Itraconazole combined with Levofloxacin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Respiratory Distress Other Serious 4/23/2005 50 Male 126 lb 4/25/2006 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 1/15/2006 59 Male 6/7/2006 Japan
Primary
Concomitant
Venoocclusive Liver Disease Disability 1/1/2004 61 Female 98 lb 6/7/2006 Physician Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 5/13/2006 58 Female 7/24/2006 Japan
Primary
Concomitant
Febrile Neutropenia Other Serious 5/15/2006 83 Female 9/13/2006 United States
Primary
Secondary
Concomitant
Pulmonary Haemorrhage Hospitalization 12/16/2005 45 Male 112 lb 9/11/2006 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 1/15/2006 59 Male 9/19/2006 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/30/2006 59 Male 9/26/2006 Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 5/13/2006 58 Female 10/17/2006 Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 3/17/2006 72 Male 11/14/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Death 8/29/2006 61 Male 11/7/2006 Japan
Primary
Concomitant
Thrombocytopenia Death 5/14/2002 65 Female 11/8/2006 Italy
Primary
Secondary
Concomitant
Respiratory Disorder Hospitalization 72 Male 11/9/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
No Therapeutic Response Hospitalization 72 Male 12/29/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Death 8/29/2006 61 Male 1/24/2007 Japan
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 45 Female 2/1/2007 Other Health Professional Italy
Primary
Secondary
Concomitant
Pneumonia Hospitalization 10/4/2006 40 Male 154 lb 2/26/2007 Physician Japan
Primary
Secondary
Concomitant
Neutropenia Other Serious 5/15/2006 83 Female 2/26/2007 Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 9/27/2006 40 Male 154 lb 3/20/2007 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 7/15/2006 61 Male 104 lb 3/28/2007 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Other Serious 5/15/2006 83 Female 3/19/2007 Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 7/15/2006 61 Male 104 lb 4/13/2007 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Other Serious 5/15/2006 83 Female 4/13/2007 Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 4/1/2005 73 Female 110 lb 5/1/2007 Physician Japan
Primary
Concomitant
Toxic Epidermal Necrolysis Death 45 Female 4/27/2007 Other Health Professional Italy
Primary
Secondary
Concomitant
Chronic Lymphocytic Leukaemia Transformation Hospitalization 73 Female 110 lb 6/21/2007 Physician Japan
Primary
Concomitant
Pneumonia Other Serious 5/15/2006 83 Female 6/21/2007 United States
Primary
Secondary
Concomitant
Intercostal Neuralgia Other Serious 1/1/2007 Male 119 lb 7/5/2007 Physician Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 5/1/2007 Female 86 lb 7/11/2007 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 3/6/2007 51 Female 7/18/2007 Physician Japan
Primary
Secondary
Platelet Count Decreased Other Serious 2/24/2007 Female 88 lb 8/22/2007 Physician Japan
Primary
Concomitant
Leukoencephalopathy Other Serious 12/5/2006 70 Female 9/3/2007 Pharmacist Japan
Primary
Secondary
Leukoencephalopathy Hospitalization 12/5/2006 70 Female 9/6/2007 Physician Japan
Primary
Secondary
Concomitant
Neutrophil Count Decreased Hospitalization 7/5/2007 64 Male 110 lb 8/31/2007 Physician Japan
Primary
Concomitant
Myelodysplastic Syndrome Death 5/1/2007 59 Male 119 lb 9/13/2007 Physician Japan
Primary
Concomitant
Mycobacterial Infection Hospitalization 65 Male 10/16/2007
Primary
Secondary
Concomitant
Lung Abscess Life Threatening 11/21/2006 Male 10/19/2007 Physician Japan
Primary
Secondary
Concomitant
Ventricular Tachycardia Life Threatening 7/17/2007 61 Male 11/8/2007 Physician Japan
Primary
