Keppra combined with Phenytoin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
White Blood Cell Count Increased Other Serious 10/2/2004 65 Female 1/23/2006 Physician United States
Primary
Secondary
Concomitant
Haemoglobin Decreased Hospitalization 9/13/2005 Female 9/14/2005 Pharmacist United States
Primary
Concomitant
Pulmonary Haemorrhage Hospitalization 10/31/2005 82 Male 2/9/2006 Physician Germany
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 12/10/2005 82 Female 120 lb 1/28/2006 Pharmacist United States
Primary
Concomitant
Psychotic Disorder Hospitalization 12/2/2004 56 Male 158 lb 1/14/2006 Physician United States
Primary
Concomitant
Treatment Noncompliance Other Serious 4/30/2005 33 Female 3/14/2006 Physician United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 12/10/2005 82 Female 120 lb 1/28/2006 Pharmacist United States
Primary
Concomitant
Premature Baby Hospitalization 1/1/2004 Male 15 lb 4/14/2006 Physician United States
Primary
Secondary
Drug Toxicity Hospitalization 1/10/2006 69 Female 99 lb 5/10/2006 Pharmacist Canada
Primary
Secondary
Concomitant
Medical Device Complication Other Serious 64 Male 115 lb 5/12/2006 United States
Primary
Secondary
Concomitant
Coma Required Intervention 40 Female 6/28/2006 Physician United Kingdom
Primary
Concomitant
Treatment Noncompliance Hospitalization 40 Female 7/11/2006 Physician United Kingdom
Primary
Concomitant
Ulcer Haemorrhage Other Serious 11/1/2001 Female 8/28/2006 United Kingdom
Primary
Concomitant
Vaginal Haemorrhage Other Serious 8/4/2005 33 Female 9/21/2006 Physician United States
Primary
Concomitant
Pregnancy Other Serious 11/4/2005 23 Female 9/29/2006 United States
Primary
Concomitant
Drug Exposure During Pregnancy Congenital Anomaly 7/27/2006 NotSpecified 10/13/2006 Physician United States
Primary
Concomitant
Lymphadenopathy 11/30/2006 Female 141 lb 12/15/2006 Pharmacist United States
Primary
Concomitant
Ileus Paralytic Life Threatening 12/2/2006 77 Female 143 lb 1/5/2007 Physician Germany
Primary
Secondary
Concomitant
Vaginal Cellulitis Required Intervention 11/17/2006 26 Female 1/22/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Muscular Weakness Hospitalization 1/20/2007 74 Female 135 lb 1/29/2007 Physician United States
Primary
Concomitant
Drug Exposure During Pregnancy Congenital Anomaly 7/27/2006 Female 2/5/2007 Other Health Professional United States
Primary
Concomitant
Supraventricular Extrasystoles Other Serious 11/4/2006 39 Female 2/26/2007 Germany
Primary
Concomitant
Drug Exposure During Pregnancy Other Serious 11/4/2005 23 Female 2/28/2007 Physician United States
Primary
Concomitant
Leukopenia Other Serious Male 3/13/2007 Germany
Primary
Concomitant
Vaginal Haemorrhage Other Serious 8/4/2005 33 Female 3/27/2007 Physician United States
Primary
Concomitant
Drug Exposure During Pregnancy Congenital Anomaly 7/27/2006 Female 3/27/2007 Physician United States
Primary
Concomitant
Drug Exposure During Pregnancy Congenital Anomaly 7/27/2006 Female 4/5/2007 Physician United States
Primary
Concomitant
Somnolence Hospitalization 4/4/2007 41 Female 4/16/2007 Pharmacist Canada
Primary
Concomitant
Tremor Hospitalization 1/20/2007 39 Male 117 lb 4/25/2007 Consumer United Kingdom
Primary
Concomitant
Fall Other Serious 2/28/2007 54 Male 3/13/2007 Pharmacist United States
Primary
Concomitant
Multiple Drug Overdose Intentional Death 61 Male 5/8/2007 Physician United States
Primary
Secondary
Drug Exposure During Pregnancy Congenital Anomaly 7/27/2006 Female 4/30/2007 Physician United States
Primary
Concomitant
Epilepsy Other Serious Female 5/15/2007 Other Health Professional United Kingdom
Primary
Secondary
Metabolic Disorder Death 6 5/7/2007 Germany
Primary
Concomitant
Insomnia Hospitalization 4/1/2007 0 Female 11 lb 5/7/2007 Physician Germany
Primary
Concomitant
