Itraconazole combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
White Blood Cell Count Decreased Other Serious 20 Male 4/3/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Paraesthesia Hospitalization 14 Male 3/27/2006 Physician United States
Primary
Secondary
Stomatitis Other Serious 14 Male 4/5/2006 Other Health Professional United States
Primary
Secondary
Splenic Lesion Hospitalization 14 Male 4/21/2006 United States
Primary
Secondary
Rash Other Serious 1/1/2006 59 Female 205 lb 4/20/2006 United States
Primary
Concomitant
Venoocclusive Liver Disease Disability 1/1/2004 61 Female 98 lb 6/7/2006 Physician Japan
Primary
Secondary
Concomitant
Hyperglycaemia Other Serious 11/13/2006 46 Female 12/15/2006 Pharmacist United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 6/20/2006 58 Male 1/17/2007 Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/20/2006 Male 117 lb 3/9/2007 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/20/2006 Male 117 lb 3/22/2007 Physician Japan
Primary
Concomitant
Streptococcal Bacteraemia Death 12 Female 4/2/2007 Physician Japan
Primary
Concomitant
Streptococcal Bacteraemia Death 12 Female 4/6/2007 Physician Japan
Primary
Concomitant
Streptococcal Bacteraemia Death 12 Female 5/7/2007 Physician Japan
Primary
Concomitant
Scedosporium Infection Death 11/1/2001 43 Male 4/24/2007 Physician United States
Primary
Secondary
Concomitant
Viral Pharyngitis Other Serious 8/26/2005 19 Male 5/11/2007 Poland
Primary
Secondary
Concomitant
Transplant Rejection Death 5/16/2006 49 Female 109 lb 4/29/2007 Physician Japan
Primary
Concomitant
Wound Drainage Death 11/1/2001 43 Male 5/9/2007 Physician United States
Primary
Secondary
Concomitant
Middle Insomnia 11/1/2006 80 Female 115 lb 4/12/2007 Consumer United States
Primary
Concomitant
Leukoencephalopathy Other Serious 12/5/2006 70 Female 9/3/2007 Pharmacist Japan
Primary
Secondary
Leukoencephalopathy Hospitalization 12/5/2006 70 Female 9/6/2007 Physician Japan
Primary
Secondary
Concomitant
Leukoencephalopathy Hospitalization 12/5/2006 70 Female 8/28/2007 Physician Japan
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 33 Male 2/15/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 53 Male 2/18/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Death 15 Male 2/18/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 27 Female 2/18/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
No Therapeutic Response Death 33 Male 2/19/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Death 15 Male 2/20/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 53 Male 2/20/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 27 Female 2/20/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Chronic Myeloid Leukaemia Death 57 Male 2/20/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 33 Male 3/10/2008 Mexico
Primary
Concomitant
Chronic Graft Versus Host Disease Death 15 Male 3/10/2008 Mexico
Primary
Concomitant
Graft Versus Host Disease Death 33 Male 3/12/2008 Mexico
Primary
Concomitant
Chronic Graft Versus Host Disease Death 15 Male 3/12/2008 Mexico
Primary
Concomitant
Vomiting Hospitalization 7/14/2007 40 Female 4/2/2008 Japan
Primary
Secondary
Concomitant
Pyrexia Death 7/17/2007 65 Male 161 lb 5/20/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 9/21/2007 25 Male 112 lb 6/4/2008 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 9/21/2007 25 Male 112 lb 6/19/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 9/21/2007 25 Male 112 lb 6/27/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 4/2/2008 19 Male 110 lb 7/16/2008 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/27/2007 52 Male 7/16/2008 Japan
Primary
Concomitant
Thrombocytopenia Other Serious 9/21/2007 25 Male 112 lb 7/28/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Trichosporon Infection Death 4/15/2008 53 Male 123 lb 9/30/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 9/3/2007 33 Female 12/1/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Trichosporon Infection Death 4/15/2008 53 Male 123 lb 12/5/2008 Physician Japan
Primary
Concomitant
Sinusitis Hospitalization 1/1/2007 60 Male 143 lb 12/16/2008 Physician Spain
Primary
Secondary
Concomitant
Sinusitis Hospitalization 1/1/2007 60 Male 143 lb 12/19/2008 Physician Spain
Primary
Secondary
Concomitant
Stomatitis Death 2/16/2008 4 Male 37 lb 12/22/2008 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Aspiration Hospitalization 1/1/2005 80 Female 77 lb 1/5/2009
Primary
Secondary
Concomitant
Pneumonia Aspiration Hospitalization 1/1/2005 80 Female 77 lb 1/5/2009
Primary
Secondary
Concomitant
Tachyarrhythmia Other Serious 57 Female 2/12/2009 Other Health Professional Germany
