Itraconazole combined with Voriconazole

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Tracheostomy Life Threatening 7/10/2005 42 Female 1/23/2006 United Kingdom
Primary
Secondary
Concomitant
Transplant Failure Life Threatening 7/1/2005 42 Female 1/24/2006 Consumer Germany
Primary
Secondary
Concomitant
Drug Ineffective Death 6/30/2004 38 Male 8/31/2006 United States
Primary
Concomitant
Toxic Skin Eruption Other Serious 5/1/2006 69 Male 4/4/2007 Other Health Professional Japan
Primary
Secondary
Toxic Skin Eruption Other Serious 5/1/2006 69 Male 4/20/2007 Other Health Professional Japan
Primary
Secondary
Death Death 30 Female 5/25/2007 Physician Australia
Primary
Secondary
Death Death 30 Female 6/4/2007 Physician Australia
Primary
Secondary
Pneumonia Other Serious 11/7/2006 30 Male 6/19/2007 Korea, Republic Of
Primary
Concomitant
Pseudomembranous Colitis Other Serious 11/17/2006 45 Male 6/25/2007 Japan
Primary
Secondary
Concomitant
Leukoencephalopathy Hospitalization 12/5/2006 70 Female 9/6/2007 Physician Japan
Primary
Secondary
Concomitant
Pruritus 5/24/2007 16 Male 99 lb 8/15/2007 Physician United States
Primary
Concomitant
Hypersensitivity 5/25/2007 16 Male 8/15/2007 Physician United States
Primary
Concomitant
Venous Occlusion Hospitalization 52 Female 9/28/2007 United States
Primary
Concomitant
Drug Resistance Other Serious 51 Male 107 lb 11/6/2007 United Kingdom
Primary
Secondary
Concomitant
Neuropathy Other Serious 52 Male 11/12/2007 Physician Belgium
Primary
Concomitant
Neuropathy Other Serious 52 Male 11/19/2007 Physician Belgium
Primary
Concomitant
Tachycardia Life Threatening 9/28/2007 21 Female 150 lb 11/21/2007 Consumer United States
Primary
Secondary
Concomitant
Hypersensitivity 5/25/2007 16 Male 11/12/2007 Physician United States
Primary
Concomitant
Unresponsive To Stimuli Life Threatening 9/28/2007 21 Female 150 lb 12/3/2007 Physician United States
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 22 Male 1/3/2008 Physician United States
Primary
Concomitant
Leukoencephalopathy Other Serious Male 2/27/2008 Netherlands
Primary
Concomitant
Death Death 4/26/2008 56 Male 208 lb 5/19/2008 Other Health Professional United Kingdom
Primary
Concomitant
Viral Haemorrhagic Cystitis Other Serious 7/1/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Transplant Failure Other Serious 39 185 lb 7/2/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Transplant Failure Other Serious 39 185 lb 7/3/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 31 Male 7/18/2008
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 3/22/2006 56 Male 128 lb 7/22/2008 Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 11/29/2005 56 Male 128 lb 7/28/2008 Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 12/1/2005 56 Male 128 lb 8/4/2008 Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 12/1/2005 56 Male 128 lb 8/15/2008 Japan
Primary
Secondary
Concomitant
Trichophytic Granuloma Other Serious 31 Male 9/25/2008 Other Health Professional Belgium
Primary
Secondary
Mucosal Inflammation Death 6 40 lb 6/18/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Neutropenia Hospitalization 1/1/2003 41 Male 10/14/2008 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Supraventricular Tachycardia Hospitalization 1/1/2003 41 Male 121 lb 10/20/2008 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Drug Resistance Other Serious 55 Male 10/21/2008 Other Health Professional United States
Primary
Concomitant
Weight Increased Other Serious 55 Male 10/22/2008 Other Health Professional United States
Primary
Concomitant
Ventricular Dysfunction Hospitalization 1/1/2003 41 Male 10/24/2008 United Kingdom
Primary
Concomitant
Interacting
Ventricular Dysfunction Hospitalization 1/1/2003 41 Male 11/28/2008 United Kingdom
Primary
Concomitant
Interacting