Somnolence Hospitalization 4/4/2007 41 Female 5/11/2007 Pharmacist Canada
Primary
Concomitant
Osteoporosis Other Serious 52 Female 5/25/2007 United States
Primary
Concomitant
Epilepsy Other Serious 5/1/2005 21 Female 6/4/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Dysarthria Other Serious 1/24/2005 32 Female 6/5/2007 Other Health Professional United Kingdom
Primary
Secondary
Premature Baby Congenital Anomaly 7/27/2006 Female 6 lb 6/29/2007 Physician United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 4/28/2007 0 Female 11 lb 6/29/2007 Physician Germany
Primary
Concomitant
Dysarthria Other Serious 1/24/2007 32 Female 7/2/2007 United Kingdom
Primary
Secondary
Vaginal Haemorrhage Hospitalization 8/4/2005 33 Female 7/2/2007 Physician United States
Primary
Concomitant
Neutropenia Other Serious 61 Male 7/9/2007 Pharmacist Ireland
Primary
Secondary
Status Epilepticus Hospitalization 8/26/2006 29 Male 8/10/2007 Other Health Professional Ireland
Primary
Concomitant
Neutropenia Hospitalization 4/2/2007 61 Male 8/10/2007 Pharmacist Ireland
Primary
Secondary
Concomitant
Presyncope Other Serious 1/24/2005 32 Female 8/27/2007 United Kingdom
Primary
Secondary
Somnolence Hospitalization 65 Male 9/4/2007 United Kingdom
Primary
Concomitant
Status Epilepticus Hospitalization 8/26/2006 29 Male 9/13/2007 Other Health Professional Ireland
Primary
Concomitant
Hypoxic Encephalopathy Death Male 9/17/2007 Other Health Professional Germany
Primary
Concomitant
Status Epilepticus Hospitalization 8/26/2006 29 Male 9/28/2007 Other Health Professional Ireland
Primary
Concomitant
Drug Level Decreased Other Serious 9/24/2007 64 Male 9/25/2007 Pharmacist United States
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 36 Female 8/24/2007 Pharmacist United States
Primary
Secondary
Ileus Death 12/2/2006 77 Female 143 lb 10/12/2007 Physician Germany
Primary
Concomitant
Insomnia 7/26/2007 52 Female 120 lb 10/5/2007 Consumer United States
Primary
Concomitant
Myelitis Transverse Hospitalization 7/19/2007 Male 240 lb 10/31/2007 Physician
Primary
Concomitant
Unresponsive To Stimuli Death 1/1/2007 55 Female 11/19/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Death 1/1/2007 55 Female 11/19/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Leukopenia Other Serious Female 11/29/2007 United Kingdom
Primary
Concomitant
Pyrexia Hospitalization Female 1/3/2008 Pharmacist United States
Primary
Concomitant
Muscular Weakness Congenital Anomaly 7/27/2006 Female 6 lb 1/2/2008 Physician United States
Primary
Concomitant
Unresponsive To Stimuli Hospitalization 36 Female 135 lb 1/10/2008 Other Health Professional United States
Primary
Concomitant
Loss Of Consciousness Other Serious 5/29/2006 70 Female 1/17/2008
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Other Serious 2/10/2004 47 Male 1/11/2008 United States
Primary
Concomitant
Rhabdomyolysis Life Threatening 1/1/2008 37 Female 231 lb 2/20/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Unevaluable Event Other Serious 1/1/2005 Male 165 lb 3/5/2008 Consumer United States
Primary
Secondary
Concomitant
Rhabdomyolysis Life Threatening 1/1/2008 37 Female 231 lb 3/7/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Death Death 1/1/2008 66 Female 132 lb 2/29/2008 Physician Malaysia
Primary
Concomitant
Tremor Other Serious 1/1/2006 Male 3/14/2008 Consumer United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 1/1/2008 Female 3/31/2008 Consumer United States
Primary
Concomitant
Acute Hepatic Failure Life Threatening 1/1/2008 Female 4/9/2008 Germany
Primary
Concomitant
Acute Hepatic Failure Life Threatening 1/1/2008 Female 4/15/2008 Germany
Primary
Concomitant
Unevaluable Event Hospitalization 36 Male 79 lb 4/24/2008 Sweden
Primary
Secondary
Femoral Neck Fracture Other Serious Female 4/30/2008 Germany
Primary
Concomitant
Status Epilepticus Life Threatening 4/1/2008 47 Female 95 lb 5/23/2008 Other Health Professional United Kingdom