Primary
Concomitant
Culture Positive Other Serious 52 Female 2/16/2009 Germany
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 4/2/2008 19 Male 110 lb 3/20/2009 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Other Serious 5/27/2008 4/20/2009 Physician Egypt
Primary
Secondary
Concomitant
Orthostatic Hypotension Other Serious 3 Male 7/9/2009 Physician Spain
Primary
Secondary
Concomitant
Relapsing Fever Hospitalization 14 Male 7/20/2009 Other Health Professional United States
Primary
Interacting
Pyrexia Required Intervention 16 Female 7/16/2009 Other Health Professional Turkey
Primary
Secondary
Concomitant
Relapsing Fever Hospitalization 14 Male 7/30/2009 Other Health Professional United States
Primary
Interacting
Urinary Tract Infection Other Serious 10/1/2008 Male 175 lb 8/11/2009 Physician United States
Primary
Concomitant
Urinary Tract Infection Other Serious 10/1/2008 Male 175 lb 9/4/2009 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/8/2009 58 Female 106 lb 12/14/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 6/30/2009 15 Male 12/8/2009 Other Health Professional Japan
Primary
Concomitant
Neutropenia Other Serious 17 Male 12/24/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Neutropenia Other Serious 17 Male 1/4/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Multi-organ Failure Death 10/1/2009 52 Male 12/22/2009 Physician Japan
Primary
Concomitant
Renal Impairment Other Serious 17 Male 1/22/2010 Other Health Professional United Kingdom
Primary
Secondary
Neutropenia Other Serious 17 Male 1/15/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 1/26/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 1/28/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 2/1/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
No Therapeutic Response Death 10/1/2009 52 Male 132 lb 1/29/2010 Physician Japan
Primary
Concomitant
Renal Impairment Other Serious 17 Male 2/22/2010 Other Health Professional United Kingdom
Primary
Secondary
Renal Impairment Other Serious 17 Male 2/25/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 2/25/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 2/25/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Stem Cell Transplant Hospitalization 6/30/2009 15 Male 2/16/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 2/26/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pyrexia Other Serious 3/22/2009 15 Male 110 lb 2/26/2010 Physician Japan
Primary
Concomitant
Renal Impairment Other Serious 17 Male 2/22/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 3/10/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 3/12/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 3/16/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/8/2009 58 Female 106 lb 3/25/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 3/29/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious Male 3/19/2010 United Kingdom
Primary
Concomitant
Renal Impairment Other Serious 17 Male 3/31/2010 Other Health Professional United Kingdom
Primary
Secondary
Respiratory Failure Hospitalization 12/16/2008 73 Male 117 lb 3/24/2010 Physician Japan
Primary
Concomitant
Renal Impairment Other Serious 17 Male 4/1/2010 Other Health Professional United Kingdom
Primary
Secondary
Renal Failure Other Serious 6/30/2009 15 Male 88 lb 4/5/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Renal Failure Other Serious 6/30/2009 15 Male 88 lb 4/7/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 12/16/2008 73 Male 117 lb 4/13/2010 Physician Japan
Primary
Concomitant
Pancreatitis Acute Hospitalization 6/24/2009 15 Male 88 lb 5/3/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Visual Impairment Disability 3/11/2009 48 Female 84 lb 4/29/2010 Physician Japan
Primary
Concomitant
Staphylococcal Infection Other Serious 4/14/2010 60 Male 110 lb 6/25/2010 Physician Japan
Primary
Concomitant
Sepsis Other Serious 11/1/2009 74 Male 7/6/2010 Physician Japan
Primary
Secondary
Concomitant
Visual Impairment Other Serious 3/11/2009 49 Female 84 lb 7/21/2010 Physician Japan
Primary
Secondary
Concomitant
Visual Impairment Other Serious 3/11/2009 49 Female 84 lb 7/27/2010 Physician Japan
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 3/11/2009 48 Female 84 lb 7/19/2010 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 9/21/2009 37 Female 93 lb 8/9/2010 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 1/9/2009 58 Female 97 lb 7/28/2010 Physician Japan
Primary
Concomitant
Sicca Syndrome Other Serious 8/31/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Skin Disorder Other Serious 55 Male 9/7/2010 Other Health Professional Japan
