Itraconazole combined with Velcade

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Sepsis Other Serious 5/2/2005 47 Female 152 lb 1/31/2006 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 5/2/2005 47 Female 152 lb 2/13/2006 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 3/15/2005 31 Female 3/2/2006 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/15/2005 31 Female 4/27/2006 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 12/21/2006 63 Female 1/16/2007 Physician Japan
Primary
Concomitant
Pulmonary Mycosis Other Serious 12/21/2006 63 Female 1/25/2007 Physician Japan
Primary
Concomitant
Stem Cell Transplant Life Threatening 12/26/2006 62 Male 2/1/2007 Physician Netherlands
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 12/21/2006 63 Female 3/5/2007 Physician Japan
Primary
Concomitant
Septic Shock Death 3/5/2007 64 Female 3/26/2007 Physician Japan
Primary
Concomitant
Vomiting Other Serious 2/23/2007 65 Female 4/12/2007 Physician Japan
Primary
Concomitant
Renal Failure Hospitalization 9/24/2006 54 Unknown 4/16/2007 Physician Netherlands
Primary
Secondary
Concomitant
Renal Failure Hospitalization 9/24/2006 54 Female 5/2/2007 Physician Netherlands
Primary
Secondary
Concomitant
Renal Failure Hospitalization 9/24/2006 54 Female 5/8/2007 Physician Netherlands
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 2/2/2007 Female 119 lb 5/18/2007 Physician Japan
Primary
Secondary
Concomitant
Septic Shock Death 3/5/2007 64 Female 6/1/2007 Physician Japan
Primary
Concomitant
Sepsis Hospitalization 4/2/2007 63 Male 6/11/2007 Physician Japan
Primary
Concomitant
Rash Other Serious 4/2/2007 71 Male 6/15/2007 Physician Japan
Primary
Concomitant
Stomatitis Other Serious 2/23/2007 63 Male 6/15/2007 Physician Japan
Primary
Concomitant
Intercostal Neuralgia Other Serious 1/1/2007 Male 119 lb 7/5/2007 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 6/18/2007 Male 117 lb 7/20/2007 Physician Japan
Primary
Secondary
Thrombocytopenia Life Threatening 6/11/2007 75 Male 194 lb 7/19/2007 Physician Greece
Primary
Concomitant
Pyrexia Other Serious 6/1/2007 62 Female 95 lb 7/20/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 5/30/2007 58 Male 163 lb 8/6/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Death 65 Female 121 lb 9/11/2007 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 6/1/2007 62 Female 95 lb 9/11/2007 Physician Japan
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Death 5/1/2007 59 Male 119 lb 9/13/2007 Physician Japan
Primary
Concomitant
Rash Other Serious 4/2/2007 71 Male 141 lb 9/17/2007 Physician Japan
Primary
Concomitant
Thrombocythaemia Hospitalization 9/11/2007 71 Female 161 lb 9/27/2007 Physician Greece
Primary
Concomitant
Thrombocytopenia Life Threatening 6/11/2007 75 Male 194 lb 10/4/2007 Physician Greece
Primary
Concomitant
Rash Other Serious 4/2/2007 71 Male 141 lb 10/10/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Death 65 Female 121 lb 10/15/2007 Physician Japan
Primary
Concomitant
Stomatitis Other Serious 2/23/2007 63 Male 10/22/2007 Physician Japan
Primary
Concomitant
Hepatitis B Virus Other Serious 7/5/2007 72 Male 134 lb 10/31/2007 Physician Japan
Primary
Concomitant
Varicella Other Serious 5/13/2007 74 Male 108 lb 12/18/2007 Physician Japan
Primary
Concomitant
Vomiting Death 5/1/2007 59 Male 119 lb 12/18/2007 Physician Japan
Primary
Secondary
Concomitant
Sepsis Life Threatening 9/1/2007 78 Male 108 lb 12/20/2007 Physician Japan
Primary
Secondary
Concomitant
Toxic Skin Eruption Hospitalization 9/29/2007 60 Male 12/31/2007 Physician Japan
Primary
Secondary
Concomitant
Bone Marrow Failure Other Serious 68 Female 97 lb 12/24/2007 Physician Japan
Primary
Concomitant