Primary
Concomitant
Retching Other Serious 9/19/2007 38 Female 125 lb 6/27/2008 United States
Primary
Concomitant
Tremor Other Serious 3/3/2008 45 Male 150 lb 7/28/2008 United States
Primary
Secondary
Skin Exfoliation Hospitalization 7/16/2008 Male 129 lb 8/11/2008 Pharmacist United States
Primary
Secondary
Vision Blurred Other Serious 1/1/2008 Female 8/20/2008 Physician United States
Primary
Concomitant
Renal Failure Acute Hospitalization 3/31/2008 65 Female 143 lb 7/7/2008 Pharmacist United States
Primary
Concomitant
Wound Infection Other Serious 7/9/2008 58 Male 196 lb 8/19/2008 Physician United States
Primary
Secondary
Concomitant
Infertility Male Other Serious Male 8/25/2008 Consumer United Kingdom
Primary
Concomitant
Nausea Hospitalization 6/4/2008 64 Male 9/3/2008 Pharmacist United States
Primary
Concomitant
Wound Infection Death 7/18/2008 Male 196 lb 9/11/2008 Consumer United States
Primary
Secondary
Concomitant
Convulsion Other Serious 6/1/2008 58 Male 225 lb 9/16/2008 Other Health Professional United States
Primary
Concomitant
Somnolence Other Serious 7/26/2008 45 Male 10/3/2008 United Kingdom
Primary
Secondary
Neutropenia Hospitalization 8/26/2008 61 Male 10/29/2008 United Kingdom
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Other Serious 48 Female 11/7/2008 United States
Primary
Concomitant
Thyroidectomy Other Serious Female 11/21/2008 Consumer United States
Primary
Secondary
Sleep Terror Other Serious Female 11/28/2008 Other Health Professional United Kingdom
Primary
Concomitant
Status Epilepticus Hospitalization 35 Female 12/11/2008 Other Health Professional Germany
Primary
Concomitant
Interacting
Pneumonia Death 11/1/2008 81 Male 12/11/2008 Germany
Primary
Concomitant
Sleep Terror Other Serious 1/14/2009 Other Health Professional United Kingdom
Primary
Concomitant
Muscular Weakness Congenital Anomaly 7/27/2006 Female 6 lb 1/23/2009 Physician United States
Primary
Concomitant
Toxic Encephalopathy Death Male 2/13/2009 Physician Germany
Primary
Secondary
Ischaemic Stroke Hospitalization 12/22/2008 43 Male 2/25/2009 Physician Malaysia
Primary
Concomitant
Ventricular Tachycardia Other Serious 73 Female 3/23/2009 Physician Germany
Primary
Concomitant
Leukopenia Other Serious 4/29/2009 Physician Switzerland
Primary
Concomitant
Torsade De Pointes Life Threatening 3/10/2009 73 Female 165 lb 5/26/2009 Physician Germany
Primary
Secondary
Concomitant
Weight Decreased Disability 32 Female 6/5/2009 Other Health Professional France
Primary
Secondary
Concomitant
Leukopenia Other Serious 4/1/2009 38 Male 190 lb 6/23/2009 Physician Germany
Primary
Concomitant
Rash Hospitalization 3/1/2008 81 6/29/2009 United Kingdom
Primary
Concomitant
Somnolence Other Serious 3/1/2008 Male 160 lb 7/30/2009 Consumer United States
Primary
Secondary
Weight Increased Other Serious 1/1/1998 Female 190 lb 7/31/2009 Consumer United States
Primary
Secondary
Concomitant
Atrial Fibrillation Other Serious 6/18/2009 Female 8/3/2009 Physician United Kingdom
Primary
Concomitant
Suicidal Ideation Other Serious 8/1/2005 38 Male 139 lb 7/30/2009 Consumer Germany
Primary
Secondary
Concomitant
Petit Mal Epilepsy Hospitalization 52 Female 98 lb 8/25/2009 Other Health Professional United Kingdom
Primary
Concomitant
Status Epilepticus Other Serious Female 8/28/2009 Consumer United States
Primary
Concomitant
Unresponsive To Stimuli Death 1/1/2007 58 Female 9/3/2009 Lawyer United States
Primary
Concomitant
Unresponsive To Stimuli Death 1/1/2007 58 Female 9/29/2009 Other Health Professional United States
Primary
Concomitant
Leukopenia Other Serious 3/23/2009 35 Female 10/22/2009 Physician Switzerland
Primary
Concomitant
Death Death Female 10/28/2009 United States
Primary
Concomitant
Respiratory Failure Death 10/1/2009 60 Male 10/30/2009 Physician United States
