Isosorbide combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Sepsis Other Serious Female 165 lb 1/16/2006 Other Health Professional United Kingdom
Primary
Concomitant
Mental Status Changes Hospitalization 10/11/2005 79 Male Pharmacist United States
Primary
Concomitant
Pulmonary Haemorrhage Hospitalization 11/6/2005 53 Male 12/27/2005 Consumer United States
Primary
Concomitant
Blood Glucose Decreased Hospitalization 4/14/2006 85 Male 194 lb 4/27/2006 Pharmacist United States
Primary
Concomitant
Myoclonus Death 4/15/2006 66 Male 214 lb 5/1/2006 Pharmacist United States
Primary
Concomitant
Vision Blurred Hospitalization 4/29/2006 84 Male 172 lb 5/9/2006 Pharmacist United States
Primary
Secondary
Concomitant
Confusional State Hospitalization 2/2/2006 64 Male 174 lb 4/18/2006 Pharmacist United States
Primary
Concomitant
Dysgeusia 11/20/2005 66 Male 270 lb 4/3/2006 Consumer United States
Primary
Concomitant
Thrombosis Other Serious 56 Male 290 lb 6/2/2006 Pharmacist United States
Primary
Concomitant
Weight Decreased Hospitalization 2/14/2006 Male 157 lb 6/9/2006 Other Health Professional United Kingdom
Primary
Concomitant
Cerebrovascular Accident Death Male 157 lb 6/21/2006 Consumer United Kingdom
Primary
Concomitant
Renal Tubular Necrosis Hospitalization 5/5/2006 73 Male 177 lb 7/10/2006 Pharmacist United States
Primary
Secondary
Concomitant
International Normalised Ratio Increased Hospitalization 4/25/2006 Male 203 lb 4/26/2006 Pharmacist United States
Primary
Concomitant
Hypersensitivity Hospitalization 67 Male 7/10/2006 United States
Primary
Concomitant
Hypercholesterolaemia Death Male 157 lb 11/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
Renal Tubular Necrosis Hospitalization 11/8/2006 82 Male 243 lb 11/17/2006 Pharmacist United States
Primary
Concomitant
Pharmaceutical Product Complaint Hospitalization 10/5/2006 82 Male 11/24/2006 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 11/17/2006 57 Female 211 lb 11/30/2006 Pharmacist United States
Primary
Concomitant
Initial Insomnia 7/6/2006 45 Male 148 lb 10/11/2006 Consumer United States
Primary
Concomitant
Weight Decreased Other Serious 2/14/2006 Male 157 lb 1/22/2007 Other Health Professional United Kingdom
Primary
Concomitant
Vitreous Haemorrhage Required Intervention 2/9/2003 83 Male 1/30/2007 United Kingdom
Primary
Concomitant
Hip Fracture Hospitalization 4/8/2006 Female 146 lb 2/9/2007 Other Health Professional United Kingdom
Primary
Concomitant
Haematemesis Other Serious 2/5/2007 Female 130 lb 2/13/2007 Consumer United States
Primary
Concomitant
Epistaxis Hospitalization 2/7/2007 74 Male 138 lb 2/12/2007 Pharmacist United States
Primary
Concomitant
Weight Decreased Hospitalization 1/30/2007 74 Male 159 lb 2/12/2007 Pharmacist United States
Primary
Concomitant
Myocardial Ischaemia Other Serious 10/1/2006 82 Male 2/12/2007 Consumer United States
Primary
Concomitant
Confusional State Hospitalization 3/1/2007 Male 214 lb 3/8/2007 Other Health Professional Poland
Primary
Secondary
Concomitant
Swollen Tongue Other Serious 2/27/2007 82 Male 186 lb 4/2/2007 Other Health Professional United Kingdom
Primary
Concomitant
Urine Output Decreased Hospitalization 3/9/2007 89 Male 156 lb 3/29/2007 Pharmacist United States
Primary
Secondary
Concomitant
Suicide Attempt Other Serious 8/31/2003 57 Male 4/11/2007 Consumer United States
Primary
Concomitant
Haemoglobin Decreased Hospitalization 3/1/2007 78 Female 4/21/2007 United States
Primary
Concomitant
Confusional State Hospitalization 3/1/2007 Male 214 lb 4/24/2007 Other Health Professional Poland
Primary
Secondary
Concomitant
Lymphoid Tissue Hyperplasia Other Serious 1/1/2005 68 Male 5/7/2007 United Kingdom
Primary
Concomitant
Lymphoid Tissue Hyperplasia Other Serious 1/1/2005 68 Male 5/10/2007 Other Health Professional United Kingdom
