286 lb 10/16/2009 Physician United States
Primary
Concomitant
Drug Interaction 5/25/2009 55 Male 165 lb 11/5/2009 Pharmacist Canada
Primary
Concomitant
Interacting
Nephrogenic Systemic Fibrosis Other Serious 5/12/2005 Female 11/30/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 10/1/2008 52 Female 11/23/2009 Spain
Primary
Concomitant
Stevens-johnson Syndrome Life Threatening 10/1/2001 Female 187 lb 12/7/2009 Physician Poland
Primary
Concomitant
Tachycardia Other Serious 7/15/2009 Female 198 lb 12/7/2009 Physician Germany
Primary
Secondary
Tachycardia Other Serious 6/16/2009 Male 141 lb 12/7/2009 Physician Germany
Primary
Secondary
Tonic Convulsion Hospitalization Male 154 lb 12/3/2009 Germany
Primary
Concomitant
Platelet Count Decreased Disability 4/15/2009 50 Female 157 lb 12/10/2009 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 10/2/2008 52 Female 12/21/2009 Spain
Primary
Concomitant
Nephrogenic Systemic Fibrosis Other Serious 5/12/2005 Female 2/4/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 12/22/2009 64 Female 2/18/2010 Pharmacist United States
Primary
Concomitant
Myalgia Other Serious 11/1/2009 Male 159 lb 2/22/2010 Germany
Primary
Secondary
Concomitant
Renal Failure Hospitalization 11/25/2008 Male 3/1/2010 Physician Germany
Primary
Concomitant
Hepatitis Hospitalization 38 Male 4/19/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Dyskinesia Required Intervention 5/14/2010 17 Female 130 lb 6/3/2010 Consumer United States
Primary
Secondary
Vomiting Other Serious 3/1/2009 19 Female 6/14/2010 Consumer United States
Primary
Secondary
Concomitant
Death Death 4/11/2010 10 Female 6/10/2010 Other Health Professional United States
Primary
Concomitant
Grand Mal Convulsion Other Serious 47 Female 203 lb 6/18/2010 Other Health Professional United States
Primary
Concomitant
Protrusion Tongue 13 Male 6/15/2010 Consumer United States
Primary
Concomitant
Drug Interaction Other Serious Male 7/15/2010 Physician Norway
Primary
Secondary
Concomitant
Myoclonus Other Serious Male 7/19/2010 Physician Norway
Primary
Secondary
Concomitant
Laboratory Test Interference Other Serious Male 7/26/2010 Physician Norway
Primary
Secondary
Concomitant
Vision Blurred Other Serious 7/1/2009 25 Female 140 lb 7/27/2010 Physician United States
Primary
Concomitant
Status Epilepticus Hospitalization 11/1/2009 73 Male 8/16/2010 Austria
Primary
Secondary
Concomitant
Unevaluable Event Other Serious 63 Female 8/24/2010 Austria
Primary
Concomitant
Hypotension Hospitalization 5/3/2010 62 Male 8/31/2010 Consumer United States
Primary
Secondary
Concomitant
Skin Plaque Death Female 141 lb 10/14/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Skin Plaque Death 1/1/2005 52 Female 141 lb 10/20/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Other Serious 9/28/2010 51 Female 113 lb 10/18/2010 Japan
Primary
Concomitant
Restlessness Other Serious 9/28/2010 51 Female 113 lb 10/15/2010 Japan
Primary
Concomitant
Lethargy Other Serious 9/1/2010 54 Male 11/16/2010 Consumer United States
Primary
Concomitant
Lethargy Other Serious 9/1/2010 53 Male 11/16/2010 Consumer United States
Primary
Concomitant
Lethargy Other Serious 9/1/2010 48 Male 11/16/2010 Consumer United States
Primary
Concomitant
Lethargy Other Serious 9/1/2010 50 Female 11/16/2010 Consumer United States
