Keppra combined with Topiramate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Precocious Puberty Other Serious 10/1/2005 4 Female 2/16/2006 United Kingdom
Primary
Concomitant
Psychotic Disorder Hospitalization 12/2/2004 56 Male 158 lb 1/14/2006 Physician United States
Primary
Concomitant
Urine Ketone Body Present Required Intervention 5/20/2003 28 Female 5/26/2006 Physician United States
Primary
Secondary
Concomitant
Vomiting Required Intervention 5/20/2003 28 Female 6/13/2006 Physician United States
Primary
Secondary
Concomitant
Coma Required Intervention 40 Female 6/28/2006 Physician United Kingdom
Primary
Concomitant
Grand Mal Convulsion Hospitalization 1/1/2006 32 Female 6/30/2006 Germany
Primary
Secondary
Somnolence Hospitalization 2/27/2003 Female 7/3/2006 Consumer United Kingdom
Primary
Concomitant
Treatment Noncompliance Hospitalization 40 Female 7/11/2006 Physician United Kingdom
Primary
Concomitant
Mental Impairment Other Serious 10/11/2004 17 Female 107 lb 10/3/2006 France
Primary
Concomitant
Unwanted Pregnancy Other Serious 1/1/2003 Female 2/13/2007 Other Health Professional United Kingdom
Primary
Secondary
Status Epilepticus Hospitalization 11/29/2006 18 Male 209 lb 2/14/2007 Physician Germany
Primary
Concomitant
Status Epilepticus Hospitalization 11/29/2006 18 Male 209 lb 2/14/2007 Germany
Primary
Concomitant
Small For Dates Baby Congenital Anomaly Male 6 lb 3/5/2007 Consumer United Kingdom
Primary
Secondary
Small For Dates Baby Congenital Anomaly Male 5 lb 3/8/2007 Other Health Professional United Kingdom
Primary
Secondary
Visual Disturbance Disability 6/15/2006 Female 3/23/2007 Physician Germany
Primary
Concomitant
Suicide Attempt Other Serious 3/16/2007 14 Female 3/27/2007 Physician Germany
Primary
Secondary
Suicide Attempt Other Serious 3/16/2007 14 Female 110 lb 4/9/2007 Physician Germany
Primary
Secondary
Joint Sprain Other Serious 10/11/2004 17 Female 107 lb 5/2/2007 Physician France
Primary
Concomitant
Failure To Thrive Hospitalization 2/28/2007 Female 15 lb 5/25/2007 Physician United States
Primary
Concomitant
Visual Disturbance Hospitalization 6/15/2006 Female 129 lb 6/13/2007 Physician Germany
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Other Serious Female 6/21/2007 Physician United Kingdom
Primary
Concomitant
Death Death Female 6/22/2007 Germany
Primary
Concomitant
Thrombocytopenia Other Serious 10 Male 10/5/2007 Germany
Primary
Secondary
Tachycardia Other Serious 1/1/2003 18 Female 126 lb 10/30/2007 United States
Primary
Secondary
Traumatic Brain Injury Other Serious 6/1/2006 62 Male 231 lb 11/10/2007 Physician Germany
Primary
Secondary
Concomitant
Drug Toxicity Hospitalization 10/12/2007 74 Male 95 lb 11/15/2007 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Radiculopathy Other Serious 10/11/2004 17 Female 107 lb 11/14/2007 Physician France
Primary
Concomitant
Tachycardia Other Serious 1/1/2003 18 Female 126 lb 11/22/2007 United States
Primary
Secondary
Bone Marrow Failure Death 9/22/2007 80 Female 11/16/2007 Pharmacist Denmark
Primary
Secondary
Concomitant
Pyrexia Hospitalization 10/12/2007 74 Male 95 lb 12/3/2007 Physician Korea, Republic Of
Primary
Concomitant
Pyrexia Hospitalization 10/12/2007 74 Male 95 lb 1/14/2008 Physician Korea, Republic Of
Primary
Concomitant
Weight Decreased Life Threatening 6/1/2002 49 Female 127 lb 1/14/2008 Consumer United Kingdom
Primary
Concomitant
Thrombocytopenic Purpura Other Serious 7/1/2006 19 Male 3/3/2008 Consumer United Kingdom
Primary
Secondary
Weight Decreased Life Threatening 6/1/2002 49 Female 127 lb 2/25/2008 Consumer United Kingdom
Primary
Concomitant
Thrombocytopenic Purpura Other Serious 7/1/2006 19 Male 3/7/2008 Physician United Kingdom
Primary
Secondary
Vomiting Hospitalization Male 57 lb 5/27/2008 Physician United Kingdom
Primary
Concomitant
Vomiting Life Threatening 8/15/2008 34 Male 198 lb 10/6/2008 Consumer France