Lung Disorder Other Serious 1/1/2008 66 Male 12/2/2008 Physician Japan
Primary
Secondary
Concomitant
Lung Disorder Life Threatening 1/1/2008 66 Male 12/9/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 12 Female 12/11/2008 Israel
Primary
Secondary
Concomitant
Sinusitis Hospitalization 1/1/2007 60 Male 143 lb 12/16/2008 Physician Spain
Primary
Secondary
Concomitant
Pyrexia Hospitalization 24 Male 12/18/2008
Primary
Secondary
Concomitant
Sinusitis Hospitalization 1/1/2007 60 Male 143 lb 12/19/2008 Physician Spain
Primary
Secondary
Concomitant
Lung Disorder Life Threatening 5/15/2008 Male 112 lb 12/29/2008 Physician Japan
Primary
Secondary
Concomitant
Ventricular Dysfunction Hospitalization 1/1/2003 1/12/2009 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Bronchopulmonary Aspergillosis Hospitalization 9/18/2008 1/20/2009 Physician Korea, Republic Of
Primary
Concomitant
Bronchopulmonary Aspergillosis Hospitalization 9/18/2008 1/21/2009 Physician Korea, Republic Of
Primary
Concomitant
Tachyarrhythmia Other Serious 57 Female 2/12/2009 Other Health Professional Germany
Primary
Concomitant
Ventricular Failure Hospitalization 1/1/2003 3/13/2009 United Kingdom
Primary
Concomitant
Interacting
Lung Disorder Death 1/1/2008 49 Male 3/31/2009 Other Health Professional Japan
Primary
Concomitant
Swelling Other Serious 2/1/2006 75 Male 4/14/2009 Japan
Primary
Secondary
Concomitant
Interacting
Neutropenia Hospitalization 1/1/2003 41 Male 4/17/2009 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Neutropenia Hospitalization 1/1/2003 41 Male 4/24/2009 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Graft Versus Host Disease Hospitalization 1/7/2008 55 5/27/2009 Physician Portugal
Primary
Concomitant
Transaminases Increased Other Serious 6/24/2009 United States
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 6/25/2009 United States
Primary
Secondary
Concomitant
Renal Failure Life Threatening 10/1/2008 70 Male 8/13/2009 Japan
Primary
Secondary
Speech Disorder Other Serious 10/10/2007 77 Female 93 lb 8/18/2009 Physician Japan
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Death 11/23/2007 62 Male 9/12/2009 Physician Japan
Primary
Concomitant
Tumour Lysis Syndrome Death 11/23/2007 62 Male 10/9/2009 Physician Japan
Primary
Concomitant
Forced Expiratory Volume Decreased Other Serious 15 Female 10/28/2009 Other Health Professional Switzerland
Primary
Concomitant
Lung Disorder Other Serious 25 Male 10/30/2009 Other Health Professional Japan
Primary
Secondary
Viral Infection Life Threatening 9/17/2008 70 Male 11/3/2009 Japan
Primary
Secondary
Concomitant
Forced Expiratory Volume Decreased Other Serious 15 Female 11/12/2009 Other Health Professional Switzerland
Primary
Concomitant
Multi-organ Failure Death 10/1/2009 52 Male 12/22/2009 Physician Japan
Primary
Concomitant
Septic Embolus Other Serious 24 Female 1/27/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Somnolence Hospitalization 3/30/2009 59 Male 1/29/2010 Physician Japan
Primary
Concomitant
Pneumonia Fungal Other Serious 22 Male 2/15/2010 Physician Japan
Primary
Secondary
Concomitant
Treatment Failure Other Serious 44 2/16/2010 Other Health Professional United Kingdom
Primary
Concomitant
Drug Resistance Death 64 Male 3/1/2010 Other Health Professional Japan
Primary
Concomitant
Pyrexia Hospitalization 6/10/2009 Female 104 lb 3/4/2010 Physician Japan
Primary
Concomitant
Treatment Failure Other Serious 44 3/12/2010 Other Health Professional Canada
Primary
Concomitant
Transaminases Increased Other Serious 3/17/2010 United States
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 3/19/2010 United States
Primary
Secondary
Concomitant
Hepatic Function Abnormal Life Threatening 6/28/2009 Male 3/30/2010 Physician Japan
Primary
Concomitant
Treatment Failure Other Serious 44 4/23/2010 Other Health Professional Canada
Primary
Concomitant