Asthma Other Serious 7/5/2007 72 Male 134 lb 12/28/2007 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 9/7/2007 67 Female 97 lb 1/3/2008 Physician Japan
Primary
Concomitant
Supraventricular Extrasystoles Other Serious 10/1/2007 55 Male 161 lb 1/3/2008 Physician Japan
Primary
Concomitant
Respiratory Tract Infection Fungal Other Serious 5/26/2007 73 Male 117 lb 1/7/2008 Physician Japan
Primary
Secondary
Concomitant
Bone Marrow Failure Other Serious 6/14/2007 68 Female 97 lb 2/6/2008 Physician Japan
Primary
Concomitant
Pneumonia Bacterial Other Serious 5/26/2007 73 Male 117 lb 2/12/2008 Physician Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 10/9/2007 56 Male 137 lb 2/12/2008 Physician Japan
Primary
Concomitant
Ventricular Extrasystoles Other Serious 5/21/2007 71 Female 121 lb 2/15/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 8/23/2007 60 Male 130 lb 2/22/2008 Physician Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 10/9/2007 56 Male 137 lb 2/27/2008 Physician Japan
Primary
Concomitant
Supraventricular Extrasystoles Other Serious 10/1/2007 55 Male 161 lb 3/10/2008 Physician Japan
Primary
Concomitant
Thrombotic Thrombocytopenic Purpura Hospitalization 11/14/2007 54 Male 132 lb 3/14/2008 Physician Japan
Primary
Secondary
Concomitant
Rash Other Serious 4/2/2007 71 Male 141 lb 3/19/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 5/30/2007 56 Male 137 lb 3/27/2008 Physician Japan
Primary
Concomitant
Platelet Count Decreased Other Serious 11/24/2007 63 Male 126 lb 3/27/2008 Physician Japan
Primary
Concomitant
Stomatitis Other Serious 2/20/2007 63 Male 3/31/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 10/10/2007 77 Female 93 lb 3/31/2008 Physician Japan
Primary
Secondary
Concomitant
Micturition Disorder Hospitalization 2/15/2008 73 Male 134 lb 4/1/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 3/21/2007 63 Female 4/2/2008 Physician Japan
Primary
Secondary
Concomitant
Ventricular Extrasystoles Other Serious 5/21/2007 71 Female 121 lb 4/2/2008 Physician Japan
Primary
Concomitant
Vomiting Life Threatening 12/6/2007 66 Male 139 lb 4/7/2008 Physician Japan
Primary
Concomitant
Renal Impairment Hospitalization 11/14/2007 54 Male 132 lb 4/10/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 6/11/2007 Male 117 lb 4/18/2008 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 5/26/2007 73 Male 117 lb 4/18/2008 Physician Japan
Primary
Secondary
Concomitant
Supraventricular Extrasystoles Other Serious 10/1/2007 55 Male 161 lb 4/21/2008 Physician Japan
Primary
Concomitant
Upper Respiratory Tract Inflammation Other Serious 10/9/2007 56 Male 137 lb 4/24/2008 Physician Japan
Primary
Concomitant
Urinary Retention Hospitalization 2/15/2008 73 Male 134 lb 4/29/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 5/30/2007 56 Male 137 lb 5/19/2008 Physician Japan
Primary
Concomitant
Septic Shock Death 5/1/2008 60 Male 123 lb 5/30/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 3/3/2007 56 Female 110 lb 6/2/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 5/30/2007 56 Male 137 lb 6/10/2008 Physician Japan
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 11/24/2007 63 Male 126 lb 6/11/2008 Physician Japan
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 11/24/2007 63 Male 126 lb 6/18/2008 Physician Japan
Primary
Concomitant
Upper Respiratory Tract Inflammation Other Serious 9/11/2007 56 Male 137 lb 6/24/2008 Physician Japan
Primary
Concomitant
Tumour Lysis Syndrome Death 11/23/2007 62 Male 6/26/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 10/29/2007 57 Male 154 lb 7/9/2008 Physician Japan
Primary
Secondary
Shock Death 4/18/2008 60 Male 123 lb 7/23/2008 Physician Japan
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Hospitalization 11/14/2007 54 Male 132 lb 7/25/2008 Physician Japan
Primary
Secondary
Concomitant
