Keppra combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Somnolence Hospitalization 6/6/2006 53 Male 6/21/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Lymphopenia Hospitalization 1/1/2006 33 Female 7/12/2006 Other Health Professional Austria
Primary
Concomitant
Drug Ineffective Hospitalization 1/1/2000 21 Female 5/24/2007 Consumer United States
Primary
Secondary
Concomitant
Neutrophil Count Decreased 6/18/2007 Male 198 lb 7/3/2007 United States
Primary
Secondary
Concomitant
Feeling Abnormal Other Serious 6/15/2007 Female 7/27/2007 Consumer Australia
Primary
Concomitant
Sensory Disturbance 8/21/2007 48 Female 161 lb 12/21/2007 Pharmacist United States
Primary
Concomitant
Varicose Vein Operation Hospitalization 1/1/2004 Female 5/2/2008 Physician United States
Primary
Concomitant
Aplasia Hospitalization 1/3/2008 Male 5/12/2008 Physician France
Primary
Secondary
Concomitant
Urosepsis Hospitalization 6/25/2008 79 Female 115 lb 7/1/2008 Physician France
Primary
Secondary
Concomitant
Wrist Fracture Other Serious 1/17/2006 72 Female 147 lb 9/10/2008 Consumer United States
Primary
Concomitant
Necrotising Fasciitis Hospitalization 12/15/2008 Female 146 lb 2/12/2009 United States
Primary
Concomitant
Necrotising Fasciitis Hospitalization 12/15/2008 Female 146 lb 3/20/2009 United States
Primary
Concomitant
Necrotising Fasciitis Hospitalization 12/15/2008 Female 146 lb 4/3/2009 United States
Primary
Concomitant
Necrotising Fasciitis Hospitalization 12/15/2008 Female 146 lb 4/16/2009 United States
Primary
Concomitant
Wrist Fracture Other Serious 1/1/2006 Female 147 lb 4/28/2009 Physician United States
Primary
Concomitant
Grand Mal Convulsion 51 Female 6/15/2009 Other Health Professional Australia
Primary
Concomitant
Grand Mal Convulsion 51 Female 6/16/2009 Other Health Professional Australia
Primary
Concomitant
Grand Mal Convulsion Other Serious 51 Female 6/16/2009 Other Health Professional Australia
Primary
Concomitant
Coronary Artery Occlusion Other Serious 6/9/2009 Male 191 lb 7/23/2009 Canada
Primary
Concomitant
Coronary Artery Occlusion Other Serious 6/9/2009 Male 191 lb 8/11/2009 Canada
Primary
Concomitant
Colon Cancer Other Serious 10/10/2008 Female 130 lb 9/4/2009 Physician United States
Primary
Concomitant
Somnolence Other Serious 8/14/2009 68 Female 9/8/2009 Other Health Professional Germany
Primary
Secondary
Somnolence Hospitalization 8/1/2009 Female 9/14/2009 Consumer France
Primary
Secondary
Renal Failure Acute Hospitalization 6/15/2009 Male 9/18/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Hypernatraemia Hospitalization 6/15/2009 Male 9/22/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Somnolence Death 8/14/2009 68 Female 9/15/2009 France
Primary
Secondary
Thrombocytopenia Hospitalization 7/8/2009 41 Male 10/21/2009 France
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 10/1/2009 55 Female 185 lb 11/2/2009 Consumer United States
Primary
Concomitant
Pain In Extremity Other Serious 10/1/2009 55 Female 185 lb 11/13/2009 Physician United States
Primary
Concomitant
Wrist Fracture Other Serious 1/1/2006 Female 147 lb 11/30/2009 Physician United States
Primary
Concomitant
Necrotising Fasciitis Hospitalization 12/15/2008 Female 146 lb 12/23/2009 United States
Primary
Concomitant
Wrist Fracture Other Serious 1/1/2006 Female 147 lb 1/21/2010 Physician United States
Primary
Concomitant
Tonic Clonic Movements Other Serious 6/1/2009 Female 2/23/2010 Physician Switzerland
Primary
Secondary
Concomitant
Tonic Clonic Movements Other Serious 6/1/2009 Female 3/11/2010 Physician Switzerland
Primary
Secondary
Concomitant
Opportunistic Infection Hospitalization 1/1/2010 42 Male 3/19/2010 Physician Italy
Primary
Concomitant
Weight Increased Other Serious 6/1/2009 59 Female 5/6/2010 Physician Switzerland
Primary
Secondary
Concomitant
Urine Odour Abnormal 1/1/2008 53 Female 6/23/2010 Consumer United States