Primary
Concomitant
Renal Colic Hospitalization 6/9/2008 Male 12/11/2008 Other Health Professional France
Primary
Secondary
Concomitant
Therapeutic Response Decreased Life Threatening 11/19/2008 46 Female 12/19/2008 Other Health Professional France
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 6/1/2008 20 Male 1/12/2009 Physician United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious 3/1/2008 35 Female 2/18/2009 United States
Primary
Secondary
Hepatic Failure Other Serious 54 Female 3/12/2009 Physician United States
Primary
Concomitant
Product Quality Issue Other Serious 5/18/2009 Physician United Kingdom
Primary
Concomitant
Product Substitution Issue Other Serious 5/1/2009 29 Female 165 lb 5/20/2009 United States
Primary
Concomitant
Hyponatraemia Death 4/17/2009 63 Female 6/19/2009 Other Health Professional United Kingdom
Primary
Secondary
Hyponatraemia Death 63 Female 6/29/2009 Other Health Professional United Kingdom
Primary
Secondary
Hyponatraemia Death Female 6/23/2009 United Kingdom
Primary
Secondary
Concomitant
Hyponatraemia Other Serious 4/17/2009 63 Female 7/2/2009 Other Health Professional United Kingdom
Primary
Secondary
Hyponatraemia Death 63 Female 7/6/2009 Other Health Professional United Kingdom
Primary
Secondary
Status Epilepticus Other Serious Female 6/29/2009 Physician Belgium
Primary
Concomitant
Hyponatraemia Other Serious 63 Female 7/7/2009 Other Health Professional United Kingdom
Primary
Secondary
Hyponatraemia Death 1/1/2008 63 Female 7/3/2009 Other Health Professional United Kingdom
Primary
Concomitant
Hyponatraemia Death 63 Female 7/13/2009 Other Health Professional United Kingdom
Primary
Secondary
Hyponatraemia Death 4/17/2009 63 Female 7/7/2009 Other Health Professional United Kingdom
Primary
Secondary
Hyponatraemia Death 63 Female 7/13/2009 Other Health Professional United Kingdom
Primary
Secondary
Psychomotor Hyperactivity Other Serious 2/1/2008 6 Female 22 lb 8/5/2009 Physician Germany
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2006 15 Male 113 lb 8/5/2009 United States
Primary
Secondary
Concomitant
Road Traffic Accident Death 7/14/2009 41 Male 8/10/2009 Germany
Primary
Concomitant
Hyponatraemia Death 4/15/2009 63 Female 8/24/2009 Other Health Professional United Kingdom
Primary
Secondary
Hyponatraemia Death 4/15/2009 63 Female 9/3/2009 Other Health Professional United Kingdom
Primary
Secondary
Hyponatraemia Other Serious 4/17/2009 63 Female 9/15/2009 Other Health Professional United Kingdom
Primary
Secondary
Hyponatraemia Other Serious 63 Female 9/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Hyponatraemia Death 63 Female 9/22/2009 United Kingdom
Primary
Concomitant
Hyponatraemia Death 63 Female 9/30/2009 United Kingdom
Primary
Secondary
Weight Decreased Life Threatening 6/1/2002 49 Female 127 lb 10/19/2009 United Kingdom
Primary
Concomitant
Wheezing Hospitalization 4/1/2009 Male 10/28/2009 Physician Canada
Primary
Secondary
Concomitant
Weight Decreased Life Threatening 6/1/2002 49 Female 127 lb 10/27/2009 Consumer United Kingdom
Primary
Concomitant
Wheezing Hospitalization 4/1/2009 Male 11/10/2009 Physician Canada
Primary
Secondary
Concomitant
Dyskinesia Other Serious 3/1/2009 13 Male 77 lb 11/5/2009 Physician United Kingdom
Primary
Concomitant
Wheezing Other Serious 4/1/2009 63 Female 12/4/2009 Other Health Professional United Kingdom
Primary
Secondary
Dyskinesia Other Serious 3/1/2009 13 Male 77 lb 12/3/2009 Physician United Kingdom
Primary
Concomitant
Tonic Convulsion Hospitalization Male 154 lb 12/3/2009 Germany
Primary
Concomitant
Status Epilepticus Life Threatening 3/10/2009 Female 44 lb 12/7/2009 Physician Poland
Primary
Concomitant
Anal Cancer Hospitalization 11/10/2009 Female 216 lb 12/15/2009 Other Health Professional Germany
Primary
Concomitant
Weight Decreased Other Serious 6/1/2002 Female 127 lb 1/18/2010 Consumer United Kingdom