Concomitant
Unresponsive To Stimuli Life Threatening 9/28/2007 21 Female 150 lb 12/3/2007 Physician United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 7/7/2007 77 Male 12/13/2007 United States
Primary
Secondary
Concomitant
Vomiting Death 5/1/2007 59 Male 119 lb 12/18/2007 Physician Japan
Primary
Secondary
Concomitant
Toxic Skin Eruption Hospitalization 9/29/2007 60 Male 12/31/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 9/7/2007 67 Female 97 lb 1/3/2008 Physician Japan
Primary
Concomitant
Supraventricular Extrasystoles Other Serious 10/1/2007 55 Male 161 lb 1/3/2008 Physician Japan
Primary
Concomitant
Ventricular Extrasystoles Other Serious 5/21/2007 71 Female 121 lb 2/15/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 8/23/2007 60 Male 130 lb 2/22/2008 Physician Japan
Primary
Secondary
Concomitant
Supraventricular Extrasystoles Other Serious 10/1/2007 55 Male 161 lb 3/10/2008 Physician Japan
Primary
Concomitant
Thrombotic Thrombocytopenic Purpura Hospitalization 11/14/2007 54 Male 132 lb 3/14/2008 Physician Japan
Primary
Secondary
Concomitant
Micturition Disorder Hospitalization 2/15/2008 73 Male 134 lb 4/1/2008 Physician Japan
Primary
Concomitant
Ventricular Extrasystoles Other Serious 5/21/2007 71 Female 121 lb 4/2/2008 Physician Japan
Primary
Concomitant
Vomiting Life Threatening 12/6/2007 66 Male 139 lb 4/7/2008 Physician Japan
Primary
Concomitant
Renal Impairment Hospitalization 11/14/2007 54 Male 132 lb 4/10/2008 Physician Japan
Primary
Secondary
Concomitant
Supraventricular Extrasystoles Other Serious 10/1/2007 55 Male 161 lb 4/21/2008 Physician Japan
Primary
Concomitant
Urinary Retention Hospitalization 2/15/2008 73 Male 134 lb 4/29/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Increased Other Serious 9/21/2007 25 Male 112 lb 6/4/2008 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 9/21/2007 25 Male 112 lb 6/19/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 9/21/2007 25 Male 112 lb 6/27/2008 Physician Japan
Primary
Secondary
Concomitant
Shock Life Threatening 4/18/2008 Male 82 lb 7/24/2008 Physician Japan
Primary
Concomitant
Thrombocytopenia Other Serious 9/21/2007 25 Male 112 lb 7/28/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 2/28/2008 73 Male 123 lb 8/13/2008 Physician Japan
Primary
Concomitant
Vomiting Other Serious 7/9/2007 66 Male 139 lb 9/29/2008 Physician Japan
Primary
Concomitant
Weight Increased Other Serious 5/21/2007 71 Female 121 lb 9/29/2008 Physician Japan
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 6/4/2008 61 Male 121 lb 10/13/2008 Physician Japan
Primary
Concomitant
Thrombocytopenia Life Threatening 6/23/2008 82 Male 237 lb 10/30/2008 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 6/23/2008 82 Male 237 lb 10/31/2008 Physician United States
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Other Serious 6/4/2008 61 Male 121 lb 11/24/2008 Physician Japan
Primary
Concomitant
Pneumonia Death 11/6/2008 Male 166 lb 12/3/2008 Korea, Republic Of
Primary
Concomitant
Vomiting Other Serious 7/9/2007 66 Male 139 lb 12/23/2008 Physician Japan
Primary
Concomitant
Ventricular Extrasystoles Other Serious 5/21/2007 71 Female 121 lb 12/24/2008 Physician Japan
Primary
Concomitant
Septic Shock Death 11/6/2008 Male 166 lb 1/6/2009 Korea, Republic Of
Primary
Concomitant
Septic Shock Death 11/6/2008 Male 166 lb 2/20/2009 Korea, Republic Of
Primary
Concomitant
Mucosal Inflammation Other Serious 69 Male 3/10/2009 Italy
Primary
Secondary
Mucosal Inflammation Other Serious 69 Male 3/20/2009 Other Health Professional Japan
Primary
Secondary
Infection Other Serious 4/14/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Pneumonia Bacterial Other Serious 11/17/2007 58 Male 192 lb 4/24/2009 Physician Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Life Threatening 12/12/2008 69 Female 99 lb 5/8/2009 Physician Japan