Primary
Concomitant
Skin Lesion Other Serious 3/1/2010 42 Female 7/1/2010 Consumer United States
Primary
Concomitant
Psoriasis Other Serious 3/1/2010 42 Female 7/9/2010 Consumer United States
Primary
Concomitant
Nystagmus Other Serious 1/1/2009 66 7/9/2010 Consumer Sweden
Primary
Secondary
Concomitant
Nystagmus Other Serious 11/1/2009 67 Female 7/7/2010 Sweden
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 10/16/2009 51 Female 228 lb 7/23/2010 Physician Puerto Rico
Primary
Concomitant
Pneumonia Other Serious 5/1/2010 73 Female 158 lb 7/27/2010 Physician United States
Primary
Concomitant
Pulmonary Embolism Other Serious 10/16/2009 51 Female 228 lb 8/3/2010 Physician Puerto Rico
Primary
Concomitant
Tinea Versicolour Hospitalization 3/28/2010 82 Male 8/13/2010 Physician United States
Primary
Secondary
Concomitant
Toothache Hospitalization 3/23/2008 19 Female 143 lb 9/28/2010 Consumer
Primary
Secondary
Concomitant
Necrotising Fasciitis Hospitalization 12/15/2008 71 Female 146 lb 9/30/2010 Physician United States
Primary
Concomitant
Tachycardia Hospitalization 10/14/2010 32 Male 10/25/2010 Physician United States
Primary
Secondary
Concomitant
Convulsion Other Serious 8/16/2010 15 Male 12/9/2010 Physician United States
Primary
Concomitant
Walking Aid User Other Serious 8/30/2010 43 Female 12/15/2010 United States
Primary
Concomitant
Thermal Burn Other Serious 6/1/2010 38 Male 250 lb 12/15/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Joint Stiffness Death 12/17/2010 58 Female 1/7/2011 Consumer United States
Primary
Secondary
Concomitant
Retinal Artery Embolism Hospitalization 9/1/2010 1/21/2011 Other Health Professional Germany
Primary
Concomitant
Sinus Disorder 6/16/2010 19 Female 1/29/2011 Consumer United States
Primary
Concomitant
Dyspnoea Hospitalization 12/10/2010 44 Female 228 lb 1/24/2011 Pharmacist United States
Primary
Concomitant
Depression Other Serious 6/1/2010 38 Male 250 lb 2/7/2011 Physician United States
Primary
Secondary
Concomitant
Blood Iron Decreased Other Serious 1/1/2010 41 Male 2/11/2011 Consumer United States
Primary
Concomitant
Abdominal Pain Hospitalization 12/15/2010 16 Male 126 lb 2/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 4/23/2010 63 Male 150 lb 3/8/2011 Physician France
Primary
Secondary
Concomitant
Hypoaesthesia Hospitalization 8/30/2010 43 Female 3/24/2011 United States
Primary
Concomitant
Weight Increased 2/18/2010 42 Female 208 lb 3/25/2011 Consumer United States
Primary
Concomitant
Toothache Disability 17 Female 143 lb 10/15/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Dyspnoea Other Serious 12/10/2010 44 Female 228 lb 3/14/2011 Pharmacist United States
Primary
Concomitant
Confusional State Hospitalization 12/19/2010 61 Female 4/11/2011 Other Health Professional France
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 4/24/2010 67 Female 223 lb 4/8/2011 Physician France
Primary
Secondary
Concomitant
Confusional State Hospitalization 11/15/2010 61 Female 4/22/2011 Other Health Professional France
Primary
Secondary
Concomitant
Optic Atrophy Other Serious Female 4/29/2011 Physician Germany
Primary
Secondary
Concomitant
Lymphadenitis Hospitalization 1/1/2008 52 Female 152 lb 5/11/2011 Physician United States
Primary
Concomitant
Status Epilepticus Other Serious 1/1/2008 52 Female 152 lb 5/19/2011 Physician United States
Primary
Concomitant
Suicidal Ideation Other Serious 6/1/2010 39 Male 250 lb 3/17/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Optic Atrophy Disability 1/1/2010 57 Female 7/21/2011 Physician Germany
Primary
Concomitant
Drug Withdrawal Convulsions Other Serious 1/1/2010 68 Male 8/11/2011 Other Health Professional France
Primary
Concomitant
Asthenia Other Serious 1/1/2011 60 Male 87 lb 8/26/2011 Physician United States
Primary
Secondary
Concomitant
Pallor Hospitalization 7/1/2011 53 Male 256 lb 9/9/2011 Other Health Professional Canada