Primary
Concomitant
Unresponsive To Stimuli Other Serious 9/15/2006 67 Female 5/17/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Neutropenia Hospitalization 11/1/2005 75 Male 182 lb 12/13/2006 Physician United States
Primary
Concomitant
Skin Necrosis Other Serious 3/29/2007 72 Male 5/23/2007 Physician Puerto Rico
Primary
Secondary
Concomitant
Weight Decreased Death 5/21/2008 79 Female 243 lb 8/20/2008 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization 12/1/2001 62 Male 205 lb 8/26/2008 Other Health Professional United States
Primary
Concomitant
Weight Increased 3/1/2007 Male 203 lb 8/27/2008 Consumer United States
Primary
Concomitant
Diarrhoea Other Serious 4/3/2008 65 Female 134 lb 9/19/2008 Consumer United States
Primary
Concomitant
Hot Flush Other Serious 6/18/2008 83 Male 161 lb 9/22/2008 Pharmacist United States
Primary
Concomitant
Renal Failure Hospitalization 12/1/2001 62 Male 205 lb 9/26/2008 Other Health Professional United States
Primary
Concomitant
Encephalopathy Hospitalization 8/7/2008 Female 10/3/2008 United States
Primary
Secondary
Concomitant
Oropharyngeal Pain 10/29/2007 86 Female 10/7/2008 Consumer United States
Primary
Concomitant
Palpitations Other Serious 1/1/2008 Female 130 lb 10/15/2008 Other Health Professional United States
Primary
Concomitant
Loss Of Consciousness Other Serious 9/29/2008 Male 267 lb 10/16/2008 Consumer United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 84 Male 10/28/2008 Consumer United States
Primary
Concomitant
Ulcer Haemorrhage Other Serious 1/1/2008 78 Female 10/31/2008 Consumer United States
Primary
Concomitant
Encephalopathy Hospitalization 8/7/2008 Female 10/31/2008 United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 9/11/2003 47 Female 260 lb 11/10/2008 United States
Primary
Concomitant
Palpitations Disability 9/2/2008 63 Male 11/7/2008 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Encephalopathy Hospitalization 8/7/2008 Female 286 lb 11/18/2008 United States
Primary
Secondary
Concomitant
Lethargy Required Intervention 9/2/2008 77 Male 165 lb 10/15/2008 Pharmacist United States
Primary
Concomitant
Pain In Extremity 9/1/2008 78 Male 11/14/2008 United States
Primary
Concomitant
Paraesthesia Female 11/26/2008 United States
Primary
Secondary
Concomitant
Pancytopenia Other Serious 6/1/2008 76 Male 11/25/2008 Physician United States
Primary
Concomitant
Myocardial Infarction Hospitalization 7/1/2008 57 Female 12/18/2008 Consumer United States
Primary
Secondary
Concomitant
Encephalopathy Hospitalization 7/7/2008 Female 286 lb 12/22/2008 Physician United States
Primary
Secondary
Concomitant
Encephalopathy Hospitalization 7/7/2008 Female 286 lb 1/5/2009 Physician United States
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 7/1/2008 57 Female 1/13/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 9/29/2008 84 Male 159 lb 1/26/2009 Physician United States
Primary
Concomitant
Pancreatitis Hospitalization 7/1/2008 57 Female 2/3/2009 Physician United States
Primary
Secondary
Concomitant
Visual Impairment Death 11/12/2008 Male 200 lb 2/11/2009 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 9/29/2008 84 Male 159 lb 2/23/2009 Physician United States
Primary
Concomitant
Intermittent Claudication 9/1/2008 78 Male 171 lb 2/16/2009 Physician United States
Primary
Concomitant
Drug Ineffective Other Serious 10/28/2008 51 Male 200 lb 2/26/2009 Consumer United States
Primary
Concomitant
Tendon Disorder Other Serious 1/1/2005 72 Female 139 lb 3/9/2009 Physician United States
Primary
Concomitant
Pericarditis Other Serious 2/11/2009 Male 264 lb 3/24/2009 Consumer United Kingdom
Primary
Concomitant
Tendon Disorder Other Serious 1/1/2005 72 Female 139 lb 3/26/2009 Physician United States