Tremor Other Serious 67 Female 4/26/2010 Other Health Professional United Kingdom
Primary
Concomitant
Hypopyon Hospitalization 48 Female 5/17/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Condition Aggravated Hospitalization 9/25/2008 51 Male 141 lb 6/11/2010 Physician Korea, Republic Of
Primary
Concomitant
Hyponatraemia Other Serious Male 6/21/2010 Physician Australia
Primary
Secondary
Concomitant
Scedosporium Infection Other Serious 11/16/2009 35 Male 132 lb 7/7/2010 Physician Japan
Primary
Secondary
Concomitant
Liver Function Test Abnormal Hospitalization 99 Male 7/14/2010 Other Health Professional Australia
Primary
Secondary
No Therapeutic Response Hospitalization Male 7/15/2010 Other Health Professional Australia
Primary
Secondary
Scedosporium Infection Other Serious 4/25/2009 34 Male 132 lb 7/20/2010 Physician Japan
Primary
Secondary
Concomitant
Organising Pneumonia Other Serious 53 Male 7/30/2010 Physician Italy
Primary
Secondary
Organising Pneumonia Other Serious 49 Male 7/30/2010 Physician Italy
Primary
Secondary
Hypophosphataemia Other Serious 5/1/2010 45 Female 7/30/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Organising Pneumonia Other Serious 53 Male 8/5/2010 Physician Italy
Primary
Secondary
Pyrexia Other Serious 9/21/2009 37 Female 93 lb 8/9/2010 Physician Japan
Primary
Concomitant
Organising Pneumonia Other Serious 49 Male 8/10/2010 Physician Italy
Primary
Secondary
Hyponatraemia Hospitalization Male 8/18/2010 Other Health Professional Australia
Primary
Secondary
Visual Acuity Reduced Other Serious 74 Male 8/19/2010 Physician United States
Primary
Secondary
Concomitant
Therapeutic Response Decreased Other Serious 7/7/2010 64 Male 117 lb 9/3/2010 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 6/10/2009 74 Female 104 lb 9/24/2010 Physician Japan
Primary
Concomitant
Pyrexia Disability 10/5/2010 72 Female 10/21/2010 Other Health Professional United Kingdom
Primary
Concomitant
Systemic Mycosis Other Serious 11/14/2009 84 Female 68 lb 10/29/2010 Physician Japan
Primary
Concomitant
Corneal Thinning Other Serious 70 Male 11/15/2010 Physician Japan
Primary
Concomitant
Hypophosphataemia Other Serious 5/1/2010 45 Female 11/17/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Corneal Thinning Other Serious 70 Male 11/19/2010 Physician Japan
Primary
Concomitant
Hypophosphataemia Other Serious 5/1/2010 45 Female 12/1/2010 Physician United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/29/2010 49 Male 110 lb 12/13/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/29/2010 49 Male 110 lb 12/13/2010 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Hospitalization 2/23/2010 69 Male 130 lb 12/30/2010 Physician Japan
Primary
Concomitant
Keratitis Fungal Other Serious 75 Female 1/5/2011 Physician United Kingdom
Primary
Secondary
Keratitis Fungal Other Serious 75 Female 1/5/2011 Other Health Professional United Kingdom
Primary
Secondary
Drug Resistance Other Serious 29 Female 1/6/2011 Other Health Professional Japan
Primary
Secondary
Bronchopulmonary Aspergillosis Other Serious 29 Female 1/7/2011 Other Health Professional Japan
Primary
Secondary
Infection Life Threatening 7/4/2010 73 Female 97 lb 1/10/2011 Physician Japan
Primary
Concomitant
Infection Life Threatening 7/4/2010 73 Female 97 lb 1/11/2011 Physician Japan
Primary
Secondary
Concomitant
Keratitis Fungal Other Serious 75 Female 1/11/2011 Consumer United Kingdom
Primary
Secondary
Infection Life Threatening 7/4/2010 73 Female 97 lb 1/13/2011 Physician Japan
Primary
Secondary
Concomitant
Keratitis Fungal Other Serious 75 Female 1/13/2011 Other Health Professional United Kingdom
Primary
Secondary
Keratitis Fungal Other Serious 75 Female 1/14/2011 Other Health Professional United Kingdom
Primary
Secondary
Keratitis Fungal Other Serious 1/1/1998 75 Female 1/11/2011 United Kingdom