Primary
Concomitant
Hypersomnia Other Serious 1/1/2011 60 Male 87 lb 9/15/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Convulsion Other Serious 8/16/2010 15 Male 9/16/2011 Physician United States
Primary
Concomitant
Blood Magnesium Decreased Other Serious 1/1/2011 60 Male 87 lb 9/19/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 10/18/2010 70 Male 181 lb 10/6/2011 Physician France
Primary
Secondary
Concomitant
Skin Irritation Other Serious 4/1/2011 33 Female 10/13/2011 Consumer United States
Primary
Concomitant
Psoriatic Arthropathy Other Serious 4/1/2011 33 Female 10/18/2011 Physician United States
Primary
Concomitant
Depression Other Serious 1/1/2011 60 Male 105 lb 10/18/2011 Consumer United States
Primary
Secondary
Concomitant
Fungal Skin Infection Other Serious 4/1/2011 33 Female 11/2/2011 Physician United States
Primary
Concomitant
Kaposi's Sarcoma Other Serious 11/23/2011 48 Male 158 lb 1/30/2012 Physician United States
Primary
Concomitant
Pain In Extremity 12/1/2010 32 Female 285 lb 1/28/2012 Consumer United States
Primary
Concomitant
Fatigue 9/12/2011 50 Female 165 lb 1/29/2012 Consumer United States
Primary
Concomitant
Arthralgia 1/1/2011 33 Female 1/28/2012 Consumer United States
Primary
Concomitant
Cognitive Disorder Other Serious 1/27/2012 68 Female 2/16/2012 Consumer Canada
Primary
Concomitant
White Blood Cell Count Increased 10/5/2011 64 Female 12/20/2011 Consumer United States
Primary
Concomitant
Nausea 9/23/2011 43 Female 150 lb 12/20/2011 Consumer United States
Primary
Concomitant
Abdominal Pain Upper Hospitalization 2/14/2012 30 Female 90 lb 3/2/2012 Physician Poland
Primary
Concomitant
Haemorrhage Death 91 Female 2/29/2012 Consumer Colombia
Primary
Concomitant
Blood Creatinine Increased Hospitalization 2/14/2012 30 Female 90 lb 3/7/2012 Physician Poland
Primary
Concomitant
Abdominal Discomfort 2/25/2012 37 Female 3/12/2012 Consumer United States
Primary
Concomitant
Intestinal Polyp Hospitalization 1/1/2008 22 Female 159 lb 3/22/2012 Physician Czech Republic
Primary
Secondary
Concomitant
Abdominal Pain Upper Hospitalization 2/14/2012 30 Female 90 lb 3/23/2012 Physician Poland
Primary
Concomitant
Haemorrhage Hospitalization 1/20/2012 91 Female 3/27/2012 Consumer Colombia
Primary
Concomitant
Enteritis Hospitalization 1/1/2008 22 Female 159 lb 3/29/2012 Physician Czech Republic
Primary
Secondary
Concomitant
Parosmia Other Serious 6/1/2009 60 Male 4/12/2012 Physician Germany
Primary
Concomitant
Bone Marrow Failure Hospitalization 1/3/2008 63 Male 4/25/2012 Physician France
Primary
Secondary
Concomitant
Nervous System Disorder Hospitalization 2/22/2012 17 Male 99 lb 4/24/2012 Physician United States
Primary
Secondary
Concomitant
Convulsion Other Serious 8/16/2010 15 Male 4/27/2012 Physician United States
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 1/1/2012 50 Female 5/1/2012 Consumer Germany
Primary
Concomitant
Platelet Count Decreased Other Serious 10/7/2011 3 Male 26 lb 5/25/2012 Physician Japan
Primary
Concomitant
Infection Life Threatening 10/7/2011 3 Male 26 lb 5/30/2012 Physician Japan
Primary
Concomitant
Radicular Syndrome Hospitalization 3/18/2012 67 Female 6/1/2012 Other Health Professional Czech Republic
Primary
Concomitant
Dizziness Hospitalization 5/1/2012 56 Female 148 lb 6/7/2012 Consumer United States
Primary
Concomitant
Upper Extremity Mass Hospitalization 5/1/2012 56 Female 148 lb 6/7/2012 Consumer United States
Primary
Concomitant
Headache Hospitalization 5/1/2012 56 Female 148 lb 6/19/2012 Consumer United States
Primary
Concomitant
Musculoskeletal Pain Hospitalization 3/18/2012 67 Female 7/8/2012 Other Health Professional Czech Republic
Primary
Concomitant
Psoriatic Arthropathy Other Serious 4/1/2011 32 Female 249 lb 7/10/2012 Physician United States
Primary
Concomitant
Headache Other Serious 5/1/2012 56 Female 148 lb 7/11/2012 Consumer United States
Primary