Primary
Secondary
Concomitant
Ventricular Extrasystoles Other Serious 5/21/2007 71 Female 121 lb 7/10/2009 Physician Japan
Primary
Concomitant
Sepsis Other Serious 7/9/2007 66 Male 139 lb 7/10/2009 Physician Japan
Primary
Concomitant
Neutrophil Count Decreased 11/21/2008 77 Female 8/12/2009 Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Life Threatening 12/12/2008 69 Female 99 lb 8/24/2009 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 20 Female 9/8/2009 Consumer China
Primary
Concomitant
Abortion Spontaneous Other Serious 20 Female 9/8/2009 Consumer China
Primary
Concomitant
Somnambulism Other Serious 10/3/2009 53 Male 160 lb 10/7/2009 Pharmacist United States
Primary
Concomitant
Thrombosis Life Threatening 6/23/2008 82 Male 238 lb 10/16/2009 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 6/23/2008 82 Male 238 lb 11/6/2009 Physician United States
Primary
Concomitant
Urinary Tract Infection Life Threatening 12/12/2008 69 Female 99 lb 11/12/2009 Physician Japan
Primary
Secondary
Concomitant
Sepsis Death 8/1/2009 83 Male 137 lb 11/9/2009 Physician Japan
Primary
Concomitant
Multi-organ Failure Death 10/1/2009 52 Male 12/22/2009 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 3/22/2009 15 Male 110 lb 2/26/2010 Physician Japan
Primary
Concomitant
Pseudomembranous Colitis Life Threatening 8/17/2009 59 Male 121 lb 1/29/2010 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 6/10/2009 Female 104 lb 3/4/2010 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Life Threatening 11/25/2008 70 Female 73 lb 3/24/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Pneumonia Death 11/1/2008 60 Male 166 lb 4/13/2010 Korea, Republic Of
Primary
Concomitant
Pyrexia Life Threatening 8/17/2009 59 Male 121 lb 4/2/2010 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 4/6/2010 39 Male 143 lb 5/25/2010 Consumer Japan
Primary
Concomitant
Pneumonia Life Threatening 11/6/2008 60 Male 166 lb 5/26/2010 Physician Korea, Republic Of
Primary
Concomitant
Pyrexia Other Serious 4/6/2010 39 Male 143 lb 6/11/2010 Consumer Japan
Primary
Concomitant
Staphylococcal Infection Other Serious 4/14/2010 60 Male 110 lb 6/25/2010 Physician Japan
Primary
Concomitant
Pyrexia Life Threatening 8/17/2009 59 Male 121 lb 6/8/2010 Physician Japan
Primary
Concomitant
Death Death 7/9/2010 Physician United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 1/9/2009 58 Female 97 lb 7/28/2010 Physician Japan
Primary
Concomitant
Respiratory Failure Death 1/1/2009 30 Male 8/26/2010 Other Health Professional Viet Nam
Primary
Concomitant
Pneumonia Death 1/18/2010 77 Female 104 lb 8/26/2010 Physician Japan
Primary
Concomitant
Septic Shock Other Serious 5/21/2009 48 Female 132 lb 9/20/2010 Physician Italy
Primary
Secondary
Concomitant
Pyrexia Hospitalization 6/10/2009 74 Female 104 lb 9/24/2010 Physician Japan
Primary
Concomitant
Uveitis Other Serious 64 Female 77 lb 10/22/2010 Physician Japan
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 45 Female 11/8/2010 Other Health Professional Italy
Primary
Secondary
Concomitant
Uveitis Other Serious 64 Female 77 lb 11/9/2010 Physician Japan
Primary
Secondary
Concomitant
Uveitis Other Serious 64 Female 77 lb 11/9/2010 Physician Japan
Primary
Concomitant
Interacting
Vomiting Other Serious 12/17/2009 73 Female 117 lb 11/15/2010 Physician Japan
Primary
Concomitant
Weight Increased Other Serious 1/17/2010 Male 168 lb 11/22/2010 Physician Japan
Primary
Concomitant
Vomiting Other Serious 6/12/2010 12/1/2010 Consumer Japan
Primary
Concomitant
Uveitis Other Serious 2/8/2009 65 Female 77 lb 12/2/2010 Physician Japan
Primary