Primary
Concomitant
Convulsion Hospitalization 5/1/2009 Female 225 lb 1/26/2010 United States
Primary
Concomitant
Granulocytopenia Other Serious 12/23/2009 48 Female 126 lb 2/16/2010 Germany
Primary
Secondary
Concomitant
Vomiting 7/1/2009 39 Female 115 lb 2/26/2010 Consumer United States
Primary
Secondary
Concomitant
Sudden Death Death 1/1/2010 Female 3/24/2010 Physician Poland
Primary
Secondary
Epilepsy Other Serious 41 Female 4/2/2010 Physician Germany
Primary
Concomitant
Vomiting Female 248 lb 4/23/2010 Physician United States
Primary
Concomitant
Vomiting Female 248 lb 4/28/2010 Physician United States
Primary
Concomitant
Nervous System Disorder Hospitalization 4/16/2010 58 Male 6/10/2010 Consumer France
Primary
Secondary
Concomitant
Hyperammonaemia Hospitalization 4/16/2010 58 Male 6/14/2010 Other Health Professional France
Primary
Secondary
Off Label Use Hospitalization 1/1/2010 58 Male 6/18/2010 Consumer France
Primary
Secondary
Concomitant
Myocardial Infarction Death 64 Male 6/11/2010 Germany
Primary
Secondary
Concomitant
Convulsion Other Serious 41 Female 7/9/2010 Physician Germany
Primary
Concomitant
Hyperlipasaemia Hospitalization 7/7/2010 19 Female 8/2/2010 Physician France
Primary
Secondary
Concomitant
Hyperlipasaemia Hospitalization 7/7/2010 19 Female 8/3/2010 Physician France
Primary
Secondary
Concomitant
Hepatitis Acute Hospitalization 7/1/2010 58 Female 8/4/2010 Other Health Professional France
Primary
Secondary
Nausea Other Serious 7/3/2010 40 Female 115 lb 7/28/2010 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 6/1/2010 46 Female 160 lb 8/13/2010 United States
Primary
Concomitant
Small For Dates Baby Other Serious Male 8/23/2010 Other Health Professional United States
Primary
Concomitant
Prothrombin Time Ratio Decreased Hospitalization 7/1/2010 58 Female 8/20/2010 United States
Primary
Secondary
Wheezing Other Serious 4/1/2009 1 Male 8/31/2010 Physician Canada
Primary
Secondary
Concomitant
Weight Decreased Other Serious 10/11/2004 17 Female 107 lb 9/1/2010 France
Primary
Concomitant
Myocardial Infarction 64 Male 9/7/2010 Physician Germany
Primary
Secondary
Concomitant
Wheezing Other Serious 4/1/2009 1 Male 9/20/2010 Physician Canada
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 3/29/2010 7 Female 49 lb 9/23/2010 Other Health Professional France
Primary
Secondary
Concomitant
Status Epilepticus Hospitalization Female 10/8/2010 Physician Norway
Primary
Concomitant
Weight Decreased Hospitalization 6/1/2010 46 Female 160 lb 10/13/2010 United States
Primary
Concomitant
Vomiting Disability 1/1/2009 42 Female 220 lb 11/9/2010 Portugal
Primary
Concomitant
Suicidal Ideation Other Serious 8/31/2010 28 Female 10/25/2010 Physician United States
Primary
Concomitant
Pregnancy Other Serious 12/1/2009 30 Female 126 lb 11/22/2010 Physician Czech Republic
Primary
Secondary
Hypothermia Life Threatening 12/11/2010 30 Female 12/15/2010 Physician France
Primary
Concomitant
Loss Of Consciousness Other Serious 1/1/2010 46 Female 200 lb 12/1/2010 Consumer United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 23 Female 110 lb 12/21/2010 Physician Denmark
Primary
Secondary
Depressed Level Of Consciousness Life Threatening 12/11/2010 36 Female 154 lb 1/11/2011 Physician France
Primary
Concomitant
Amnesia Hospitalization 7/3/2010 40 Female 97 lb 1/12/2011 Consumer United States
Primary
Concomitant
No Adverse Event 1/12/2009 48 Male 196 lb 1/21/2011 Other Health Professional Germany
Primary
Concomitant
Granulocytopenia Other Serious 12/23/2009 48 Female 126 lb 2/10/2011 Germany
Primary
Secondary
Concomitant
Drug Interaction Hospitalization 11/16/2010 33 Female 80 lb 2/15/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Persecutory Delusion Other Serious 40 Female 3/1/2011 Physician France
Primary
Secondary
Concomitant
Blood Amylase Increased Hospitalization 2/1/2011 6 Female 3/1/2011 Other Health Professional Russian Federation