Primary
Secondary
Staphylococcal Infection Hospitalization 9/10/2009 18 Male 137 lb 1/24/2011 Physician Japan
Primary
Concomitant
Disorientation Death 4/13/2009 52 Male 117 lb 1/10/2011 Physician Japan
Primary
Concomitant
Keratitis Other Serious 75 Female 1/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Platelet Count Decreased Other Serious 13 Male 1/28/2011 Other Health Professional China
Primary
Concomitant
Disseminated Intravascular Coagulation Life Threatening 4/25/2009 34 Male 132 lb 1/18/2011 Physician Japan
Primary
Secondary
Concomitant
Fungal Infection Hospitalization 6/24/2009 15 Male 126 lb 2/14/2011 Consumer Japan
Primary
Concomitant
Sepsis Other Serious 9/10/2009 18 Male 137 lb 2/15/2011 Physician Japan
Primary
Concomitant
Chills Death 1/21/2011 62 Female 110 lb 3/4/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 76 Male 3/17/2011 Physician Taiwan, Province Of China
Primary
Secondary
Circulatory Collapse Hospitalization 1/21/2011 62 Female 110 lb 3/27/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Therapeutic Response Decreased Other Serious 7/7/2010 64 Male 117 lb 3/28/2011 Physician Japan
Primary
Concomitant
Supraventricular Tachycardia Hospitalization 9/3/2004 41 Male 121 lb 3/29/2011 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Toothache Hospitalization 9/21/2009 37 Female 93 lb 4/14/2011 Physician Japan
Primary
Concomitant
Fungal Infection Other Serious 10/13/2009 36 Male 143 lb 4/27/2011 Physician Japan
Primary
Concomitant
Eye Pruritus Other Serious 75 Female 5/9/2011 Other Health Professional United Kingdom
Primary
Secondary
Petechiae Other Serious 1/29/2010 49 Male 110 lb 5/20/2011 Physician Japan
Primary
Concomitant
Acute Graft Versus Host Disease In Skin Other Serious 7/21/2010 7/5/2011 Physician Japan
Primary
Secondary
Concomitant
Hepatic Failure Death 6/8/2011 62 Male 159 lb 7/20/2011 Consumer Netherlands
Primary
Secondary
Concomitant
Pseudomonal Sepsis Other Serious 8/25/2009 66 Male 110 lb 7/29/2011 Physician Japan
Primary
Concomitant
Hepatic Failure Death 6/8/2011 62 Male 159 lb 8/24/2011 Consumer Netherlands
Primary
Secondary
Concomitant
Pulmonary Cavitation Other Serious 61 Male 93 lb 9/13/2011 Other Health Professional Japan
Primary
Concomitant
Interacting
Neuropathy Peripheral Other Serious 9/15/2011 Other Health Professional Netherlands
Primary
Concomitant
Interacting
Haemorrhage Hospitalization 9/16/2011 Other Health Professional Germany
Primary
Interacting
Acute Graft Versus Host Disease In Skin Life Threatening 10/21/2009 22 Female 104 lb 9/26/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Skin Other Serious 10/21/2009 22 Female 104 lb 9/26/2011 Physician Japan
Primary
Secondary
Concomitant
Somnolence Hospitalization 3/30/2009 59 Male 9/27/2011 Physician Japan
Primary
Concomitant
Bronchopulmonary Aspergillosis Death 66 Female 10/3/2011 Other Health Professional Korea, Republic Of
Primary
Secondary
Concomitant
Periorbital Oedema Life Threatening 1/27/2011 6 Female 40 lb 10/3/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Deep Vein Thrombosis Death 12/7/2010 6 Female 40 lb 10/4/2011 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Multi-organ Failure Life Threatening 5/7/2009 50 Female 90 lb 10/6/2011 Physician Japan
Primary
Concomitant
Fungal Infection Hospitalization 5/1/2010 45 Female 10/11/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Pseudomonal Sepsis Other Serious 10/21/2009 22 Female 104 lb 10/11/2011 Physician Japan
Primary
Secondary
Concomitant
Febrile Neutropenia Life Threatening 6 Female 40 lb 10/6/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cough Other Serious 61 Male 93 lb 10/19/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Interacting
Pancreatic Disorder Hospitalization 6/30/2008 58 Female 101 lb 11/9/2011 Pharmacist Japan
Primary
Concomitant

Drug Data