Primary
Concomitant
Tendon Disorder Other Serious 1/1/2005 72 Female 139 lb 3/31/2009 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 8/12/2003 60 Male 216 lb 4/3/2009 United States
Primary
Concomitant
Swelling Face Hospitalization 3/28/2009 63 Female 4/9/2009 Other Health Professional United States
Primary
Concomitant
Oral Herpes Other Serious 2/1/2008 Male 4/10/2009 Consumer United States
Primary
Secondary
Concomitant
Haematuria Other Serious 9/15/2008 Male 176 lb 4/15/2009 United Kingdom
Primary
Secondary
Concomitant
Bladder Cancer Other Serious 9/15/2008 54 Male 176 lb 4/20/2009 Other Health Professional United Kingdom
Primary
Concomitant
Death Death 1/18/2009 61 Female 4/20/2009 Consumer United States
Primary
Concomitant
Haematuria Other Serious 9/15/2008 Male 206 lb 4/27/2009 United Kingdom
Primary
Secondary
Concomitant
Death Death 1/18/2009 61 Female 5/5/2009 Consumer United States
Primary
Concomitant
Hernia Hospitalization 69 Male 146 lb 5/7/2009 Other Health Professional United States
Primary
Concomitant
Productive Cough 5/6/2009 Male 5/13/2009 Consumer
Primary
Concomitant
Visual Impairment Other Serious 1/1/2009 Female 244 lb 5/15/2009 Physician United States
Primary
Concomitant
Productive Cough 5/6/2009 Male 5/22/2009 Consumer
Primary
Concomitant
Peripheral Ischaemia 9/1/2008 78 Male 171 lb 5/15/2009 Other Health Professional United States
Primary
Concomitant
Pain In Extremity 11/1/2008 62 Female 5/15/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 59 Male 215 lb 6/1/2009 United States
Primary
Concomitant
Pain Hospitalization 1/30/2006 50 Male 211 lb 6/5/2009 Lawyer United States
Primary
Concomitant
Vomiting Other Serious 5/1/2008 79 Female 4/6/2009 Consumer United States
Primary
Concomitant
Photosensitivity Reaction 4/1/2009 Male 6/15/2009 Physician United States
Primary
Concomitant
Sinusitis 5/6/2009 Male 6/17/2009 Consumer
Primary
Concomitant
Cardiac Arrest Death 4/26/2009 70 Male 7/2/2009 Other Health Professional United States
Primary
Concomitant
Unevaluable Event Death 67 Male 6/30/2009 Lawyer United States
Primary
Concomitant
Wheelchair User Other Serious 1/1/2007 Male 296 lb 7/6/2009 Physician United States
Primary
Concomitant
Oropharyngeal Discomfort 1/1/2009 67 Male 6/25/2009 Consumer United States
Primary
Secondary
Concomitant
Unevaluable Event Death 65 Female 155 lb 7/10/2009 United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2007 Male 296 lb 7/31/2009 Physician United States
Primary
Concomitant
Pain In Extremity Hospitalization 54 Female 7/22/2009 Lawyer United States
Primary
Concomitant
Thirst Other Serious 6/2/2009 Female 140 lb 8/11/2009 Other Health Professional United States
Primary
Concomitant
Renal Disorder Death 67 Male 8/3/2009 Lawyer United States
Primary
Concomitant
Visual Impairment Other Serious 2/1/2008 Male 8/17/2009 Consumer United States
Primary
Secondary
Concomitant
Troponin Increased Hospitalization 54 Female 8/26/2009 United States
Primary
Concomitant
Weight Decreased Death 73 Female 8/28/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 65 Female 155 lb 8/24/2009 United States
Primary
Concomitant
Unevaluable Event Hospitalization 50 Male 8/31/2009 United States
Primary
Concomitant
Urosepsis Death 91 Female 9/4/2009 Physician United Kingdom
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 50 Male 9/4/2009 United States
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 11/23/2007 66 Male 802 lb 9/3/2009 Lawyer United States
Primary
Concomitant
Injury Death 64 Female 9/10/2009 Lawyer United States
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 50 Male 9/10/2009 United States
Primary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 1/1/2000 45 Male 258 lb 9/23/2009 United States