Primary
Secondary
Respiratory Failure Death 10/1/2009 60 Male 11/3/2009 Physician United States
Primary
Secondary
Hyponatraemia Other Serious Male 11/6/2009 Physician United States
Primary
Concomitant
Tachycardia Death 10/30/2009 29 Male 247 lb 11/4/2009 Pharmacist United States
Primary
Concomitant
Tonic Convulsion Hospitalization Male 154 lb 12/3/2009 Germany
Primary
Concomitant
Mean Arterial Pressure Decreased Required Intervention 9/28/2009 46 Male 181 lb 10/2/2009 Pharmacist United States
Primary
Concomitant
Vomiting Hospitalization 11/14/2009 25 Male 154 lb 11/16/2009 Pharmacist United States
Primary
Concomitant
Weight Increased Other Serious 1/1/1998 Female 190 lb 1/27/2010 Consumer United States
Primary
Secondary
Concomitant
Grand Mal Convulsion Hospitalization 12/21/2009 Female 119 lb 1/21/2010 Other Health Professional United Kingdom
Primary
Concomitant
Weight Increased Other Serious 1/1/1998 Female 153 lb 2/3/2010 Consumer United States
Primary
Secondary
Concomitant
Convulsion Hospitalization Male 1/26/2010 Physician United States
Primary
Concomitant
Vomiting 7/1/2009 39 Female 115 lb 2/26/2010 Consumer United States
Primary
Secondary
Concomitant
Grand Mal Convulsion Hospitalization 1/1/2010 Male 3/11/2010 Other Health Professional United States
Primary
Concomitant
Thrombosis Other Serious 1/26/2010 19 Female 3/17/2010 Consumer France
Primary
Secondary
Concomitant
Epilepsy Other Serious 2/23/2010 88 Male 3/25/2010 Other Health Professional United Kingdom
Primary
Concomitant
Epilepsy Other Serious 2/23/2010 88 Male 3/26/2010 Other Health Professional United Kingdom
Primary
Concomitant
Weight Increased Other Serious 1/1/1998 32 Female 153 lb 4/8/2010 Consumer United States
Primary
Secondary
Concomitant
Neutropenia Hospitalization 4/21/2009 69 Male 4/19/2010 Spain
Primary
Secondary
Therapeutic Agent Toxicity Hospitalization 78 Female 117 lb 4/26/2010 United States
Primary
Concomitant
Death Death 4/11/2010 10 Female 6/10/2010 Other Health Professional United States
Primary
Concomitant
International Normalised Ratio Abnormal 65 Female 6/29/2010 Consumer United States
Primary
Concomitant
Tinea Versicolour Hospitalization 3/28/2010 82 Male 7/23/2010 Physician United States
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 6/1/2010 60 Male 7/28/2010 Spain
Primary
Secondary
Renal Failure Other Serious 8/1/2008 45 Female 163 lb 8/3/2010 Lawyer United States
Primary
Concomitant
Myoclonus Other Serious 1/1/2010 36 Male 8/3/2010 Spain
Primary
Concomitant
Tinea Versicolour Hospitalization 3/28/2010 82 Male 8/13/2010 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 6/1/2010 46 Female 160 lb 8/13/2010 United States
Primary
Concomitant
Status Epilepticus Hospitalization 11/1/2009 73 Male 8/16/2010 Austria
Primary
Secondary
Concomitant
Hypotension Hospitalization 5/3/2010 62 Male 8/31/2010 Consumer United States
Primary
Secondary
Concomitant
Subarachnoid Haemorrhage Death 8/31/2010 45 Male 9/10/2010 Physician Puerto Rico
Primary
Secondary
Concomitant
Renal Failure Other Serious 8/1/2008 45 Female 163 lb 9/30/2010 Other Health Professional United States
Primary
Concomitant
Vomiting Other Serious 20 Female 10/6/2010 Lawyer United States
Primary
Concomitant
Road Traffic Accident Other Serious Male 10/6/2010 Consumer United States
Primary
Secondary
Subarachnoid Haemorrhage Death 8/31/2010 45 Male 10/8/2010 Physician Puerto Rico
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 6/1/2010 46 Female 160 lb 10/13/2010 United States
Primary
Concomitant
Subarachnoid Haemorrhage Death 8/31/2010 45 Male 10/29/2010 Physician Puerto Rico
Primary
Secondary
Concomitant
Haemorrhage Intracranial Other Serious 73 Female 115 lb 10/25/2010 United States
Primary
Secondary
Concomitant
Suicide Attempt Other Serious 8/16/2008 48 Female 11/19/2010 Lawyer United States
Primary
Concomitant

Drug Data