Concomitant
Interacting
No Adverse Event Death 11/10/2010 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/29/2010 49 Male 110 lb 12/13/2010 Physician Japan
Primary
Concomitant
Pneumonia Death 2/1/2010 77 Female 104 lb 12/13/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/29/2010 49 Male 110 lb 12/13/2010 Physician Japan
Primary
Concomitant
Hiccups Death 7/30/2010 49 Male 110 lb 12/17/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 12/12/2009 76 Male 119 lb 12/23/2010 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious 3/19/2010 31 Male 139 lb 12/27/2010 Physician Japan
Primary
Concomitant
Endophthalmitis Other Serious 22 Female 12/27/2010 Other Health Professional Croatia (Local Name: Hrvatska)
Primary
Secondary
Endophthalmitis Other Serious 22 Female 12/29/2010 Other Health Professional Japan
Primary
Secondary
Urinary Tract Infection Bacterial Death 3/25/2010 58 Male 150 lb 12/29/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Life Threatening 12/12/2009 76 Male 119 lb 12/29/2010 Physician Japan
Primary
Concomitant
Pyrexia Death 3/25/2010 58 Male 150 lb 12/29/2010 Physician Japan
Primary
Concomitant
Hypertension Hospitalization 3/20/2010 71 Female 106 lb 12/30/2010 Physician Japan
Primary
Concomitant
Pseudomonal Sepsis Hospitalization 8/17/2009 54 Female 108 lb 1/7/2011 Consumer Japan
Primary
Concomitant
Acute Myeloid Leukaemia Recurrent Other Serious 2/26/2010 56 Male 134 lb 1/10/2011 Physician Japan
Primary
Concomitant
Acute Graft Versus Host Disease In Skin Hospitalization 2/26/2010 56 Male 134 lb 1/11/2011 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Infection Death 4/14/2010 60 Male 110 lb 1/20/2011 Physician Japan
Primary
Concomitant
Chills Death 1/21/2011 62 Female 110 lb 3/4/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Systemic Candida Other Serious 3/15/2011 Other Health Professional United States
Primary
Concomitant
Fusarium Infection Death 3/15/2011 Other Health Professional United States
Primary
Concomitant
Circulatory Collapse Hospitalization 1/21/2011 62 Female 110 lb 3/27/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Mycosis Death 80 Female 3/30/2011 Physician Japan
Primary
Secondary
Abdominal Pain Other Serious 12/17/2009 73 Female 117 lb 4/5/2011 Physician Japan
Primary
Concomitant
Hepatic Failure Death 4/2/2010 65 Male 141 lb 4/13/2011 Physician Spain
Primary
Secondary
Concomitant
Hepatic Failure Death 4/2/2010 65 Male 141 lb 4/14/2011 Physician Spain
Primary
Secondary
Concomitant
Hepatic Failure Death 4/2/2010 65 Male 141 lb 4/25/2011 Physician Spain
Primary
Secondary
Concomitant
Pneumonia Bacterial Death 11/17/2007 58 Male 192 lb 4/14/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Bacterial Life Threatening 11/17/2007 58 Male 192 lb 4/14/2011 Physician Japan
Primary
Secondary
Concomitant
Fungal Infection Other Serious 10/13/2009 36 Male 143 lb 4/27/2011 Physician Japan
Primary
Concomitant
Interleukin-2 Receptor Increased Hospitalization 12/24/2010 76 Male 5/4/2011 Physician Japan
Primary
Concomitant
Disseminated Intravascular Coagulation Death 7/30/2010 49 Male 110 lb 5/20/2011 Physician Japan
Primary
Secondary
Concomitant
Petechiae Other Serious 1/29/2010 49 Male 110 lb 5/20/2011 Physician Japan
Primary
Concomitant
Renal Disorder Life Threatening 7/25/2010 60 Female 93 lb 5/24/2011 Physician Japan
Primary
Secondary
Concomitant
Hypotension Death 4/1/2011 65 Male 117 lb 5/26/2011 Physician China
Primary
Concomitant
Neuropathy Peripheral Death 1/1/2010 5/26/2011 Pharmacist Japan
Primary
Concomitant
Renal Failure Disability 1/1/2011 59 Male 5/27/2011 Other Health Professional Japan
Primary
Concomitant
Pneumonia Death 5/10/2010 72 Male 6/3/2011 Physician Japan
Primary
Concomitant

Drug Data