Primary
Concomitant
Haemangioma Other Serious Male 8 lb 1/5/2011 Physician United States
Primary
Concomitant
Acute Myocardial Infarction 1/4/2011 45 Male 1/7/2011 Other Health Professional Greece
Primary
Secondary
Concomitant
Transaminases Increased Life Threatening Female 187 lb 2/1/2011 Physician Poland
Primary
Concomitant
Chest Discomfort Hospitalization 1/4/2011 45 Male 2/8/2011 Physician Greece
Primary
Secondary
Concomitant
Mastication Disorder 8/1/2009 57 Male 3/4/2011 Physician United States
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious 1/1/2009 39 Male 3/7/2011 Physician Germany
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious 71 Male 3/23/2011 Physician Germany
Primary
Secondary
Concomitant
Bone Marrow Disorder Other Serious Male 4/5/2011 Physician Ireland
Primary
Concomitant
Psychomotor Hyperactivity Other Serious 14 Male 4/1/2011 Physician Poland
Primary
Concomitant
Acne Other Serious Male 4/18/2011 Physician Germany
Primary
Secondary
Optic Atrophy Other Serious Female 4/29/2011 Physician Germany
Primary
Secondary
Concomitant
Amnestic Disorder Other Serious 71 Male 5/3/2011 Physician Germany
Primary
Secondary
Concomitant
Akathisia Death 4/29/2010 12 Male 46 lb 5/3/2011 Physician United States
Primary
Concomitant
Fatigue Other Serious Male 175 lb 5/10/2011 Physician Germany
Primary
Concomitant
Iron Deficiency Anaemia Hospitalization Male 5/31/2011 Pharmacist Germany
Primary
Concomitant
Pneumonia Life Threatening Female 154 lb 5/3/2011 Pharmacist United States
Primary
Secondary
Concomitant
Choreoathetosis Hospitalization 11/1/2010 18 Male 6/14/2011 Physician Japan
Primary
Secondary
Concomitant
Choreoathetosis Hospitalization 11/1/2010 18 Male 6/16/2011 Physician Japan
Primary
Secondary
Concomitant
Status Epilepticus Death 80 Male 6/27/2011 Other Health Professional Denmark
Primary
Secondary
Polyuria Hospitalization 1/1/2011 46 Male 7/19/2011 Pharmacist Germany
Primary
Concomitant
Optic Atrophy Disability 1/1/2010 57 Female 7/21/2011 Physician Germany
Primary
Concomitant
Convulsion Other Serious 7/26/2011 Other Health Professional Korea, Republic Of
Primary
Concomitant
Convulsion Other Serious 2/1/2011 76 Female 8/1/2011 Physician Germany
Primary
Secondary
Tremor Other Serious 3/1/2010 Female 8/5/2011 Consumer United States
Primary
Secondary
Concomitant
Anuria Other Serious 7/1/2011 Male 8/10/2011 Physician Germany
Primary
Concomitant
Joint Range Of Motion Decreased Death 1/1/2005 51 Female 141 lb 8/15/2011 Consumer United States
Primary
Secondary
Concomitant
Polyneuropathy Other Serious 1/1/2010 49 Male 143 lb 8/16/2011 Physician Germany
Primary
Secondary
Concomitant
Fatigue Hospitalization 8/6/2010 29 Female 8/23/2011 Consumer Germany
Primary
Concomitant
Grand Mal Convulsion Hospitalization Female 8/31/2011 Pharmacist Germany
Primary
Concomitant
Brain Cancer Metastatic Hospitalization Male 9/6/2011 Pharmacist Netherlands
Primary
Concomitant
Pallor Hospitalization 7/1/2011 53 Male 256 lb 9/9/2011 Other Health Professional Canada
Primary
Concomitant
Aphasia Hospitalization 6/7/2011 38 Female 198 lb 9/9/2011 Physician Switzerland
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Other Serious 6/13/2011 38 Female 198 lb 9/13/2011 Physician Switzerland
Primary
Secondary
Concomitant

Drug Data