Primary
Concomitant
Visual Impairment Other Serious 60 Male 215 lb 9/16/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 64 Female 155 lb 9/17/2009 United States
Primary
Concomitant
Varices Oesophageal Hospitalization 11/23/2007 64 Male 364 lb 9/18/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Required Intervention 64 Female 155 lb 9/24/2009 United States
Primary
Concomitant
Weight Increased Other Serious 55 Male 215 lb 9/28/2009 United States
Primary
Concomitant
Urinary Tract Infection Other Serious 4/23/2007 54 Female 258 lb 9/24/2009 United States
Primary
Concomitant
Rhabdomyolysis Other Serious 77 Female 10/8/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Required Intervention 64 Female 10/12/2009 United States
Primary
Concomitant
Weight Increased Other Serious 55 Male 215 lb 10/17/2009 United States
Primary
Concomitant
Hyperhidrosis Hospitalization 8/28/2009 67 Male 123 lb 8/31/2009 Pharmacist United States
Primary
Concomitant
Myositis Other Serious 6/11/2008 78 Male 10/23/2009 United Kingdom
Primary
Concomitant
Ventricular Dysfunction Hospitalization 54 Female 10/22/2009 United States
Primary
Concomitant
Vision Blurred Other Serious 59 Female 10/26/2009 United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2003 Male 160 lb 11/6/2009 Consumer United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 59 Female 11/2/2009 United States
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 82 Female 11/9/2009 Physician United States
Primary
Secondary
Concomitant
Cardiac Disorder Other Serious 9/23/2009 Female 11/11/2009 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Weight Increased Other Serious 55 Male 215 lb 11/4/2009 United States
Primary
Concomitant
Weight Decreased Death 73 Female 11/5/2009 United States
Primary
Concomitant
Weight Decreased Other Serious Male 11/9/2009 United States
Primary
Concomitant
Vision Blurred Other Serious 56 Female 11/18/2009 United States
Primary
Concomitant
Ulcer Hospitalization 67 Male 11/20/2009 United States
Primary
Concomitant
Weight Decreased Other Serious 73 Male 11/17/2009 United States
Primary
Concomitant
Weight Decreased Hospitalization 61 Female 11/17/2009 Lawyer United States
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 50 Male 11/18/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 4/23/2007 54 Female 258 lb 11/18/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Required Intervention 64 Female 155 lb 11/20/2009 United States
Primary
Concomitant
Weight Increased Other Serious 55 Male 215 lb 11/24/2009 Consumer United States
Primary
Concomitant
Renal Failure Other Serious Male 11/30/2009 Lawyer United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2007 Male 296 lb 12/1/2009 Physician United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 2/27/2009 67 Male 214 lb 12/4/2009 Other Health Professional United Kingdom
Primary
Concomitant
Visual Impairment Other Serious 2/1/2002 Female 12/7/2009 Consumer United States
Primary
Secondary
Concomitant
Blood Urea Increased Other Serious 10/1/2009 83 Female 12/10/2009 Other Health Professional United States
Primary
Concomitant
Skin Lesion 5/15/2008 Male 235 lb 12/11/2009 Consumer United States
Primary
Concomitant
Pleural Effusion Hospitalization 2/28/2009 78 Male 12/17/2009 United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 79 Male 12/10/2009 United States
Primary
Concomitant
Drug Ineffective Hospitalization 1/1/2008 Male 12/23/2009 Consumer
Primary
Concomitant
Dyspnoea Other Serious 11/8/2009 62 Male 173 lb 12/23/2009 United States
Primary
Concomitant
Tremor Other Serious 12/1/2009 Male 12/23/2009 Consumer United States
Primary
Concomitant
Weight Increased Other Serious 55 Male 215 lb 12/23/2009 Lawyer United States
Primary
Concomitant

Drug Data