Concomitant
Candidiasis Hospitalization 5/1/2012 63 Female 7/13/2012 Other Health Professional France
Primary
Secondary
Concomitant
Aplasia Other Serious 6/4/2012 64 Female 7/27/2012 Other Health Professional France
Primary
Secondary
Concomitant
Hypertension Other Serious 10/7/2011 3 Male 26 lb 7/27/2012 Physician Japan
Primary
Concomitant
Amnesia Other Serious 8/1/2011 56 Female 8/2/2012 Physician Italy
Primary
Secondary
Concomitant
Osteoarthritis Other Serious 7/1/2012 51 Female 160 lb 8/21/2012 Physician United States
Primary
Concomitant
Rash Maculo-papular Other Serious 7/4/2012 8 Male 8/29/2012 Other Health Professional Fr
Primary
Secondary
Concomitant
Stomatitis Other Serious 8/10/2012 11 Male 1/18/2013 Physician Us
Primary
Secondary
Concomitant
Stomatitis Hospitalization 8/10/2012 11 Male 2/4/2013 Physician Us
Primary
Secondary
Concomitant
Central Nervous System Lesion Other Serious 25 Female 10/15/2012 Physician Nl
Primary
Concomitant
Central Nervous System Lymphoma Hospitalization 12/6/2011 64 Male 10/2/2012 Consumer Us
Primary
Concomitant
Convulsion Other Serious Male 11/8/2012 Physician Us
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious Female 190 lb 1/28/2013 Physician Us
Primary
Concomitant
Tooth Fracture 11/2011 60 Female 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Contusion 5/17/2012 47 Female 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Pain 5/2012 47 Female 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Musculoskeletal Stiffness 8/2011 Female 160 lb 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Paraesthesia 10/2012 76 Female 2/1/2013 Consumer Country Not Specified
Primary
Concomitant
Hypersensitivity 2012 Female 2/1/2013 Consumer Country Not Specified
Primary
Concomitant
Migraine 5/14/2012 57 Female 2/19/2013 Physician Us
Primary
Concomitant
Periorbital Cellulitis Other Serious 3/2013 31 Female 212 lb 5/11/2013 Other Health Professional Ca
Primary
Concomitant
Regurgitation Hospitalization 5/22/2013 21 Male 8/1/2013 Other Health Professional Country Not Specified
Primary
Concomitant
Vomiting Life Threatening 5/2013 84 Female 12/2/2013 Physician Fr
Primary
Concomitant
White Blood Cell Count Increased Other Serious 12/2011 64 Female 159 lb 7/5/2013 Consumer Us
Primary
Concomitant
Urticaria Other Serious 6/26/2013 35 Female 141 lb 7/17/2013 Other Health Professional Ca
Primary
Concomitant
Renal Failure Acute Hospitalization 7/21/2013 66 Male 9/25/2013 Physician Fr
Primary
Concomitant
Interacting
Renal Failure Acute Hospitalization 7/21/2013 67 Male 9/24/2013 Physician Fr
Primary
Concomitant
Interacting
Renal Failure Acute Hospitalization 7/21/2013 66 Male 8/19/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 7/21/2013 66 Male 8/19/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Hypersensitivity Hospitalization 8/9/2011 62 Male 234 lb 8/20/2013 Consumer Us
Primary
Secondary
Concomitant
Weight Decreased Other Serious 2010 Female 102 lb 9/26/2013 Country Not Specified
Primary
Secondary
Concomitant
Vomiting Other Serious 2010 35 Female 9/30/2013 Consumer Country Not Specified
Primary
Concomitant
Melaena Death 7/2013 64 Male 10/8/2013 Physician Fr
Primary
Secondary
Concomitant
Melaena Death 7/2013 64 Male 10/16/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Suicidal Ideation Other Serious 2013 Male 264 lb 10/23/2013 Consumer Ca
Primary
Concomitant
Rash Generalised Hospitalization 11/14/2013 60 Female 291 lb 11/15/2013 Physician Us
Primary
Secondary
Concomitant
Weight Decreased 3/7/2013 70 Female 210 lb 11/26/2013 Physician Us
Primary
Concomitant
Convulsion Other Serious 11/4/2013 61 Female 202 lb 11/27/2013 Physician Country Not Specified
Primary
Concomitant
Myoclonus Other Serious 8/19/2013 83 Female 11/29/2013 Physician Fr
Primary
Secondary
Concomitant
Liver Function Test Abnormal Female 125 lb 12/6/2013 Pharmacist Us
Primary
Concomitant

Drug Data