Sepsis Life Threatening 6/24/2008 53 Female 93 lb 8/7/2008 Physician Japan
Primary
Concomitant
Respiratory Failure Other Serious 6/27/2008 70 Male 139 lb 8/7/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 5/23/2008 71 Male 132 lb 8/14/2008 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 2/28/2008 73 Male 123 lb 8/13/2008 Physician Japan
Primary
Concomitant
Productive Cough Other Serious 12/15/2007 Female 8/15/2008 Physician Japan
Primary
Secondary
Concomitant
Bone Marrow Failure Other Serious 6/14/2007 68 Female 97 lb 8/15/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 5/30/2007 56 Male 137 lb 8/18/2008 Physician Japan
Primary
Concomitant
Urine Flow Decreased Other Serious 8/5/2008 67 Male 8/18/2008 Physician Japan
Primary
Concomitant
Platelet Count Decreased Other Serious 6/14/2007 68 Female 97 lb 9/11/2008 Physician Japan
Primary
Concomitant
Vomiting Other Serious 7/9/2007 66 Male 139 lb 9/29/2008 Physician Japan
Primary
Concomitant
Weight Increased Other Serious 5/21/2007 71 Female 121 lb 9/29/2008 Physician Japan
Primary
Concomitant
Pancytopenia Hospitalization 7/31/2008 58 Female 10/1/2008 Physician Japan
Primary
Concomitant
Thrombocytopenia Other Serious 5/12/2008 71 Male 132 lb 10/7/2008 Physician Japan
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Other Serious 6/4/2008 61 Male 121 lb 10/13/2008 Physician Japan
Primary
Concomitant
Pneumonia Other Serious 12/15/2007 Female 11/7/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 6/24/2008 53 Female 93 lb 11/7/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 8/4/2008 67 Male 11/14/2008 Physician Japan
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 6/4/2008 61 Male 121 lb 11/24/2008 Physician Japan
Primary
Concomitant
Platelet Count Decreased Other Serious 6/14/2007 68 Female 97 lb 12/12/2008 Physician Japan
Primary
Concomitant
Vomiting Other Serious 7/9/2007 66 Male 139 lb 12/23/2008 Physician Japan
Primary
Concomitant
Thrombocytopenia Other Serious 5/12/2008 71 Male 132 lb 12/22/2008 Physician Japan
Primary
Secondary
Concomitant
Ventricular Extrasystoles Other Serious 5/21/2007 71 Female 121 lb 12/24/2008 Physician Japan
Primary
Concomitant
Rash Vesicular Other Serious 10/2/2007 74 Male 117 lb 12/30/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 5/12/2008 71 Male 132 lb 1/2/2009 Physician Japan
Primary
Secondary
Concomitant
Sepsis Life Threatening 9/22/2007 78 Male 108 lb 1/8/2009 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 6/24/2008 53 Female 93 lb 2/13/2009 Physician Japan
Primary
Concomitant
Thrombocytopenia Hospitalization 6/11/2007 75 Male 194 lb 2/13/2009 Physician Greece
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Other Serious 1/5/2009 74 Male 139 lb 3/19/2009 Physician Japan
Primary
Concomitant
Tumour Lysis Syndrome Death 8/4/2008 68 Male 121 lb 3/19/2009 Physician Japan
Primary
Concomitant
Renal Failure Acute Hospitalization 2/29/2008 63 Female 99 lb 3/25/2009 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/3/2007 56 Female 110 lb 4/8/2009 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Bacterial Other Serious 11/17/2007 58 Male 192 lb 4/24/2009 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 6/23/2008 53 Female 93 lb 4/23/2009 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 6/23/2008 53 Female 93 lb 4/28/2009 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 6/23/2008 53 Female 93 lb 4/30/2009 Physician Japan
Primary
Concomitant
Urinary Tract Infection Life Threatening 12/12/2008 69 Female 99 lb 5/8/2009 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 9/26/2007 74 Male 117 lb 5/15/2009 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 3/3/2007 56 Female 110 lb 6/10/2009 Physician Japan