Primary
Secondary
Psychotic Disorder Other Serious 1/1/2009 39 Male 3/7/2011 Physician Germany
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious 71 Male 3/23/2011 Physician Germany
Primary
Secondary
Concomitant
Persecutory Delusion Life Threatening 58 Male 3/29/2011 Physician Japan
Primary
Concomitant
Malnutrition Other Serious 1/1/2009 46 Female 150 lb 4/13/2011 Other Health Professional France
Primary
Secondary
Concomitant
Visual Acuity Reduced Disability 1/1/2011 35 Male 4/18/2011 Physician Germany
Primary
Secondary
Concomitant
Hallucination, Auditory Life Threatening Male 4/6/2011 Physician Japan
Primary
Secondary
Concomitant
Psychotic Disorder Due To A General Medical Condition Life Threatening 1/1/2011 58 Male 4/11/2011 Physician Japan
Primary
Secondary
Concomitant
Glioblastoma Death Male 4/11/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Glioblastoma Death Male 187 lb 4/21/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Amnestic Disorder Other Serious 71 Male 5/3/2011 Physician Germany
Primary
Secondary
Concomitant
Partial Seizures Other Serious 1/1/2007 19 Male 5/5/2011 Physician Germany
Primary
Secondary
Concomitant
Postictal Psychosis Other Serious 4/10/2011 30 Male 5/16/2011 Physician Japan
Primary
Concomitant
Psychotic Behaviour Other Serious 4/2/2011 23 Female 5/17/2011 Other Health Professional United Kingdom
Primary
Concomitant
Fatigue Other Serious Male 175 lb 5/10/2011 Physician Germany
Primary
Concomitant
Petit Mal Epilepsy Other Serious 40 Female 5/18/2011 Consumer Canada
Primary
Secondary
Concomitant
Delusion Other Serious 4/2/2011 23 Female 5/23/2011 Other Health Professional United Kingdom
Primary
Concomitant
Tubulointerstitial Nephritis Other Serious 10/1/2009 51 Female 5/27/2011 Physician United Kingdom
Primary
Concomitant
Ileus Other Serious 12/2/2010 3 Male 19 lb 5/27/2011 Physician Japan
Primary
Secondary
Concomitant
Petit Mal Epilepsy Other Serious 40 Female 5/24/2011 Consumer
Primary
Secondary
Concomitant
Pneumonia Aspiration Other Serious 3/21/2011 23 Female 90 lb 6/16/2011 Pharmacist United States
Primary
Secondary
Concomitant
Hallucination, Auditory Hospitalization 15 Male 6/17/2011 Other Health Professional Japan
Primary
Secondary
Headache Hospitalization 6/1/2011 15 Male 7/7/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Feeling Hot Other Serious 3/1/2011 40 Female 120 lb 7/8/2011 Consumer Canada
Primary
Secondary
Concomitant
Pregnancy Other Serious 1/1/2011 37 Female 287 lb 7/13/2011 Physician Belgium
Primary
Secondary
Concomitant
Headache Hospitalization 6/1/2011 15 Male 7/15/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Feeling Hot Other Serious 3/1/2011 40 Female 7/19/2011 Consumer Canada
Primary
Secondary
Grand Mal Convulsion Other Serious 1/1/2011 20 Male 235 lb 7/19/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Feeling Hot Other Serious 3/1/2011 40 Female 7/24/2011 Consumer Canada
Primary
Secondary
Concomitant
Gliosarcoma Other Serious 7/26/2011 Other Health Professional Korea, Republic Of
Primary
Concomitant
Deja Vu Other Serious 3/1/2011 40 Female 120 lb 7/15/2011 Consumer United States
Primary
Secondary
Concomitant
Polyneuropathy Other Serious 1/1/2010 49 Male 143 lb 8/16/2011 Physician Germany
Primary
Secondary
Concomitant
Product Substitution Issue Other Serious 8/4/2009 42 Female 148 lb 8/11/2011 Other Health Professional United States
Primary
Concomitant
Gingival Bleeding Disability 1/1/2008 59 Female 193 lb 8/19/2011 Consumer France
Primary
Concomitant
Delirium Other Serious 1/1/2011 Male 8/23/2011 Physician Japan
Primary
Concomitant
Affect Lability Other Serious 8/1/2009 35 Male 456 lb 8/26/2011 Consumer United States
Primary
Concomitant
Guillain-barre Syndrome Hospitalization 10/11/2004 17 Female 107 lb 8/30/2011 Physician France
Primary
Concomitant

Drug Data