Primary
Concomitant
Deep Vein Thrombosis Disability 63 Male 265 lb 9/8/2010 Other Health Professional Switzerland
Primary
Concomitant
Sicca Syndrome Other Serious 7/1/2009 48 Male 9/22/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Sicca Syndrome Other Serious 7/1/2009 48 Male 9/22/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Skin Disorder Other Serious 1/1/2007 55 Male 9/30/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Skin Disorder 4/5/2007 55 Male 10/7/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/8/2009 58 Female 106 lb 10/28/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/8/2009 58 Female 106 lb 11/2/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/17/2010 Male 168 lb 11/22/2010 Physician Japan
Primary
Concomitant
Venoocclusive Liver Disease Hospitalization 5/26/2010 Male 18 lb 11/24/2010 Physician Japan
Primary
Concomitant
Visual Impairment Other Serious 3/11/2009 48 Female 84 lb 11/8/2010 Physician Japan
Primary
Concomitant
Tendonitis Other Serious 4/5/2007 55 Male 12/10/2010 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/29/2010 49 Male 110 lb 12/13/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/29/2010 49 Male 110 lb 12/13/2010 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 12/12/2009 76 Male 119 lb 12/23/2010 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious 3/19/2010 31 Male 139 lb 12/27/2010 Physician Japan
Primary
Concomitant
Pyrexia Life Threatening 12/12/2009 76 Male 119 lb 12/29/2010 Physician Japan
Primary
Concomitant
Chronic Graft Versus Host Disease Death 1/5/2011 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 10/23/2009 62 Male 130 lb 1/6/2011 Physician Japan
Primary
Concomitant
Therapeutic Response Decreased Other Serious 7/1/2009 48 Female 115 lb 1/6/2011 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Death 10/23/2009 62 Male 130 lb 1/7/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Recurrent Death 8/6/2010 67 Female 110 lb 1/7/2011 Physician Japan
Primary
Secondary
Concomitant
Cystitis Haemorrhagic Hospitalization 5/17/2010 43 Female 1/10/2011 Physician Japan
Primary
Concomitant
Blood Pressure Increased Other Serious 8/9/2009 48 Female 115 lb 1/10/2011 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Infection Death 4/14/2010 60 Male 110 lb 1/20/2011 Physician Japan
Primary
Concomitant
Staphylococcal Infection Hospitalization 9/10/2009 18 Male 137 lb 1/24/2011 Physician Japan
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 5/17/2010 43 Female 119 lb 1/26/2011 Physician Japan
Primary
Concomitant
Sepsis Other Serious 9/10/2009 18 Male 137 lb 2/15/2011 Physician Japan
Primary
Concomitant
Renal Impairment Other Serious 17 Male 2/17/2011 Physician United Kingdom
Primary
Secondary
Renal Impairment Other Serious 17 Male 2/17/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 2/25/2011 Consumer United Kingdom
Primary
Secondary
Autoimmune Thrombocytopenia Death 3/2/2011 Physician Mexico
Primary
Secondary
Concomitant
Neutropenia Other Serious 17 Male 3/3/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 3/7/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Neutropenia Other Serious 17 Male 3/7/2011 Consumer United Kingdom
Primary
Secondary
Renal Impairment Other Serious 17 Male 3/9/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Liver Disorder Hospitalization 10/24/2010 19 Male 115 lb 3/10/2011 Physician Japan
Primary
Concomitant
Cystitis Haemorrhagic Hospitalization 5/17/2010 43 Female 119 lb 3/10/2011 Physician Japan
Primary
Concomitant
Lymphoproliferative Disorder Other Serious 17 Male 3/14/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Other Serious 17 Male 3/14/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Skin Hospitalization 37 Female 115 lb 3/16/2011 Physician Japan
Primary
Concomitant
Acute Graft Versus Host Disease In Skin Other Serious 29 Male 3/18/2011 Physician Japan
Primary
Concomitant
Cystitis Haemorrhagic Hospitalization 5/17/2010 43 Female 119 lb 3/25/2011 Physician Japan
Primary
Concomitant
Bronchiectasis Hospitalization 35 Male 3/30/2011 Other Health Professional Japan
Primary
Concomitant
Eosinophilic Pneumonia Hospitalization 9/9/2009 36 Female 115 lb 4/6/2011 Physician Japan
Primary
Secondary
Concomitant
Toothache Hospitalization 9/21/2009 37 Female 93 lb 4/14/2011 Physician Japan
Primary
Concomitant
Posterior Reversible Encephalopathy Syndrome Hospitalization 13 Female 4/15/2011 Physician Spain
Primary
Concomitant
Neck Pain 9/1/2010 31 Male 239 lb 5/6/2011 Consumer United States
Primary
Concomitant
Petechiae Other Serious 1/29/2010 49 Male 110 lb 5/20/2011 Physician Japan
Primary
Concomitant

Drug Data