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Other Serious 1/5/2009 74 Male 139 lb 6/26/2009 Physician Japan
Primary
Concomitant
Bone Marrow Failure Other Serious 6/14/2007 68 Female 97 lb 7/3/2009 Physician Japan
Primary
Concomitant
Ventricular Extrasystoles Other Serious 5/21/2007 71 Female 121 lb 7/10/2009 Physician Japan
Primary
Concomitant
Sepsis Other Serious 7/9/2007 66 Male 139 lb 7/10/2009 Physician Japan
Primary
Concomitant
Bone Marrow Failure Other Serious 6/14/2007 68 Female 97 lb 7/13/2009 Physician Japan
Primary
Concomitant
Sepsis Life Threatening 9/22/2007 78 Male 108 lb 8/6/2009 Physician Japan
Primary
Secondary
Concomitant
Varicella Life Threatening 8/20/2007 58 Male 152 lb 8/10/2009 Physician Japan
Primary
Secondary
Concomitant
Speech Disorder Other Serious 10/10/2007 77 Female 93 lb 8/18/2009 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 3/23/2007 60 Female 108 lb 8/21/2009 Physician Japan
Primary
Concomitant
Subileus Other Serious 9/11/2007 56 Male 137 lb 8/24/2009 Physician Japan
Primary
Concomitant
Urinary Tract Infection Life Threatening 12/12/2008 69 Female 99 lb 8/24/2009 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 3/23/2007 60 Female 108 lb 9/11/2009 Physician Japan
Primary
Concomitant
Tumour Lysis Syndrome Death 11/23/2007 62 Male 9/12/2009 Physician Japan
Primary
Concomitant
Unresponsive To Stimuli Hospitalization 6/13/2009 75 Female 79 lb 9/14/2009 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 6/1/2007 62 Female 95 lb 9/22/2009 Physician Japan
Primary
Concomitant
Tumour Lysis Syndrome Death 11/23/2007 62 Male 10/9/2009 Physician Japan
Primary
Concomitant
Platelet Count Decreased Other Serious 3/12/2007 70 Male 157 lb 10/12/2009 Physician Japan
Primary
Concomitant
Upper Respiratory Tract Inflammation Other Serious 9/11/2007 56 Male 137 lb 10/22/2009 Physician Japan
Primary
Concomitant
Varicella Life Threatening 8/20/2007 58 Male 152 lb 10/22/2009 Physician Japan
Primary
Concomitant
Staphylococcal Sepsis Hospitalization 5/8/2009 71 Male 137 lb 10/23/2009 Physician Japan
Primary
Concomitant
Speech Disorder Hospitalization 6/13/2009 75 Female 79 lb 11/2/2009 Physician Japan
Primary
Secondary
Concomitant
Weight Increased Life Threatening 8/20/2007 58 Male 152 lb 11/11/2009 Physician Japan
Primary
Concomitant
Urinary Tract Infection Life Threatening 12/12/2008 69 Female 99 lb 11/12/2009 Physician Japan
Primary
Secondary
Concomitant
Trichophytosis Hospitalization 7/17/2007 60 Female 11/19/2009 Physician Korea, Republic Of
Primary
Concomitant
Pyrexia Other Serious 6/1/2007 62 Female 95 lb 11/24/2009 Physician Japan
Primary
Concomitant
Incoherent Hospitalization 6/13/2009 75 Female 79 lb 12/12/2009 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Life Threatening 9/17/2009 73 Female 95 lb 12/15/2009 Physician Japan
Primary
Concomitant
Loss Of Consciousness Hospitalization 6/13/2009 75 Female 79 lb 12/21/2009 Physician Japan
Primary
Secondary
Concomitant
Shock Haemorrhagic Hospitalization 7/30/2009 69 Male 134 lb 2/12/2010 Physician Japan
Primary
Secondary
Concomitant
Multiple Myeloma Other Serious 6/14/2007 68 Female 97 lb 2/12/2010 Physician Japan
Primary
Concomitant
Shock Haemorrhagic Hospitalization 7/30/2009 69 Male 134 lb 2/12/2010 Physician Japan
Primary
Secondary
Concomitant
Multiple Myeloma Other Serious 6/14/2007 68 Female 97 lb 2/12/2010 Physician Japan
Primary
Concomitant
Multiple Myeloma Other Serious 6/14/2007 68 Female 97 lb 3/29/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/12/2007 70 Male 157 lb 4/14/2010 Physician Japan
Primary
Concomitant
Platelet Count Decreased Other Serious 3/12/2007 70 Male 157 lb 6/10/2010 Physician Japan
Primary
Concomitant
Sudden Death Other Serious 11/14/2008 76 Female 154 lb 6/23/2010 Physician Japan
Primary
Secondary
Concomitant

Drug Data